IF 9.7 1区化学

Journal of Colloid and Interface Science Pub Date : 2025-12-15 Epub Date: 2025-08-06 DOI: 10.1016/j.jcis.2025.138645

Yan Zhuang, Shuang Meng, Yousen Wu, Jinlong Li, Xue Yang, Changxin Yuan, Tai Peng, Dongxuan Guo

{"title":"Enhanced overall water splitting performance in alkaline solutions using hollow nanocage nickel‑cobalt‑iron layered double hydroxide derived from zeolitic imidazolate framework-67: The synergy of fast etching and metallic ions.","authors":"Yan Zhuang, Shuang Meng, Yousen Wu, Jinlong Li, Xue Yang, Changxin Yuan, Tai Peng, Dongxuan Guo","doi":"10.1016/j.jcis.2025.138645","DOIUrl":"10.1016/j.jcis.2025.138645","url":null,"abstract":"The development of highly active, cost-effective, and durable electrocatalysts is critical for efficient water splitting. Layered double hydroxides (LDHs), with their excellent conductivity, large surface area, and three-dimensional (3D) open framework facilitating mass transport and active site accessibility, are ideal candidates. In this work, a ternary nickel‑cobalt‑iron LDH (NiCoFe-LDH) is synthesized via metal ion etching, leveraging synergistic intermetallic electronic interactions to enhance electrocatalytic performance. The as-prepared NiCoFe-LDH exhibits outstanding electrocatalytic performance under alkaline conditions, achieving low overpotentials of 79.60 ± 0.50 mV for the hydrogen evolution reaction (HER) and 373.40 ± 0.50 mV for the oxygen evolution reaction (OER) at 10 mA cm-2, along with Tafel slopes of 149.61 ± 0.50 and 77.84 ± 0.50 mV dec-1, respectively. It also demonstrates exceptional stability, with negligible performance degradation after 72 h of rigorous testing. For overall water splitting, NiCoFe-LDH requires only 1.56 ± 0.1 V to deliver 10 mA cm-2, highlighting its potential for efficient hydrogen production. The incorporation of Fe into NiCo-LDH induces significant electronic structure modifications, including electron delocalization and an upshift in the d-band center, while simultaneously modulating the spin states of Ni/Co ions. These synergistic effects collectively enhance both electrical conductivity and intermediate adsorption capacity. This work highlights cation exchange as an effective strategy for tailoring the electronic properties of layered hydroxides, demonstrating its potential for optimizing material performance in electrocatalysis applications.","PeriodicalId":351,"journal":{"name":"Journal of Colloid and Interface Science","volume":"700 Pt 3","pages":"138645"},"PeriodicalIF":9.7,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144803153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Construction of interlayer-structured MnS@MXene cathode via a electrostatic anchoring combined with confined sulfidation strategy for high-performance zinc-ion batteries. 高性能锌离子电池层间结构MnS@MXene阴极静电锚定与受限硫化策略的构建。

IF 9.7 1区化学

Journal of Colloid and Interface Science Pub Date : 2025-12-15 Epub Date: 2025-08-05 DOI: 10.1016/j.jcis.2025.138634

