Cancer Science最新文献

{"title":"Real-world genome profiling in Japanese patients with pancreatic ductal adenocarcinoma focusing on HRD implications","authors":"Toshifumi Doi,&nbsp;Takeshi Ishikawa,&nbsp;Tomoki Sakakida,&nbsp;Junichiro Itani,&nbsp;Daiki Sone,&nbsp;Ryuichi Morita,&nbsp;Seita Kataoka,&nbsp;Hayato Miyake,&nbsp;Yuya Seko,&nbsp;Kanji Yamaguchi,&nbsp;Michihisa Moriguchi,&nbsp;Yoshio Sogame,&nbsp;Hideyuki Konishi,&nbsp;Kyoko Murashima,&nbsp;Masahiro Iwasaku,&nbsp;Koichi Takayama,&nbsp;Yoshito Itoh","doi":"10.1111/cas.16329","DOIUrl":"10.1111/cas.16329","url":null,"abstract":"<p>Pancreatic ductal adenocarcinoma (PDAC) poses significant challenges due to its high mortality, making it a critical area of research. This retrospective observational study aimed to analyze real-world data from comprehensive genome profiling (CGP) of Japanese patients with PDAC, mainly focusing on differences in gene detection rates among panels and the implications for homologous recombination deficiency (HRD) status. This study enrolled 2568 patients with PDAC who had undergone CGP between June 2019 and December 2021 using data from the nationwide Center for Cancer Genomics and Advanced Therapeutics database. Two types of CGP assays (tissue and liquid biopsies) were compared and a higher detection rate of genetic abnormalities in tissue specimens was revealed. HRD-related gene alterations were detected in 23% of patients, with <i>BRCA1/2</i> mutations accounting for 0.9% and 2.9% of patients, respectively. Treatment outcome analysis indicated that patients with <i>BRCA1/2</i> mutations had a longer time to treatment discontinuation with FOLFIRINOX than gemcitabine plus nab-paclitaxel as first-line therapy (9.3 vs. 5.6 months, <i>p</i> = 0.028). However, no significant differences were observed in the treatment response among the other HRD-related genes. Logistic regression analysis identified younger age and family history of breast, prostate, and ovarian cancers as predictive factors for HRD-related gene alterations. Despite the lack of progression-free survival data and the inability to discriminate between germline and somatic mutations, this study provides valuable insights into the clinical implications of CGP in Japanese patients with PDAC. Further research is warranted to optimize panel selection and elucidate the efficacy of platinum-based therapies depending on the HRD status.</p>","PeriodicalId":9580,"journal":{"name":"Cancer Science","volume":"115 11","pages":"3729-3739"},"PeriodicalIF":4.5,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11531956/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142308857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BBOX1-AS1 promotes gastric cardia adenocarcinoma progression via interaction with CtBP2 to facilitate the epithelial–mesenchymal transition process","authors":"Wenxu Zou,&nbsp;Qing Yin,&nbsp;Wei Guo,&nbsp;Zhiming Dong,&nbsp;Yanli Guo","doi":"10.1111/cas.16350","DOIUrl":"10.1111/cas.16350","url":null,"abstract":"<p>It is recognized that lncRNA BBOX1-AS1 exerts a crucial oncogenic property in several cancer types. However, the functions and underlying mechanisms of BBOX1-AS1 in the epithelial–mesenchymal transition (EMT) process of gastric cardia adenocarcinoma (GCA) have remained unclarified. The findings of this study demonstrated that GCA tissues had elevated BBOX1-AS1 expression levels, which was associated with a worse prognosis in GCA patients. BBOX1-AS1 dramatically enhanced cell proliferation, invasion, and TGF-β1-induced the EMT process in vitro. Further mechanism analysis revealed that BBOX1-AS1 could combine with CtBP2 and strengthen the interaction of CtBP2 and ZEB1. BBOX1-AS1 might regulate the E-cadherin expression through CtBP2/ZEB1 transcriptional complex-mediated transcriptional repression, further affecting the activation of the Wnt/β-catenin pathway and the EMT process. Overall, our findings demonstrate that BBOX1-AS1 might act as an lncRNA associated with EMT for facilitating GCA advancement via interaction with CtBP2 to facilitate the activation of Wnt/β-catenin pathway and the EMT process, which indicated that it might function as an exploitable treatment target for GCA patients.