Cardio-oncology最新文献

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Using machine learning in pediatric cardio-oncology: we have the questions, we need the answers. 在儿科心脏肿瘤学中使用机器学习:我们有问题,我们需要答案。
IF 3.2
Cardio-oncology Pub Date : 2024-11-06 DOI: 10.1186/s40959-024-00279-1
Thomas D Ryan, Jose Carlos Villalobos Lizardi
{"title":"Using machine learning in pediatric cardio-oncology: we have the questions, we need the answers.","authors":"Thomas D Ryan, Jose Carlos Villalobos Lizardi","doi":"10.1186/s40959-024-00279-1","DOIUrl":"10.1186/s40959-024-00279-1","url":null,"abstract":"","PeriodicalId":9804,"journal":{"name":"Cardio-oncology","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11539750/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142582281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Accuracy of mitral annular plane systolic excursion in diagnosing anthracycline-induced subclinical cardiotoxicity in patients with breast cancer - a retrospective cohort study. 二尖瓣环平面收缩期偏移在诊断乳腺癌患者由蒽环类药物引起的亚临床心脏毒性方面的准确性--一项回顾性队列研究。
IF 3.2
Cardio-oncology Pub Date : 2024-11-04 DOI: 10.1186/s40959-024-00280-8
Luís Fábio Barbosa Botelho, Marcelo Dantas Tavares de Melo, André Luiz Cerqueira de Almeida, Vera Maria Cury Salemi
{"title":"Accuracy of mitral annular plane systolic excursion in diagnosing anthracycline-induced subclinical cardiotoxicity in patients with breast cancer - a retrospective cohort study.","authors":"Luís Fábio Barbosa Botelho, Marcelo Dantas Tavares de Melo, André Luiz Cerqueira de Almeida, Vera Maria Cury Salemi","doi":"10.1186/s40959-024-00280-8","DOIUrl":"10.1186/s40959-024-00280-8","url":null,"abstract":"<p><strong>Background: </strong>The mitral annular plane systolic excursion (MAPSE) is used to analyze the left ventricle longitudinal function. However, the accuracy of MAPSE in diagnosing oncological populations is unclear. In this study, we aimed to assess the accuracy of MAPSE in diagnosing subclinical cardiotoxicity in women with breast cancer undergoing anthracycline treatment.</p><p><strong>Methods: </strong>This retrospective cohort study included echocardiographic assessments of patients with breast cancer who underwent anthracycline treatment as part of their therapeutic regimen. Assessments were performed before treatment, after administering the first dose of anthracycline, after completing anthracycline treatment, and 6 and 12 months after treatment. Left ventricular ejection fraction was calculated using the modified biplane Simpson method. The performances of MAPSE and global longitudinal strain (GLS) were analyzed using receiver operating characteristic (ROC) curves. Their accuracies were measured using the area under the ROC curves.</p><p><strong>Results: </strong>Sixty-one patients were included in this study. Of them, 8.2% presented cardiotoxicity 6 months after treatment completion. Patients with cardiotoxicity had lower LVEF (47% vs. 63%; p < 0.001), MAPSE (10.23 mm vs. 12.25 mm; p = 0.012), and LV GLS (16.13% vs. 19.05%; p = 0.005) values than those without. A 12% reduction in the GLS exhibited sensitivity, specificity, and overall accuracy of 80%, 70%, and 78%, respectively. A relative reduction of 15% in MAPSE exhibited a sensitivity, specificity, and accuracy of 80%, 77%, and 81.2%, respectively. An absolute MAPSE reduction of 2 mm exhibited a sensitivity, specificity, and accuracy of 80%, 73.21%, and 81.2%, respectively. No differences were observed between the ROC curves.</p><p><strong>Conclusion: </strong>MAPSE showed similar accuracy to GLS in diagnosing subclinical cardiotoxicity in women with breast cancer undergoing anthracycline treatment.</p>","PeriodicalId":9804,"journal":{"name":"Cardio-oncology","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11533289/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142575110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cardiotoxicity of venetoclax in patients with acute myeloid leukemia: comparison with anthracyclines. venetoclax对急性髓性白血病患者的心脏毒性:与蒽环类药物的比较。
IF 3.2
Cardio-oncology Pub Date : 2024-11-01 DOI: 10.1186/s40959-024-00275-5
