C&EN Global Enterprise最新文献

{"title":"2023 EPA Green Chemistry Challenge Awards recipients named","authors":"None Nina Notman, special to C&EN","doi":"10.1021/cen-10137-acsnews1","DOIUrl":"https://doi.org/10.1021/cen-10137-acsnews1","url":null,"abstract":"On Oct. 23, the US Environmental Protection Agency announced the winners of this year’s Green Chemistry Challenge Awards during a ceremony at the National Academy of Sciences in Washington, DC. One academic researcher and five companies were recognized for efforts including transforming waste products into useful materials and creating greener industrial processes. “The Green Chemistry Challenge Awards demonstrate how sustainable alternatives in chemistry are flourishing and improve upon traditional methods,” Albert G. Horvath, American Chemical Society CEO, says in a press release . “Green chemistry can play a vital role in protecting human health and the environment by increasing efficiency, avoiding hazardous chemicals and preventing waste while improving the competitiveness of American companies,” Jennie Romer, deputy assistant administrator at the EPA Office of Chemical Safety and Pollution Prevention, says in the EPA’s press release . Richard Laine , a professor of materials science and engineering and macromolecular science and engineering","PeriodicalId":9517,"journal":{"name":"C&EN Global Enterprise","volume":"29 22","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136281521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Merck KGaA expands oncology portfolio","authors":"None Laura Howes","doi":"10.1021/cen-10137-buscon16","DOIUrl":"https://doi.org/10.1021/cen-10137-buscon16","url":null,"abstract":"Merck KGaA has signed a deal with the Chinese firm Jiangsu Hengrui Pharmaceuticals to bring to market two of Hengrui’s oncology drugs: HRS-1167, a PARP1 inhibitor, and SHR-A1904, an antibody-drug conjugate. For $169 million up front, Merck gets the rights to both drugs outside China. Merck says that the acquisition of HRS-1167 aligns with its in-house expertise in DNA damage response. The firm is exploring whether the inhibitor could be combined with other drugs for maximum effect.","PeriodicalId":9517,"journal":{"name":"C&EN Global Enterprise","volume":"29 8","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136281529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"C&EN’s 10 Start-Ups to Watch","authors":"","doi":"10.1021/cen-10137-cover1","DOIUrl":"https://doi.org/10.1021/cen-10137-cover1","url":null,"abstract":"START-UPS C&EN’s 10 Start-Ups to WatchAiming for impact through entrepreneurship ShareShare onFacebookTwitterWechatLinked InRedditEmail C&EN, 2023, 101 (37), pp 16–17November 13, 2023Cite this:C&EN 101, 37, 16-17(Credit: Kay Youn/Will Ludwig/C&EN)Figure1of1The standard career path for promising young chemists has long involved earning a PhD, honing skills further in a postdoctoral research position, and ultimately landing a job at a university, a national laboratory, or a multinational chemical firm. But there is an alternative route. Rather than trying to fill their curriculum vitae with as many peer-reviewed publications as possible, chemists from all over the world are using their skills to start new companies. Often, they’re motivated by the chance to slow climate change, combat pollution, or feed hungry people. Several of the founders in this year’s 10 Start-Ups to Watch fit this description.For Samantha Anderson, it was impossible to stand on the sidelines watching plastic pollution get worse. So while finishing a PhD at the Swiss Federal Institute of Technology, Lausanne (EPFL), she cofounded DePoly, a company that’s developing a better way to recycle polyethylene terephthalate.Similarly, after earning his PhD, Ryan Pearson went straight to Cyclotron Road, a fellowship program at Lawrence Berkeley National Laboratory that helps scientists turn their research into companies. That’s where Cypris Materials got off the ground. The company is developing new colorants that it hopes will reduce carbon emissions and pollution from coloring clothes, cars, and other products.Lately, C&EN’s pages have been filled with stories about start-ups founded by young chemists. A piece in July dug into Pivot Bio, a company trying to replace carbon-intensive synthetic fertilizers with microbes. The firm, now valued at more than $1 billion, was founded in 2011 by a pair of PhD candidates. A cover story in March featured Twelve, which hopes to make jet fuel out of carbon dioxide. That company took shape during Etosha Cave’s 2015 Activate Fellowship, a 2-year program that gives scientists funding and technical resources to turn themselves into founders.Not all companies in this year’s selection have stories like this. Some of them were founded by serial entrepreneurs with several companies under their belts. Others were catalyzed by government support or started by veterans from big companies who abandoned the security of incumbent firms to try something audacious.We considered hundreds of start-ups before settling on our finalists. They came from reader submissions, the pages of C&EN, and our reporters, who talked to chemists and entrepreneurs. Keep an eye on them. We’re excited to see what they do. Know about an interesting chemistry start-up? Nominate it for our 2024 feature at cenm.ag/startupnom. ContentsBelharra Therapeutics P.18Cypris Materials P.20DePoly P.22Elicit Plant P.24H2Pro P.26Halda Therapeutics P.28Mitra Chem P.30Septerna P.32Sublime Systems P.34Tr","PeriodicalId":9517,"journal":{"name":"C&EN Global Enterprise","volume":"24 14","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136282127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitra Chem","authors":"None Matt Blois","doi":"10.1021/cen-10137-cover8","DOIUrl":"https://doi.org/10.1021/cen-10137-cover8","url":null,"abstract":"By the beginning of 2020, the range of new electric cars had surpassed 330 km, up from 130 km a decade earlier. But drivers in the US were still pushing for more. “More range, more power, faster acceleration,” Vivas Kumar, then a principal with the battery material research firm Benchmark Mineral Intelligence, said in a talk at Stanford University that spring . “That’s the kind of attitude that drives Western automotive design decision-making.” To boost the capacity of their batteries, carmakers were increasing the amount of nickel they contained. Kumar, who previously managed Tesla’s battery material supply chain, predicted that they would continue to do so. But he warned that future shortages of nickel and cobalt could prove a roadblock for the industry. After