化学最新文献

{"title":"Three Cases of Hematoma in the Retropharyngeal Space.","authors":"Mitsuo P Sato, Naoki Otsuki, Satoru Koike, Ryuji Yasumatsu","doi":"10.1177/01455613221141231","DOIUrl":"10.1177/01455613221141231","url":null,"abstract":"<p><p>ObjectivesHematoma in the retropharyngeal space (RPS) is a life-threatening condition that leads to rapid airway obstruction. However, the indication for airway management remains unclear. Additionally, the requirement for surgical hematoma evacuation remains undetermined. Therefore, we attempt to suggest some criteria for the management of hematoma in such cases.MethodsWe report three cases of hematoma in the RPS wherein one patient was treated without surgery and the other two underwent tracheotomy followed by hematoma evacuation.ResultsWe found that airway management should be based on whether the glottis could be visible on laryngoscopy and dyspnea severity. The degree of hematoma, swelling, subcutaneous bleeding in the anterior neck, and emotional stability should also be considered. Proper management during the acute phase may allow for conservative treatments. Hematomas extending below the tracheal bifurcation may help ease upper airway obstruction due to pressure distribution, allowing for conservative treatment. When hematomas are surgically evacuated, tracheotomy should be performed simultaneously. Our report suggests that mediastinal hematoma evacuation could be avoided.ConclusionWe should determine a therapeutic strategy for hematoma in RPS based on glottis visualization, patient's condition, and extent of hematoma growth under careful observation.</p>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":" ","pages":"NP594-NP598"},"PeriodicalIF":17.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40701363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Preliminary Study on the Characteristics and Standard Diagnosis and Treatment of Vestibular Dysfunction in Children.","authors":"Ruru Tian, Haiqin Zhang, Daoyu Xie, Jinv Ding, Jianhua Jiang","doi":"10.1177/01455613221139399","DOIUrl":"10.1177/01455613221139399","url":null,"abstract":"<p><p>ObjectiveTo understand the pathogenesis of vestibular dysfunction in children and to provide a reference for the diagnosis and treatment of vestibular dysfunction in children.MethodsA retrospective analysis was conducted on 80 children who visited our hospital from June 2011 to July 2020, aged between 4 and 17 years, with a duration of 1 day to 3 years. They were admitted to the hospital for treatment upon vestibular function-related examinations confirmed that there was peripheral vestibular function impairment.ResultsChildren aged 6-12 years old who are diagnosed are significantly more than other two age groups (4-6) and (12-17) (X² = 101.738, <i>P</i> < .001). There was a significant statistical difference (X² = 91.195, <i>P</i> < .001) in comparison of abnormal rates of vestibular function-related examinations. The Mann test had the highest abnormal rate and the lowest <i>Cervical Vestibular Evoked Myogenic Potential</i> (cVEMP) abnormality rate. Comparison of abnormal consistency rates for quantitative and qualitative examination of vestibular function, the abnormal rates (double temperature test and Mann test) were significantly better than other abnormal consistency rates, and there were statistical differences (X² = 7.485, <i>P</i> = .024 < .05). Among the children with vestibular dysfunction, the etiology was most common in 58 cases (72.50%) of benign paroxysmal vertigo, 4 cases of vestibular migraine (5.00%), 8 cases (10.00%) of vestibular neuronitis, of which 22 cases (27.50%) were combined with other diseases, and the most common was 15 cases (18.75%) of sinusitis.ConclusionA limited number of studies were conducted on vestibular dysfunction in children. The current retrospective analysis suggests that age, gender, and side of ear pain have no significant effects, while children aged 6-12 are more likely to suffer from vestibular dysfunction. On children's vestibular dysfunction, more etiology is unclear, and special attention should be paid to differential diagnosis when giving treatment and the child's medical history should be examined in detail and appropriate vestibular function tests should be selected in order to provide timely, effective, and accurate treatment for the child.