化学最新文献_第9页

Urinary Incontinence and Quality of Life: A Cross-Sectional Study. 尿失禁与生活质量：一项横断面研究

IF 16.4 4区医学

Otjr-Occupation Participation and Health Pub Date : 2025-01-01 Epub Date: 2024-06-08 DOI: 10.1177/15394492241256869

Tania L Shearon, Jeffrey L Alexander

引用次数: 0

Fabrication of polyoxometalate dispersed cobalt oxide nanowires for electrochemically monitoring superoxide radicals from Hela cell mitochondria. 制备聚氧化铝分散氧化钴纳米线，用于电化学监测 Hela 细胞线粒体中的超氧自由基。

IF 5.6 1区化学

Talanta Pub Date : 2025-01-01 Epub Date: 2024-10-18 DOI: 10.1016/j.talanta.2024.127037

Chaoyao Geng, Xiujuan Zhang, Xinyao Zhu, Bingjie Li, Zhenhua Ren, Xiuhua Liu, Jadranka Travas-Sejdic, Xiaoqiang Liu

{"title":"Fabrication of polyoxometalate dispersed cobalt oxide nanowires for electrochemically monitoring superoxide radicals from Hela cell mitochondria.","authors":"Chaoyao Geng, Xiujuan Zhang, Xinyao Zhu, Bingjie Li, Zhenhua Ren, Xiuhua Liu, Jadranka Travas-Sejdic, Xiaoqiang Liu","doi":"10.1016/j.talanta.2024.127037","DOIUrl":"10.1016/j.talanta.2024.127037","url":null,"abstract":"An ultrasensitive electrochemical sensor is constructed by electrostatically adsorbing negatively charged hourglass-shape Cu-Polyoxometalate (POM) onto a positively charged CoO nanowires modified carbon cloth. The petaloid CoO nanowires have a large specific surface area that can well disperse open-structured Cu-POM to form Cu-POM@CoONWs@CC, which can maximumly expose catalytic active centers (Co2+ and Cu2+) and accelerate mass/charge transfer. In addition to the above advantages, the excellent electron exchange ability of Cu-POM and good conductivity of CoONWs@CC endow the sensor with good detection capability to H2O2 including a linear detection range of 0.05-1.4 μA μM-1, a low detection limit of 0.022 μM, high sensitivity of 110.48 μA μM-1, good selectivity and long-term stability. Due to the fast transformation of superoxide anion (O2∙-) to H2O2, the sensor can indirectly monitor the electron leakage resulting in the formation of O2∙- via detecting H2O2. Afterwards, Hela cell mitochondria were extracted from the living cells that cultured with different mitochondrial inhibitors and the release of O2∙- from the corresponding mitochondrial complexes was monitored by the sensor. Through comparing the current signals, we determined that complex I is probably the main electron leakage site. This work could provide meaningful information for the diagnosis of certain oxidative stress diseases.","PeriodicalId":435,"journal":{"name":"Talanta","volume":"282 ","pages":"127037"},"PeriodicalIF":5.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142455164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surface acoustic wave platform integrated with ultraviolet activated rGO-SnS₂ nanocomposites to achieve ppb-level dimethyl methylphosphonate detection at room-temperature. 表面声波平台与紫外线激活的 rGO-SnS2 纳米复合材料集成，实现室温下 ppb 级甲基膦酸二甲酯检测。

IF 5.6 1区化学

Talanta Pub Date : 2025-01-01 Epub Date: 2024-10-17 DOI: 10.1016/j.talanta.2024.127063

Jinbo Zhang, Jian Zhou, Hui Chen, Yihao Guo, Qikun Tian, Yanhong Xia, Guangzhao Qin, Jianfei Xie, Yongqing Fu

