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Methods to evaluate vascular function: a crucial approach towards predictive, preventive, and personalised medicine 评估血管功能的方法:预测、预防和个性化医疗的关键途径
The EPMA journal Pub Date : 2022-05-20 DOI: 10.1007/s13167-022-00280-7
C. Sena, Lino Gonçalves, R. Seiça
{"title":"Methods to evaluate vascular function: a crucial approach towards predictive, preventive, and personalised medicine","authors":"C. Sena, Lino Gonçalves, R. Seiça","doi":"10.1007/s13167-022-00280-7","DOIUrl":"https://doi.org/10.1007/s13167-022-00280-7","url":null,"abstract":"","PeriodicalId":94358,"journal":{"name":"The EPMA journal","volume":"361 1","pages":"209 - 235"},"PeriodicalIF":0.0,"publicationDate":"2022-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82642148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Mitochondrial health quality control: measurements and interpretation in the framework of predictive, preventive, and personalized medicine 线粒体健康质量控制:预测、预防和个性化医学框架中的测量和解释
The EPMA journal Pub Date : 2022-05-12 DOI: 10.1007/s13167-022-00281-6
Lenka Koklesová, Alena Mazurakova, Marek Samec, E. Kudela, K. Biringer, P. Kubatka, O. Golubnitschaja
{"title":"Mitochondrial health quality control: measurements and interpretation in the framework of predictive, preventive, and personalized medicine","authors":"Lenka Koklesová, Alena Mazurakova, Marek Samec, E. Kudela, K. Biringer, P. Kubatka, O. Golubnitschaja","doi":"10.1007/s13167-022-00281-6","DOIUrl":"https://doi.org/10.1007/s13167-022-00281-6","url":null,"abstract":"","PeriodicalId":94358,"journal":{"name":"The EPMA journal","volume":"5 1","pages":"177 - 193"},"PeriodicalIF":0.0,"publicationDate":"2022-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82068748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 22
Anti-breast cancer effects of phytochemicals: primary, secondary, and tertiary care 植物化学物质的抗乳腺癌作用:初级、二级和三级护理
The EPMA journal Pub Date : 2022-04-14 DOI: 10.1007/s13167-022-00277-2
Alena Mazurakova, Lenka Koklesová, Marek Samec, E. Kudela, K. Kajo, V. Skuciova, S. Csizmár, V. Mestanova, M. Péč, M. Adamkov, R. Al-Ishaq, K. Šmejkal, F. Giordano, Dietrich Büsselberg, K. Biringer, O. Golubnitschaja, P. Kubatka
{"title":"Anti-breast cancer effects of phytochemicals: primary, secondary, and tertiary care","authors":"Alena Mazurakova, Lenka Koklesová, Marek Samec, E. Kudela, K. Kajo, V. Skuciova, S. Csizmár, V. Mestanova, M. Péč, M. Adamkov, R. Al-Ishaq, K. Šmejkal, F. Giordano, Dietrich Büsselberg, K. Biringer, O. Golubnitschaja, P. Kubatka","doi":"10.1007/s13167-022-00277-2","DOIUrl":"https://doi.org/10.1007/s13167-022-00277-2","url":null,"abstract":"","PeriodicalId":94358,"journal":{"name":"The EPMA journal","volume":"75 10 1","pages":"315 - 334"},"PeriodicalIF":0.0,"publicationDate":"2022-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83434109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 29
Prostate cancer treatment costs increase more rapidly than for any other cancer—how to reverse the trend? 前列腺癌的治疗费用比其他癌症增长得更快——如何扭转这一趋势?
The EPMA journal Pub Date : 2022-03-01 DOI: 10.1007/s13167-022-00276-3
J. Ellinger, A. Alajati, P. Kubatka, F. Giordano, M. Ritter, V. Costigliola, O. Golubnitschaja
{"title":"Prostate cancer treatment costs increase more rapidly than for any other cancer—how to reverse the trend?","authors":"J. Ellinger, A. Alajati, P. Kubatka, F. Giordano, M. Ritter, V. Costigliola, O. Golubnitschaja","doi":"10.1007/s13167-022-00276-3","DOIUrl":"https://doi.org/10.1007/s13167-022-00276-3","url":null,"abstract":"","PeriodicalId":94358,"journal":{"name":"The EPMA journal","volume":" 1","pages":"1 - 7"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91410830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 22
Evaluation of thermal sensitivity is of potential clinical utility for the predictive, preventive, and personalized approach advancing metabolic syndrome management 评估热敏性对于预测、预防和个性化的方法推进代谢综合征的管理具有潜在的临床应用价值
The EPMA journal Pub Date : 2022-02-18 DOI: 10.1007/s13167-022-00273-6
Sujeong Mun, Kihyun Park, Siwoo Lee
{"title":"Evaluation of thermal sensitivity is of potential clinical utility for the predictive, preventive, and personalized approach advancing metabolic syndrome management","authors":"Sujeong Mun, Kihyun Park, Siwoo Lee","doi":"10.1007/s13167-022-00273-6","DOIUrl":"https://doi.org/10.1007/s13167-022-00273-6","url":null,"abstract":"","PeriodicalId":94358,"journal":{"name":"The EPMA journal","volume":"24 1","pages":"125 - 135"},"PeriodicalIF":0.0,"publicationDate":"2022-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78022268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Metabolic phenotyping of tear fluid as a prognostic tool for personalised medicine exemplified by T2DM patients 以T2DM患者为例，泪液代谢表型作为个体化用药的预后工具
The EPMA journal Pub Date : 2021-12-02 DOI: 10.1007/s13167-022-00272-7
Julia Brunmair, A. Bileck, D. Schmidl, G. Hagn, S. Meier‐Menches, Nikolaus Hommer, A. Schlatter, C. Gerner, G. Garhöfer
