化学最新文献

{"title":"Tellurium nanoparticles and Fucoidan-loaded dissolvable microneedles for combined photothermal therapy and anti-angiogenesis in melanoma treatment.","authors":"Zhaoyi Ye, Yushan Li, Yu Sun, Huiling Ye, Junze Tang, Guining Cao, Zhenzhen Feng, Ying Bao, Yaoxun Zeng, Zhenxing Pan, Xujie Liu, Yan He","doi":"10.1016/j.ijbiomac.2024.139153","DOIUrl":"10.1016/j.ijbiomac.2024.139153","url":null,"abstract":"<p><p>Melanoma, an aggressive skin tumor, is prone to metastasis, significantly reducing patient survival rates once it occurs. Tumor microvascularity is a key factor in metastasis, making the inhibition of microvascular formation crucial. Emerging photothermal therapy (PTT) and microneedles (MNs) have garnered attention due to their non-invasive and controllable nature. In this study, we designed dissolvable MNs loaded with bovine serum albumin (BSA)-coated tellurium nanoparticles (Te NPs) and fucoidan for comprehensive melanoma treatment. Poly (2-ethyl-2-oxazoline) (PetOx) and chondroitin sulfate (CS) were employed to fabricate dissolvable MNs. Polycaprolactone (PCL), a non-water-soluble material, was used as the substrate. Te NPs, with their strong photothermal conversion capability, acted as the photothermal agent. Fucoidan, derived from brown algae, possesses anti-tumor and angiogenesis inhibition activities. Upon insertion into the skin, the microneedle tip dissolves in the tissue fluid, releasing Te NPs and fucoidan, while the substrate is removed. Under near-infrared (NIR) laser irradiation, Te NPs achieve PTT, effectively killing tumor cells. Fucoidan inhibits tumor growth by obstructing angiogenesis, thereby cutting off the tumor's nutrient supply. The designed MNs achieved effective tumor suppression through combination therapy with minimal in vivo side effects, providing a safe and effective melanoma treatment.</p>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"139153"},"PeriodicalIF":7.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142906297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the bone regenerative effect of glycogen synthase kinase 3 antagonist Tideglusib carried by different scaffolds on rat calvarial defects.","authors":"Mümin Çalık, Semra Unal, Berna Alemdag, Oğuzhan Gündüz, Merva Soluk Tekkeşin, Bensu Ozen, Ipek Islek, Leyla Kuru, Omer Birkan Agrali","doi":"10.1016/j.ijbiomac.2024.139350","DOIUrl":"10.1016/j.ijbiomac.2024.139350","url":null,"abstract":"<p><p>The aim was to explore the efficiency of Tideglusib in bone tissue healing by carrying it with different scaffolds on rat calvarial lesions. Twentyfour male Dawley rats were utilized. Two bone defects of 5 mm in diameter were formed (n = 8). Groups constituted negative control, collagen sponge + Tideglusib (CT), bacterial cellulose carrier (BC), bacterial cellulose carrier + Tideglusib (BC + T), PCL/Gel nanocarrier (Nano) and PCL/Gel + Tideglusib (Nano+T). After four week, histomorphometric and immunohistochemistry investigations were performed. Pairwise comparisons by means of the new bone formation (NBF) effect of Tideglusib demonstrated a significant difference between the control and the Nano+T groups solely (p < 0.05). BC group demonstrated reduced NBF in comparison to the CT group (p < 0.05), Nano group (p < 0.01) and Nano+T group (p < 0.01). Similarly, the BC + T group exhibited a diminished rate of NBF in comparison to both the Nano (p < 0.01) and Nano+T groups (p < 0.01). Type I collagen expression decreased in the BC group (p < 0.05) and BC + T group (p < 0.05) relative to the control. Axin2 expression was increased in the Nano+T group (p < 0.05) compared to the control. Within the limits, Tideglusib delivered with a nanocarrier containing PCL/Gel may have favorable impact on bone regeneration. However, the impact may vary with different carrier.</p>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"139350"},"PeriodicalIF":7.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142913288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of an indirect competitive lateral flow immunoassay for the detection of acetaminophen (paracetamol) in bovine urine.","authors":"Samantha Sasse, Ariadni Geballa-Koukoula, Toine F H Bovee","doi":"10.1007/s00216-024-05721-y","DOIUrl":"10.1007/s00216-024-05721-y","url":null,"abstract":"<p><p>Paracetamol (PCM) is a commonly used analgesic and antipyretic agent for humans worldwide. However, PCM overdoses or overuse can cause health issues, such as hepatoxicity. As PCM is also used for the treatment of farm animals, it is essential to monitor these residues in animal-derived matrices at risk-based sites in order to minimize the intake of PCM through the food chain. In the present study, we have developed a novel carbon nanoparticle (CNP)-based indirect competitive lateral flow immunoassay (icLFIA) for the rapid detection of PCM in bovine urine. The developed icLFIA can detect PCM residues within 10 min, and its performance was validated according to Commission Implementing Regulation (EU) 2021/808, i.e., determination of the detection capability (CCβ), specificity, robustness, and stability. The CCβ of the icLFIA for PCM in bovine urine is 5 mg/L and the icLFIA is proven to be selective and specific towards PCM in bovine urine, as no matrix interference and cross-reactivity were observed, except for high concentrations of orthocetamol. The icLFIA for PCM in bovine urine is robust to (small) variations in reading time, but it remains necessary to strictly use a dilution ratio of running buffer/bovine urine of 80/20. Moreover, the produced icLFIAs are stable for at least 56 days under the stored conditions. In conclusion, the developed and validated icLFIA provides a rapid and cost-effective method for on-site monitoring of PCM abuse in cattle.</p>","PeriodicalId":462,"journal":{"name":"Analytical and Bioanalytical Chemistry","volume":" ","pages":"1177-1186"},"PeriodicalIF":3.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11802664/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142942333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Bombyx mori UFBP1 regulates apoptosis and promotes BmNPV proliferation by affecting the expression of ER chaperone BmBIP\" [Int. J. Biol. Macromol. 283 (2024) 137681-137692].","authors":"Haonan Meng, Heng Ai, Danting Li, Xiaochun Jiang, Hualing Zhang, Jiaping Xu, Shoujun Huang","doi":"10.1016/j.ijbiomac.2024.139214","DOIUrl":"10.1016/j.ijbiomac.2024.139214","url":null,"abstract":"","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":"292 ","pages":"139214"},"PeriodicalIF":7.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142908928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of chitosan/diosgenin-infused manganese dioxide nanocomposite for highly effective photocatalytic and antibacterial activity.","authors":"C Krishna Raj, R Siranjeevi, R Susmitha, S Sameera Shabnum, P Nivetha, K Benazir, A Saravanan, A S Vickram","doi":"10.1016/j.ijbiomac.2024.139380","DOIUrl":"10.1016/j.ijbiomac.2024.139380","url":null,"abstract":"<p><p>The efficacy of the nanocomposite of manganese dioxide and diosgenin-incorporated chitosan (MnO₂/Dio@CS) was assessed by studying the photodegradation of two organic dyes, Acid Green (AG) and Malachite Green Oxalate (MGO), under visible light irradiation. The synthesized MnO₂/Dio@CS nanocomposites were characterized by Field Emission Scanning Electron Microscopy (FESEM), High-Resolution Transmission Electron Microscopy (HRTEM), Fourier Transform Infrared Spectroscopy (FTIR), X-ray diffraction (XRD), UV-vis spectroscopy. The MnO₂/Dio@CS nanocomposites exhibited exceptional photocatalytic efficacy, prolonged durability, and quick degradation of the dye solution to 87.55 % (AG) and 85.47 % (MGO) within a mere 60 min. The degrading effectiveness of the MnO₂/Dio@CS nanocomposites was much greater when compared to pure MnO₂ nanoparticles. It demonstrates remarkable efficacy in decomposing the AG and MGO dyes. This research evaluated and revealed the antibacterial efficacy of the MnO₂/Dio@CS nanocomposite against Bacillus subtilis and Pseudomonas aeruginosa. The nanocomposite exhibited significant antibacterial activity, as evidenced by its ability to effectively inhibit bacterial growth and form distinct zones of inhibition. This suggests that the MnO₂/Dio@CS nanocomposite could serve as a dual-functional material with both photocatalytic and antibacterial properties, making it a promising candidate for environmental and wastewater treatment applications.</p>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"139380"},"PeriodicalIF":7.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142913285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxidized yeast glucan alleviates lead-induced toxicity in mice by improving intestinal health to inhibit Pb absorption and reducing kidney oxidative stress.","authors":"Shuai Chen, Xinyi Zhu, Yujie Guo, Ningzhe Kang, Qilin Huang","doi":"10.1016/j.ijbiomac.2024.139205","DOIUrl":"10.1016/j.ijbiomac.2024.139205","url":null,"abstract":"<p><p>This study investigated the protective effects and Pb-excretion mechanisms of yeast glucans (YG) with varying oxidation degrees in Pb-exposed mice. Results demonstrated that all three glucans effectively reduced blood lead levels, alleviated inflammation, and mitigated liver damage in Pb-exposed mice, with highly oxidized yeast glucan (OYG2) exhibiting the greatest efficacy. Furthermore, the glucans attenuated Pb-induced oxidative stress and pathological changes in the kidney by elevating glutathione and superoxide dismutase levels, thereby restoring renal excretory function (blood urea nitrogen and creatinine). This restoration contributed to maintaining electrolyte homeostasis (Na⁺, Cl^-, K⁺) and significantly enhanced lead excretion efficiency via urine. Additionally, the glucans modulated intestinal microbiota balance, promoted short-chain fatty acid production, and repaired Pb-induced intestinal barrier damage by upregulating tight junction proteins (ZO-1, Occludin, Claudin-1). In conclusion, yeast glucans, particularly OYG2, effectively inhibited Pb absorption and facilitated its excretion through feces, highlighting their potential as a therapeutic strategy for lead toxicity.