{"title":"Surface acoustic wave platform integrated with ultraviolet activated rGO-SnS2 nanocomposites to achieve ppb-level dimethyl methylphosphonate detection at room-temperature.","authors":"Jinbo Zhang, Jian Zhou, Hui Chen, Yihao Guo, Qikun Tian, Yanhong Xia, Guangzhao Qin, Jianfei Xie, Yongqing Fu","doi":"10.1016/j.talanta.2024.127063","DOIUrl":"10.1016/j.talanta.2024.127063","url":null,"abstract":"Dimethyl methylphosphonate (DMMP) is commonly used as an alternative for demonstrating to detect sarin, which is one of the most toxic but odorless chemical nerve agents. Among various types of DMMP sensors, those utilizing surface acoustic wave (SAW) technology provide notable advantages such as wireless/passive monitoring, digital output, and a compact, portable design. However, key challenges for SAW-based DMMP sensors operated at room temperature lies in simultaneous enhancement of sensitivities and reduction of detection limits. In this study, we developed a binary material strategy by combining reduced graphene oxide (rGO) and tin disulfide (SnS2) with (100)-facets orientation as sensing layers of SAW device for DMMP detection utilized at room temperature. Ultraviolet (UV) light was applied to activate the sensitive film and reduce the sensor's response time. The developed SAW DMMP sensor demonstrated a superior sensitivity (-1298.82 Hz/ppm), a low detection limit of 50 ppb, and a hysteresis below 1.5%, along with fast response/recovery time (39.2 s/28.4 s), excellent selectivity, long-term stability and repeatability. The formation of shrub-like rGO-SnS2 heterojunctions with abundant surface defects and large specific surface areas, high-energy (100) crystalline surfaces of SnS2, and photogenerated carriers generated by UV irradiation were pinpointed as the crucial sensing mechanisms. These factors collectively enhanced adsorption and reaction dynamics of DMMP molecules.","PeriodicalId":435,"journal":{"name":"Talanta","volume":"282 ","pages":"127063"},"PeriodicalIF":5.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142455173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Elucidating the genetic basis of bulb-related traits in garlic (Allium sativum) through genome-wide association study. 通过全基因组关联研究阐明大蒜（Allium sativum）鳞茎相关性状的遗传基础。

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-01-01 Epub Date: 2024-11-22 DOI: 10.1016/j.ijbiomac.2024.137842

Yamei Wang, Wenjing Han, Taotao Wang, Chunying Jia, Jiajia Liu, Xiaorong Fan, Jingguang Chen

{"title":"Elucidating the genetic basis of bulb-related traits in garlic (Allium sativum) through genome-wide association study.","authors":"Yamei Wang, Wenjing Han, Taotao Wang, Chunying Jia, Jiajia Liu, Xiaorong Fan, Jingguang Chen","doi":"10.1016/j.ijbiomac.2024.137842","DOIUrl":"10.1016/j.ijbiomac.2024.137842","url":null,"abstract":"The genetic architecture of garlic bulb related traits were still not well elucidated due to its big and complex genome. In this study, genotyping-by-sequencing (GBS) in 163 garlic accessions mainly from China were conducted. All the 163 garlic accessions were divided into three subpopulations, and largely consistent with geographic origins. Genome-wide association study (GWAS) was conducted for 5 garlic bulb related traits across four environments. Totally, 26 significantly loci were identified in two or more environments and located within or near 431 genes, and explain 14.0-31.7 % of the phenotypic variances. Among these, qBW5.1 was nearly with the qBH5.1. Four loci were reported previously, whereas the remaining 22 are likely to be new. Gene ontology enrichment analysis showed that the candidate genes were significantly enriched in metabolic process, biosynthetic process and catalytic activity. Nine candidate genes encode the zinc finger domain-containing protein, serine/threonine-protein kinase, peroxygenase, auxin-induced protein, ethylene-responsive transcription and E3-Ubiquitin protein ligases were identified and validated. Additionally, a meaningful achievement is one kompetitive allele-specific PCR marker, Kasp_chr7_BW for bulb weight were successfully developed and validated in a diverse panel. These results uncover the genetic mechanism of garlic bulb related traits and provide accessions and KASP markers for further garlic molecular breeding.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"137842"},"PeriodicalIF":7.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142694951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combination transcriptomic and metabolomic reveal deterioration of the blue honeysuckle (Lonicera caerulea L.) fruit and candidate genes regulating metabolism in the post-harvest stage. 转录组学和代谢组学的结合揭示了蓝色金银花（Lonicera caerulea L.）果实的变质以及采后阶段调节代谢的候选基因。

