Jenny Guo, M. Assmus, N. Dean, Matthew S. Lee, Clarissa Wong, Jordan Rich, Jessica Helon, Mitchell M. Huang, Amy E. Krambeck
{"title":"Comparison of outcomes in patients with and without neurologic diseases undergoing holmium laser enucleation of the prostate.","authors":"Jenny Guo, M. Assmus, N. Dean, Matthew S. Lee, Clarissa Wong, Jordan Rich, Jessica Helon, Mitchell M. Huang, Amy E. Krambeck","doi":"10.5489/cuaj.8683","DOIUrl":"https://doi.org/10.5489/cuaj.8683","url":null,"abstract":"INTRODUCTION\u0000We aimed to compare holmium laser enucleation of the prostate (HoLEP) outcomes in patients with and without neurologic diseases (ND).\u0000\u0000\u0000METHODS\u0000A prospectively maintained database of patients undergoing HoLEP from January 2021 to April 2022 was reviewed. The following NDs were included: diabetes-related neuropathy/neurogenic bladder, Parkinson's disease, dementia, cerebrovascular accident, multiple sclerosis, traumatic brain injury, transient ischemic attack, brain/spinal tumors, myasthenia gravis, spinal cord injury, and other. Statistical analysis was performed using t-tests, Chi-squared, and binomial tests (p<0.05).\u0000\u0000\u0000RESULTS\u0000A total of 118 ND patients were identified with 135 different neurologic diseases. ND patients were more likely to have indwelling catheters (57% vs. 39%, p=0.012) and urinary tract infections (UTIs) preoperatively (32% vs. 19%, p=0.002). Postoperatively, ND patients were more likely to fail initial trial of void (20% vs. 8.1%, p<0.001) and experience an episode of acute urinary retention (16% vs. 8.5%, p=0.024). Within 90 days postoperative, the overall complication rate was higher in the ND group (26% vs. 13%, p=0.001). Within the ND group, 30/118 (25%) had ≥1 UTI within 90 days preoperative, which decreased to 10/118 (8.7%) 90 days postoperative (p<0.001). At last followup (mean 6.7 months [ND] vs. 5.4 months [non-ND], p=0.03), four patients (4.4%) in the ND group required persistent catheter/clean intermittent catheterization compared to none in the non-ND group (p=0.002).\u0000\u0000\u0000CONCLUSIONS\u0000Patients with ND undergoing HoLEP are more likely to experience postoperative retention and higher complication rates compared to non-ND patients. While UTI rates are higher in this population, HoLEP significantly reduced three-month UTI and catheterization rates.","PeriodicalId":9574,"journal":{"name":"Canadian Urological Association journal = Journal de l'Association des urologues du Canada","volume":"27 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140753905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jennifer A. Locke, S. Neu, Joanne Lawrence, S. Herschorn
{"title":"Pilot study to assess the feasibility of self-administered, low-dose methoxyflurane for cystoscopic procedures.","authors":"Jennifer A. Locke, S. Neu, Joanne Lawrence, S. Herschorn","doi":"10.5489/cuaj.8676","DOIUrl":"https://doi.org/10.5489/cuaj.8676","url":null,"abstract":"INTRODUCTION\u0000Methoxyflurane (MEOF) (Penthrox™) is an inhaled, self-administered, non-opioid analgesic approved by Health Canada for the short-term relief of moderate to severe acute pain associated with trauma or interventional medical procedures. In this pilot study, we evaluated the feasibility of using MEOF as an anesthetic agent in 11 patients undergoing outpatient cystoscopic procedures.\u0000\u0000\u0000METHODS\u0000The average duration of the procedure was 24 (range 20-35) minutes and this included 10 minutes of administration time of the drug and five minutes of wait time before the procedure. The average monitoring time from start to end of the procedure was 23 (range 20-35) minutes and this included 15 minutes of monitoring post-procedure. On a scale of 0-10, patients on average rated the pain 4/10 (standard deviation [SD] 2.6).\u0000\u0000\u0000RESULTS\u0000Global performance was on average 3/4 (SD 1.3) for the patients and 3/4 (SD 1.1) for the operator. Of the 11 patients, four reported adverse events; two experienced euphoria, one experienced dizziness, and one was unable to tolerate the medication. Two patients noted their adverse events to be of moderate intensity, while the other two were of mild intensity. None of the adverse events was deemed serious.\u0000\u0000\u0000CONCLUSIONS\u0000Our findings in this pilot study provide proof of principle for the design of a randomized control trial to evaluate MEOF as an anesthetic in an outpatient cystoscopic procedural setting. As more urologic procedures are being performed in an outpatient setting, this may offer significant clinical benefit.","PeriodicalId":9574,"journal":{"name":"Canadian Urological Association journal = Journal de l'Association des urologues du Canada","volume":"24 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140753307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Patrick Albers, J. Bennett, Moira Evans, Ella St Martin, Betty Wang, Stacey Broomfield, Anaïs Medina Martín, Wendy Tu, Christopher Fung, Adam Kinnaird