</p>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":" ","pages":"NP606-NP612"},"PeriodicalIF":17.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40686789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Sphenoid Mucocele Causing Hypopituitarism.","authors":"Elif Gozgec, Hayri Ogul","doi":"10.1177/01455613221142123","DOIUrl":"10.1177/01455613221142123","url":null,"abstract":"<p><p>Mucocele is rarely seen in the sphenoid sinus. It may cause compression of neighboring structures due to significant destruction of the bony structure and its expansile nature. Although headache is the main symptom, it may present with different symptoms. Imaging methods play an important role in the diagnosis and differential diagnosis.</p>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":" ","pages":"548-549"},"PeriodicalIF":17.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40707315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Asthma control in normal weight and overweight/obese asthmatic children following adenotonsillectomy.","authors":"Gary D Josephson, Joshua B Bradshaw, Cheyenne Roohani, Jobayer Hossain, Steven M Andreoli, Jason E Lang","doi":"10.1177/01455613221101085","DOIUrl":"10.1177/01455613221101085","url":null,"abstract":"<p><p>ObjectivesChildhood adenotonsillar hypertrophy (ATH) with sleep-disordered breathing (SDB) frequently occurs concomitant with asthma. Adenotonsillectomy and reduction in asthma severity association has been reported. We describe changes in asthma control in nonobese or normal weight and obese/overweight children undergoing adenotonsillectomy for SDB.MethodsThis prospective, nonrandomized cohort trial with 6-month follow-up at a tertiary children's hospital enrolled 41 children with persistent asthma undergoing adenotonsillectomy for SDB. Children with significant chronic medical conditions, premature birth (< 28 weeks), or recent respiratory infection were excluded. Patients were stratified by baseline BMI into nonobese or normal weight (BMI <u><</u> 85 percentile) and obese/overweight (BMI > 85%). The primary outcome was change in Childhood Asthma Control Test (cACT) scores 3 and 6 months following adenotonsillectomy. Secondary outcome examined improvement in Pediatric Asthma Caregiver's Quality of Life Questionnaire (PACQLQ) 3 and 6 months following adenotonsillectomy.ResultsBaseline characteristics were similar except for anthropometric measures and mean PACQLQ (<i>P</i> = .03). Children with nonobese or normal weight (n = 26) had statistically significant improvement in change in cACT at 3 (22.80 ± 2.33 vs. 17.86 ± 3.53, <i>P</i> < .001) and 6 (20.71±3.29 vs. 18.24 ± 4.16, <i>P</i> = .044) months compared with baseline. PACQLQ scores also improved at 3 (6.20 ± 0.87 vs. 4.56 ± 1.12, <i>P</i> < .001) and 6 (6.36 ± 0.72 vs. 4.93 ± 0.96, <i>P</i> < .001) months. Obese/overweight children (n = 10) had significant improvement in cACT scores at 6 months (20.00 ± 3.90 vs. 15.00 ± 6.90, <i>P</i> = .048). Change of cACT scores at 3 months (17.86 ± 3.53 vs. 14.86 ± 6.31, <i>P</i> = .272) was not significantly different. PACQLQ scores improved at 3 (5.47 ± 1.09 vs. 3.70 ± 0.85, <i>P</i> < .001) and 6 (5.75 ± 2.19 vs. 3.67 ± 1.04, <i>P</i> = .016) months.ConclusionNonobese or normal-weight children undergoing adenotonsillectomy demonstrated significant improvement in asthma control scores at 3 and 6 and obese/overweight children at 6 months. Using the PACQLQ, caregiver quality of life improved for all children at 3 and 6 months. Surgical management of ATH in children with comorbid SBD and asthma is a good treatment option.</p>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":" ","pages":"NP613-NP617"},"PeriodicalIF":17.