Cancer Research and Treatment : Official Journal of Korean Cancer Association最新文献

{"title":"Ovarian, Fallopian Tube, and Primary Peritoneal Cancer","authors":"R. Morgan, A. Clamp, G. Jayson","doi":"10.1201/9780429026638-19","DOIUrl":"https://doi.org/10.1201/9780429026638-19","url":null,"abstract":"","PeriodicalId":9541,"journal":{"name":"Cancer Research and Treatment : Official Journal of Korean Cancer Association","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87252792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Renal Cell Cancer","authors":"S. Ellis, J. Hack","doi":"10.1201/9780429026638-18","DOIUrl":"https://doi.org/10.1201/9780429026638-18","url":null,"abstract":"","PeriodicalId":9541,"journal":{"name":"Cancer Research and Treatment : Official Journal of Korean Cancer Association","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82792127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Natural Plants and Cancer Therapy","authors":"Ahmed M. Kabel","doi":"10.12691/JCRT-8-2-5","DOIUrl":"https://doi.org/10.12691/JCRT-8-2-5","url":null,"abstract":"Cancer chemotherapy represents the cornerstone of management of a vast majority of neoplastic lesions. Adverse reactions of chemotherapy may affect the major body organs and represent deleterious health hazards for cancer patients. Recent studies are directed towards discovery of natural compounds of plant origin that have potential anticancer properties and may ameliorate the toxic effects induced by the traditional anticancer agents. This manuscript throws light on the potential role of the natural plants in cancer therapy.","PeriodicalId":9541,"journal":{"name":"Cancer Research and Treatment : Official Journal of Korean Cancer Association","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87422395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anxiety and Pain Level Associated with Mammography and the Impact of the Preexistence of Knowledge","authors":"F. Aldhafeeri, M. Abozeed","doi":"10.12691/jcrt-8-2-4","DOIUrl":"https://doi.org/10.12691/jcrt-8-2-4","url":null,"abstract":"Background: Breast cancer is the most common type of cancer in women, after skin cancer. Early detection and treatment are recommended for reducing mortality and suffering. However, screening behaviors are often avoided for many reasons, such as anxiety and stress. Mammography screening is the main recommended test for the early detection of breast cancer. The objective of this study was to assess the knowledge, level of pain, and stress in women during the early screening of breast cancer with a mammogram. Materials and methods: This study has been approved by the Local Research Ethics Committee. The study was conducted at Hafr Elbatin Central Hospital in Saudi Arabi among 100 women. Data were collected via a structured interview questionnaire before and immediately after the mammography procedure. The questionnaire consisted of three parts: (1) sociodemographic data and knowledge about the mammogram examination, (2) pain scale, and (3) anxiety scale. Data were entered and analyzed using SPSS version 25. Results: A total of 75% (n=75) of the women reported moderate to severe pain during the mammogram examination. Up to 57% (n=57) of the women expressed severe anxiety about the mammogram procedure. Most of the women-85% (n=85)-were found to have poor knowledge related to mammograms and mammogram preparation. There was a strong correlation between pain before and during the mammogram procedure, P-Value (0.00001*) with Chi-squared (33.40) and a highly significant correlation between satisfactory and unsatisfactory knowledge in women's P-Value (0.00001*) with z test (6.57). A poor knowledge about breast cancer was detected in the overall studied women and those who had never undergone mammography, particularly knowledge related to the risk factors for breast cancer. The most important predictors of the barriers to mammography were incorrect beliefs about mammography and its procedures. Conclusion: Pain expectations can be approached in various ways to make the mammography experience much more tolerable for women, thereby encouraging them to attend and return for their scans. It was determined that women who had mammography had a moderate level of anxiety.","PeriodicalId":9541,"journal":{"name":"Cancer Research and Treatment : Official Journal of Korean Cancer Association","volume":"52 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85878726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pituitary Adenomas: Insights into the Recent Trends","authors":"Ahmed M. Kabel","doi":"10.12691/jcrt-8-2-3","DOIUrl":"https://doi.org/10.12691/jcrt-8-2-3","url":null,"abstract":"Pituitary adenoma is a type of pituitary neoplasms that is typically a benign, slow-growing tumor that arises from cells in the pituitary gland. Pituitary adenomas are classified according to their secretory products into functioning (Endocrine-active) tumors that represent almost 70% of pituitary tumors, and non-functioning adenomas (Endocrine-inactive). Because of physiologic effects of excess hormones, the functioning tumors present earlier than non-functioning adenomas. Patients with pituitary adenomas usually present with symptoms related to hormonal disturbances. However, pressure symptoms, such as headache, visual field defects, cranial nerve palsies and hypopituitarism may occur due to the mass effect of large tumors. Treatment of pituitary adenomas include transsphenoidal surgery and adjunctive therapy including supervoltage radiation and pharmacologic agents. This review throws light on pituitary adenoma regarding its prevalence, predisposing factors, types, clinical presentation, diagnosis and possible lines of management in view of the recent trends.","PeriodicalId":9541,"journal":{"name":"Cancer Research and Treatment : Official Journal of Korean Cancer Association","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90615151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"VEGF and KRAS are Potential Targets of miR-206 Modulation in Triple Negative Breast Cancer","authors":"Shaymaa E. El Feky, Fawziya A. R. Ibrahim, A. Nassar, N. A. E. Moneim, S. A. Ebeid, Mohammad Ahmad, Sanaa