{"title":"Micro-ultrasound for the detection of clinically significant prostate cancer in biopsy-naive men with negative MRI.","authors":"Patrick Albers, J. Bennett, Moira Evans, Ella St Martin, Betty Wang, Stacey Broomfield, Anaïs Medina Martín, Wendy Tu, Christopher Fung, Adam Kinnaird","doi":"10.5489/cuaj.8626","DOIUrl":"https://doi.org/10.5489/cuaj.8626","url":null,"abstract":"INTRODUCTION\u0000Despite a negative magnetic resonance imaging (MRI), some patients may still harbor clinically significant prostate cancer (csPCa, Gleason grade group ≥2). High-resolution micro-ultrasound (microUS) is a novel imaging technology that could visualize csPCa that is missed by MRI.\u0000\u0000\u0000METHODS\u0000This retrospective review included 1011 consecutive patients biopsied between September 2021 and July 2023 in Alberta, Canada. Among them were 103 biopsy-naive patients with negative MRI (Prostate Imaging Reporting & Data System [PI-RADS] ≤2) undergoing microUS-informed prostate biopsy (n=56) scored using Prostate Risk Identification Using Micro-ultrasound (PRI-MUS) or standard transrectal ultrasound prostate biopsy (n=47). The primary outcome was detection rate of csPCa stratified by biopsy technique and PRI-MUS score.\u0000\u0000\u0000RESULTS\u0000MicroUS biopsy identified csPCa in 14/56 (25%) compared to standard biopsy in 8/47 (17%) (p=0.33). Patients with lesions PRI-MUS ≥3 had csPCa detected at a higher rate compared to patients with PRI-MUS ≤2 (42% vs. 16%, p=0.03). The csPCa detection rate was significantly different comparing patients with PSA density <0.15 and PRI-MUS ≤2 compared to patients with PSA density ≥0.15 and PRI-MUS ≥3 (14% vs. 60%, p=0.02).\u0000\u0000\u0000CONCLUSIONS\u0000MicroUS may aid in the detection of csPCa for patients with negative MRI.","PeriodicalId":9574,"journal":{"name":"Canadian Urological Association journal = Journal de l'Association des urologues du Canada","volume":"61 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140755078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. G. Fagan, W. C. I. Janes, Matthew Andrews, David R. Harvey, Geoff M. Warden, Michael K. Organ, Paul H. Johnston
{"title":"Restricted access and advanced disease in post-pandemic testicular cancer.","authors":"M. G. Fagan, W. C. I. Janes, Matthew Andrews, David R. Harvey, Geoff M. Warden, Michael K. Organ, Paul H. Johnston","doi":"10.5489/cuaj.8648","DOIUrl":"https://doi.org/10.5489/cuaj.8648","url":null,"abstract":"INTRODUCTION\u0000Urologists observed reduced cancer consultations and surgeries during the SARS-CoV-2 pandemic, raising concern about treatment delays. Testicular cancer serves as a particularly sensitive marker of this phenomenon, as the clinical stage of testicular cancer at presentation is predictive of cancer-specific survival. We aimed to investigate whether COVID-related restrictions to primary care access resulted in increased incidence of metastatic germ cell testis cancer.\u0000\u0000\u0000METHODS\u0000A retrospective chart review was conducted on all cases of testicular cancer managed surgically at our center from March 1, 2018, to February 28, 2023. Patients were categorized into temporal cohorts, representing before, during, and following the implementation of COVID-19 public health restrictions in the province of Newfoundland and Labrador.\u0000\u0000\u0000RESULTS\u0000Forty-one cases of testicular germ cell tumors were identified during the study period. The mean age at diagnosis was 40.8 years (standard deviation ±13.7). Demographics did not vary across the cohorts. Clinical stage 3 disease remained stable before and during the pandemic at 10.5% and 9.1% of cases, respectively. In the post-pandemic period, there was an increase to 27.3% (p=0.617). Surgical wait times remained stable across the pandemic (p=0.151).