Jianjiang Mao, Yu Huang, Fei Cheng

{"title":"Construction of interlayer-structured MnS@MXene cathode via a electrostatic anchoring combined with confined sulfidation strategy for high-performance zinc-ion batteries.","authors":"Jianjiang Mao, Yu Huang, Fei Cheng","doi":"10.1016/j.jcis.2025.138634","DOIUrl":"10.1016/j.jcis.2025.138634","url":null,"abstract":"MnS materials have gained prominence as a promising cathode material for aqueous zinc-ion batteries (AZIBs) due to their exceptional electrical conductivity and superior electrochemical reactivity, but their practical applications are limited by the suboptimal reaction kinetics, inadequate cycle durability, as well as the ambiguities in the fundamental charge storage mechanisms. Herein, a unique interlayer-structured MnS@MXene cathode is designed and synthesized through an electrostatic anchoring combined with confined sulfidation approach, which enables in situ growth of MnS in MXene matrices, overcoming the challenges of weak interfacial bonding and uneven particle distribution encountered in traditional composite fabrication methods. The periodic stacking of MnS nanoparticles and MXene lamellae forms a large number of heterogeneous interfaces, which construct a good conductive network while offering an increased number of active sites for electrochemical reactions. When employed as a cathode material for AZIBs, the electrochemical activity of MnS is unlocked by the initial charging process, and it exhibits considerable capacity of 325 mAh g-1 at a current density of 0.2 A g-1 and superior cycling performance with a specific discharge capacity of 274 mAh g-1 even after 400 cycles at a current density of 0.5 A g-1. Even at a high current density of 2 A g-1, a reversible specific capacity of 105 mA g-1 is still achieved after 2500 cycles. The superior performance originates from the synergistic effect between the high electrical conductivity of MXene and the nanoscale dimension of MnS, which facilitates the electrochemical activation process of MnS involving a reversible conversion between MnOOH/ZnMn2O4 and Mn2O3/ZnMnO3 accompanied by the co-insertion/extraction of H+ and Zn2+.","PeriodicalId":351,"journal":{"name":"Journal of Colloid and Interface Science","volume":"700 Pt 3","pages":"138634"},"PeriodicalIF":9.7,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144797782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multilevel supramolecular assemblies achieving cascaded enhancement of superoxide anion radical generation for visible-light-driven thiocyanation of anilines. 实现级联增强可见光驱动苯胺硫氰化超氧阴离子自由基生成的多层超分子组装体。

IF 9.7 1区化学

Journal of Colloid and Interface Science Pub Date : 2025-12-15 Epub Date: 2025-08-05 DOI: 10.1016/j.jcis.2025.138580

Rong-Xin Zhu, Shi-Qian Jia, Ruizhi Dong, Hui Liu, Shengsheng Yu, Ling-Bao Xing

{"title":"Multilevel supramolecular assemblies achieving cascaded enhancement of superoxide anion radical generation for visible-light-driven thiocyanation of anilines.","authors":"Rong-Xin Zhu, Shi-Qian Jia, Ruizhi Dong, Hui Liu, Shengsheng Yu, Ling-Bao Xing","doi":"10.1016/j.jcis.2025.138580","DOIUrl":"10.1016/j.jcis.2025.138580","url":null,"abstract":"The significant enhancement in molecular oxygen activation via multilevel supramolecular assembly provides an effective strategy for advancing the design and development of high-efficiency supramolecular photosensitizer. Here, we designed and constructed a multilevel supramolecular assembly based on anthracene derivative (PA), cucurbit[7]uril (CB[7]), poly(sodium 4-styrenesulfonate) (PSS) and commercial dyes Cyanine 5 (Cy5). Among them, PA can efficiently absorb light energy and act as an energy donor, while CB[7] and PSS serve as the primary macrocycle and secondary assembly constraint to prominently enhance the fluorescence emission performance of PA. Meanwhile, Cy5 serves as an energy acceptor and efficiently participates in the fluorescence resonance energy transfer (FRET) process. By leveraging the synergistic effect of the cascade assembly process and FRET, the activation ability of molecular oxygen is significantly enhanced, which leads to an increased generation of superoxide anion radicals (O2•-), thereby facilitating efficient thiocyanation of aniline in an aqueous environment. It is worth noting that compared with PA-CB[7]-PSS, PA-CB[7]-PSS + Cy5 exhibits a higher O2•- generation and photocatalytic activity. Meanwhile, the cascade assembly PA-CB[7]-PSS also shows a similar performance improvement compared to PA-CB[7]. This indicates that the cascade assembly and FRET play a crucial role in enhancing O2•- generation and photocatalytic activity. This study highlights the crucial role of multilevel supramolecular assembly in the design and development of highly efficient supramolecular photosensitizers.","PeriodicalId":351,"journal":{"name":"Journal of Colloid and Interface Science","volume":"700 Pt 3","pages":"138580"},"PeriodicalIF":9.7,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144797785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thermodynamic descriptor-guided ligand screening enables dendrite-free zinc deposition in alkaline flow batteries. 热力学描述符引导配体筛选使碱性液流电池中的无枝晶锌沉积成为可能。

IF 9.7 1区化学

Journal of Colloid and Interface Science Pub Date : 2025-12-15 Epub Date: 2025-08-05 DOI: 10.1016/j.jcis.2025.138637