</p>","PeriodicalId":9580,"journal":{"name":"Cancer Science","volume":"115 12","pages":"3875-3889"},"PeriodicalIF":4.5,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cas.16350","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142330531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “Expression of concern: Hydroxychavicol, a Piper betle leaf component, induces apoptosis of CML cells through mitochondrial reactive oxygen species-dependent JNK and endothelial nitric oxide synthase activation and overrides imatinib resistance”","authors":"","doi":"10.1111/cas.16357","DOIUrl":"10.1111/cas.16357","url":null,"abstract":"<p><i>Cancer Science</i> 115, no. 6 (2024): 2086–2086, https://doi.org/10.1111/cas.16155.</p><p>The originally published version of this Expression of Concern has been updated to include new information raised to us by a third party. The additional text is found below:</p><p>“Subsequently, additional concerns have been raised about Figure 1e DAPI panels, that show high similarity with images from the authors' previous publication, and about Figure 3b HCH subpanel, which includes highly similar cellular sections. The authors were unable to provide a satisfactory explanation, and due to the elapsed time, the original images and the raw data of the manuscript were no longer available.”</p><p>The online version of the originally published Expression of Concern has been corrected accordingly.</p>","PeriodicalId":9580,"journal":{"name":"Cancer Science","volume":"115 12","pages":"4081"},"PeriodicalIF":4.5,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cas.16357","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142308855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interpretable machine learning model predicting immune checkpoint inhibitor-induced hypothyroidism: A retrospective cohort study","authors":"Su-Yan Zhu,&nbsp;Tong-Tong Yang,&nbsp;Yi-Zhuo Zhao,&nbsp;Yu Sun,&nbsp;Xiao-Meng Zheng,&nbsp;Hong-Bin Xu","doi":"10.1111/cas.16352","DOIUrl":"10.1111/cas.16352","url":null,"abstract":"<p>Hypothyroidism is a known adverse event associated with the use of immune checkpoint inhibitors (ICIs) in cancer treatment. This study aimed to develop an interpretable machine learning (ML) model for individualized prediction of hypothyroidism in patients treated with ICIs. The retrospective cohort of patients treated with ICIs was from the First Affiliated Hospital of Ningbo University. ML methods applied include logistic regression (LR), random forest classifier (RFC), support vector machine (SVM), and extreme gradient boosting (XGBoost). The area under the receiver-operating characteristic curve (AUC) was the main evaluation metric used. Furthermore, the Shapley additive explanation (SHAP) was utilized to interpret the outcomes of the prediction model. A total of 458 patients were included in the study, with 59 patients (12.88%) observed to have developed hypothyroidism. Among the models utilized, XGBoost exhibited the highest predictive capability (AUC = 0.833). The Delong test and calibration curve indicated that XGBoost significantly outperformed the other models in prediction. The SHAP method revealed that thyroid-stimulating hormone (TSH) was the most influential predictor variable. The developed interpretable ML model holds potential for predicting the likelihood of hypothyroidism following ICI treatment in patients. ML technology offers new possibilities for predicting ICI-induced hypothyroidism, potentially providing more precise support for personalized treatment and risk management.