\u0000\u0000\u0000CONCLUSIONS\u0000There was a 16.8% rise in clinical stage III disease from the pre-pandemic to post-pandemic period. Our study failed to identify a statistically significant increase in metastatic testis cancer incidence upon lifting of pandemic restrictions. Further study is necessary to confirm suspicions that pandemic restrictions contributed to increased incidence of metastatic testis cancer.","PeriodicalId":9574,"journal":{"name":"Canadian Urological Association journal = Journal de l'Association des urologues du Canada","volume":"28 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140753759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nick Lee, Patricia Nadeau, M. Berjaoui, Anis Assad, Ben H. Chew, Kate Penniston, N. Bhojani
{"title":"Treatment modalities for small-sized urolithiases and their impact on health-related quality of life.","authors":"Nick Lee, Patricia Nadeau, M. Berjaoui, Anis Assad, Ben H. Chew, Kate Penniston, N. Bhojani","doi":"10.5489/cuaj.8698","DOIUrl":"https://doi.org/10.5489/cuaj.8698","url":null,"abstract":"INTRODUCTION\u0000Health-related quality of life (HRQoL) is often reduced in patients with urolithiasis. The objective of this study was to perform a systematic review to describe impact on HRQoL based on different modalities of treatment for small urolithiases with a diameter smaller or equal to 10 mm.\u0000\u0000\u0000METHODS\u0000Electronic databases were searched with no language or date restrictions to identify studies which were included if they reported: adult patients (≥18 years old), renal or ureteral stone(s) confirmed on imagery, validated reporting of HRQoL, and stone diameter equal or smaller than 10 mm undergoing active surveillance, medical expulsive therapy (MET), shockwave lithotripsy (SWL), or ureteroscopy (URS).\u0000\u0000\u0000RESULTS\u0000Of 672 citations, nine articles were eligible. Five studies (all ureteral) reported HRQoL according to medical stone management. Three of them found that HRQoL in MET patients was better than in active surveillance patients and two studies found no difference in HRQoL between MET and active surveillance groups. Four studies (three ureteral, one renal) reported HRQoL according to surgical stone management. Of the ureteral stone studies, two reported better HRQoL in URS patients than in SWL patients, while one study found no difference between URS and SWL groups. In the renal stone study, SWL patients had better HRQoL than URS patients.\u0000\u0000\u0000CONCLUSIONS\u0000Patients with urinary stones 10 mm or smaller have better HRQoL when treated with MET vs. active surveillance, when treated with SWL vs. URS for renal stones, and when treated with URS vs. SWL for ureteral stones. There is an important need for more studies on this topic.","PeriodicalId":9574,"journal":{"name":"Canadian Urological Association journal = Journal de l'Association des urologues du Canada","volume":"31 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140753080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kaveh Masoumi-Ravandi, Ross J. Mason, Ricardo A Rendon
{"title":"Robotic-assisted laparoscopic partial nephrectomy vs. laparoscopic and open partial nephrectomy: A single-site, two-surgeon, retrospective cohort study.","authors":"Kaveh Masoumi-Ravandi, Ross J. Mason, Ricardo A Rendon","doi":"10.5489/cuaj.8585","DOIUrl":"https://doi.org/10.5489/cuaj.8585","url":null,"abstract":"INTRODUCTION\u0000In 2019, our center attempted to transition all partial nephrectomies (PNs) to robotic-assisted laparoscopic PN (RALPN). The purpose of this study was to compare RALPN outcomes to laparoscopic PN (LPN) and open PN (OPN) at our institution, as there is limited literature from Canadian centers.\u0000\u0000\u0000METHODS\u0000In this single-center, two-surgeon, retrospective cohort study, we compared RALPN outcomes during the early phase of our robotics program to OPN and LPN performed just before the introduction of RALPN.\u0000\u0000\u0000RESULTS\u0000A total of 106 patients underwent OPN, 83 LPN, and 82 RALPN during the study period. Median RALPN RENAL score was 7 vs. 6 for LPN (p<0.05) and 8 for OPN (p=0.10). Median RALPN length of stay (LOS) was two days vs. three and four days for LPN and OPN (p<0.05), respectively. OPN median procedure time was 104 minutes vs. 94 and 82 minutes for LPN and RALPN (p<0.05), respectively. Median OPN operating room (OR) time was 160 minutes vs. 150 and 146 minutes for LPN and RALPN (p<0.05), respectively. There were no significant differences in intraoperative (p=0.92) or postoperative complications rates (p=0.47). RALPN warm ischemia time (WIT) was 17 minutes vs 14.5 and 15 minutes for OPN and LPN (p<0.05), respectively. Median RALPN estimated blood loss (EBL) was 165 ml vs. 250 ml for OPN (p<0.05) and 125 ml for LPN (p=0.15).