Xusheng Cheng, Tao Xuan, Haoran Hu, Jianchi Wang, Jiantao Zai, Liwei Wang

{"title":"Thermodynamic descriptor-guided ligand screening enables dendrite-free zinc deposition in alkaline flow batteries.","authors":"Xusheng Cheng, Tao Xuan, Haoran Hu, Jianchi Wang, Jiantao Zai, Liwei Wang","doi":"10.1016/j.jcis.2025.138637","DOIUrl":"10.1016/j.jcis.2025.138637","url":null,"abstract":"Alkaline zinc-based flow batteries suffer from poor zinc reversibility due to dendrite growth and parasitic reactions, which significantly shorten their cycling lifespan. A key challenge lies in the rational design of ligands to eliminate concentration polarization caused by mismatched diffusion and interfacial reaction rates, thereby inducing and regulating uniform zinc deposition. In this study, we propose a thermodynamic descriptor-guided ligand screening strategy, using the metal-ligand stability constant (log K) as a quantitative criterion to simultaneously optimize deposition morphology and interfacial ion kinetics. Guided by this principle, nitrilotriacetic acid (NTA, log K = 11.98) is identified as a robust chelating agent under strongly alkaline conditions (pH > 14). Its moderate coordination strength enables the disruption of the native Zn2+-H2O network, effectively suppressing hydrogen evolution while maintaining near-theoretical Zn2+ desolvation kinetics. In situ microscopy and electrochemical analyses reveal that NTA directs preferential Zn(002) growth, yielding dendrite-free deposition at ultrahigh current densities (80 mA cm-2) and high areal capacities (40 mAh cm-2). Furthermore, NTA facilitates efficient Zn2+ diffusion (5.77 × 10-7 cm2/s), outperforming strong chelators such as ethylenediaminetetraacetic acid. As a result, Zn//Zn symmetric cells exhibit stable cycling over 400 h, while NTA-enabled ZnFe flow batteries achieve 700 cycles with 99 % coulombic efficiency and minimal capacity decay. This work establishes log K as a practical screening descriptor for multi-objective electrolyte optimization and provides a scalable pathway for the development of high-performance alkaline zinc flow batteries.","PeriodicalId":351,"journal":{"name":"Journal of Colloid and Interface Science","volume":"700 Pt 3","pages":"138637"},"PeriodicalIF":9.7,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144833659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

N-methylpyrrolidone-based electrolyte modulated CF bond weakening and Interface optimization synergistically enhances Li/CF_x batteries energy density. 基于n -甲基吡咯烷酮的电解质调制CF键弱化和界面优化协同提高Li/CFx电池能量密度。

IF 9.7 1区化学

Journal of Colloid and Interface Science Pub Date : 2025-12-15 Epub Date: 2025-08-05 DOI: 10.1016/j.jcis.2025.138638

Fei Zhou, Jiangmin Jiang, Gaoyu Zhou, Lingbang Qiu, Wenxuan Fu, Chencheng Xu, Yanhua Cui, Quanchao Zhuang

{"title":"N-methylpyrrolidone-based electrolyte modulated CF bond weakening and Interface optimization synergistically enhances Li/CFx batteries energy density.","authors":"Fei Zhou, Jiangmin Jiang, Gaoyu Zhou, Lingbang Qiu, Wenxuan Fu, Chencheng Xu, Yanhua Cui, Quanchao Zhuang","doi":"10.1016/j.jcis.2025.138638","DOIUrl":"10.1016/j.jcis.2025.138638","url":null,"abstract":"Lithium/fluorinated carbon (Li/CFx) batteries have garnered substantial interest from researchers due to their superior energy density and low self-discharge characteristics. However, the strong covalent CF bond in the CFx cathode limits its discharge kinetics, affecting the actual power density and operating voltage. In this work, N-methylpyrrolidone (NMP) with high donor number has proposed as the main solvent of the electrolyte to facilitate the breaking of the CF bond through a bimolecular nucleophilic substitution (SN2) reaction. This strategy effectively reduces the energy barrier for Li+ embedding and improves interfacial reaction potential. Notably, NMP forms a nitrogen-rich cathode-electrolyte interface (CEI) membrane during the discharge process, which enhances interfacial ionic conductivity and stabilizes the electrode-electrolyte interface. The optimized electrolyte system achieves a discharge plateau of 2.7 V and an energy density of 2128 Wh kg-1 at 50 mA g-1, significantly surpassing that of the conventional electrolyte (COE). This study provides a low-cost electrolyte optimization strategy, offering a promising approach to maintaining the high energy density and discharge voltage of Li/CFx batteries.","PeriodicalId":351,"journal":{"name":"Journal of Colloid and Interface Science","volume":"700 Pt 3","pages":"138638"},"PeriodicalIF":9.7,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144803157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A novel fluorescent sensing platform for miRNA-210 detection based on signal amplification via SDA and self-assembly Cas12a system via RCT. 基于SDA信号放大和RCT自组装Cas12a系统的新型miRNA-210检测荧光传感平台