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-01-01 Epub Date: 2024-11-26 DOI: 10.1016/j.ijbiomac.2024.138074

Jing Chen, Chunlin Fu, Haoyu Wang, Xueqing Sun, Ke Ma, Hao Yang, Dong Qin, Junwei Huo, Huixin Gang

{"title":"Combination transcriptomic and metabolomic reveal deterioration of the blue honeysuckle (Lonicera caerulea L.) fruit and candidate genes regulating metabolism in the post-harvest stage.","authors":"Jing Chen, Chunlin Fu, Haoyu Wang, Xueqing Sun, Ke Ma, Hao Yang, Dong Qin, Junwei Huo, Huixin Gang","doi":"10.1016/j.ijbiomac.2024.138074","DOIUrl":"10.1016/j.ijbiomac.2024.138074","url":null,"abstract":"Blue honeysuckle, a new berry with high nutritional value, possesses typical berry postharvest properties, including extreme perishability, rapid quality loss, and high sensitivity to microbial infections. At present, the underlying mechanisms of postharvest quality deterioration, senescence, and low-temperature regulation remain largely unknown. This study aimed to elucidate the metabolic shifts and genetic regulation underlying the preservation or deterioration of blue honeysuckle during storage at room temperature (25 °C) and low temperature (4 °C). Storage at 4 °C inhibited fruit decay and preserved better visual quality, weight, firmness, and total soluble solid and acid contents. We identified 24 key differentially accumulated metabolites that specifically changed during the qualitative shift at room temperature and were effectively regulated by 4 °C. Commonly associated metabolites, sorbitol, succinic acid, malic acid, naringenin, pinobanksin, and taxifolin, characterize the deterioration of blue honeysuckle. These metabolites were integrated with transcriptomic data for weighted correlation network analysis (WGCNA). Regulatory networks were used for the identification of key genes and transcription factors (TFs) influencing sugar, organic acid, flavonoid, and phenolic acid metabolism during storage. The findings provide insight into metabolic regulation and the improvement of flavor in postharvest blue honeysuckle fruit.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"138074"},"PeriodicalIF":7.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142737975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of ultrasonic-alkali integrated extraction combined with Mannesi reaction on the antimicrobial properties of rice straw lignin and enhancement strategies. 超声波-碱综合萃取结合曼内斯反应对稻草木质素抗菌性能的影响及增强策略。

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-01-01 Epub Date: 2024-11-26 DOI: 10.1016/j.ijbiomac.2024.138047

Xiaoying Zhang, Fang Duan, Yue Su, Mengyu Wang, Jun Wang

{"title":"Effects of ultrasonic-alkali integrated extraction combined with Mannesi reaction on the antimicrobial properties of rice straw lignin and enhancement strategies.","authors":"Xiaoying Zhang, Fang Duan, Yue Su, Mengyu Wang, Jun Wang","doi":"10.1016/j.ijbiomac.2024.138047","DOIUrl":"10.1016/j.ijbiomac.2024.138047","url":null,"abstract":"Lignin is one of the most abundant and underused biopolymers in nature with limited antimicrobial activities. Herein, this work aimed to enhance the antimicrobial activity of lignin extracted from waste rice straw by ultrasonic-alkali integrated extraction (USP-AT) and modify the alkali lignin through Mannich reaction to improve its antimicrobial properties. The effects of ultrasonic pretreatment (USP) time on the chemical structure, morphology, antioxidant, and antibacterial activities of lignin were studied. The results demonstrated that the total phenolic content of USP-AT lignin was higher than that of lignin extracted by alkali treatment. Moreover, the antioxidant activity of USP-AT lignin was increased by 49.69 %-69.42 %. The antibacterial activity of USP-AT lignin against Escherichia coli and Staphylococcus aureus increased by more than 40 %. However, the antibacterial capacity of USP-AT lignin is far from meeting the requirements of antibacterial food packaging. The alkali lignin was modified by Mannich reaction in order to improve its antimicrobial properties against common spoilage microorganisms or pathogenic bacteria in food and packaging. The modified USP-AT lignin exhibit remarkable antimicrobial capacities to representative bacteria, molds, and yeasts. The antifungal capacity of modified USP-AT lignin against A. niger and P. citrinum were improved by more than 40 %.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"138047"},"PeriodicalIF":7.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142737999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Studying the role of thrombomodulin-plasminogen interaction in spatial and interfacial invasion of melanoma metastatic progression. 研究血栓调节蛋白-血浆蛋白酶相互作用在黑色素瘤转移进展的空间和界面侵袭中的作用。

