Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine最新文献

The Potential Mechanisms of Extracellular Vesicles in Transfusion-Related Adverse Reactions: Recent Advances. 细胞外小泡在输血相关不良反应中的潜在机制：最新进展。

Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine Pub Date : 2025-04-01 DOI: 10.1016/j.tracli.2025.03.006

Keyi Tao, Keran Tao, Jing Wang

{"title":"The Potential Mechanisms of Extracellular Vesicles in Transfusion-Related Adverse Reactions: Recent Advances.","authors":"Keyi Tao, Keran Tao, Jing Wang","doi":"10.1016/j.tracli.2025.03.006","DOIUrl":"https://doi.org/10.1016/j.tracli.2025.03.006","url":null,"abstract":"Blood transfusion is an irreplaceable clinical treatment. Blood components are differentiated and stored according to specific guidelines. Storage temperatures and times vary depending on the blood component, but they all release extracellular vesicles (EVs) during storage. Although blood transfusions can be life-saving, they can also cause many adverse transfusion reactions, among which the effects of EVs are of increasing interest to researchers. EVs are submicron particles that vary in size, composition, and surface biomarkers, are encapsulated by a lipid bilayer, and are not capable of self-replication. EVs released by blood cells are important contributors to pathophysiologic states through proinflammatory, coagulant, and immunosuppressive effects, which in turn promote or inhibit the associated disease phenotype. Therefore, this review explores the potential mechanisms of hematopoietic-derived EVs in transfusion-associated adverse reactions and discusses the potential of the latest proteomics tools to be applied to the analysis of EVs in the field of transfusion medicine with a view to reducing the risk of blood transfusion.","PeriodicalId":94255,"journal":{"name":"Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143782320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Platelet Demand Forecasting Based on the SARIMA Model: Optimizing Blood Bank Resource Allocation and Clinical Supply.

Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine Pub Date : 2025-03-27 DOI: 10.1016/j.tracli.2025.03.005

Wang Feng, Xu Wen-Long, Xu Zhi-Guo, Wang Yun, Yang Hai-Ying, Chen Yi-Zhu, Lv Ke, Shi Lei

{"title":"Platelet Demand Forecasting Based on the SARIMA Model: Optimizing Blood Bank Resource Allocation and Clinical Supply.","authors":"Wang Feng, Xu Wen-Long, Xu Zhi-Guo, Wang Yun, Yang Hai-Ying, Chen Yi-Zhu, Lv Ke, Shi Lei","doi":"10.1016/j.tracli.2025.03.005","DOIUrl":"https://doi.org/10.1016/j.tracli.2025.03.005","url":null,"abstract":"Background: With advances in medical technology and an aging population, the demand for single-donor platelet transfusions is increasing because of their significant therapeutic effects. However, the short shelf-life of platelets and the lack of large-scale reserves make accurate demand forecasting crucial for blood bank inventory management, resource allocation and clinical supply.Objective: This study aims to forecast platelet demand trends via time series analysis, specifically the SARIMA model, to provide scientific evidence for blood banks, optimize resource allocation and improve clinical supply efficiency.Methods: Monthly aggregate data from type A BPC units supplied by Huzhou Central Blood Station from January 2015 to December 2023 were collected. By analyzing these data, a SARIMA model was constructed to predict platelet demand in the first half of 2024.Results: The SARIMA(0,1,1)(0,1,1)12 model performed best in terms of goodness of fit and Bayesian information criterion (BIC) tests and accurately predicted platelet demand. The predicted results revealed that the actual monthly supply in the first half of 2024 was within the 95% confidence interval of the forecast, with a mean relative error of 3.61%.Conclusion: The SARIMA model effectively predicts platelet demand, providing a practical tool for blood banks to optimize inventory management and clinical supply. Future research should explore further optimizations and improvements to better serve clinical needs and resource management.","PeriodicalId":94255,"journal":{"name":"Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143744607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comprehensive Review of Thrombophilia: Pathophysiology, Prevalence, Risk Factors, and Molecular Diagnosis.

Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine Pub Date : 2025-03-27 DOI: 10.1016/j.tracli.2025.03.004

Reham Altwayan, Huseyin Tombuloglu, Galyah Alhamid, Aysel Karagoz, Thamer Alshammari, Moneerah Alsaeed, Mohammed Al-Hariri, Ali Rabaan, Turgay Unver

{"title":"Comprehensive Review of Thrombophilia: Pathophysiology, Prevalence, Risk Factors, and Molecular Diagnosis.","authors":"Reham Altwayan, Huseyin Tombuloglu, Galyah Alhamid, Aysel Karagoz, Thamer Alshammari, Moneerah Alsaeed, Mohammed Al-Hariri, Ali Rabaan, Turgay Unver","doi":"10.1016/j.tracli.2025.03.004","DOIUrl":"https://doi.org/10.1016/j.tracli.2025.03.004","url":null,"abstract":"Thrombophilia, characterized by an imbalance between fibrinolysis and coagulation leading to inappropriate blood clotting, is a significant medical condition. The CDC has designated it as an underdiagnosed, serious, and potentially preventable disorder, contributing to an estimated 600,000-900,000 cases and 100,000 deaths annually in the United States. These figures surpass the combined annual mortality of AIDS, breast cancer, and motor vehicle accidents. The pathogenesis of thrombophilia involves complex interactions between genetic predispositions, such as mutations in Factor V Leiden, Factor II, MTHFR, and Serpine-1, and environmental factors, including unhealthy lifestyles, prolonged hospitalization, obesity, and cancer. Prevalence of specific genetic mutations varies across populations. Additional risk factors include age, family history, and pregnancy, with recent attention to increased susceptibility in SARS-CoV-2 infection. While molecular diagnostic techniques are available, there remains a need for robust, cost-effective, and accurate screening methods for large populations. This systematic review provides an updated overview of thrombophilia, encompassing pathophysiology, epidemiology, genetic and environmental risk factors, coagulation cascade, population-specific mutation prevalence, and diagnostic approaches. By synthesizing clinical and molecular evidence, this review aims to guide researchers, hematologists, and clinicians in the diagnosis and management of thrombophilia.","PeriodicalId":94255,"journal":{"name":"Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143744605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Donor vigilance - Current situation and future directions.

Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine Pub Date : 2025-03-13 DOI: 10.1016/j.tracli.2025.03.001

Tomislav Vuk, Constantina Politis, Olivier Garraud

引用次数: 0

Impact of oral iron supplementation on first-time whole blood donors deferred due to low haemoglobin. 口服铁质补充剂对因血红蛋白低而延期的首次全血献血者的影响。

Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine Pub Date : 2025-03-12 DOI: 10.1016/j.tracli.2025.03.002

Apalak Garg, Ravneet Kaur, Tanvi Sood, Anshu Palta, Kshitija Mittal, Paramjit Kaur, Gagandeep Kaur

{"title":"Impact of oral iron supplementation on first-time whole blood donors deferred due to low haemoglobin.","authors":"Apalak Garg, Ravneet Kaur, Tanvi Sood, Anshu Palta, Kshitija Mittal, Paramjit Kaur, Gagandeep Kaur","doi":"10.1016/j.tracli.2025.03.002","DOIUrl":"10.1016/j.tracli.2025.03.002","url":null,"abstract":"Background and objectives: Low haemoglobin (Hb) in whole blood donors account for 15.5% to 55.8% deferrals which is easily treatable. The present study was planned to determine the number of blood donors deferred due to low Hb becoming eligible to donate whole blood after iron supplementation.Material and methods: The prospective interventional study was conducted over 18 months. Blood donors presenting for whole blood donation but deferred for low Hb (<125 g/L) were included. First-time whole blood donors showing a picture of iron deficiency based on complete blood counts (CBC) and peripheral blood film (PBF) on the sample collected before the initiation of oral iron supplementation (Day 0) were contacted and requested to visit the blood centre. They were counselled and provided ferrous sulphate tablets (325 mg containing 100 mg elemental iron) to be taken daily after meals for 60 days. Compliance with the intake of iron supplementation was ensured. After completing oral iron supplementation for 60 days, a repeat sample was collected.Results: A total of 126 donors were provided with iron supplementation for 60 days. A significant increase in mean haemoglobin was observed in the blood donors who completed iron supplementation therapy for 60 days [109 (15) to 126 (15) g/L; p value < 0.001]. Seventy-six (60%) donors became eligible to donate blood. Regression models indicated that Hb levels on Day 60 were independently predicted by gender in donors who became eligible to donate.Conclusion: Iron supplementation has the potential to enhance donor eligibility and significantly expand the safe donor pool.","PeriodicalId":94255,"journal":{"name":"Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143631159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comments on "Effect of platelet storage duration on platelet increment and clinical outcomes in critically ill patients - A randomised controlled trial".

Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine Pub Date : 2025-03-11 DOI: 10.1016/j.tracli.2025.03.003

Shunsuke Kondo

引用次数: 0

Efficient quality improvement through the monitoring of Key Performance Indicators in the Quality management Review of a Blood Establishment (BE).

Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine Pub Date : 2025-02-28 DOI: 10.1016/j.tracli.2025.02.008

Dimitra Moschandreou, Elisavet Grouzi

{"title":"Efficient quality improvement through the monitoring of Key Performance Indicators in the Quality management Review of a Blood Establishment (BE).","authors":"Dimitra Moschandreou, Elisavet Grouzi","doi":"10.1016/j.tracli.2025.02.008","DOIUrl":"10.1016/j.tracli.2025.02.008","url":null,"abstract":"Efficient quality improvement in Blood Establishments (BE) relies on monitoring Key Performance Indicators (KPIs) within the Quality Management Review (QMR). KPIs serve as objective measures to identify system weaknesses and promote continuous quality improvement. The QMR integrates KPI data with inputs from various sources like non-conformities and audit reports, facilitating informed decision-making for improvement initiatives. This study was conducted at the Transfusion Medicine Department of a General Oncology Hospital with the aim of evaluating the quality improvement. Over a period of 6 years (2018-2023) some interventions were implemented to enhance blood sufficiency and blood stock management. The aim of the present study was to assess the impact of these interventions on the values of KPIs and, consequently, on the effectiveness of the system regarding the examined issues. The values of the KPIs before and after the interventions were compared to identify statistically significant differences. The years following the interventions the WAPI% index for expired red blood cell units was reduced, the acceptance limits of units collected per blood drive were met, the blood units collected in the BE increased and the deficit in red blood unit was reduced. The selected KPIs were significantly improved with minor exceptions. In conclusion, the systematic monitoring of KPIs and strategic interventions underscored in this study illustrate how targeted quality management practices can enhance operational efficiency and ensure sustainable improvements in BEs. Ongoing efforts to refine these approaches aim to achieve broader quality enhancement goals across blood management practices.","PeriodicalId":94255,"journal":{"name":"Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143538085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Conservative blood priming for extracorporeal photopheresis to reduce allogenic blood exposure in pediatric patients.

Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine Pub Date : 2025-02-27 DOI: 10.1016/j.tracli.2025.02.009

Andriana Pavlovich, Paxton Barco, Brian Cook, Ashley Peck, Faith Matthews, Yembur Ahmad, Craig Fletcher, Yamac Akgun

{"title":"Conservative blood priming for extracorporeal photopheresis to reduce allogenic blood exposure in pediatric patients.","authors":"Andriana Pavlovich, Paxton Barco, Brian Cook, Ashley Peck, Faith Matthews, Yembur Ahmad, Craig Fletcher, Yamac Akgun","doi":"10.1016/j.tracli.2025.02.009","DOIUrl":"10.1016/j.tracli.2025.02.009","url":null,"abstract":"Extracorporeal photopheresis (ECP) is a vital therapeutic option for pediatric patients with immune-mediated conditions. However, the high extracorporeal volume (ECV) involved in ECP poses a risk of hypovolemia, often necessitating red blood cell (RBC) priming to maintain hemodynamic stability. This study evaluates a conservative approach to ECP without RBC priming in pediatric patients, aiming to reduce allogenic blood exposure. A retrospective review of 16 ECP procedures across 3 pediatric patients with ECV exceeding 15% of total blood volume (TBV) found no significant adverse events or hemodynamic instability. The absence of RBC priming did not result in any documented complications. These findings suggest that conservative blood priming can safely reduce allogenic blood exposure in pediatric ECP, potentially minimizing transfusion-related risks. Further research is needed to establish guidelines for patient selection and monitoring during non-prime ECP in pediatric populations.","PeriodicalId":94255,"journal":{"name":"Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143538101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incidence and risk factors of acute transfusion reactions in patients admitted in intensive care unit on active monitoring after transfusion.

Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine Pub Date : 2025-02-27 DOI: 10.1016/j.tracli.2025.02.007

Disha Sharma, Ravneet Kaur, Tanvi Sood, Sanjeev Palta, Kshitija Mittal, Paramjit Kaur, Gagandeep Kaur, Shivangi Sharma

{"title":"Incidence and risk factors of acute transfusion reactions in patients admitted in intensive care unit on active monitoring after transfusion.","authors":"Disha Sharma, Ravneet Kaur, Tanvi Sood, Sanjeev Palta, Kshitija Mittal, Paramjit Kaur, Gagandeep Kaur, Shivangi Sharma","doi":"10.1016/j.tracli.2025.02.007","DOIUrl":"10.1016/j.tracli.2025.02.007","url":null,"abstract":"Background and objectives: Transfusion reaction is often masked in critically ill patients because of underlying disease or certain pre-medications. The study was planned to know the incidence and determine risk factors associated with these acute transfusion reactions (ATRs) in intensive care (ICU) patients by actively monitoring the transfusion events.Material and methods: In this prospective observational study, critically ill patients admitted to ICU and having an ICU stay of 24 h prior to transfusion were enrolled. Each enrolled patient was actively monitored after each transfusion of blood component at 15 min, 1 h, 6 h and 24 h. Transfusion reactions reported from ICU during the study period were considered as passively reported ATRs.Results: Transfusion of 850 components translating to 430 transfusion episodes was actively monitored. Thirty-three ATRs were observed in 27 patients. Incidence of ATR on active monitoring (0.039) was higher than on passive reporting (0.006). On active monitoring, 06 cases of TACO, 2 cases of TAD, 1 case each of TRALI and TTBI, 3 cases of FNHTR were recorded. A significant association between positive fluid balance (p = 0.01) and generalised oedema (p = 0.01) was observed with TACO. Twelve cases were labelled as unclassifiable complication of transfusion. Rise in BP was the only symptom observed in all these cases. The mean post-transfusion systolic blood pressure and diastolic blood pressure at 1 h, 6 h and 24 h were significantly higher (p < 0.05) than pre-transfusion values.Conclusion: Active monitoring provides us with a true insight into the incidence of various ATRs.","PeriodicalId":94255,"journal":{"name":"Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143538215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of isotonic applied muscle tension in reducing the vasovagal event in first-time blood donors: A cohort study.

Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine Pub Date : 2025-02-27 DOI: 10.1016/j.tracli.2025.02.006

Somnath Mukherjee, Ayan Bose, Ansuman Sahu, Debasish Mishra, Satya Prakash

{"title":"The impact of isotonic applied muscle tension in reducing the vasovagal event in first-time blood donors: A cohort study.","authors":"Somnath Mukherjee, Ayan Bose, Ansuman Sahu, Debasish Mishra, Satya Prakash","doi":"10.1016/j.tracli.2025.02.006","DOIUrl":"10.1016/j.tracli.2025.02.006","url":null,"abstract":"Background and objectives: Prevention of vasovagal events has been a major concern for blood centres to reduce the negative impact of decreased donor return for whole blood donation. This study aims to find out the effectiveness of applied muscle tension in reducing vasovagal events in first-time blood donors.Materials and methods: This cohort study involves the active application of applied muscle tension given by the donor with an inbuilt mechanism through an adjustable spring-fitted footrest in the blood donor couch (Remi India Pvt. Ltd). The outcome measure was encountering vasovagal events from the beginning of whole blood donation till at least 15 min of the observation period after blood donation in the blood donation complex. Vasovagal events were monitored objectively by measuring heart rate and blood pressure before, during whole blood donation, and after recovery from vasovagal events. Various signs of VVRs, such as dizziness, facial pallor, and sweating, were taken into consideration.Results: This study includes the observation of adverse donor events among first-time blood donors in a total of 2192 whole blood donations. The vaso-vagal events were associated significantly with the muscle tension applied, education, and anxiety level of the blood donors. The regression analysis showed the muscle tension applied, education level, anxiety scale, hemoglobin percentage, volume of blood collected and BMI as an independent predictor of adverse vaso-vagal events in whole blood donation.Conclusion: Applied muscle tension is an effective tool to reduce the incidence of VVRs in first-time blood donors. Pre-donation counseling of first-time donors may reduce the anxiety level and, in turn, the VVRs.","PeriodicalId":94255,"journal":{"name":"Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143538217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0