{"title":"Metabolic phenotyping of tear fluid as a prognostic tool for personalised medicine exemplified by T2DM patients","authors":"Julia Brunmair, A. Bileck, D. Schmidl, G. Hagn, S. Meier‐Menches, Nikolaus Hommer, A. Schlatter, C. Gerner, G. Garhöfer","doi":"10.1007/s13167-022-00272-7","DOIUrl":"https://doi.org/10.1007/s13167-022-00272-7","url":null,"abstract":"","PeriodicalId":94358,"journal":{"name":"The EPMA journal","volume":"1988 1","pages":"107 - 123"},"PeriodicalIF":0.0,"publicationDate":"2021-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88190055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Nomogram prediction for the 3-year risk of type 2 diabetes in healthy mainland China residents 中国大陆健康居民3年2型糖尿病发病风险的Nomogram预测
The EPMA journal Pub Date : 2019-08-06 DOI: 10.1007/s13167-019-00181-2
Kun Wang, Meihua Gong, Songpu Xie, Meng Zhang, Huabo Zheng, Xiaofang Zhao, Chengyun Liu
{"title":"Nomogram prediction for the 3-year risk of type 2 diabetes in healthy mainland China residents","authors":"Kun Wang, Meihua Gong, Songpu Xie, Meng Zhang, Huabo Zheng, Xiaofang Zhao, Chengyun Liu","doi":"10.1007/s13167-019-00181-2","DOIUrl":"https://doi.org/10.1007/s13167-019-00181-2","url":null,"abstract":"","PeriodicalId":94358,"journal":{"name":"The EPMA journal","volume":"174 1","pages":"227 - 237"},"PeriodicalIF":0.0,"publicationDate":"2019-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85020009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 32
Inappropriate modeling of chronic and complex disorders: How to reconsider the approach in the context of predictive, preventive and personalized medicine, and translational medicine. 慢性和复杂疾病的不适当建模：如何在预测性、预防性和个性化医学以及转化医学的背景下重新考虑该方法。
The EPMA journal Pub Date : 2019-07-31 eCollection Date: 2019-09-01 DOI: 10.1007/s13167-019-00176-z
Soroush Seifirad, Vahid Haghpanah
{"title":"Inappropriate modeling of chronic and complex disorders: How to reconsider the approach in the context of predictive, preventive and personalized medicine, and translational medicine.","authors":"Soroush Seifirad,&nbsp;Vahid Haghpanah","doi":"10.1007/s13167-019-00176-z","DOIUrl":"https://doi.org/10.1007/s13167-019-00176-z","url":null,"abstract":"<p><p>Preclinical investigations such as animal modeling make the basis of clinical investigations and subsequently patient care. Predictive, preventive, and personalized medicine (PPPM) not only highlights a patient-tailored approach by choosing the right medication, the right dose at the right time point but it as well essentially requires early identification, by the means of complex and state-of-the-art technologies of unmanifested pathological processes in an individual, in order to deliver targeted prevention early enough to reverse manifestation of a pathology. Such an approach can be achieved by taking into account clinical, pathological, environmental, and psychosocial characteristics of the patients or an individual who has a suboptimal health condition. Inappropriate modeling of chronic and complex disorders, in this context, may diminish the predictive potential and slow down the development of PPPM and consequently modern healthcare. Therefore, it is the common goal of PPPM and translational medicine to find the solution for the problem we present in our review. Both, translational medicine and PPPM in parallel, essentially need accurate surrogates for misleading animal models. This study was therefore undertaken to provide shreds of evidence against the validity of animal models. Limitations of current animal models and drug development strategies based on animal modeling have been systematically discussed. Finally, a variety of potential surrogates have been suggested to change the unfavorable situation in medical research and consequently in healthcare.</p>","PeriodicalId":94358,"journal":{"name":"The EPMA journal","volume":"10 3","pages":"195-209"},"PeriodicalIF":0.0,"publicationDate":"2019-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s13167-019-00176-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41224849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 20
Status of stem cells in diabetic nephropathy: predictive and preventive potentials 干细胞在糖尿病肾病中的地位:预测和预防潜力
The EPMA journal Pub Date : 2016-10-04 DOI: 10.1186/s13167-016-0070-6
B. Baban, J. Liu, S. Payne, W. Abebe, Jack C. Yu, M. Mozaffari
{"title":"Status of stem cells in diabetic nephropathy: predictive and preventive potentials","authors":"B. Baban, J. Liu, S. Payne, W. Abebe, Jack C. Yu, M. Mozaffari","doi":"10.1186/s13167-016-0070-6","DOIUrl":"https://doi.org/10.1186/s13167-016-0070-6","url":null,"abstract":"","PeriodicalId":94358,"journal":{"name":"The EPMA journal","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86981097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 14
Environmental and lifestyle risk factors of breast cancer in Malta—a retrospective case-control study 马耳他乳腺癌的环境和生活方式危险因素:回顾性病例对照研究
The EPMA journal Pub Date : 2016-09-20 DOI: 10.1186/s13167-016-0069-z
J. Cauchi, L. Camilleri, C. Scerri
{"title":"Environmental and lifestyle risk factors of breast cancer in Malta—a retrospective case-control study","authors":"J. Cauchi, L. Camilleri, C. Scerri","doi":"10.1186/s13167-016-0069-z","DOIUrl":"https://doi.org/10.1186/s13167-016-0069-z","url":null,"abstract":"","PeriodicalId":94358,"journal":{"name":"The EPMA journal","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87308937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 24
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