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-01-01 Epub Date: 2024-11-24 DOI: 10.1016/j.ijbiomac.2024.138053

Thi Kim Ngan Ngo, Hua-Lin Wu, Cheng-Hsiang Kuo, Ting-Yuan Tu

引用次数: 0

Corrigendum to "Dose dependent safety implications and acute intravenous toxicity of aminocellulose-grafted-polycaprolactone coated gelatin nanoparticles in mice" [Int. J. Biol. Macromol. 192 (2021) 1150-1159].

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-01-01 Epub Date: 2024-12-03 DOI: 10.1016/j.ijbiomac.2024.137885

Rehan Khan, Anas Ahmad, Md Meraj Ansari, Abdullah F Alasmari, Nemat Ali, Mir Tahir Maqbool, Syed Shadab Raza

引用次数: 0

Corrigendum to "Effects of ultrasound combined with pH shift modification on functional and structural properties of peanut proteins" [Int. J. Biol. Macromol. 283 (2024) 137874].

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-01-01 Epub Date: 2024-11-30 DOI: 10.1016/j.ijbiomac.2024.138184

Xuan Zhang, Dongmei Yan, Wenjuan Qiu, Siyu Chen, Yu Hu, Jian Jin, Chibuike C Udenigwe

引用次数: 0

Effect of deep eutectic solvents on activity, stability, and selectivity of enzymes: Novel insights and further prospects.

IF 7.7 1区化学

International Journal of Biological Macromolecules Pub Date : 2025-01-01 Epub Date: 2024-11-28 DOI: 10.1016/j.ijbiomac.2024.138148

Duan Zhou, Xuefeng Chen, Gaimiao Li, Mouming Zhao, Daoming Li

{"title":"Effect of deep eutectic solvents on activity, stability, and selectivity of enzymes: Novel insights and further prospects.","authors":"Duan Zhou, Xuefeng Chen, Gaimiao Li, Mouming Zhao, Daoming Li","doi":"10.1016/j.ijbiomac.2024.138148","DOIUrl":"10.1016/j.ijbiomac.2024.138148","url":null,"abstract":"Deep eutectic solvents (DESs) have been extensively concerned since 2008 as reaction media in biocatalysis because of their excellent solvent performances. Here, we try to clarify the effects of DESs on the catalytic properties, structure, and conformation of enzymes. Through comprehensive analysis, it is found that the catalytic properties of enzymes can be designed in different DESs through modulating the hydrogen bond acceptors, hydrogen bond donors, and their molar ratio. Structural changes of different enzymes in various DESs are not always consistent, which may be attributed to the original structure of enzymes, DES composition, and the interactions between enzymes and DESs. Moreover, we try to elucidate how DESs interact with varying amounts of water, and furthermore how water in DES affects the catalytic properties of enzymes. The available researches indicate that proper amount of water can integrate into the network of DESs and strengthen the hydrogen-bonding interactions while excessive water will destroy the integrity of DESs. Water affects the performance of enzymes in two possible ways: 1) affecting enzyme affinity and structure directly; 2) influencing the properties of DESs, thus modulating the efficiency of enzymes. This review paves road for researchers to design DESs with desired properties for specific applications.","PeriodicalId":333,"journal":{"name":"International Journal of Biological Macromolecules","volume":" ","pages":"138148"},"PeriodicalIF":7.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142754423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0