</p>","PeriodicalId":9580,"journal":{"name":"Cancer Science","volume":"115 11","pages":"3767-3775"},"PeriodicalIF":4.5,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11531944/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142308856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cholesterol synthesis is essential for the growth of liver metastasis-prone colorectal cancer cells","authors":"Kumiko Taniguchi,&nbsp;Kei Sugihara,&nbsp;Takashi Miura,&nbsp;Daisuke Hoshi,&nbsp;Susumu Kohno,&nbsp;Chiaki Takahashi,&nbsp;Eishu Hirata,&nbsp;Etsuko Kiyokawa","doi":"10.1111/cas.16331","DOIUrl":"10.1111/cas.16331","url":null,"abstract":"<p>Metastasis to the liver is a leading cause of death in patients with colorectal cancer. To investigate the characteristics of cancer cells prone to metastasis, we utilized an isogenic model of BALB/c and colon tumor 26 (C26) cells carrying an active <i>KRAS</i> mutation. Liver metastatic (LM) 1 cells were isolated from mice following intrasplenic transplantation of C26 cells. Subsequent injections of LM1 cells generated LM2 cells, and after four cycles, LM4 cells were obtained. In vitro, using a perfusable capillary network system, we found comparable extravasation frequencies between C26 and LM4 cells. Both cell lines showed similar growth rates in vitro. However, C26 cells showed higher glucose consumption, whereas LM4 cells incorporated more fluorescent fatty acids (FAs). Biochemical analysis revealed that LM4 cells had higher cholesterol levels than C26 cells. A correlation was observed between fluorescent FAs and cholesterol levels detected using filipin III. LM4 cells utilized FAs as a source for cholesterol synthesis through acetyl-CoA metabolism. In cellular analysis, cholesterol accumulated in punctate regions, and upregulation of NLRP3 and STING proteins, but not mTOR, was observed in LM4 cells. Treatment with a cholesterol synthesis inhibitor (statin) induced LM4 cell death in vitro and suppressed LM4 cell growth in the livers of nude mice. These findings indicate that colorectal cancer cells prone to liver metastasis show cholesterol-dependent growth and that statin therapy could help treat liver metastasis in immunocompromised patients.</p>","PeriodicalId":9580,"journal":{"name":"Cancer Science","volume":"115 11","pages":"3817-3828"},"PeriodicalIF":4.5,"publicationDate":"2024-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11531946/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142299281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improved platelet separation performance from whole blood using an acoustic fluidics system","authors":"Kazuko Sakai,&nbsp;Shuta Ohara,&nbsp;Junko Tanaka,&nbsp;Kenichi Suda,&nbsp;Takamichi Muramatsu,&nbsp;Chihiro Uematsu,&nbsp;Yasuhiro Tsutani,&nbsp;Tetsuya Mitsudomi,&nbsp;Kazuto Nishio","doi":"10.1111/cas.16337","DOIUrl":"10.1111/cas.16337","url":null,"abstract":"<p>This study investigated the effectiveness of acoustic separation for platelet analysis in patients with non–small-cell lung cancer (NSCLC), comparing it with traditional centrifugation methods. In total, 10 patients with NSCLC and 10 healthy volunteers provided peripheral blood samples, which were processed using either acoustic separation or centrifugation to isolate platelets. The study included whole transcriptome analysis of platelets, peripheral blood mononuclear cells, and tumor tissue samples, employing hierarchical clustering and Gene Ontology analysis to explore gene expression differences. Acoustic separation proved more efficient than centrifugation in terms of platelet yield, recovery rate, and RNA yield. Gene expression profiles of platelets from patients with NSCLC showed distinct patterns compared with healthy volunteers, indicating tumor-influenced alterations. Gene Ontology analysis revealed enrichment in pathways associated with platelet activation and the tumor microenvironment. This finding indicates the potential of acoustic isolation in platelet separation and its relevance in understanding the unique gene expression profile of platelets in patients with NSCLC. The findings of this study suggested that platelets from cancer patients separated by acoustic techniques exhibited tumor-specific alterations and provided new insights into the diagnosis of cancer in platelet analysis systems in clinical practice.