IF 6.1 1区化学

Talanta Pub Date : 2025-12-01 Epub Date: 2025-05-24 DOI: 10.1016/j.talanta.2025.128382

Chen Shen, Xiang Chen, Yan Yu, Lulu Qin, Guanhong Xu, Fangdi Wei, Jing Yang, Qin Hu, Yao Cen

{"title":"A novel fluorescent sensing platform for miRNA-210 detection based on signal amplification via SDA and self-assembly Cas12a system via RCT.","authors":"Chen Shen, Xiang Chen, Yan Yu, Lulu Qin, Guanhong Xu, Fangdi Wei, Jing Yang, Qin Hu, Yao Cen","doi":"10.1016/j.talanta.2025.128382","DOIUrl":"10.1016/j.talanta.2025.128382","url":null,"abstract":"In this work, a biosensing platform for miR-210 which is a potent biomarker for the early diagnosis of breast cancer was innovatively designed based on CRISPR/Cas12a by integrating strand displacement amplification and rolling circle transcription. The target opened the hairpin through toe-hold, allowing polymerization, incision and extension to occur which involved SDA. This process produced two chains: cycle chain and trigger. The cycle chain then complemented to the loop of the hairpin to open it, repeating the above process to generate additional trigger circularly. The trigger was bound to the notched dumbbell through base complementary pairing and then the dumbbell became intact by T4 DNA ligase. The closed dumbbell strand served as the initiator of transcription and the template for crRNA under the influence of T7 enzyme, and was responsible for the transcription of numerous crRNA sequences in a process called RCT. These sequences subsequently bound to Cas12a proteins, forming a binary complex. In the transcriptional state, the dumbbell was in an unwinding configuration, with the stem portion served as activator binding to the binary complex to facilitate trans-cleavage activity of Cas12a, which resulted in cleavage of the F-Q, generating fluorescent signals. The above platform could sensitively detect miR-210 with a detection limit of 6.67 fM. The platform has the advantages of being easy to use and flexible to sequence according to different target, making it feasible to detect different biomarkers in clinic settings.","PeriodicalId":435,"journal":{"name":"Talanta","volume":"295 ","pages":"128382"},"PeriodicalIF":6.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144179564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Speciation of inorganic and organometallic arsenic in various matrices with a novel SPME fiber functionalized with iron nanoparticles prior to LC-ICP-MS determination. 在LC-ICP-MS测定之前，一种新型的具有铁纳米粒子功能化的SPME纤维在不同基质中的无机和有机金属砷的形态。

IF 6.1 1区化学

Talanta Pub Date : 2025-12-01 Epub Date: 2025-05-24 DOI: 10.1016/j.talanta.2025.128373