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40548597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recently progress in molten salt-assisted synthesis catalysts for photo−/electrocatalytic carbon dioxide reduction","authors":"Jungang Zhao ,&nbsp;Yueling Suo ,&nbsp;Jing Zhang ,&nbsp;Xuan Liu ,&nbsp;Caiting Li ,&nbsp;Yiming Liu","doi":"10.1016/j.ccr.2025.217085","DOIUrl":"10.1016/j.ccr.2025.217085","url":null,"abstract":"<div><div>To address the challenges posed by fossil fuel dependence and carbon neutrality goals, photo−/electrocatalytic carbon dioxide reduction (CO₂RR) technology has garnered significant attention due to its high-efficiency carbon conversion potential. However, the development of high-performance catalysts remains a core challenge. In the past five years, catalysts prepared by molten salt-assisted synthesis (MSAS) have rapidly emerged in the field of CO₂RR due to their unique physical and chemical properties, but there has been no comprehensive review of this system. Therefore, this paper innovatively conducts a systematic analysis of the structure-property relationships of MSAS catalysts in CO₂RR in recent years, filling the gap in this field. Additionally, the paper delves into the role of MSAS in optimizing light absorption, charge carrier separation, charge transport, and active site construction, revealing the intrinsic connection between material properties and catalytic performance. This review further proposes targeted synthesis strategies and performance enhancement pathways for catalysts, providing theoretical support for the development of efficient and stable CO₂RR catalysts, which hold significant implications for advancing carbon neutrality technologies.</div></div>","PeriodicalId":289,"journal":{"name":"Coordination Chemistry Reviews","volume":"546 ","pages":"Article 217085"},"PeriodicalIF":23.5,"publicationDate":"2025-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144858121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Empirical charge model taking into account the inductive effect to describe electrostatic interactions in compounds relevant to medicinal chemistry: assessment of applicability","authors":"V. S. Frolov,&nbsp;D. A. Shulga,&nbsp;A. R. Shaimardanov,&nbsp;V. A. Palyulin","doi":"10.1007/s11172-025-4684-5","DOIUrl":"10.1007/s11172-025-4684-5","url":null,"abstract":"<div><p>The applicability of the empirical charge model DENR (dynamic electronegativity relaxation) accounting for the inductive effect to the description of electrostatic interactions in compounds relevant to medicinal chemistry was assessed. Using a representative set of biologically relevant molecules selected from the PDBbind refined set, parameters of the DENR model were optimized to achieve the best fit to the reference molecular electrostatic potential (MEP) values calculated at the RHF/6-31G* level of theory. The results obtained using the DENR model and certain popular charge models aimed at reproducing the quantum chemical MEP values at RHF/6-31G* were compared. The cases were established where the DENR model provides better description of the electrostatic component of the energy of molecular interactions than the models that do not include the inductive effect. The scope of applicability of the DENR model was determined.</p></div>","PeriodicalId":756,"journal":{"name":"Russian Chemical Bulletin","volume":"74 7","pages":"1992 - 2006"},"PeriodicalIF":1.7,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144853570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis and spectral properties of zinc and magnesium phthalocyaninates containing diazenylphenoxy groups","authors":"T. V. Tikhomirova,&nbsp;A. N. Bychkova,&nbsp;A. A. Shishlova,&nbsp;A. S. Vashurin","doi":"10.1007/s11172-025-4690-7","DOIUrl":"10.1007/s11172-025-4690-7","url":null,"abstract":"<div><p>Optimum conditions were selected for the preparation of new phenols: azo dyes of various compositions, namely, 2-phenyldiazenyl-4-(2-phenylpropan-2-yl)phenol and (2,6-dibromo)phenyldiazenyl-4-(2-phenylpropan-2-yl)phenol. Nucleophilic substitution with 3- and 4-nitrophthalonitrile was carried out using the synthesized dyes to form 3/4-[2-phenyldiazenyl-4-(2-phenylpropan-2-yl]phenoxy- and 3/4-[2-(2,6-dibromo)-phenyl)diazenyl]-4-(2-phenylpropan-2-yl)phenoxyphthalonitriles. The metal complexes were synthesized by template condensation in a solution of the corresponding phthalonitrile with zinc or magnesium acetate. The compositions and structures of the synthesized compounds were confirmed by mass spectrometry and NMR, IR, and electronic absorption spectroscopy. The spectral and luminescence properties were studied, the yield of singlet oxygen generation of the synthesized phthalocyanines was determined, and the acid-base properties of the synthesized complexes were investigated.