CHEMPUBLISH JOURNAL最新文献

Anticancer Activities of Seven Peronemins (A2, A3, B1, B2, B3, C1, and D1) from Peronema canescens Jack: A Prediction Studies 7种钙蛋白(A2、A3、B1、B2、B3、C1、D1)抗肿瘤活性的预测研究

CHEMPUBLISH JOURNAL Pub Date : 2023-07-30 DOI: 10.22437/chp.v7i1.23726

Muhammad Fikriansyah, Nelson Nelson, Madyawati Latief, Indra Lasmana Tarigan

{"title":"Anticancer Activities of Seven Peronemins (A2, A3, B1, B2, B3, C1, and D1) from Peronema canescens Jack: A Prediction Studies","authors":"Muhammad Fikriansyah, Nelson Nelson, Madyawati Latief, Indra Lasmana Tarigan","doi":"10.22437/chp.v7i1.23726","DOIUrl":"https://doi.org/10.22437/chp.v7i1.23726","url":null,"abstract":"Cancer is one of the leading causes of human death. In 2019, it was reported that cancer was the second (22%) cause of death due to non-communicable diseases in the world's population. Research for alternative anticancer drugs is still being done, including anticancer from plants. One of the plants that have the potential to be developed as an anticancer alternative is the sungkai plant. Sungkai leaves contain many bioactive compounds, one of which is the clerodane-type diterpenoids, peronemins, A2 (1), A3 (2), B1 (3), B2 (4), B3 (5), C1 (6), and D1 (7). The aim of this study was to initial screen the potential of seven Peronemins compounds in Sungkai leaves extract as anticancer candidates. Initial screening was carried out by predicting in-silico anticancer activity of the seven compounds. Dihydrofolate reductase inhibitor (DHFR inhibitor) is one of the anticancer activity screening approaches. DHFR Inhibitor activity from perenomins derivatives with pIC50 values of 0.785 (A2), respectively; 0.785 (A3); 0.799 (B2); 0.799 (B3); 0.799 (C1 and D1). In addition, from compounds 1,2,3,4,5 peronemin derivatives have potential anticancer activity through interaction with the target protein Voltage-gated potassium channel subunit while compounds 6, 7 also have biological activity potential anticancer on target protein Dihydrofolate reductase.","PeriodicalId":9741,"journal":{"name":"CHEMPUBLISH JOURNAL","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135397883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Calcium Reduction Using Variations of Thickness and Retention Time of Cocoa Shell Activated Carbon 可可壳活性炭厚度和停留时间变化对钙还原的影响

CHEMPUBLISH JOURNAL Pub Date : 2023-07-30 DOI: 10.22437/chp.v7i1.24768

Afidatul Muadifah, Arif Santoso, Khoirul Ngibad, Rahma Diyan Martha, Siti Nurriyatul Kholifah

{"title":"Calcium Reduction Using Variations of Thickness and Retention Time of Cocoa Shell Activated Carbon","authors":"Afidatul Muadifah, Arif Santoso, Khoirul Ngibad, Rahma Diyan Martha, Siti Nurriyatul Kholifah","doi":"10.22437/chp.v7i1.24768","DOIUrl":"https://doi.org/10.22437/chp.v7i1.24768","url":null,"abstract":"High levels of hardness can lead to increased cases of kidney stones. Hardness levels can be reduced by using activated carbon from the cocoa rind as an adsorbent. The purpose of this research was to determine the variation of activated carbon thickness and optimum retention time in reducing the calcium content of dug well water, to determine the percent decrease in calcium ion levels at the optimum variation, and to determine the significance of the difference in the decreased in calcium levels between the treatment groups. The research method used the principle of adsorption of activated carbon from cocoa shells to calcium ions, which are activated by KOH. There were ten treatment samples with different variations of activated carbon thickness and retention time. The results showed that the thickness of activated carbon of 60 cm with a retention time of 50 minutes had the optimum ability to reduce the calcium content of dug well water. The percentage decrease in calcium levels reached 89,041 % with a decreased concentration of 234 ppm. The result of the statistical test showed a significance value of 0,05. The conclusion of the research is that activated carbon of cocoa shells can reduce calcium levels to the levels of soft water hardness, with variations in activated carbon thickness and retention time having a significant effect.","PeriodicalId":9741,"journal":{"name":"CHEMPUBLISH JOURNAL","volume":"59 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135399407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular Docking Study of Chalcone Analogue Compounds with Hydroxy and Methoxy Subtituents as Bcl-2 Inhibitors 羟基和甲氧基取代查尔酮类似物作为Bcl-2抑制剂的分子对接研究