Takeshi Onoue, Andrew H Matthews, Azin Vakilpour, Yu Kang, Bénédicte Lefebvre, Amanda M Smith, Shannon R McCurdy, Michael G Fradley, Joseph Carver, Jesse Chittams, Marielle Scherrer-Crosbie
{"title":"Cardiotoxicity of venetoclax in patients with acute myeloid leukemia: comparison with anthracyclines.","authors":"Takeshi Onoue, Andrew H Matthews, Azin Vakilpour, Yu Kang, Bénédicte Lefebvre, Amanda M Smith, Shannon R McCurdy, Michael G Fradley, Joseph Carver, Jesse Chittams, Marielle Scherrer-Crosbie","doi":"10.1186/s40959-024-00275-5","DOIUrl":"10.1186/s40959-024-00275-5","url":null,"abstract":"<p><p>Venetoclax is a promising drug for patients with acute myeloid leukemia (AML) ineligible for anthracycline-based treatments. In rats, venetoclax is reported to cause myocardial injury. Our objectives were to report the frequency of cardiovascular (CV) events in patients treated with venetoclax, and, subsequently, to compare CV outcomes in matched patients treated with venetoclax or anthracyclines. Patients diagnosed with AML and treated with venetoclax or anthracyclines from January 2017 to July 2021 were identified. Major adverse cardiac events (MACE, including new-onset heart failure (HF), acute myocardial infarction, new onset atrial fibrillation (AF)) were recorded. Propensity-score method was then used to compare patients treated with venetoclax or anthracyclines. Patients treated with venetoclax (n=103) were older, with more hyperlipidemia than patients treated with anthracyclines (n=217). However, only 63% of patients treated with venetoclax underwent echocardiographic screening (vs. 93% of patients treated with anthracyclines, P< 0.001). Eighteen patients with venetoclax (17%) and 27 patients with anthracyclines (12%) developed MACE, including 10 % of new HF in each group. The median time to MACE was 8 days (interquartile range 5-98 days). In the matched cohort (n=132 patients), the cumulative incidence of MACE at one year was not different (17.5 % venetoclax, 9.2% anthracyclines, p =0.27). Thus, MACE incidence is similar in matched patients receiving venetoclax or anthracyclines. Close CV monitoring during the early phase of treatment may be helpful in patients treated with venetoclax.</p>","PeriodicalId":9804,"journal":{"name":"Cardio-oncology","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11529003/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142563557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unsupervised machine learning identifies distinct phenotypes in cardiac complications of pediatric patients treated with anthracyclines. 无监督机器学习识别出接受蒽环类药物治疗的儿科患者心脏并发症的不同表型。
IF 3.2
Cardio-oncology Pub Date : 2024-10-28 DOI: 10.1186/s40959-024-00276-4
Xander Jacquemyn, Bhargava K Chinni, Benjamin T Barnes, Sruti Rao, Shelby Kutty, Cedric Manlhiot
{"title":"Unsupervised machine learning identifies distinct phenotypes in cardiac complications of pediatric patients treated with anthracyclines.","authors":"Xander Jacquemyn, Bhargava K Chinni, Benjamin T Barnes, Sruti Rao, Shelby Kutty, Cedric Manlhiot","doi":"10.1186/s40959-024-00276-4","DOIUrl":"10.1186/s40959-024-00276-4","url":null,"abstract":"<p><strong>Background: </strong>Anthracyclines are essential in pediatric cancer treatment, but patients are at risk cancer therapy-related cardiac dysfunction (CTRCD). Standardized definitions by the International Cardio-Oncology Society (IC-OS) aim to enhance precision in risk assessment.</p><p><strong>Objectives: </strong>Categorize distinct phenotypes among pediatric patients undergoing anthracycline chemotherapy using unsupervised machine learning.</p><p><strong>Methods: </strong>Pediatric cancer patients undergoing anthracycline chemotherapy at our institution were retrospectively included. Clinical and echocardiographic data at baseline, along with follow-up data, were collected from patient records. Unsupervised machine learning was performed, involving dimensionality reduction using principal component analysis and K-means clustering to identify different phenotypic clusters. Identified phenogroups were analyzed for associations with CTRCD, defined following contemporary IC-OS definitions, and hypertensive response.