Chemical Research in Chinese Universities最新文献

{"title":"Graphdiyne: from Preparation to Biomedical Applications.","authors":"Xiaodan Li,&nbsp;Mengyu Guo,&nbsp;Chunying Chen","doi":"10.1007/s40242-021-1343-8","DOIUrl":"10.1007/s40242-021-1343-8","url":null,"abstract":"<p><p><b>G</b>raphdiyne(GDY) is a kind of two-dimensional carbon nanomaterial with specific configurations of <i>sp</i> and <i>sp</i> ² carbon atoms. The key progress in the preparation and application of GDY is bringing carbon materials to a brand-new level. Here, the various properties and structures of GDY are introduced, including the existing strategies for the preparation and modification of GDY. In particular, GDY has gradually emerged in the field of life sciences with its unique properties and performance, therefore, the development of biomedical applications of GDY is further summarized. Finally, the challenges of GDY toward future biomedical applications are discussed.</p>","PeriodicalId":9785,"journal":{"name":"Chemical Research in Chinese Universities","volume":"37 6","pages":"1176-1194"},"PeriodicalIF":3.1,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8536907/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39682574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrospun Aspirin/Eudragit/Lipid Hybrid Nanofibers for Colon-targeted Delivery Using an Energy-saving Process.","authors":"Yibin Wang, Liang Tian, Tianhao Zhu, Jing Mei, Zezhong Chen, Deng-Guang Yu","doi":"10.1007/s40242-021-1006-9","DOIUrl":"10.1007/s40242-021-1006-9","url":null,"abstract":"<p><p><b>B</b>oth electrospinning apparatus and their commercial products are extending their applications in a wide variety of fields. However, very limited reports can be found about how to implement an energy-saving process and in turn to reduce the production cost. In this paper, a brand-new type of coaxial spinneret with a solid core and its electrospinning methods are developed. A novel sort of medicated Eudragit/lipid hybrid nanofibers are generated for providing a colon-targeted sustained release of aspirin. A series of characterizations demonstrates that the as-prepared hybrid nanofibers have a fine linear morphology with the aspirin/lipid separated from the matrix Eudragit to form many tiny islands. <i>In vitro</i> dissolution tests exhibit that the hybrid nanofibers are able to effectively prevent the release of aspirin under an acid condition (8.7%±3.4% for the first two hours), whereas prolong the drug release time period under a neutral condition(99.7±4.2% at the seventh hour). The energy-saving mechanism is discussed in detail. The prepared aspirin-loaded hybrid nanofibers can be further transferred into an oral dosage form for potential application in countering COVID-19 in the future.</p>","PeriodicalId":9785,"journal":{"name":"Chemical Research in Chinese Universities","volume":"37 3","pages":"443-449"},"PeriodicalIF":3.1,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8010490/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25557617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling the Dynamics of Antibody-Antigen Interaction by DNA Origami.","authors":"Zhou Nie","doi":"10.1007/s40242-020-0252-6","DOIUrl":"https://doi.org/10.1007/s40242-020-0252-6","url":null,"abstract":"<p><p>To investigate the dynamic interaction between antibody and antigen, Fan <i>et al.</i> rationally designed a triangular DNA origami framework to spatially organize the antigenic epitopes at the nanoscale and thus to monitor the transient binding kinetics of the dynamic antigen-antibody complexes at room temperature. This study provides a straightforward, designable and programmable strategy to investigate the transition kinetics of antibody-antigen interaction at a single-molecule level and improve the understanding toward the design of the next-generation antibodies and vaccines for various biomedical applications. This work has been published online in <i>Nature Communications</i> on June 19, 2020.