Cancer Microenvironment最新文献_第6页

Characterization of M1/M2 Tumour-Associated Macrophages (TAMs) and Th1/Th2 Cytokine Profiles in Patients with NSCLC. 非小细胞肺癌患者M1/M2肿瘤相关巨噬细胞(tam)和Th1/Th2细胞因子谱的特征

Cancer Microenvironment Pub Date : 2016-04-01 Epub Date: 2015-08-30 DOI: 10.1007/s12307-015-0174-x

S A Almatroodi, C F McDonald, I A Darby, D S Pouniotis

{"title":"Characterization of M1/M2 Tumour-Associated Macrophages (TAMs) and Th1/Th2 Cytokine Profiles in Patients with NSCLC.","authors":"S A Almatroodi, C F McDonald, I A Darby, D S Pouniotis","doi":"10.1007/s12307-015-0174-x","DOIUrl":"https://doi.org/10.1007/s12307-015-0174-x","url":null,"abstract":"Lung cancer is one of the most commonly reported cancers, and is known to be associated with a poor prognosis. The function of tumour-associated macrophages (TAMs) in lung cancer patients is multifaceted and the literature shows conflicting roles. (I) To analyze the Th1 and Th2 cytokine levels that contribute to the differentiation of M1 and M2 macrophage populations in the serum of patients with NSCLC versus non-cancer controls; and (II) To characterize the M1 and M2 macrophage populations within TAMs in different subtypes of NSCLC compared to non-tumour tissue. The Th1 and Th2 cytokine levels were analyzed in serum using the Bio-Plex assay. In addition, TAMs subsets from non-tumour and tumour tissues were analyzed using immunohistochemistry (IHC). The level of IL-1β, IL-4, IL-6 and IL-8 was found to be increased in the serum of patients with large cell carcinoma but not in other NSCLC subtypes compared to non-cancer controls. In addition, the expression of CD68 and M2 marker CD163 was found to be increased (P ≤ 0.0001) in all NSCLC subtypes compared to non-tumour tissues. In contrast, the expression of iNOS (M1 marker) was decreased in the tumour tissue of patients with adenocarcinoma (P ≤ 0.01) and squamous carcinoma (P ≤ 0.05) but not in large cell carcinoma compared to non-tumour tissue. The results of this study indicate that NSCLC might have the ability to alter phenotype within the lung tumour areas in the local environment (TAMs) but not in the bloodstream in the systemic environment (serum) except for large cell carcinoma. ","PeriodicalId":9425,"journal":{"name":"Cancer Microenvironment","volume":"9 1","pages":"1-11"},"PeriodicalIF":0.0,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12307-015-0174-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33961885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 112

SLUG and SOX9 Cooperatively Regulate Tumor Initiating Niche Factors in Breast Cancer. SLUG和SOX9在乳腺癌中协同调控肿瘤启动因子

Cancer Microenvironment Pub Date : 2016-04-01 Epub Date: 2015-09-28 DOI: 10.1007/s12307-015-0176-8

Hassan Fazilaty, Mossa Gardaneh, Parvin Akbari, Ali Zekri, Babak Behnam

{"title":"SLUG and SOX9 Cooperatively Regulate Tumor Initiating Niche Factors in Breast Cancer.","authors":"Hassan Fazilaty, Mossa Gardaneh, Parvin Akbari, Ali Zekri, Babak Behnam","doi":"10.1007/s12307-015-0176-8","DOIUrl":"https://doi.org/10.1007/s12307-015-0176-8","url":null,"abstract":"Presence of tumor initiating cells and a proper niche is essential for metastatic colonization. SLUG and SOX9 transcription factors play essential roles in induction and maintenance of tumor initiating capacity in breast cancer cells. On the other hand, Tenascin-C and Periostin are crucial factors in metastatic niche that support tumor initiating capability in breast cancer. In this study, regulatory effect of SLUG and SOX9 transcription factors on the expression of Tenascin-C and Periostin was examined. SLUG and SOX9 were overexpressed and knocked-down in MCF7 and MDA-MB-231 cells, respectively. The cells as little and highly invasive breast cancer-derived cells were infected by inducing and shRNA lentivirus constructs. Then, Tenascin-C and Periostin as well as SLUG and SOX9 expression levels were measured in the cells via Real-Time PCR. Simultaneous overexpression of SLUG and SOX9 significantly induced Tenascin-C and Periostin expression. SLUG and SOX9 knock-down also significantly reduced the expression of Tenascin-C and Periostin. In this analysis Periostin showed the most deviation in both up- and down-regulation levels. This regulatory effect might shed light to a crosstalk between factors involved in the tumor initiating capacity and metastatic niche of the breast cancer. ","PeriodicalId":9425,"journal":{"name":"Cancer Microenvironment","volume":"9 1","pages":"71-4"},"PeriodicalIF":0.0,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12307-015-0176-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34108389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Review: the Contribution of both Nature and Nurture to Carcinogenesis and Progression in Solid Tumours. 综述:自然因素和后天因素对实体肿瘤发生和发展的影响。