</p><p><strong>Results: </strong>A total of 187 patients (63.1% male, median age 15.5 years [10.4-18.7]) were included and received anthracycline chemotherapy with a median treatment duration of 0.66 years [0.35-1.92]. Median follow-up duration was 2.78 years [1.31-4.21]. Four phenogroups were identified with following distribution: Cluster 0 (32.6%, n = 61), Cluster 1 (13.9%, n = 26), Cluster 2 (24.6%, n = 46), and Cluster 3 (28.9%, n = 54). Cluster 0 showed the highest risk of moderate CTRCD (HR: 3.10 [95% CI: 1.18-8.16], P = 0.022) compared to other clusters. Cluster 3 demonstrated a protective effect against hypertensive response (HR: 0.30 [95% CI: 0.13- 0.67], P = 0.003) after excluding baseline hypertensive patients. Longitudinal assessments revealed differences in global longitudinal strain and systolic blood pressure among phenogroups.</p><p><strong>Conclusions: </strong>Unsupervised machine learning identified distinct phenogroups among pediatric cancer patients undergoing anthracycline chemotherapy, offering potential for personalized risk assessment.</p>","PeriodicalId":9804,"journal":{"name":"Cardio-oncology","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11514752/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142521151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent radiotherapy could reduce heart-related death in patients with esophageal cancer: SEER database analysis. 近期放射治疗可减少食管癌患者因心脏原因死亡的人数:SEER 数据库分析。
IF 3.2
Cardio-oncology Pub Date : 2024-10-18 DOI: 10.1186/s40959-024-00274-6
Yuta Sato, Rei Umezawa, Takaya Yamamoto, Noriyoshi Takahashi, Yu Suzuki, Keita Kishida, So Omata, Hinako Harada, Yasuhiro Seki, Nanae Chiba, Shinsaku Okuda, Keiichi Jingu
{"title":"Recent radiotherapy could reduce heart-related death in patients with esophageal cancer: SEER database analysis.","authors":"Yuta Sato, Rei Umezawa, Takaya Yamamoto, Noriyoshi Takahashi, Yu Suzuki, Keita Kishida, So Omata, Hinako Harada, Yasuhiro Seki, Nanae Chiba, Shinsaku Okuda, Keiichi Jingu","doi":"10.1186/s40959-024-00274-6","DOIUrl":"https://doi.org/10.1186/s40959-024-00274-6","url":null,"abstract":"<p><strong>Background: </strong>There have been several reports showing that heart-related deaths are common in long-term survivors of esophageal cancer after radiation therapy; however, radiotherapy technology is evolving year by year. This study was carried out using the SEER database to determine whether the frequency of mortality from heart disease after radiotherapy has improved over time in patients with esophageal cancer.</p><p><strong>Methods: </strong>SEER*Stat statistical software version 8.3.9.2 (National Cancer Institute) was used to perform case listing and data extraction. We reviewed causes of death in 8,297 patients who were treated by radiotherapy without surgery between 2004 and 2015 (radiotherapy group). For comparison with this group, we also reviewed causes of death in 5,149 patients who were treated by surgery without radiotherapy (surgery group).</p><p><strong>Results: </strong>In the radiotherapy group, the cumulative heart-related death rate in patients with carcinoma in the middle to abdominal esophagus, for which it was considered that the heart was irradiated with a higher dose, was significantly higher than that in patients with carcinoma in the cervical to upper thoracic esophagus (p = 0.017). However, in the surgery group, the cumulative heart-related death rate in patients with carcinoma in the middle to abdominal esophagus tended to be lower than that in patients with carcinoma in the cervical to upper thoracic esophagus (p = 0.063). The cumulative heart-related death rate in patients treated in 2010-2015 was significantly lower than that in patients treated in 2004-2009 in the radiotherapy group (p = 0.011), although the cumulative heart-related death rate was not significantly different between patients treated in 2010-2015 and patients treated in 2004-2009 in the surgery group (p = 0.90).