the talk, a university administrator introduced Kumar to William Chueh, a materials scientist working on batteries at Stanford. Over the next several months, they brainstormed ways","PeriodicalId":9517,"journal":{"name":"C&EN Global Enterprise","volume":"25 14","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136282267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One US lithium mine is paused, another advances","authors":"None Matt Blois","doi":"10.1021/cen-10137-buscon6","DOIUrl":"https://doi.org/10.1021/cen-10137-buscon6","url":null,"abstract":"Compass Minerals says it is pausing development of a lithium mine on Utah’s Great Salt Lake because of state regulations that the firm says introduce new obstacles for the project. Compass already extracts potassium, sodium, and magnesium from brine at the site. The company says that it’s hopeful future regulatory developments will make it easier to pursue lithium extraction. It is also seeking a partner for the project. Meanwhile, the battery materials firm EcoPro will work with the mining company Ioneer to develop a process for extracting lithium from clay at a mine Ioneer is developing in Nevada. If successful, EcoPro would develop a commercial-scale plant to refine lithium hydroxide from the clay. The US Department of Energy agreed in January to give Ioneer a $700 million loan to pay for on-site lithium processing as long as the project gets permits and meets other conditions. The company expects a permitting","PeriodicalId":9517,"journal":{"name":"C&EN Global Enterprise","volume":"28 16","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136282588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Project SEED enhancements for the 2023 summer research program","authors":"None Angele Kwimi, chair, ACS Committee on Project SEED","doi":"10.1021/cen-10137-comment2","DOIUrl":"https://doi.org/10.1021/cen-10137-comment2","url":null,"abstract":"Summer 2023 saw 333 high school students carry out in-person Project SEED research internships. An additional 13 students from across the US participated in eight Virtual Research Programs, allowing them to connect with mentors remotely. Since 1968, Project SEED has provided sustained research, learning, and growth opportunities for high school students with diverse identities and backgrounds to help them advance and enrich the chemical science enterprise. Project SEED appeals to a broad range of student populations. The self-reported races and ethnicities for the 2023 cohort were 32% Hispanic or Latino, 23% Asian, 20% Black, 20% White, 3% Middle Eastern or North African, and 2% Indigenous. A successful summer The 2023 in-person and Virtual Research Program students all engaged in centralized, online orientation sessions, which focused on laboratory and personal safety training, career exploration, and professional development. The online training program was developed and deployed by ACS staff in collaboration with","PeriodicalId":9517,"journal":{"name":"C&EN Global Enterprise","volume":"55 10","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136283239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AlphaFold goes all atom","authors":"None Laura Howes","doi":"10.1021/cen-10137-scicon3","DOIUrl":"https://doi.org/10.1021/cen-10137-scicon3","url":null,"abstract":"The team behind DeepMind’s protein structure prediction software AlphaFold announced Oct. 31 that it is expanding its model beyond proteins: ligands, nucleic acids, and posttranslational modifications will be included in the update. The announcement comes hot on the heels of a preprint describing a similar expansion to the RoseTTAFold model built by David Baker’s group at the University of Washington. Neither team has yet made its new software or code available to the broader scientific community. Modeling biomolecules, as well as the chemicals that can interact with them, has been a huge topic of research interest in recent years. One key application is in drug discovery, and established pharma companies and start-ups have been investing in the area. For example, in 2021, DeepMind CEO and cofounder Demis Hassabis launched Isomorphic Labs to design new medicines using AlphaFold models. But the rapid developments in computational protein structure modeling and design have","PeriodicalId":9517,"journal":{"name":"C&EN Global Enterprise","volume":"55 22","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136283231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A piperidine proxy","authors":"None Bethany Halford","doi":"10.1021/cen-10136-scicon1","DOIUrl":"https://doi.org/10.1021/cen-10136-scicon1","url":null,"abstract":"The molecular motif 1-azaspiro[3.3]heptane may look peculiar, with its two four-membered rings that share a single carbon. But the structure can behave like a mimic of piperidine, a popular heterocycle in many drugs. Until now, however, this molecular motif has been tough to make. Chemists led by Pavel K. Mykhailiuk at the Kyiv, Ukraine–based pharmaceutical chemical firm Enamine report a synthesis of monosubstituted 1-azaspiro[3.3]heptanes. The route expands the molecular toolbox for medicinal chemists looking to add diverse motifs to their molecules. 2-Azaspiro[3.3]heptanes have been popular piperidine mimics, or bioisosteres, since they were first proposed for this purpose in 2010. The motif has appeared in at least 100 research manuscripts, 500 patents, and 7,000 new compounds. But the isomeric 1-azaspiro[3.3]heptane has been rare because there was no modular route to make this motif with just one substituent. Mykhailiuk and colleagues decided to take up this challenge because of perceived demand from","PeriodicalId":9517,"journal":{"name":"C&EN Global Enterprise","volume":"44 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136023067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From the archives: The 1990s","authors":"None Alex Tullo","doi":"10.1021/cen-10136-feature3","DOIUrl":"https://doi.org/10.1021/cen-10136-feature3","url":null,"abstract":"","PeriodicalId":9517,"journal":{"name":"C&EN Global Enterprise","volume":"81 5","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136102406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Why hasn’t Kristie Koski made tenure?","authors":"None Samuel Lemonick, special to C&EN","doi":"10.1021/cen-10136-feature1","DOIUrl":"https://doi.org/10.1021/cen-10136-feature1","url":null,"abstract":"","PeriodicalId":9517,"journal":{"name":"C&EN Global Enterprise","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136102612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}