Cancer drug resistance最新文献

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Establishment of head and neck squamous cell carcinoma mouse models for cetuximab resistance and sensitivity 建立头颈部鳞状细胞癌小鼠西妥昔单抗耐药和敏感性模型

Cancer drug resistance Pub Date : 2023-10-17 DOI: 10.20517/cdr.2023.62

Hannah Zaryouh, Ines De Pauw, Hasan Baysal, Jöran Melis, Valentin Van den Bossche, Christophe Hermans, Ho Wa Lau, Hilde Lambrechts, Céline Merlin, Cyril Corbet, Marc Peeters, Jan Baptist Vermorken, Jorrit De Waele, Filip Lardon, An Wouters

{"title":"Establishment of head and neck squamous cell carcinoma mouse models for cetuximab resistance and sensitivity","authors":"Hannah Zaryouh, Ines De Pauw, Hasan Baysal, Jöran Melis, Valentin Van den Bossche, Christophe Hermans, Ho Wa Lau, Hilde Lambrechts, Céline Merlin, Cyril Corbet, Marc Peeters, Jan Baptist Vermorken, Jorrit De Waele, Filip Lardon, An Wouters","doi":"10.20517/cdr.2023.62","DOIUrl":"https://doi.org/10.20517/cdr.2023.62","url":null,"abstract":"Aim: Acquired resistance to the targeted agent cetuximab poses a significant challenge in finding effective anti-cancer treatments for head and neck squamous cell carcinoma (HNSCC). To accurately study novel combination treatments, suitable preclinical mouse models for cetuximab resistance are key yet currently limited. This study aimed to optimize an acquired cetuximab-resistant mouse model, with preservation of the innate immunity, ensuring intact antibody-dependent cellular cytotoxicity (ADCC) functionality. Methods: Cetuximab-sensitive and acquired-resistant HNSCC cell lines, generated in vitro , were subcutaneously engrafted in Rag2 knock-out (KO), BALB/c Nude and CB17 Scid mice with/without Matrigel or Geltrex. Once tumor growth was established, mice were intraperitoneally injected twice a week with cetuximab for a maximum of 3 weeks. In addition, immunohistochemistry was used to evaluate the tumor and its microenvironment. Results: Despite several adjustments in cell number, cell lines and the addition of Matrigel, Rag2 KO and BALB/C Nude mice proved to be unsuitable for xenografting our HNSCC cell lines. Durable tumor growth of resistant SC263-R cells could be induced in CB17 Scid mice. However, these cells had lost their resistance phenotype in vivo . Immunohistochemistry revealed a high infiltration of macrophages in cetuximab-treated SC263-R tumors. FaDu-S and FaDu-R cells successfully engrafted into CB17 Scid mice and maintained their sensitivity/resistance to cetuximab. Conclusion: We have established in vivo HNSCC mouse models with intact ADCC functionality for cetuximab resistance and sensitivity using the FaDu-R and FaDu-S cell lines, respectively. These models serve as valuable tools for investigating cetuximab resistance mechanisms and exploring novel drug combination strategies.","PeriodicalId":9538,"journal":{"name":"Cancer drug resistance","volume":"253 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135995174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances in natural compounds inducing non-apoptotic cell death for anticancer drug resistance 诱导非凋亡细胞死亡的天然化合物抗肿瘤耐药研究进展

Cancer drug resistance Pub Date : 2023-10-16 DOI: 10.20517/cdr.2023.78

Jia-Wen Chen, Sibao Chen, Guo-Qing Chen

引用次数: 0

Drug resistance in glioblastoma: from chemo- to immunotherapy 胶质母细胞瘤的耐药性:从化疗到免疫治疗

Cancer drug resistance Pub Date : 2023-10-11 DOI: 10.20517/cdr.2023.82

Sachin Sharma, Oksana Chepurna, Tao Sun

{"title":"Drug resistance in glioblastoma: from chemo- to immunotherapy","authors":"Sachin Sharma, Oksana Chepurna, Tao Sun","doi":"10.20517/cdr.2023.82","DOIUrl":"https://doi.org/10.20517/cdr.2023.82","url":null,"abstract":"As the most common and aggressive type of primary brain tumor in adults, glioblastoma is estimated to end over 10,000 lives each year in the United States alone. Stand treatment for glioblastoma, including surgery followed by radiotherapy and chemotherapy (i.e., Temozolomide), has been largely unchanged since early 2000. Cancer immunotherapy has significantly shifted the paradigm of cancer management in the past decade with various degrees of success in treating many hematopoietic cancers and some solid tumors, such as melanoma and non-small cell lung cancer (NSCLC). However, little progress has been made in the field of neuro-oncology, especially in the application of immunotherapy to glioblastoma treatment. In this review, we attempted to summarize the common drug resistance mechanisms in glioblastoma from Temozolomide to immunotherapy. Our intent is not to repeat the well-known difficulty in the area of neuro-oncology, such as the blood-brain barrier, but to provide some fresh insights into the molecular mechanisms responsible for resistance by summarizing some of the most recent literature. Through this review, we also hope to share some new ideas for improving the immunotherapy outcome of glioblastoma treatment.","PeriodicalId":9538,"journal":{"name":"Cancer drug resistance","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136059348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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