</p>","PeriodicalId":9580,"journal":{"name":"Cancer Science","volume":"115 11","pages":"3795-3803"},"PeriodicalIF":4.5,"publicationDate":"2024-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11531943/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142299284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of ENO-1 positive extracellular vesicles as a circulating biomarker for monitoring of Ewing sarcoma","authors":"Koji Uotani,&nbsp;Tomohiro Fujiwara,&nbsp;Koji Ueda,&nbsp;Aki Yoshida,&nbsp;Shintaro Iwata,&nbsp;Takuya Morita,&nbsp;Masahiro Kiyono,&nbsp;Toshiyuki Kunisada,&nbsp;Ken Takeda,&nbsp;Joe Hasei,&nbsp;Yusuke Yoshioka,&nbsp;Takahiro Ochiya,&nbsp;Toshifumi Ozaki","doi":"10.1111/cas.16343","DOIUrl":"10.1111/cas.16343","url":null,"abstract":"<p>The lack of circulating biomarkers for tumor monitoring is a major problem in Ewing sarcoma management. The development of methods for accurate tumor monitoring is required, considering the high recurrence rate of drug-resistant Ewing sarcoma. Here, we describe a sensitive analytical technique for tumor monitoring of Ewing sarcoma by detecting circulating extracellular vesicles secreted from Ewing sarcoma cells. Proteomic analysis of Ewing sarcoma cell-derived extracellular vesicles identified 564 proteins prominently observed in extracellular vesicles from three Ewing sarcoma cell lines. Among these, CD99, SLC1A5, and ENO-1 were identified on extracellular vesicles purified from sera of patients with Ewing sarcoma before treatment but not on extracellular vesicles from those after treatment and healthy individuals. Notably, not only Ewing sarcoma-derived extracellular vesicles but also Ewing sarcoma cells demonstrated proteomic expression of CD99 and ENO-1 on their surface membranes. ENO-1⁺CD63⁺ extracellular vesicle detection was reduced after tumor resection while both CD99⁺CD63⁺ and ENO-1⁺CD63⁺ extracellular vesicles were detected in serum from Ewing sarcoma-bearing mice. Finally, the accuracy of liquid biopsy targeting these candidates was assessed using extracellular vesicles from the sera of patients with Ewing sarcoma. Elevated ENO-1⁺CD81⁺ extracellular vesicles in the serum of patients before treatments distinguished patients with Ewing sarcoma from healthy individuals with an area under the curve value of 0.92 (<i>P</i> &lt; 0.001) and reflected the tumor burden in patients with Ewing sarcoma during multidisciplinary treatments. Collectively, circulating ENO-1⁺CD81⁺ extracellular vesicle detection could represent a novel tool for tumor monitoring of Ewing sarcoma.</p>","PeriodicalId":9580,"journal":{"name":"Cancer Science","volume":"115 11","pages":"3660-3671"},"PeriodicalIF":4.5,"publicationDate":"2024-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11531948/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142299283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Growth pattern of de novo small clusters of colorectal cancer is regulated by Notch signaling at detachment","authors":"Yi-Kai Lin,&nbsp;Roberto Coppo,&nbsp;Kunishige Onuma,&nbsp;Hiroko Endo,&nbsp;Jumpei Kondo,&nbsp;Sadahiro Iwabuchi,&nbsp;Shinichi Hashimoto,&nbsp;Yoshiro Itatani,&nbsp;Kazutaka Obama,&nbsp;Masahiro Inoue","doi":"10.1111/cas.16299","DOIUrl":"10.1111/cas.16299","url":null,"abstract":"<p>Cancer cell clusters have a higher capacity for metastasis than single cells, suggesting cancer cell clusters have biological properties different from those of single cells. The nature of de novo cancer cell clusters that are newly formed from tumor masses is largely unknown. Herein, we generated small cell clusters from colorectal cancer organoids and tracked the growth patterns of the clusters up to four cells. Growth patterns were classified into actively growing and poorly growing spheroids (PG). Notch signaling was robustly activated in small clusters immediately after dissociation, and Notch signaling inhibition markedly increased the proportion of PG spheroids. Only a limited number of PG spheroids grew under growth-permissive conditions in vitro, but xenograft tumors derived from Notch inhibited clusters showed growth rates comparable to those of untreated spheroids. Thus, de novo clusters are composed of cells with interchangeable growth fates, which are regulated in a context-dependent manner by Notch signaling.