</p>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"139205"},"PeriodicalIF":7.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142902400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functionalization of almond gum through covalent and non-covalent interactions for biomedical applications.","authors":"Vikrant Sharma, Priyanka Sharma, Baljit Singh","doi":"10.1016/j.ijbiomac.2024.139364","DOIUrl":"10.1016/j.ijbiomac.2024.139364","url":null,"abstract":"<p><p>The versatile properties of carbohydrate polymers make them a relevant, promising precursor to design innovative materials for use in biomedical applications. Recent research mainly focuses on the development of the polysaccharide based functional materials. Hydrogel derived materials are a source of great motivation for the development of drug delivery (DD) carriers with inherent therapeutic potential. Herein, almond gum-based hydrogels were synthesized for the delivery of the anticancer drug methotrexate after impregnation to improve the DD profile. Hydrogels were characterized by FESEM, EDS, AFM, ¹³C NMR, FTIR, TGA, DSC, XRD, mechanical strength & biomedical assay. The optimized network hydrogel exhibited a mesh size of 19.764 mm and a cross-linking density of 5.002 × 10^-5 mol/cm³ of the hydrogels. Morphological features revealed irregular, uneven internal morphology of hydrogels in FE-SEM. The inclusion of sulphated and amide polymers in hydrogels was found in elemental composition (C = 60.72 %, O = 29.79 %, N = 6.63 % and S = 2.86 %) of hydrogels inferred from EDS. Spectroscopic characterization by FT-IR and ¹³C NMR confirmed the inclusion of PVP and PVSA through grafting reaction. The crosslinked product formed was found thermally stable and amorphous in nature through TGA and XRD analysis. The sustained release was found through supramolecular interactions and release complied a non-Fickian mechanism for drug diffusion (n = 0.73) and the release profile was best described by the Hixson-Crowell kinetic model in colonic pH. The hydrogels were mucoadhesive in nature and required 144 ± 10.54 mN force for the separation of hydrogels from the mucosal surface during the adhesion test. Hydrogel illustrated antioxidant activity (32.68 ± 0.83 μg GAE) during their radical scavenging test by FC reagent assay. Drug encapsulated hydrogels demonstrated antimicrobial efficacy against microbes. The results of physico-chemical and biomedical properties of hydrogels suggested their suitability for biomedical uses.</p>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"139364"},"PeriodicalIF":7.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142913332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multifunctional nanocellulose hybrid films: From packaging to photovoltaics.","authors":"Joaquin Valdez Garcia, Anna Boding, Xuan Yang, Rustem Nizamov, Michael S Reid, Kristina Junel, Kati Miettunen, Tiffany Abitbol, Joice Kaschuk","doi":"10.1016/j.ijbiomac.2024.139203","DOIUrl":"10.1016/j.ijbiomac.2024.139203","url":null,"abstract":"<p><p>This study aimed to develop eco-friendly multifunctional nanocellulose (NC) hybrid films with tailored properties for versatile applications including packaging and photovoltaics. Hybrid films composed by cellulose nanocrystals (CNC) and carboxymethylated cellulose nanofibrils (CNF) were produced at various mass ratio (CNC - 100:0 to 0:100). Montmorillonite clay (MTM) was incorporated (50 % by mass) into the CNC:CNF films. CNC-only films easily dispersed in water, but by adding CNF or MTM, the structural integrity was enhanced. Films with ≥50 % CNF and MTM had a strength reduction of 9-35 % and increased brittleness. The hybrid films presented transmittance above 60 % and haze varying from 5 % to 60 % at 550 nm which can be a beneficial for light management. All films kept color stability over 1000 h of artificial sunlight, a critical packaging feature for long-term storage. CNC: CNF films without MTM showed better potential for optoelectronic applications due to higher transmittance and smoother surfaces, while those with MTM presented UV protection (up to 250 nm) and swelling resistance (28-53 %) which could also benefit optoelectronics increasing their lifespan. Balancing the hybrid films composition is key for optoelectronics, while packaging applications tolerate broader compositions. These findings demonstrate the versatility of NC hybrid films in creating sustainable materials for diverse applications.