Shawky, Mohammad M. Nasef","doi":"10.12691/jcrt-7-1-2","DOIUrl":"https://doi.org/10.12691/jcrt-7-1-2","url":null,"abstract":"Triple negative is a subtype of breast cancer characterized by lack of expression of hormone receptors (ER, PR and Her2/neu). Due to the limited treatment options, the search for novel treatment targets continues. The aim of this study was to assess the differential expression of miR-206, VEGF and KRAS in TNBC and non-TNBC tissues and cell lines and to evaluate the modulatory effect of miR-206 on the key oncogenic targets VEGF and KRAS. The expression of miR-206, VEGF and KRAS was quantified using real time PCR in both paraffin embedded breast cancer and adjacent tissues as well as in MDA-MB-231 and MCF-7 cell lines. Cell lines were transfected with different concentrations of miR-206 mimic and their viability were assessed using MTT assay. Our results indicated that miR-206 was significantly downregulated in cancerous compared to non-cancerous tissues with a more pronounced downregulation in TNBC than non-TNBC tissues. VEGF and KRAS were significantly upregulated in TNBC compared to non-TNBC and their expression was negatively correlated to miR-206 expression. Transfection of TNBC and non-TNBC cell lines with miR-206 mimic resulted in a dose dependent reduction in cell viability as well as a significant reduction in VEGF and KRAS expression. In conclusion, based on our combined human tissues and cell line-based investigations we can suggest that VEGF and KRAS may be potential targets for miR-206-mediated regulation and that their targeting by miR-206 can be a highly efficient therapeutic strategy in TNBC.","PeriodicalId":9541,"journal":{"name":"Cancer Research and Treatment : Official Journal of Korean Cancer Association","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80177805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Astrocytoma: Insights into Risk Factors, Pathogenesis, Diagnosis and Management","authors":"Ahmed M. Kabel, Kholoud Modais, A. Salim, R. Ahmad, A. Ahmad, Khaled A. Alnumari","doi":"10.12691/JCRT-6-3-2","DOIUrl":"https://doi.org/10.12691/JCRT-6-3-2","url":null,"abstract":"Astrocytoma is one of the most common types of brain tumors. It arises from astrocytes-star-shaped cells that make up the i°glue-likei± or supportive tissue of the brain. There are different types and severities of Astrocytomas. According to (WHO),It can be classified into grades from I to IV. The most frequently diagnosed types of astrocytoma are pilocytic astrocytoma, grade II astrocytoma, anaplastic astrocytoma and glioblastoma multiforme. They may or may not be cancerous. The exact cause of astrocytoma is unknown. Astrocytomas occur slightly more often in men than in women. They are slightly more common in Caucasians. Astrocytomas can develop in both children and adults. The diagnosis of astrocytoma is based on a thorough clinical evaluation, characteristic physical findings, a careful patient history, and specialized tests. Astrocytomas may be treated with surgery, radiation therapy, chemotherapy or a combination of treatments.","PeriodicalId":9541,"journal":{"name":"Cancer Research and Treatment : Official Journal of Korean Cancer Association","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76086108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pancreatic Cancer","authors":"K. Mann, A. Sheel, P. Ghaneh","doi":"10.1201/9781315379678-18","DOIUrl":"https://doi.org/10.1201/9781315379678-18","url":null,"abstract":"","PeriodicalId":9541,"journal":{"name":"Cancer Research and Treatment : Official Journal of Korean Cancer Association","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89064125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anticancer Effect of Medicinal Mushroom with Prooxidant Activity on Human Bladder Cancer Cells","authors":"C. Fox, R. Yau, M. Choudhury, J. Phillips, S. Konno","doi":"10.12691/JCRT-6-2-5","DOIUrl":"https://doi.org/10.12691/JCRT-6-2-5","url":null,"abstract":"Oxidative stress (OXS) has been recently considered as one of anticancer strategies by taking advantage of higher vulnerability of cancer cells (than normal cells) to OXS. In fact, the successful outcomes using OXS have been reported in several cancer cases. A medicinal mushroom extract, PE isolated from Poria mushroom, has been shown to have anticancer/antitumor activity, although its anticancer mechanism has not been fully understood but may involve OXS. We investigated if PE might have anticancer effect on human bladder cancer cells through OXS in vitro. A dose-dependent (0-200 g/ml of PE) study was first performed to assess cell viability using MTT assay. PE led to a significant reduction in cell viability with the IC50 (50% inhibitory concentration) of 100 g/ml. A possible anticancer role of OXS was then assessed by lipid peroxidation (LPO) assay. The results indicated that PE indeed exerted ~2.1-fold greater OXS (than controls) on the cells. The anticancer mechanism of PE was further explored, focusing on glycolysis, metabolic signaling pathways, and apoptosis. Two glycolytic parameters, hexokinase (HK) activity and cellular ATP level, have significantly declined, suggesting the inhibition of glycolysis. Coupled with the reduced ATP level, AMP-activated protein kinase (AMPK) was activated, while protein kinase B (Akt) was inactivated and concomitantly mammalian target of rapamycin (mTOR) was inhibited. These results imply the growth cessation, followed by cell death. Western blot analysis also revealed that such cell death was more likely linked to apoptosis, indicated by the bcl-2 down-regulation and the Bax up-regulation. Therefore, PE is a natural anticancer agent with prooxidant activity exerting OXS, which leads to inhibition of glycolysis, modulations of metabolic signaling pathways, and ultimately apoptosis. It may have clinical implications in oral and/or intravesical administration for a safer and better therapeutic option for bladder cancer.","PeriodicalId":9541,"journal":{"name":"Cancer Research and Treatment : Official Journal of Korean Cancer Association","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79039755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}