</p><p><strong>Conclusions: </strong>The results suggest that recent advances in radiotherapy have enabled a reduction in radiation-induced heart disease in patients with esophageal cancer.</p>","PeriodicalId":9804,"journal":{"name":"Cardio-oncology","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11487852/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142459180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recurrent melanoma 25 years after initial diagnosis, presenting as metastatic disease early after heart transplantation. 初诊 25 年后复发的黑色素瘤,在心脏移植手术后早期出现转移性疾病。
IF 3.2
Cardio-oncology Pub Date : 2024-10-16 DOI: 10.1186/s40959-024-00273-7
Gal Rubinstein, Benjamin Izar, Diana E McDonnell, Andrea Fernandez Valledor, Justin A Fried, Kevin Clerkin, Edward F Lin, Dor Lotan, Farhana Latif, Gabriel Sayer, Nir Uriel, Jayant K Raikhelkar
{"title":"Recurrent melanoma 25 years after initial diagnosis, presenting as metastatic disease early after heart transplantation.","authors":"Gal Rubinstein, Benjamin Izar, Diana E McDonnell, Andrea Fernandez Valledor, Justin A Fried, Kevin Clerkin, Edward F Lin, Dor Lotan, Farhana Latif, Gabriel Sayer, Nir Uriel, Jayant K Raikhelkar","doi":"10.1186/s40959-024-00273-7","DOIUrl":"https://doi.org/10.1186/s40959-024-00273-7","url":null,"abstract":"<p><strong>Background: </strong>Cancer survivors (CS) comprise a particularly high-risk group for both de-novo and recurrent malignancies after solid organ transplantation.</p><p><strong>Case presentation: </strong>We report a case of relapsed melanoma, presented as metastatic disease seven months after heart transplantation in a patient who had an early-stage melanoma resected 25 years prior. Treatment with a combination of dabrafenib, a BRAF inhibitor, and trametinib, a mitogen-activated protein kinase (MEK) inhibitor resulted in a near-complete metabolic response, without major adverse effects.</p><p><strong>Conclusion: </strong>This case demonstrates the increased risk of recurrence in CS with melanoma, which can persist decades after cancer diagnosis. These patients may be amenable to treatment using modern treatment modalities in oncology.</p>","PeriodicalId":9804,"journal":{"name":"Cardio-oncology","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11481582/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142459181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cardiac events among a cohort of 17,389 patients receiving cancer chemotherapy: short and long term implications. 接受癌症化疗的 17,389 名患者中发生的心脏事件:短期和长期影响。
IF 3.2
Cardio-oncology Pub Date : 2024-10-16 DOI: 10.1186/s40959-024-00269-3
Saifei Liu, John D Horowitz, Bogda Koczwara, Aaron L Sverdlov, Natalie Packer, Robyn A Clark
{"title":"Cardiac events among a cohort of 17,389 patients receiving cancer chemotherapy: short and long term implications.","authors":"Saifei Liu, John D Horowitz, Bogda Koczwara, Aaron L Sverdlov, Natalie Packer, Robyn A Clark","doi":"10.1186/s40959-024-00269-3","DOIUrl":"https://doi.org/10.1186/s40959-024-00269-3","url":null,"abstract":"<p><strong>Background: </strong>The association between cardiovascular disease and carcinogenesis is bidirectional and well-established. Furthermore, cancer treatment improves overall patient survival, potentially at the cost of incremental and fatal cardiovascular disease (CVD).</p><p><strong>Aim: </strong>To evaluate (a) In a real-world cohort, the proportion of patients offered cancer chemotherapy who have antecedent CVD (CVD<sub>A</sub>); (b) The rates of patient admission with subsequent development of CVD (CVD<sub>S</sub>) requiring hospital admission post assignment to chemotherapy; (c) The impact of CVD<sub>A</sub> and CVD<sub>S</sub> on mortality rates relative to those seen in patients without overt CVD (CVD<sup>-</sup>) and (d) The time course of mortality in CVD<sup>-</sup> versus CVD<sub>S</sub> patients.</p><p><strong>Methods: </strong>Retrospective analysis was performed in deidentified linked health data sets. Correlates of mortality were evaluated by Cox proportional hazards evaluation. Relative and absolute time-variability of CVD as a primary cause of death were determined.