</p>","PeriodicalId":9785,"journal":{"name":"Chemical Research in Chinese Universities","volume":"36 5","pages":"983-984"},"PeriodicalIF":3.1,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40242-020-0252-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38304843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The expression of DAMP proteins HSP70 and cancer-testis antigen SPAG9 in peripheral blood of patients with HCC and lung cancer.","authors":"Biqiong Ren, Shudi Luo, Fei Xu, Guoying Zou, Guofeng Xu, Junyu He, Yiran Huang, Haowen Zhu, Yong Li","doi":"10.1007/s12192-016-0758-5","DOIUrl":"10.1007/s12192-016-0758-5","url":null,"abstract":"<p><p>There are different views of how the immune system participates in the reaction to cancer. Here, we evaluated expression of DAMP proteins HSP70 and cancer-testis antigen SPAG9 in patients with hepatocellular carcinoma (HCC) and lung cancer to explore tumor immunity. Our analysis showed that levels of HSP70 and SPAG9 antibody were significantly higher in the serum of lung cancer and HCC patients than in the serum of healthy subjects (P < 0.001), but there were no differences in levels of HSP70 antibody in patients and controls. Levels of serum SPAG9 antibody in newly diagnosed lung cancer patients were significantly higher than in treated lung cancer patients (P < 0.05), but there were no differences in levels of HSP70 or HSP70 antibody. Levels of serum HSP70 and SPAG9 antibody, but not HSP70 antibody, were also higher in hepatitis/cirrhosis patients than in healthy subjects (P = 0.005, P < 0.001). Levels of serum SPAG9 antibody were significantly higher in HCC patients than in hepatitis/cirrhosis patients, but there were no differences in HSP70 or HSP70 antibody levels. Finally, levels of serum HSP70 and SPAG9 antibody were significantly higher in HCC patients than in lung cancer patients (P < 0.05, P < 0.001). These results indicate that cancer-testis antigen SPAG9 induces a strong humoral immune response in cancer patients but HSP70 does not. These results show that SPAG9 has potential as a tumor-specific biomarker.</p>","PeriodicalId":9785,"journal":{"name":"Chemical Research in Chinese Universities","volume":"39 1","pages":"237-244"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352597/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90257913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advances on smart TiO₂ nanotube platforms for sustainable drug delivery applications.","authors":"Qun Wang, Jian-Ying Huang, Hua-Qiong Li, Allan Zi-Jian Zhao, Yi Wang, Ke-Qin Zhang, Hong-Tao Sun, Yue-Kun Lai","doi":"10.2147/IJN.S117498","DOIUrl":"10.2147/IJN.S117498","url":null,"abstract":"<p><p>To address the limitations of traditional drug delivery, TiO₂ nanotubes (TNTs) are recognized as a promising material for localized drug delivery systems. With regard to the excellent biocompatibility and physicochemical properties, TNTs prepared by a facile electrochemical anodizing process have been used to fabricate new drug-releasing implants for localized drug delivery. This review discusses the development of TNTs applied in localized drug delivery systems, focusing on several approaches to control drug release, including the regulation of the dimensions of TNTs, modification of internal chemical characteristics, adjusting pore openings by biopolymer coatings, and employing polymeric micelles as drug nanocarriers. Furthermore, rational strategies on external conditions-triggered stimuli-responsive drug release for localized drug delivery systems are highlighted. Finally, the review concludes with the recent advances on TNTs for controlled drug delivery and corresponding prospects in the future.</p>","PeriodicalId":9785,"journal":{"name":"Chemical Research in Chinese Universities","volume":"24 1","pages":"151-165"},"PeriodicalIF":8.0,"publicationDate":"2016-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5191578/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78280993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An early parallel group trial in cardiology.","authors":"John Hampton","doi":"10.1177/0141076816663089","DOIUrl":"10.1177/0141076816663089","url":null,"abstract":"","PeriodicalId":9785,"journal":{"name":"Chemical Research in Chinese Universities","volume":"30 1","pages":"393-394"},"PeriodicalIF":17.3,"publicationDate":"2016-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066534/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74436971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tree