\u0000\u0000\u0000CONCLUSIONS\u0000Although patients who underwent RALPN had longer WIT, they had similar rates of complications, required less total OR time, and had shorter procedure time and LOS compared with OPN and LPN despite similar RENAL score compared to OPN and greater score than LPN.","PeriodicalId":9574,"journal":{"name":"Canadian Urological Association journal = Journal de l'Association des urologues du Canada","volume":"58 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140754521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anindyo Chakraborty, Dean S. Elterman, Nicholas J Corsi, D. Bouhadana, Gregory Bailly, Premal Patel, Rowen McLellan, Liam Hickey, Daniel Costa, Matthew Andrews, Howard Evans, Connor M. Forbes, H. Elmansy, M. Meskawi, N. Bhojani, Bilal Chugtai, K. Zorn
{"title":"An analysis of benign prostatic hyperplasia surgical treatment reimbursement trends across Canada: Examining provincial changes over the recent decade with comparison to cost of living changes.","authors":"Anindyo Chakraborty, Dean S. Elterman, Nicholas J Corsi, D. Bouhadana, Gregory Bailly, Premal Patel, Rowen McLellan, Liam Hickey, Daniel Costa, Matthew Andrews, Howard Evans, Connor M. Forbes, H. Elmansy, M. Meskawi, N. Bhojani, Bilal Chugtai, K. Zorn","doi":"10.5489/cuaj.8638","DOIUrl":"https://doi.org/10.5489/cuaj.8638","url":null,"abstract":"INTRODUCTION\u0000A variety of procedures for the endoscopic surgical treatment of symptomatic benign prostatic hyperplasia (BPH) refractory to medical therapy have existed for decades. The present study examines trends in surgeon compensation for these treatments within Canada.\u0000\u0000\u0000METHODS\u0000The physician fee schedule for BPH surgery across 10 Canadian provinces for the years 2010 and 2023 were obtained. A descriptive study examining first, the provincial reimbursement for transurethral resection of prostate (TURP) and laser ablative/enucleation surgery; second, the difference in TURP reimbursement between 2010 and 2023; and third, the annual change in TURP reimbursement juxtaposed with the annual change in the provincial Consumer Price Index (CPI) and annual salary for the working population aged 35-44.\u0000\u0000\u0000RESULTS\u0000Seven of 10 Canadian provinces reimburse laser BPH surgery equally to TURP. The average provincial TURP reimbursement is $545, ranging from $451 in Ontario to $688 in Saskatchewan. Since 2010, TURP reimbursement has varied by province from a 0% net change in Ontario to an increase of 21% in Nova Scotia. Reimbursement for TURP has increased at a slower pace than the local CPI, and for half of the provinces at a slower pace than the annual salary for people aged 35-44.\u0000\u0000\u0000CONCLUSIONS\u0000The compensation model for endoscopic BPH surgery does not have a unified structure in Canada that is consistent across provinces, nor does it keep up with inflation, possibly impacting future recruitment, increasing geographic disparities, and most importantly, limiting the adoption of new BPH therapies.","PeriodicalId":9574,"journal":{"name":"Canadian Urological Association journal = Journal de l'Association des urologues du Canada","volume":"26 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140753676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
David-Dan Nguyen, Ahmad Mousa, Laurence Klotz, T. Niazi, Frédéric Pouliot, Andrea Kokorovic, Luke T Lavallée, Melissa Huynh, Nathalie Lapointe, Michelle Di Risio, C. J. Wallis
{"title":"Screening and management of metabolic, cardiac, and bone health in prostate cancer patients on androgen deprivation therapy: A survey of specialized physicians.","authors":"David-Dan Nguyen, Ahmad Mousa, Laurence Klotz, T. Niazi, Frédéric Pouliot, Andrea Kokorovic, Luke T Lavallée, Melissa Huynh, Nathalie Lapointe, Michelle Di Risio, C. J. Wallis","doi":"10.5489/cuaj.8687","DOIUrl":"https://doi.org/10.5489/cuaj.8687","url":null,"abstract":"","PeriodicalId":9574,"journal":{"name":"Canadian Urological Association journal = Journal de l'Association des urologues du Canada","volume":"17 21","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140754140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Wyatt MacNevin, Morgan MacDonald, Dawn L. MacLellan, Daniel T. Keefe