</p><p><strong>Results: </strong>Of the total 17,389 patients, there were 2,159 with CVD<sub>A</sub>. Over a median follow-up time of 4.6 years, CVD<sub>S</sub> admissions (n = 8,529) occurred more commonly in the presence of CVD<sub>A</sub> (70.0% vs. 46.1%, p < 0.001), and more than 50% of CVD<sub>S</sub> cases occurred in the first 12 months of follow-up. The 5-year mortality rates were 71.5% for CVD<sub>A</sub>, 64.7% for CVD<sub>S</sub>, and 40.8% for CVD<sup>-</sup> (p < 0.001). Development of CVD<sub>S</sub> was associated with a substantially increased risk of mortality in the next 12 months. The development of CVDs was also associated with an increased risk of cardiovascular, as against non-cardiovascular, mortality (7.1% vs. 1.6%, p < 0.001).</p><p><strong>Conclusions: </strong>Approximately 50% of patients assigned to cancer chemotherapy developed CVD<sub>S</sub>, heralding a particularly high risk of mortality over the next 12 months. Both CVD<sub>A</sub> and CVD<sub>S</sub> are associated with substantial increases in mortality rates relative to those in CVD<sup>-</sup> patients. This increased risk merits close individual monitoring.</p>","PeriodicalId":9804,"journal":{"name":"Cardio-oncology","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11481733/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142459177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expect the unexpected: fulminant myocardial cytotoxic Injury from Trabectedin. 出乎意料:曲安奈德引起的暴发性心肌细胞毒性损伤。
IF 3.2
Cardio-oncology Pub Date : 2024-10-15 DOI: 10.1186/s40959-024-00257-7
Annie J Tsay, Mohan Satish, Elizabeth Corley, Ashley Ezema, Neisha DeJesus, Stephen Wisely, Eileen McAleer, Chen Zhang, Su Yuan, Edwin Homan, Jennifer E Liu, Jonathan W Weinsaft, Sandra D'Angelo, Stephanie A Feldman, Angel T Chan
{"title":"Expect the unexpected: fulminant myocardial cytotoxic Injury from Trabectedin.","authors":"Annie J Tsay, Mohan Satish, Elizabeth Corley, Ashley Ezema, Neisha DeJesus, Stephen Wisely, Eileen McAleer, Chen Zhang, Su Yuan, Edwin Homan, Jennifer E Liu, Jonathan W Weinsaft, Sandra D'Angelo, Stephanie A Feldman, Angel T Chan","doi":"10.1186/s40959-024-00257-7","DOIUrl":"https://doi.org/10.1186/s40959-024-00257-7","url":null,"abstract":"<p><strong>Background: </strong>Trabectedin (Tbt) is an alkylating agent prescribed for soft tissue sarcomas after treatment failure of first line agents. While cardiomyopathy can occur with Tbt treatment after anthracycline exposure, Tbt-induced fulminant myocardial cytotoxic injury in the setting of other systemic cytotoxicity associated with Tbt has not been reported.</p><p><strong>Case presentation: </strong>51-year-old female with hypertension, hyperlipidemia, metastatic leiomyosarcoma with progression of disease despite several lines of chemotherapy including doxorubicin-based therapy was started on Trabectedin (Tbt) 5 days prior to presentation with symptoms of fever, myalgias, arthralgias, and palpitations. She was admitted for management of rhabdomyolysis, acute kidney and liver injuries which were reportedly known to be associated with Tbt treatment. A baseline electrocardiogram (ECG) revealed sinus tachycardia with non-specific T-wave changes, and a transthoracic echocardiogram (TTE) was unremarkable. However, on day 3 of hospitalization, an episode of asymptomatic sustained monomorphic ventricular tachycardia with a heart rate of 150 beats per minute was captured on telemetry. A 12-lead ECG revealed new septal T-wave inversions. Labs revealed rising hs-TnI levels (peak at 37,933ng/L) and serum markers suggested multi-organ failure. Steroids were initiated given its role in treating multi-organ Tbt-induced toxicity. A cardiac MRI to rule out myocarditis and left heart catheterization to rule out obstructive coronary artery disease were forgone due to acute renal failure. A right heart catheterization with an endomyocardial biopsy was performed revealing normal cardiac filling pressures and indices. Pathology showed cytoplasmic vacuoles indicating drug-induced myocardial cytotoxicity. Serial echocardiograms revealed preserved biventricular function. The patient's clinical condition deteriorated with multi-organ failure despite maximal supportive care in the intensive care unit. She ultimately passed away, and an autopsy was declined.