Plantation Systems Influence Nitrogen Retention and the Abundance of Nitrogen Functional Genes in the Solomon Islands.","authors":"Frédérique Reverchon, Shahla H Bai, Xian Liu, Timothy J Blumfield","doi":"10.3389/fmicb.2015.01439","DOIUrl":"10.3389/fmicb.2015.01439","url":null,"abstract":"<p><p>Tree mono-plantations are susceptible to soil nutrient impoverishment and mixed species plantations have been proposed as a way of maintaining soil fertility while enhancing biodiversity. In the Solomon Islands, mixed species plantations where teak (Tectona grandis) is inter-planted with a local tree species (Flueggea flexuosa) have been used as an alternative to teak mono-plantations and are expected to increase soil microbial diversity and modify microbial biogeochemical processes. In this study, we quantified the abundance of microbial functional genes involved in the nitrogen (N) cycle from soil samples collected in teak, flueggea, and mixed species plantations. Furthermore, we measured soil properties such as pH, total carbon (C) and total N, stable N isotope composition (δ(15)N), and inorganic N pools. Soil pH and δ(15)N were higher under teak than under flueggea, which indicates that intercropping teak with flueggea may decrease bacterial activities and potential N losses. Higher C:N ratios were found under mixed species plantations than those under teak, suggesting an enhancement of N immobilization that would help preventing fast N losses. However, inorganic N pools remained unaffected by plant cover. Inter-planting teak with flueggea in mixed species plantations generally increased the relative abundance of denitrification genes and promoted the enrichment of nosZ-harboring denitrifiers. However, it reduced the abundance of bacterial amoA (ammonia monooxygenase) genes compared to teak mono-plantations. The abundance of most denitrification genes correlated with soil total N and C:N ratio, while bacterial and archeal nitrification genes correlated positively with soil NH4 (+) concentrations. Altogether, these results show that the abundance of bacterial N-cycling functional guilds vary under teak and under mixed species plantations, and that inter-planting teak with flueggea may potentially alleviate N losses associated with nitrification and denitrification and favor N retention. Mixed plantations could also allow an increase in soil C and N stocks without losing the source of income that teak trees represent for local communities. </p>","PeriodicalId":9785,"journal":{"name":"Chemical Research in Chinese Universities","volume":"37 1","pages":"1439"},"PeriodicalIF":5.2,"publicationDate":"2015-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686685/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69559424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of porcine reproductive and respiratory syndrome virus inhibitors through an oriented screening on natural products.","authors":"Wen-Gui Li,&nbsp;Fei-Yan Dai,&nbsp;Yong-Xian Cheng,&nbsp;Ge-Fen Yin,&nbsp;Jun-Long Bi,&nbsp;Dian-Peng Li","doi":"10.1007/s40242-013-2300-y","DOIUrl":"https://doi.org/10.1007/s40242-013-2300-y","url":null,"abstract":"<p><p>Porcine reproductive and respiratory syndrome(PRRS) caused by porcine reproductive and respiratory syndrome virus(PRRSV) is one of the most infectious diseases in the swine industry worldwide, causing big economic losses. Vaccines are major weapons against PRRSV, however, current available vaccines have several limitations. Developing chemical drugs as alternatives is required. On the basis of traditional medical knowledge, we purposely selected 15 natural products originated from Chinese herbs with anti-infectious effects. Their antiviral activities were evaluated by PRRSV-induced cytopathic effect(CPE) on MARC-145 cells and reverse transcription polymerase chain reaction(RT-PCR) assay. Compounds ethoxysanguinarine(EOSG) and atractylodinol were found to be the hits which could significantly reduce PRRSV-associated CPE with 50% inhibited concentration(IC₅₀) values of 7.9 and 39.4 μmol/L, respectively. Meanwhile, compounds ethoxysanguinarine and atractylodinol significantly decreased mRNA expression of ORF7 gene in a dose-dependent manner. Study results suggest that compounds ethoxysanguinarine and atractylodinol may be useful anti-PRRSV drugs for swine industry or the hits for further lead optimization.