</p>","PeriodicalId":9580,"journal":{"name":"Cancer Science","volume":"115 11","pages":"3648-3659"},"PeriodicalIF":4.5,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11531966/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142299282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic profiles and clinical features in subcutaneous panniculitis-like T-cell lymphomas","authors":"Yui Okamura,&nbsp;Kenichi Makishima,&nbsp;Yasuhito Suehara,&nbsp;Sakurako Suma,&nbsp;Yoshiaki Abe,&nbsp;Ryota Matsuoka,&nbsp;Tatsuhiro Sakamoto,&nbsp;Keiichiro Hattori,&nbsp;Yasuhisa Yokoyama,&nbsp;Takayasu Kato,&nbsp;Toru Nanmoku,&nbsp;Takeshi Iwasaki,&nbsp;Kenichi Nishiyama,&nbsp;Koji Kato,&nbsp;Yasuhide Takeuchi,&nbsp;Hideki Makishima,&nbsp;Naoya Nakamura,&nbsp;Shigeru Chiba,&nbsp;Mamiko Sakata-Yanagimoto","doi":"10.1111/cas.16345","DOIUrl":"10.1111/cas.16345","url":null,"abstract":"<p>Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a rare peripheral T-cell lymphoma characterized by cutaneous lesions and immunologic manifestations. The five-year survival rate of SPTCL has been reported to be over 80%, indicating a favorable prognosis. Recent studies have uncovered recurrent germline variants in <i>HAVCR2</i>, encoding an immunomodulator. In this study, we integrated whole-exome sequencing data from 60 samples collected from 36 SPTCL patients, encompassing six patients of our cohort and 30 patients of publicly available data. We identified 138 somatic mutations in skin tumors of 24 patients and <i>HAVCR2</i> germline mutations in 23 of 29 patients. <i>HAVCR2</i> p.Tyr82Cys mutations were identified in four of six Japanese patients. During the clinical courses of four patients, cyclophosphamide, hydroxydaunomycin, vincristine, and prednisone were administered to all patients, but it resulted in incomplete responses in all four patients. However, disease conditions of all patients remained stable with additional treatment, including autologous peripheral blood stem cell transplantation. Over a 7.5-year median follow-up, one patient developed autoimmune-related diseases, while one developed other hematological malignancy, resulting in death. To our knowledge, this is the first report of recurrent <i>HAVCR2</i> germline mutations in Japanese patients, suggesting the necessity for long-term follow-up.</p>","PeriodicalId":9580,"journal":{"name":"Cancer Science","volume":"115 11","pages":"3788-3794"},"PeriodicalIF":4.5,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cas.16345","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142248672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTION: Zebularine Enhances Apoptosis of Human Osteosarcoma Cells by Suppressing Methylation of ARHI","authors":"","doi":"10.1111/cas.16346","DOIUrl":"10.1111/cas.16346","url":null,"abstract":"<p><b>RETRACTION</b>: K. Ye, S. Wang, J. Wang, H. Han, B. Ma and Y. Yang, “Zebularine Enhances Apoptosis of Human Osteosarcoma Cells by Suppressing Methylation of ARHI,” <i>Cancer Science</i> 107, no. 12 (2016): 1851–1857, https://doi.org/10.1111/cas.13088.</p><p>The above article, published online on 29 September 2016 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Masanori Hatakeyama; the Japanese Cancer Association; and John Wiley &amp; Sons Australia, Ltd. The retraction has been agreed following an investigation into concerns raised by a third party, which revealed that the western blots presented in figure 4a and 4d contain duplicated bands. Furthermore, duplications were found between bands within figure 4d itself, some of which appear to have been horizontally flipped. The authors did not respond to the concerns raised and did not provide their original data. The editors consider the results and conclusion reported in this article unreliable.</p>","PeriodicalId":9580,"journal":{"name":"Cancer Science","volume":"115 12","pages":"4080"},"PeriodicalIF":4.5,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cas.16346","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142249030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}