CHEMPUBLISH JOURNAL Pub Date : 2023-07-30 DOI: 10.22437/chp.v7i1.17487

Neni Frimayanti, Rahma Dona, Tabah Solihin

引用次数: 0

Anticaries Potential of Temu Kunci-Serai Ethyl Acetate Extract Combination: In Vitro and Molecular Studies Approach 铁木苦刺-赛莱乙酸乙酯联合提取物的体外及分子研究

CHEMPUBLISH JOURNAL Pub Date : 2023-07-30 DOI: 10.22437/chp.v7i1.26098

Muhammad Priyadi, Rizki Rachmad Saputra

{"title":"Anticaries Potential of Temu Kunci-Serai Ethyl Acetate Extract Combination: In Vitro and Molecular Studies Approach","authors":"Muhammad Priyadi, Rizki Rachmad Saputra","doi":"10.22437/chp.v7i1.26098","DOIUrl":"https://doi.org/10.22437/chp.v7i1.26098","url":null,"abstract":"Dental caries is one of the problems in dental disorders suffered by many people. There have been many ways of handling such as using temu kunci and lemongrass plants. This study aims to determine the antibacterial activity of caries in vitro and predict the mechanism of action of the bacteria that cause caries Streptococcus mutans. Temu kunci and lemongrass were extracted using ethyl acetate solvent. antibacterial tests against Streptococcus mutans were carried out using diffusion tests with a combination treatment of temu kunci: serai extracts 5% b/v: 5% b/v, 5% b/v: 10% b/v, and 10% b/v: 5% b/v. The positive control used amoxicillin and DMSO as a negative control. Potency as an anticaries drug of drived compound from Temu Kunci and Serai were evaluated by molecular docking using glucosyltransferase (3AIC). The results showed that the combination of temu kunci and serai with concentration 10% b/v: 5% b/v has potential as anticaries against Streptococcus mutans. Molecular studies depicted that Panduratin A, Isopanduratin, and 1,3-O-di-p-coumaroylglycerol have great activity toward 3AIC, respectively. Especially for Panduratin A and Isopanduratin, those compound depicted great and similar binding affinity (-8.4 kcal mol-1) that lower than Acarbose as native ligand (-8.3 kcal mol-1). Furthermore, those compound binding similarity ilustrated activity mechanism similarly with native ligand toward receptor. Additionally, the profiling drug-target interaction suggested Temu Kunci’s derived compounds have great potential as anticaries treatment.","PeriodicalId":9741,"journal":{"name":"CHEMPUBLISH JOURNAL","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135399411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immobilization of Dibenzalacetone on TiO2 Surface and its Potential as Anti-UV Material 二苯甲丙酮在TiO2表面的固定化及其作为抗紫外线材料的潜力

CHEMPUBLISH JOURNAL Pub Date : 2023-07-30 DOI: 10.22437/chp.v7i1.26109

Mokhamat Ariefin, Rokiy Alfanaar

引用次数: 0

Porous Bioceramics use Albumin as a Pore-Forming Material 多孔生物陶瓷使用白蛋白作为成孔材料

CHEMPUBLISH JOURNAL Pub Date : 2023-07-30 DOI: 10.22437/chp.v7i1.8131

Ahmad Fadli, Komalasari Komalasari, Irdoni Irdoni, Wan Elsa Novtari Adiani

引用次数: 0

Sintesis kalsium pirofospat (Ca2P2O7) dari limbah cangkang telur dengan metode solvothermal 用溶剂培养蛋壳废物中的磷酸钙(Ca2P2O7)

CHEMPUBLISH JOURNAL Pub Date : 2020-05-31 DOI: 10.22437/CHP.V5I1.8669

Ihsanul Huda, Retno Kusumaningrum, Mi'raj Shabrin Jamil, W. B. Widayatno, A. S. Wismogroho, Nurul Taufiqu Rochman, Alfian Noviyanto