Ezel Boyacı, Ali Çağır, Talal Shahwan, Ahmet E Eroğlu

{"title":"Speciation of inorganic and organometallic arsenic in various matrices with a novel SPME fiber functionalized with iron nanoparticles prior to LC-ICP-MS determination.","authors":"Ezel Boyacı, Ali Çağır, Talal Shahwan, Ahmet E Eroğlu","doi":"10.1016/j.talanta.2025.128373","DOIUrl":"10.1016/j.talanta.2025.128373","url":null,"abstract":"A novel SPME-LC-ICP-MS methodology is described for the simultaneous microextraction/speciation/determination of the metabolically critical inorganic and organoarsenic species, namely, As(III), As(V), dimethylarsinic acid (DMA), and monomethylarsonic acid (MMA) in natural waters such as drinking and geothermal waters, and biological fluids such as urine. The novelty of the study stems also from the use of home-made SPME fibers for the extraction process, and from the proposed methodology needing no derivatization step. SPME fibers were prepared with in-tube capillary template approach through the immobilization of iron nanoparticles into agarose matrix. The fibers demonstrated reproducible extraction (<10 % RSD), good mechanical strength and good solvent resistivity. The separation of the analytes was realized by HPLC with a strong anion exchange column via gradient elution using different concentrations of (NH4)2CO3 (pH 8.50), and the on-line detection of eluted analytes was achieved by ICP-MS. The validity of the proposed methodology was verified via the analysis of certified reference materials (SRM 1643e, Natural Water-Trace Elements, and SRM 2669, Arsenic Species in Frozen Human Urine) and through spike recovery tests. The values of percentage recovery for SRM 2669 were 90.7 % for As(III), 99.8 % for As(V), 93.6 % for DMA, and 85.9 % for MMA. A good correlation was also found between the certified (60.45 μgL-1) and determined (59.00 μgL-1) values for SRM 1643e. Moreover, the speciation capability of the method was demonstrated on various natural waters and biological fluids.","PeriodicalId":435,"journal":{"name":"Talanta","volume":"295 ","pages":"128373"},"PeriodicalIF":6.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The research on artificial intelligence-based Deer Velvet Antler traceability model based on emergent data features. 基于突发数据特征的人工智能鹿茸溯源模型研究。

IF 6.1 1区化学

Talanta Pub Date : 2025-12-01 Epub Date: 2025-05-22 DOI: 10.1016/j.talanta.2025.128357

Ke Shen, Peng Chen, Xiaoyu Yao, Xinru Nie, Herong Yu, Yu Li, Xiaoli Zhao, Chunqin Mao, Wei Zhang, Hui Xie, Tulin Lu

{"title":"The research on artificial intelligence-based Deer Velvet Antler traceability model based on emergent data features.","authors":"Ke Shen, Peng Chen, Xiaoyu Yao, Xinru Nie, Herong Yu, Yu Li, Xiaoli Zhao, Chunqin Mao, Wei Zhang, Hui Xie, Tulin Lu","doi":"10.1016/j.talanta.2025.128357","DOIUrl":"10.1016/j.talanta.2025.128357","url":null,"abstract":"Deer velvet antler(DVA) is highly valued for its nutritional properties, but its complex origins and widespread adulteration in the market have led to significant quality discrepancies. Therefore, this study aims to establish an efficient and accurate method for identifying different species of DVA to enhance classification accuracy and traceability. A total of 120 samples were collected from four species of deer antler velvet: Sika Deer Velvet Antler (SVA), Wapiti Velvet Antler (WVA), Reindeer Velvet Antler (RVA), and Moose Velvet Antler (MVA). Multidimensional features such as color, texture, odor, and composition were extracted using Computer Vision, Ultra-fast Gas Phase Electronic Nose, and High-Performance Liquid Chromatography (HPLC) techniques. Through multivariate statistical analysis (VIP >1, P < 0.05), 162 key discriminative factors were identified. Based on the principle of emergence, a classification model, Whale Optimization Algorithm- Random Forest (WOA-RF), was developed by combining Whale Optimization Algorithm (WOA) and Random Forest (RF) to optimize the classification process. The results demonstrated that the WOA-RF model achieved a 100 % success rate in classifying different DVA species. The proposed intelligent classification algorithm, based on the fusion of multidimensional data, not only enables highly efficient identification of DVA species but also reveals the emergent effects generated by the interaction of multidimensional features combined with optimization algorithms. This approach significantly surpasses the limitations of single techniques and provides crucial technical support and methodological guidance for food species identification and traceability.","PeriodicalId":435,"journal":{"name":"Talanta","volume":"295 ","pages":"128357"},"PeriodicalIF":6.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

AND logic gate-based alternating PER-Cas12a signal amplification system for ultrasensitive detection of sEVs. 基于AND逻辑门的交替PER-Cas12a信号放大系统，用于sev的超灵敏检测。

IF 6.1 1区化学

Talanta Pub Date : 2025-12-01 Epub Date: 2025-05-27 DOI: 10.1016/j.talanta.2025.128411