{"title":"Pediatric testicular torsion management practices: A survey of Canadian urologists.","authors":"Wyatt MacNevin, Morgan MacDonald, Dawn L. MacLellan, Daniel T. Keefe","doi":"10.5489/cuaj.8644","DOIUrl":"https://doi.org/10.5489/cuaj.8644","url":null,"abstract":"INTRODUCTION\u0000Pediatric testicular torsion (TT) is a urologic emergency that may result in testicular loss if left untreated. Testicular salvage is dependent on prompt intervention, and thus delays in diagnosis and management may threaten testicular viability. Knowledge of real-world Canadian practice patterns for pediatric TT will allow optimization of practices based on resource availability and geographic limitations to improve care.\u0000\u0000\u0000METHODS\u0000An electronic survey on pediatric TT management was distributed to Canadian urologists. Descriptive statistics were performed on respondent demographic factors, hospital policies and barriers to care, surgical approaches, and transfer practices. Respondent practice patterns were analyzed based on geographic location and training.\u0000\u0000\u0000RESULTS\u0000Thirty-four urologists responded, with the majority of respondents operating a community practice. Ultrasonography (US) was frequently used to support TT diagnosis. Despite this, poor US access was often cited as a barrier to care, with particular impact on rural urologists. Neonatal patients and <10 years old were commonly transferred to a pediatric hospital for definitive management due to surgeon discomfort and hospital policies. Reported transport methods commonly included use of the patient's own vehicle or ambulance based on availability and timing.\u0000\u0000\u0000CONCLUSIONS\u0000Neonatal patients and patients under 10 years old are most commonly reported to be transferred to pediatric hospitals for TT management. Patients located in rural locations and at centers with limited US access may be at risk for delayed diagnosis and treatment. Pathways for prompt management of suspected TT may better serve these younger pediatric patients.","PeriodicalId":9574,"journal":{"name":"Canadian Urological Association journal = Journal de l'Association des urologues du Canada","volume":"57 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140754522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sophie Wittenberg, Raghav Madan, Aron Liaw, Steven Lucas, Alaa Hamada, Nivedita Dhar
{"title":"Amniotic bladder therapy in patients with recalcitrant interstitial cystitis and bladder pain syndrome.","authors":"Sophie Wittenberg, Raghav Madan, Aron Liaw, Steven Lucas, Alaa Hamada, Nivedita Dhar","doi":"10.5489/cuaj.8441","DOIUrl":"10.5489/cuaj.8441","url":null,"abstract":"INTRODUCTION Bladder pain, urgency and frequency are common symptoms that are generally seen in patients with interstitial cystitis/bladder pain syndrome (IC/BPS) [1]. These symptoms often arise due to excessive inflammation that disrupts the urothelial homeostasis and results in dysfunction of the bladder urothelium, which serves as a barrier to prevent injurious stimuli, toxins, or microorganisms from invading the stroma [2, 3]. Unfortunately, existing treatment options are palliative and do not modulate the underlying issues contributing to the symptoms. Hence, there remains an unmet clinical need for patients presenting with recalcitrant IC/BPS. Human amniotic membrane (AM) has been used in various clinical applications such as ocular and dermal wound healing due to its ability to modulate inflammation and promote tissue regeneration in the wound healing process [4, 5]. As AM has been shown to improve wound healing in many other medical practices, likewise it may improve urothelial wound healing in patients with recalcitrant IC/BPS. Herein, we detail the outcomes of five consecutive patients KEY MESSAGES","PeriodicalId":9574,"journal":{"name":"Canadian Urological Association journal = Journal de l'Association des urologues du Canada","volume":" ","pages":"E402-E404"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10657225/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9951117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}