</p><p><strong>Conclusion: </strong>This is the first reported case of fulminant myocardial injury after initiation of Tbt with histologic evidence of drug-induced myocardial cytotoxicity. While it is unclear if anthracyclines potentiate Tbt cytotoxic injury as in this case, it is plausible; and that Tbt-induced cardiotoxicity ranges from subclinical to fulminant. Given increasing use of Tbt in refractory high-grade sarcomas, raising awareness of its toxicity profile will improve early detection and outcomes.</p>","PeriodicalId":9804,"journal":{"name":"Cardio-oncology","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11476495/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142459178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between QT prolongation and cardiovascular mortality in cancer patients. 癌症患者 QT 间期延长与心血管疾病死亡率之间的关系。
IF 3.2
Cardio-oncology Pub Date : 2024-10-12 DOI: 10.1186/s40959-024-00271-9
Cheng-Han Chan, Chih-Min Liu, Pei-Fen Chen, Li-Lien Liao, I-Chien Wu, Yu-Feng Hu
{"title":"Association between QT prolongation and cardiovascular mortality in cancer patients.","authors":"Cheng-Han Chan, Chih-Min Liu, Pei-Fen Chen, Li-Lien Liao, I-Chien Wu, Yu-Feng Hu","doi":"10.1186/s40959-024-00271-9","DOIUrl":"https://doi.org/10.1186/s40959-024-00271-9","url":null,"abstract":"<p><strong>Background: </strong>Cancer patients' vulnerability to QT prolongation contradicts certain anti-cancer drug usage. Until now, the QT prolongation's impact on CV mortality in cancer patients remains unclear, potentially biasing therapeutic decisions.</p><p><strong>Methods: </strong>This retrospective observational cohort included adult cancer patients with an electrocardiogram (ECG) performed in a tertiary hospital in Taiwan. The first performed ECGs after cancer diagnosis (n = 59,568) were analyzed. The corrected QT intervals by Bazett (QTcB), Fridericia (QTcFri), and Framingham (QTcFra) formulae were used to predict the 90-day and one-year CV mortality according to the Taiwan death registry.</p><p><strong>Results: </strong>The AUC of QTcB (90 days: 0.70, 1 year: 0.68) for predicting CV mortality was better than QTcFri and QTcFra (90 days: 0.63 and 0.50, 1 year: 0.65 and 0.56). Using the restricted cubic spline regression model adjusted by age and comorbidities, QTcB increased a significant but trivial risk of CV mortality at 90 days (hazard ratio, 1.007, P = 0.02) and one year (1.006, P < 0.01). Compared to those with QTcB < 500ms, the patients with QTcB ≥ 500ms were older and had more comorbidities and mortalities within one year. The incidence of sudden death and ventricular arrhythmias was only 0.2%. After adjusting for comorbidities, QTcB was neither associated with 90-day nor one-year CV mortality. In the patients already with QTcB ≥ 500ms, the patients receiving the unexpected uses of QT-prolonging drugs were not associated with higher one-year CV mortality than those without (P = 0.14).</p><p><strong>Conclusions: </strong>Rather than a prolonged QT interval per se, comorbidities contributed to CV mortality and irreversible outcomes in cancer patients.</p>","PeriodicalId":9804,"journal":{"name":"Cardio-oncology","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11470720/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142459176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Predictors of trastuzumab-induced cardiotoxicity among racially and ethnically diverse patients with HER2-positive breast cancer. 不同种族和族裔的 HER2 阳性乳腺癌患者中曲妥珠单抗诱发心脏毒性的预测因素。
IF 3.2
Cardio-oncology Pub Date : 2024-10-12 DOI: 10.1186/s40959-024-00272-8
Anna Vaynrub, Leila Mishalani, Jayant Raikhelkar, Katherine D Crew
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