Cancer Microenvironment Pub Date : 2016-04-01 Epub Date: 2016-04-11 DOI: 10.1007/s12307-016-0183-4

Iain Joseph Hyndman

{"title":"Review: the Contribution of both Nature and Nurture to Carcinogenesis and Progression in Solid Tumours.","authors":"Iain Joseph Hyndman","doi":"10.1007/s12307-016-0183-4","DOIUrl":"https://doi.org/10.1007/s12307-016-0183-4","url":null,"abstract":"Cancer is a leading cause of mortality worldwide. Cancer arises due to a series of somatic mutations that accumulate within the nucleus of a cell which enable the cell to proliferate in an unregulated manner. These mutations arise as a result of both endogenous and exogenous factors. Genes that are commonly mutated in cancer cells are involved in cell cycle regulation, growth and proliferation. It is known that both nature and nurture play important roles in cancer development through complex gene-environment interactions; however, the exact mechanism of these interactions in carcinogenesis is presently unclear. Key environmental factors that play a role in carcinogenesis include smoking, UV light and oncoviruses. Angiogenesis, inflammation and altered cell metabolism are important factors in carcinogenesis and are influenced by both genetic and environmental factors. Although the exact mechanism of nature-nurture interactions in solid tumour formation are not yet fully understood, it is evident that neither nature nor nurture can be considered in isolation. By understanding more about gene-environment interactions, it is possible that cancer mortality could be reduced. ","PeriodicalId":9425,"journal":{"name":"Cancer Microenvironment","volume":"9 1","pages":"63-9"},"PeriodicalIF":0.0,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12307-016-0183-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34391282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 26

Influence of Immune Myeloid Cells on the Extracellular Matrix During Cancer Metastasis 免疫髓细胞对肿瘤转移过程中细胞外基质的影响

Cancer Microenvironment Pub Date : 2016-03-09 DOI: 10.1007/s12307-016-0181-6

David Jiang, S. Lim

引用次数: 25

Stomach Cancer: Interconnection between the Redox State, Activity of MMP-2, MMP-9 and Stage of Tumor Growth 胃癌:氧化还原状态、MMP-2、MMP-9活性与肿瘤生长阶段之间的联系

Cancer Microenvironment Pub Date : 2016-02-23 DOI: 10.1007/s12307-016-0182-5

A. Burlaka, I. Ganusevich, M. Gafurov, S. Lukin, E. Sidorik

引用次数: 33

Angiopoietins Modulate Survival, Migration, and the Components of the Ang-Tie2 Pathway of Chronic Lymphocytic Leukaemia (CLL) Cells In Vitro 血管生成素在体外调节慢性淋巴细胞白血病(CLL)细胞的存活、迁移和Ang-Tie2通路成分

Cancer Microenvironment Pub Date : 2016-02-05 DOI: 10.1007/s12307-016-0180-7

Luis Mario Aguirre Palma, H. Flamme, Iris Gerke, K. Kreuzer

引用次数: 16

Preface. 前言。

Cancer Microenvironment Pub Date : 2016-01-09 DOI: 10.1007/s12307-015-0178-6

Elena Voronov,Ron N Apte

引用次数: 0

Tumour Microenvironment: Overview with an Emphasis on the Colorectal Liver Metastasis Pathway. 肿瘤微环境:综述，重点是结直肠肝转移途径。

