{"title":"Self-biomineralized in situ injectable CaSO4 nanorods-enriched collagen-hyaluronic acid composite hydrogels for biomimetic bone reconstruction in a minimally invasive manner","authors":"Xingzhu Liu, Yajie Zhang, Zahid Hussain, Penghui Zheng, Mingsheng Xu, Hongbo Zhao, Yuanshan Liu, Yi Cao, Ismat Ullah, Akiyoshi Osaka, Renjun Pei","doi":"10.1016/j.apmt.2022.101693","DOIUrl":"https://doi.org/10.1016/j.apmt.2022.101693","url":null,"abstract":"In situ injectable natural polymer-based hydrogels can be utilized to fill irregular defects and promote tissue regeneration. However, most hydrogels showed limited ability for self-biomineralization and can not guide the formation of new bone. Herein, according to the challenges encountered in advancing materials to clinical research, an injectable collagen-hyaluronic acid (Col-HA) hydrogel embedded with calcium sulfate nanorods (CSN) was developed via a bio-orthogonal reaction between norbornene (Nb) and tetrazine (Tz). The formulated [email protected] composite hydrogels not only have the potential to enhance cell adhesion and proliferation, but also serve as the system to control Ca2+ release. This composite hydrogel displayed impressive injectability, allowing straightforward in situ injection and subsequent adaption of composite hydrogels to irregularly shaped bone defects. CSN-incorporated composite hydrogels facilitate self-biomineralization, thereby fast-forming bone-like hydroxyapatite (HAp) within the hydrogel. Furthermore, Ca2+ released in a steady and sustained way from the composite hydrogels stimulated the differentiation of preosteoblasts, and promoted in situ bone growth. Our findings suggested that [email protected] composite hydrogels can successfully mediate the optimized CSN degradation, effectively accelerate HAp formation, and boost in situ bone development via the minimally invasive application.","PeriodicalId":94299,"journal":{"name":"Applied materials today","volume":"204 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136097246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Applied materials todayPub Date : 2019-03-01Epub Date: 2018-12-06DOI: 10.1016/j.apmt.2018.11.011
Hui Wang, Qingxin Mu, Kui Wang, Richard A Revia, Charles Yen, Xinyu Gu, Bowei Tian, Jun Liu, Miqin Zhang
{"title":"Nitrogen and Boron Dual-Doped Graphene Quantum Dots for Near-Infrared Second Window Imaging and Photothermal Therapy.","authors":"Hui Wang, Qingxin Mu, Kui Wang, Richard A Revia, Charles Yen, Xinyu Gu, Bowei Tian, Jun Liu, Miqin Zhang","doi":"10.1016/j.apmt.2018.11.011","DOIUrl":"10.1016/j.apmt.2018.11.011","url":null,"abstract":"<p><p>Fluorescence imaging of biological systems in the second near-infrared window (NIR-II) has recently drawn much attention because of its negligible background noise of autofluorescence and low tissue scattering. Here we present a new NIR-II fluorescent agent, graphene quantum dots dual-doped with both nitrogen and boron (N-B-GQDs). N-B-GQDs have an ultra-small size (~ 5 nm), are highly stable in serum, and demonstrate a peak fluorescent emission at 1000 nm and high photostability. In addition to the NIR-II imaging capability, N-B-GQDs efficiently absorb and convert NIR light into heat when irradiated by an external NIR source, demonstrating a photothermal therapeutic effect that kills cancer cells in vitro and completely suppresses tumor growth in a glioma xenograft mouse model. N-B-GQDs demonstrate a safe profile, prolonged blood half-life, and rapid excretion in mice, which are the characteristics favorable for in vivo biomedical applications.</p>","PeriodicalId":94299,"journal":{"name":"Applied materials today","volume":"14 ","pages":"108-117"},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6752708/pdf/nihms-1516204.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41224663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}