VirologyPub Date : 2024-02-01DOI: 10.1016/j.virol.2024.110013
Qi Liu, Menglin Li, Xuanyu Dong, Chengxiao Zuo, Zhangyao Nie, Zongying Zhang, Cheng-Gui Han, Ying Wang
{"title":"Development of full-length infectious cDNA clones and host range identification of an echinacea strain of tobacco streak virus","authors":"Qi Liu, Menglin Li, Xuanyu Dong, Chengxiao Zuo, Zhangyao Nie, Zongying Zhang, Cheng-Gui Han, Ying Wang","doi":"10.1016/j.virol.2024.110013","DOIUrl":"https://doi.org/10.1016/j.virol.2024.110013","url":null,"abstract":"","PeriodicalId":94266,"journal":{"name":"Virology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139883195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
VirologyPub Date : 2014-05-01DOI: 10.1016/j.virol.2014.03.015
Tommy Tong, Ema T Crooks, Keiko Osawa, James E Robinson, Mary Barnes, Cristian Apetrei, James M Binley
{"title":"Multi-Parameter Exploration of HIV-1 Virus-Like Particles as Neutralizing Antibody Immunogens in Guinea Pigs, Rabbits and Macaques.","authors":"Tommy Tong, Ema T Crooks, Keiko Osawa, James E Robinson, Mary Barnes, Cristian Apetrei, James M Binley","doi":"10.1016/j.virol.2014.03.015","DOIUrl":"10.1016/j.virol.2014.03.015","url":null,"abstract":"<p><p>Virus-like particles (VLPs) offer a platform to test the hypothesis that, since antibody binding to native envelope glycoprotein (Env) trimers results in HIV-1 neutralization, that native Env trimers presented in membranes may be useful for inducing neutralizing antibodies (nAbs) in a vaccine setting. So far, VLPs have not fulfilled this potential. Here, using a \"shotgun\" approach, we evaluated a wide cross-section of variables in a series of VLP immunizations. We identified 3 tentative leads. First, that VLP doses may not have been sufficient for optimal nAb induction. Second, that dampening the antigenicity of non-functional Env (for example uncleaved gp160) using either protease digests or IgG masking may be useful. Third, that guinea pig sera preferentially target non-conserved epitopes and exhibit relatively high background activity, suggesting that rabbits may be preferable as small animal vaccine models. Recent immunogenicity studies in rabbits appear to bear out all 3 of these leads.</p>","PeriodicalId":94266,"journal":{"name":"Virology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4037872/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141285706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The <ce:italic>potato virus x</ce:italic> TGBp2 protein association with the endoplasmic reticulum plays a role in but is not sufficient for viral cell-to-cell movement","authors":"Ruchira Mitra, Konduru Krishnamurthy, Jeanmarie Verchot-Lubicz","doi":"10.1016/S0042-6822(03)00180-6","DOIUrl":"https://doi.org/10.1016/S0042-6822(03)00180-6","url":null,"abstract":"","PeriodicalId":94266,"journal":{"name":"Virology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2003-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142014040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The <ce:italic>potato virus x</ce:italic> TGBp2 protein association with the endoplasmic reticulum plays a role in but is not sufficient for viral cell-to-cell movement","authors":"Ruchira Mitra, Konduru Krishnamurthy, Jeanmarie Verchot-Lubicz","doi":"10.1016/S0042-6822(03)00180-6","DOIUrl":"https://doi.org/10.1016/S0042-6822(03)00180-6","url":null,"abstract":"","PeriodicalId":94266,"journal":{"name":"Virology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2003-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142014002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}