Cancer Microenvironment Pub Date : 2015-12-01 Epub Date: 2014-10-03 DOI: 10.1007/s12307-014-0155-5

Alexandros Giakoustidis, Satvinder Mudan, Thorsten Hagemann

{"title":"Tumour Microenvironment: Overview with an Emphasis on the Colorectal Liver Metastasis Pathway.","authors":"Alexandros Giakoustidis, Satvinder Mudan, Thorsten Hagemann","doi":"10.1007/s12307-014-0155-5","DOIUrl":"https://doi.org/10.1007/s12307-014-0155-5","url":null,"abstract":"The tumour microenvironment (TME) represents a dynamic network that plays an important role in tumour initiation, proliferation, growth, and metastasis. Cell behaviour may be regulated by interplay of molecular interactions involving positive and negative reinforcement as well as a high level of cross-talk, which determines this system. Additionally, cancer involves cell proliferation, its malignancy defined by the tumour's ability to break down normal tissue architecture and by a dynamic process of invasion and metastasis. The metastatic cascade is regulated by a chain of molecular steps which triggers the progression of the developing cancer cell in the primary tumour into a number of transformations, leading to invasion and proceeding to metastases. Tumour-associated macrophages (TAMs) play a key-role in the progression from inflammatory conditions to cancer; TAMs are also capable of infiltrating the tumour microenvironment. Furthermore, myeloid-derived suppressor cells (MDSCs), a population of inhibitory immune cells, have been reported to increase in various cancer types, although characterising human MDSCs remains difficult, as their phenotype is quite variable. The future of cancer treatment is likely to involve creating more drugs that target these elements as well as others. An overview of the tumour's microenvironment is, therefore, presented in this paper, focusing on the metastatic pathways of primary colorectal cancer to the liver. ","PeriodicalId":9425,"journal":{"name":"Cancer Microenvironment","volume":"8 3","pages":"177-86"},"PeriodicalIF":0.0,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12307-014-0155-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32713954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Clinical Impact of Regulatory T cells (Treg) in Cancer and HIV. 调节性T细胞(Treg)在癌症和HIV中的临床影响。

Cancer Microenvironment Pub Date : 2015-12-01 Epub Date: 2014-11-12 DOI: 10.1007/s12307-014-0159-1

Theresa L Whiteside

引用次数: 22

Stroma as an Active Player in the Development of the Tumor Microenvironment. 基质在肿瘤微环境发展中的积极作用。

Cancer Microenvironment Pub Date : 2015-12-01 Epub Date: 2014-08-09 DOI: 10.1007/s12307-014-0150-x

L Vannucci

{"title":"Stroma as an Active Player in the Development of the Tumor Microenvironment.","authors":"L Vannucci","doi":"10.1007/s12307-014-0150-x","DOIUrl":"https://doi.org/10.1007/s12307-014-0150-x","url":null,"abstract":"The stroma is a considerable part of the tumor microenvironment. Because of its complexity, it can influence both cancer and immune cells in their behavior and cross-talk. Aside from soluble products released by non-cancer and cancer cells, extracellular matrix components have been increasingly recognized as more than just minor players in the constitution, development and regulation of the tumor microenvironment. The variations in the connective scaffold architecture, induced by transforming growth factor beta, lysyl oxidase and metalloproteinase activity, create different conditions of ECM density and stiffness. They exert broad effects on immune cells (e.g. physical barriers, modulation by release of stored TGF-β1), mesenchymal cells (transition to myofibroblasts), epithelial cells (epithelial-to-mesenchymal transition), cancer cells (progression to metastatic phenotype) and stem cells (activation of differentiation addressed by the microenvironment characteristics). Physiological mechanisms of the wound healing process, as well as mechanisms of fibrosis in some chronic pathologies, closely recall aspects of cancer deregulated biology. Their elucidation can provide a better understanding of tumor microenvironment immunobiology. In the following short review, we will focus on some aspects of the fibrous stroma to highlight its active participation in the tumor microenvironment constitution, tumor progression and the local immunological network. ","PeriodicalId":9425,"journal":{"name":"Cancer Microenvironment","volume":"8 3","pages":"159-66"},"PeriodicalIF":0.0,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12307-014-0150-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32571343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 45