</p>","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":"292 ","pages":"139203"},"PeriodicalIF":7.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142891138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gold nanoclusters/manganese dioxide nanosheets hybrid nanozyme with fluorescence and oxidase-like activity for dual-mode detection of acetylcholinesterase and inhibitors screening.","authors":"Jie Lv, Chengcai He, Jingcheng Cao, Qiuyan Shuai, Xifang Liu, Meng Li, Yulong Lin","doi":"10.1007/s00216-024-05712-z","DOIUrl":"10.1007/s00216-024-05712-z","url":null,"abstract":"<p><p>The abnormal expression of acetylcholinesterase (AChE) is linked to the development of various diseases. Accurate determination of AChE activity as well as screening AChE inhibitors (AChEIs) holds paramount importance for early diagnosis and treatment of AChE-related diseases. Herein, a fluorescent and colorimetric dual-channel probe based on gold nanoclusters (AuNCs) and manganese dioxide nanosheets (MnO₂ NSs) was developed. The fluorescence of AuNCs was suppressed in the presence of MnO₂ NSs, providing a platform for fluorescence-based detection. For colorimetric, the nanocomposites exhibited oxidase-like activity, rapidly catalyzing 3,3',5,5'-tetramethylbenzidine (TMB) to generate a blue color. Thiocholine (TCh), produced through the enzymatic reaction of acetylthiocholine (ATCh) in the presence of AChE, can reduce the MnO₂ NSs, thus recovering the suppressed fluorescence of AuNCs and decreasing oxidase-like activity. Based on this principle, a dual-mode assay for AChE detection was achieved. Compared to the commonly used single-signal detection, multi-mode detection can offer reliable and accurate results, due to its inherent self-validation and self-regulation capabilities. Under optimum conditions, the limit of detection (LOD) for AChE activity was 0.067 mU mL^-1 (fluorescent mode) and 0.042 mU mL^-1 (colorimetric mode). Moreover, the probe realized AChE detection in biological samples and AChEIs screening. This work showed the great prospects for early diagnosis of AChE-related diseases.</p>","PeriodicalId":462,"journal":{"name":"Analytical and Bioanalytical Chemistry","volume":" ","pages":"1093-1104"},"PeriodicalIF":3.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142891278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation of ofloxacin molecularly imprinted polymer Raman sensor based on magnetic graphene oxide.","authors":"Minyi Hui, Xi Ma, Jiayu Yuan, Zhouping Wang, Xiaoyuan Ma","doi":"10.1007/s00216-024-05714-x","DOIUrl":"10.1007/s00216-024-05714-x","url":null,"abstract":"<p><p>Ofloxacin is a commonly used quinolone antibiotic that is also used as a feed supplement in livestock production and in plant disease prevention and treatment. However, the excessive use and abuse of ofloxacin will accumulate along the food chain and endanger human health. Therefore, the development of a simple, rapid, and sensitive detection method for the determination of ofloxacin is critical. Herein, a detection method combining molecularly imprinted magnetic solid-phase extraction (MISPE) and surface-enhanced Raman spectroscopy (SERS) was developed for the detection of ofloxacin. Graphene oxide supported by magnetic beads was synthesized by a one-pot method, producing what was subsequently referred to as magnetic graphene oxide (MGO), and a molecularly imprinted membrane was synthesized on its surface by exploiting the ability of dopamine to self-polymerize under alkaline conditions. MGO@MIPs were obtained as the adsorbent for magnetic solid-phase extraction, which was used for the extraction and enrichment of ofloxacin in complex sample matrix, and then quantitative analysis was conducted by SERS. The developed method exhibited an excellent linear relationship with respect to ofloxacin concentration (10^-5 to 10² μg mL^-1), with a detection limit of 9.7 × 10^-6 μg mL^-1 in ultrapure water. Blank honey, milk, and pork samples spiked with ofloxacin at concentrations of 0.005, 0.1, 1, and 10 μg mL^-1 were extracted and determined using the developed method, with recoveries ranging from 93.1% to 105.6%. The results support the strong application prospects for the method, demonstrating simple and time-efficient operation and high accuracy.</p>","PeriodicalId":462,"journal":{"name":"Analytical and Bioanalytical Chemistry","volume":" ","pages":"1127-1138"},"PeriodicalIF":3.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142963400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}