</p></div>","PeriodicalId":756,"journal":{"name":"Russian Chemical Bulletin","volume":"74 7","pages":"2052 - 2061"},"PeriodicalIF":1.7,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144853521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gallium complexes based on aminobisphenol ligands","authors":"G. A. Khromov,&nbsp;S. V. Timofeev,&nbsp;B. N. Mankaev,&nbsp;K. A. Lyssenko,&nbsp;S. S. Karlov","doi":"10.1007/s11172-025-4691-6","DOIUrl":"10.1007/s11172-025-4691-6","url":null,"abstract":"<div><p>A series of aminobisphenol ligands containing different substituents both on the aromatic moieties and at the central nitrogen atom were synthesized by the Mannich reaction. The reaction of dilithium derivatives of these ligands with gallium trichloride affords the corresponding ONO-type gallium monochloride complexes. The replacement of the chlorine atom by a <i>tert</i>-butoxide moiety allows the preparation of reactive complexes, which efficiently initiate the ε-caprolactone polymerization. The activity of the synthesized complexes as polymerization initiators was studied. The structures of three aminobisphenols and three gallium complexes were determined by X-ray diffraction.</p></div>","PeriodicalId":756,"journal":{"name":"Russian Chemical Bulletin","volume":"74 7","pages":"2062 - 2080"},"PeriodicalIF":1.7,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144853522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of the medium on the pathway of the reaction of S-(1S,2R,3S,5R)-2-formyl-6,6-dimethylnorpinan-3-yl thioacetate with chlorine dioxide","authors":"O. M. Lezina,&nbsp;S. N. Subbotina,&nbsp;O. N. Grebyonkina,&nbsp;D. P. Gerasimova,&nbsp;O. A. Lodochnikova,&nbsp;S. A. Lisovskaya,&nbsp;S. A. Rubtsova,&nbsp;A. V. Kutchin","doi":"10.1007/s11172-025-4692-5","DOIUrl":"10.1007/s11172-025-4692-5","url":null,"abstract":"<div><p>The reaction of <i>S</i>-(1<i>S</i>,2<i>R</i>,3<i>S</i>,5<i>R</i>)-2-formyl-6,6-dimethylnorpinan-3-yl thioacetate with chlorine dioxide in a pyridine—water solution was studied. The oxidative cleavage of the C—C bond between the carbonyl carbon and α-carbon atoms of the starting 2-formyl thioacetate of the pinane structure afforded new polyfunctional derivatives, (3<i>S</i>)- and (3<i>R</i>)-2-keto-3-sulfonic acids and 2-keto-3-chloro-3-sulfonic acid. The structure of the latter compound was determined by X-ray diffraction. The antifungal activity of the starting thioacetate and its keto derivative was evaluated against micellar forms of the fungi <i>Aspergillus niger</i> and <i>Fusarium oxysporum</i> and the yeast fungi of the genus <i>Candida</i>.</p></div>","PeriodicalId":756,"journal":{"name":"Russian Chemical Bulletin","volume":"74 7","pages":"2081 - 2091"},"PeriodicalIF":1.7,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144853523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"α-Alkyl-α-nitro ketones as 1,2- and 1,1-biselectrophiles. Synthesis of benzoxazoles, benzimidazoles, and quinoxalines","authors":"A. V. Aksenov,&nbsp;I. Yu. Grishin,&nbsp;V. V. Malyuga,&nbsp;D. A. Aksenov,&nbsp;R. G. Dzhioeva,&nbsp;N. A. Aksenov","doi":"10.1007/s11172-025-4695-2","DOIUrl":"10.1007/s11172-025-4695-2","url":null,"abstract":"<div><p>The reactivity of α-alkyl-α-nitroacetophenones with 1,2-phenylenediamines and <i>o</i>-aminophenols in acidic medium was examined. The reaction pathway depends on the catalyst used and provides access to the corresponding benzoxazoles, benzimidazoles, and quinoxalines <i>via</i> the aza-Nef-type reaction.</p></div>","PeriodicalId":756,"journal":{"name":"Russian Chemical Bulletin","volume":"74 7","pages":"2114 - 2124"},"PeriodicalIF":1.7,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144853526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}