{"title":"Sintesis kalsium pirofospat (Ca2P2O7) dari limbah cangkang telur dengan metode solvothermal","authors":"Ihsanul Huda, Retno Kusumaningrum, Mi'raj Shabrin Jamil, W. B. Widayatno, A. S. Wismogroho, Nurul Taufiqu Rochman, Alfian Noviyanto","doi":"10.22437/CHP.V5I1.8669","DOIUrl":"https://doi.org/10.22437/CHP.V5I1.8669","url":null,"abstract":"Kalsium pirofospat telah berhasil disintesis dengan menggunakan metode solvothermal. Bahan dasar yang digunakan adalah limbah cangkang telur ayam dan bebek. Cangkang telur ayam dan bebek dibersihkan dan digerus, kemudian dikalsinasi pada temperatur 1000°C selama 2 jam untuk mendapatkan serbuk CaO. Serbuk CaO kemudian dicampurkan dengan H3PO4 dan dimasukkan ke dalam bejana solvothermal. Proses solvothermal dilakukan pada temperatur 130°C selama 16 jam. Fasa tunggal CaHPO4 diperoleh setelah proses solvothermal. Kalsinasi serbuk CaHPO4 dilakukan pada tungku muffle dengan temperatur 800°C selama 2 jam dan kondisi atmosfir biasa. Hasil analisa fasa menunjukkan terbentuknya fasa tunggal kalsium pirofospat (Ca2P2O7) tanpa adanya fasa pengotor lainnya. Hasil ini menunjukkan perbandingan Ca dan P adalah 1. Mikrostruktur kalsium pirofospat yang terbentuk agak kasar dengan ukuran partikel rata-rata 590 ± 43 nm untuk cangkang telur ayam dan 455 ± 32 nm untuk cangkang telur bebek. Studi lebih lanjut diperlukan untuk mendapatkan kondisi optimum dari proses solvothermal limbah cangkang telur sehingga bisa didapatkan kalsium pirofospat yang mempunyai ukuran lebih halus dan seragam.","PeriodicalId":9741,"journal":{"name":"CHEMPUBLISH JOURNAL","volume":"52 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84101460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analisis GC-MS ekstrak tanaman terfermentasi (ETT) dari kulit buah jengkol (Pithecellobium jiringa Prain) 甜菜根果皮发酵的GC-MS提取物分析

CHEMPUBLISH JOURNAL Pub Date : 2020-05-31 DOI: 10.22437/CHP.V5I1.7957

Refilda Suhaili, Lucy Prima Ardi, E. Salim, Mai Efdi

引用次数: 0

Analisis pewarna Rhodamin B pada kerupuk merah di Payakumbuh 在Payakumbuh的红色饼干上分析菱形B染料

CHEMPUBLISH JOURNAL Pub Date : 2020-05-31 DOI: 10.22437/CHP.V5I1.7912

Linda Hevira, Desmi Alwinda, Najmi Hilaliyati

引用次数: 4

Pengaruh konsentrasi PEG 400 sebagai kosurfaktan pada formulasi nanoemulsi minyak kepayang 这种浓度的PEG 400浓度作为防腐剂纳米乳液配方的系数

CHEMPUBLISH JOURNAL Pub Date : 2020-05-31 DOI: 10.22437/CHP.V5I1.7604

Maharini, Rismarika, Yusnelti

{"title":"Pengaruh konsentrasi PEG 400 sebagai kosurfaktan pada formulasi nanoemulsi minyak kepayang","authors":"Maharini, Rismarika, Yusnelti","doi":"10.22437/CHP.V5I1.7604","DOIUrl":"https://doi.org/10.22437/CHP.V5I1.7604","url":null,"abstract":"Kepayang oil has a high content of linoleic and oleic acids. Linoleic and oleic acids act as emollients in the cosmetic field. Nanotechnology is one of the latestinnovations that can be used in cosmetics preparation delivery systems because it can improve the drug delivery process. This study aims to examine the effect of PEG 400 on the formulation of Kepayang oil nanoemulsion. The concentrations of tween 80 and variation concentrations of PEG 400 used in F1, F2, and F3 are 36%: 0%, 36%: 24% and 36%: 14% using the SNEDDS method. The characteristics of nanoemulsion preparations include organoleptic, particle size, polydispersity index, and zeta potential. The result of nanoemulsion production has the organoleptic form in bright yellow color and has a distinctive odor, the particle size in F1, F2 and F3 are 11.8, 13.2 and 11.3 with a polydispersity index of 0.315, 0.147 and 0.121 and zeta potential -16.2, 13.4 and 1.8. The effect of variations in surfactant concentration in the nanoemulsion formulations of kepayang oil is that the higher the level of PEG 400, it will reduce the pH and viscosity of the preparation, increase the particle size, the uniformity of droplet size uniformity, but does not affect the potential zeta value. The best formula is F2.","PeriodicalId":9741,"journal":{"name":"CHEMPUBLISH JOURNAL","volume":"256 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76173873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3