Man Wang, XuZhen Zhang, Jiayi Fan, Cuiling Zhang, Yuezhong Xian

{"title":"AND logic gate-based alternating PER-Cas12a signal amplification system for ultrasensitive detection of sEVs.","authors":"Man Wang, XuZhen Zhang, Jiayi Fan, Cuiling Zhang, Yuezhong Xian","doi":"10.1016/j.talanta.2025.128411","DOIUrl":"10.1016/j.talanta.2025.128411","url":null,"abstract":"Protein biomarkers on breast cancer-derived small extracellular vesicles (BC-sEVs) hold great promise in liquid biopsy. However, it remains challenging due to their inherent heterogeneity and low abundance. Herein, we developed an AND logic gate-based DNA cascade signal amplification strategy, termed Alternating Primer Exchange Reaction-activated Cas12a (Alt-PER-Cas12a), for the ultrasensitive detection of BC-sEVs in clinic samples. This dual-protein recognition system employs EpCAM/MUC1-specific capture probes to release two DNA hairpins (Hep and Hmu) as AND gate inputs in Alt-PER. The corresponding Hep and Hmu hairpins can initiate the Alt-PER with a large amount of primers to generate long single-stranded DNA products with alternating repeat units. Each repeating unit serves as a CRISPR activator, inducing the trans-cleavage activity of Cas12a and enabling cascade signal amplification. The as-constructed strategy exhibits excellent sensitivity with LOD of 2.6 × 103 particles/mL. It has been successfully used to discriminate breast cancer patients from healthy donors (AUC = 0.992) in clinical validation, and shows great potential for liquid biopsy.","PeriodicalId":435,"journal":{"name":"Talanta","volume":"295 ","pages":"128411"},"PeriodicalIF":6.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144191341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bisphenol A sensing using carbon fibre transducers with and without metal-organic frameworks modification: towards greener tools for fish safety and surveil ecosystems. 双酚A传感使用碳纤维换能器有或没有金属有机框架修改：迈向更环保的鱼类安全和监测生态系统的工具。

IF 6.1 1区化学

Talanta Pub Date : 2025-12-01 Epub Date: 2025-06-09 DOI: 10.1016/j.talanta.2025.128434

Vitória Dibo, Cristina Delerue-Matos, Simone Morais, Álvaro Torrinha

{"title":"Bisphenol A sensing using carbon fibre transducers with and without metal-organic frameworks modification: towards greener tools for fish safety and surveil ecosystems.","authors":"Vitória Dibo, Cristina Delerue-Matos, Simone Morais, Álvaro Torrinha","doi":"10.1016/j.talanta.2025.128434","DOIUrl":"10.1016/j.talanta.2025.128434","url":null,"abstract":"Bisphenol A (BPA) is widely used in plastic production; however, it has raised concerns about its human health implications and presence in aquatic ecosystems, as it is also known as an endocrine-disrupting compound. Given the urgency of developing eco-friendly monitoring tools, this study proposes and compares two novel green sensing platforms based on carbon paper (CP) for the determination of BPA in fish samples. One consists in the modification with a leaf-like shape zeolitic imidazolate framework (CP/ZIF-L), by a simple and water-based synthesis at room temperature, and the other uses a bare CP electrochemically pre-treated with sulfuric acid (CPP). Both sensors were morphologically and electrochemically characterized by scanning electron microscopy, energy-dispersive X-ray spectroscopy, X-ray diffraction, X-ray photoelectron spectroscopy, Fourier transform infrared spectroscopy, cyclic voltammetry and differential pulse voltammetry, and their greenness assessed by GAPI, Eco-scale and AGREE metrics. Under the optimum conditions, CP/ZIF-L and CPP exhibited a limit of detection of 15 ± 0.01 and 86 ± 2.9 nmol L-1, as well as a linear range over BPA concentration up to 1 μmol L-1 and 2 μmol L-1 with sensitivity up to 53.80 ± 0.17 and 31.62 ± 0.35 μA (μmol L-1) cm-2, respectively, confirming the superiority in performance of the MOF-based sensor for BPA detection. Upon validation in fish samples, both sensors achieved excellent accuracy (92.5 ± 5.9-103.1 ± 4.6 %), repeatability (4.1-5.7 %), reproducibility (7.1-7.3 %) and selectivity towards organic and inorganic interferents (-2.8-8.8 %). The sensors demonstrated superior greenness metrics compared to the traditional chromatographic method. Altogether, the results highlight the environmental friendliness, reliability and potential of the proposed sensors as green tools for BPA monitoring in complex environmental and food samples.","PeriodicalId":435,"journal":{"name":"Talanta","volume":"295 ","pages":"128434"},"PeriodicalIF":6.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144281925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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