</p>","PeriodicalId":9785,"journal":{"name":"Chemical Research in Chinese Universities","volume":"29 2","pages":"290-293"},"PeriodicalIF":3.1,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40242-013-2300-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37783139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis and Structural Characterization of Manganese Carbonyl Incorporated Polyoxomolybdate (n-Bu4N)2[Mo6O16(OCH3)2{HOCH2C(CH2O)3}2{Mn(CO)3}2]","authors":"Jing-ping WANG,&nbsp;Ji-li LI,&nbsp;Jing-yang NIU","doi":"10.1016/S1005-9040(09)60004-0","DOIUrl":"10.1016/S1005-9040(09)60004-0","url":null,"abstract":"<div><p>The polyoxoanion incorporated [Mn(CO)₃⁺} complex, (<em>n</em>-Bu₄N)₂[Mo₆O₁₆(OCH₃)₂{HOCH₂C(CH₂O)₃}₂·{Mn(CO)₃}₂](<strong>1</strong>). has been synthesized by the reaction of (<em>n</em>-Bu₄N)₄[Mo₈O₂₆] with Mn(CO)₅Br in methanol, in the presence of C(CH₂OH)₄. The complex <strong>1</strong> has been characterized by IR, UV-Vis, X-ray single crystal diffraction, and TG. Crystal data for the complex <strong>1</strong>: C₂₅H₄₈MnMo₃NO₁₆(<strong>1</strong>), Triclinic <em>P</em><figure><img></figure>. <em>a</em>=0.9405(3) nm, <em>b</em>=1.3351(4) nm, <em>c</em>=1.5455(4) nm, α= 103.206(5)°, β=102.165(5)°, γ=100.784(5)°, <em>V</em>=1.7896(9) nm³, <em>Z</em>=2, <em>R</em>₁,=0.0703, <em>wR</em>₂= 0.1495. The structure analysis of complex <strong>1</strong> shows that the complex consists of two tetrabutylammonium cations and a polyoxomolybdate anion that incorporates two <em>fac</em>-Mn(CO)₃⁺ units. The anion of complex <strong>1</strong> can be considered as the dimer of two rhomb-like anions by sharing of two corners.</p></div>","PeriodicalId":9785,"journal":{"name":"Chemical Research in Chinese Universities","volume":"24 6","pages":"Pages 675-678"},"PeriodicalIF":3.1,"publicationDate":"2008-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1005-9040(09)60004-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"56328673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation, Crystal Structure, and Thermal Analysis of Carbohydrazide Trinitrophloroglucinolate","authors":"Zhen-hua LIU ,&nbsp;Tong-lai ZHANG ,&nbsp;Xiao-chun HU ,&nbsp;Jian-guo ZHANG ,&nbsp;Li YANG ,&nbsp;Xiao-jing QIAO","doi":"10.1016/S1005-9040(09)60006-4","DOIUrl":"10.1016/S1005-9040(09)60006-4","url":null,"abstract":"<div><p>A new compound (CHZ)(HTNPG)·0.5H₂O was synthesized by mixing carbohydrazide(CHZ) and trinilrophloroglucinol(TNPG) and characterized by elemental analysis and Fourier transform infrared (FTIR) spectrum. Its crystal structure was determined by single crystal X-ray diffraction analysis. The crystal belongs to triclinic system, <em>P</em><figure><img></figure> space group, with <em>a</em>=0.45578(9) nm, <em>b</em>=1.0142(2) nm, <em>c</em>=1.3041(3) nm, α=86.53(3)°, β=99.56(3)°, γ=81.94(3)°, <em>V</em>= 0.5958(2) nm³, <em>Z</em>=2, <em>D_c</em>=2.008 g/cm³, <em>R₁</em>,=0.0476, and <em>wR₂</em>=0.1139. The compound is a di-substituted salt of TNPG, which consists of a cation (CHZ)²⁺ and an anion (HTNPG)²⁺. The thermal analysis of the compound was studied by means of differential scanning calorimetry(DSC) and thermogravimetry-derivative thermogravimetry(TG-DTG). Under nitrogen atmosphere at a heating rate of 10 °C/min, the thermal decomposition of the compound contained one endothermic process of dehydrating stage and two intense exothermic decomposition processes in a temperature range of 140—232 °C on the DSC trace. The decomposition products of the title compound are nearly gaseous products. The existing complicated hydrogen bond networks and electrostatic attraction between (CHZ)²⁺ and (HTNPG)^2- enhance the thermal stability of the title compound.</p></div>","PeriodicalId":9785,"journal":{"name":"Chemical Research in Chinese Universities","volume":"24 6","pages":"Pages 683-687"},"PeriodicalIF":3.1,"publicationDate":"2008-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1005-9040(09)60006-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"56328694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}