Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine最新文献

{"title":"Do we need point-of-care testing to detect sickle cell trait before whole blood donation?","authors":"Satya Prakash, Namrata Datta, Debasish Mishra, Ansuman Sahu, Somnath Mukherjee","doi":"10.1016/j.tracli.2025.09.265","DOIUrl":"https://doi.org/10.1016/j.tracli.2025.09.265","url":null,"abstract":"","PeriodicalId":94255,"journal":{"name":"Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145126173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond fibrinogen counts: rethinking cryoprecipitate use in haemato-oncology.","authors":"RishiRaj Sinha","doi":"10.1016/j.tracli.2025.09.005","DOIUrl":"10.1016/j.tracli.2025.09.005","url":null,"abstract":"","PeriodicalId":94255,"journal":{"name":"Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145093331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cryoprecipitate utilization review in light of recent guidelines: a single-center prospective analysis of haemato-oncology patients.","authors":"Joyisa Deb, Daljit Kaur, Gita Negi, Zikra Syed, Aswin K Mohan, Priyanka Rathod, Ashish Jain, Uttam Kumar Nath","doi":"10.1016/j.tracli.2025.09.004","DOIUrl":"10.1016/j.tracli.2025.09.004","url":null,"abstract":"<p><strong>Background: </strong>Cryoprecipitate, a cost-effective fibrinogen replacement, remains vital in managing coagulopathies, particularly in resource-limited settings. There is a wide variation of cryoprecipitate transfusion practices worldwide, even though it is widely transfused in various clinical settings.</p><p><strong>Study design and methods: </strong>This prospective observational study investigated cryoprecipitate utilization patterns in a tertiary care center in Northern India, focusing on Haemato-Oncology patients. This study was conducted over a period of one year, analyzing 350 transfusion events across 286 patients. Data on patient demographics, clinical and laboratory parameters, and transfusion indications were collected and evaluated for adherence to established guidelines.</p><p><strong>Results: </strong>Cryoprecipitate accounted for 2.1 % of blood component requests, predominantly from the Haemato-Oncology department (73 %). Among the transfusion events, 65.7 % were deemed appropriate based on guidelines, with the majority (85.6 %) occurring in Haemato-Oncology patients. Pre- and post-transfusion fibrinogen levels were documented in 45.4 % of events, revealing a mean fibrinogen increase of 0.71 g/L per dose. However, 34.3 % of events were inappropriate, largely due to transfusions without pre-transfusion fibrinogen measurements.</p><p><strong>Discussion: </strong>Key findings include hypofibrinogenemia as the leading indication for cryoprecipitate transfusion (74.3%) and significant differences in transfusion practices between Haemato-Oncology and non-Haemato-Oncology population cohorts. The study highlights the need for periodic utilization audits and continuous training of stakeholders to ensure adherence to evidence-based guidelines and reduce empirical transfusion practices. Future multi-center studies are recommended to establish standardized cryoprecipitate administration protocols and assess clinical outcomes.</p>","PeriodicalId":94255,"journal":{"name":"Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145035036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Voluntary plasma donation 2.0: building trust, technology, and tomorrow's donor.","authors":"RishiRaj Sinha","doi":"10.1016/j.tracli.2025.09.003","DOIUrl":"10.1016/j.tracli.2025.09.003","url":null,"abstract":"","PeriodicalId":94255,"journal":{"name":"Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145007022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When blood types collide: misinformation, ethics, and the transfusion dilemma.","authors":"RishiRaj Sinha, Rajkumar Kundavaram","doi":"10.1016/j.tracli.2025.09.002","DOIUrl":"10.1016/j.tracli.2025.09.002","url":null,"abstract":"","PeriodicalId":94255,"journal":{"name":"Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145002338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Closing the gap: blending CBME, simulation, and digital reinforcement in transfusion medicine education.","authors":"RishiRaj Sinha, Aakriti Puri","doi":"10.1016/j.tracli.2025.08.007","DOIUrl":"10.1016/j.tracli.2025.08.007","url":null,"abstract":"","PeriodicalId":94255,"journal":{"name":"Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145002374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond haemoglobin: peronsalised iron strategies for safer donor return.","authors":"RishiRaj Sinha, Devanshi Khare","doi":"10.1016/j.tracli.2025.09.001","DOIUrl":"10.1016/j.tracli.2025.09.001","url":null,"abstract":"","PeriodicalId":94255,"journal":{"name":"Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145002382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From chance to precision: formula-based transfusion as the future of red cell therapy.","authors":"RishiRaj Sinha","doi":"10.1016/j.tracli.2025.08.004","DOIUrl":"10.1016/j.tracli.2025.08.004","url":null,"abstract":"","PeriodicalId":94255,"journal":{"name":"Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144994883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clustering of adverse perinatal outcomes in women with multiple sensitising events: a data-driven approach using clinical and immunohematologic profiles.","authors":"Anubhav Gupta, Meenakshi Gothwal, Garima Yadav, Swati Asati, Pratibha Singh","doi":"10.1016/j.tracli.2025.08.005","DOIUrl":"10.1016/j.tracli.2025.08.005","url":null,"abstract":"<p><strong>Background: </strong>Red-cell alloimmunisation is a preventable driver of haemolytic disease of the foetus and newborn, yet most risk scores rely on single-parameter thresholds and overlook clinically important heterogeneity.</p><p><strong>Objective: </strong>To uncover latent phenotypes among sensitised pregnancies by clustering routinely collected clinical and immunohaematologic variables.</p><p><strong>Methods: </strong>We retrospectively analysed 2084 antenatal records (2020-2021). Five variables-maternal antibody status, haemoglobin (Hb) concentration, cumulative number of sensitising events, gestational age at first positive antibody screen, and parity-were multiply imputed and scaled. A rule-based approximation of Gaussian mixture modelling and HDBSCAN assigned women to five clusters. Internal validity was assessed with the silhouette coefficient (0.41) and Davies-Bouldin index (0.88). Multivariable logistic regression evaluated the association between cluster membership and a composite adverse perinatal outcome, adjusting for maternal age and comorbidities.</p><p><strong>Results: </strong>Five clinically coherent clusters emerged (Cluster 1 = 13, Cluster 2 = 848, Cluster 3 = 26, Cluster 4 = 36, Cluster 5 = 513; 648 records lacked sufficient data for assignment). Cluster 1 combined antibody positivity with marked anaemia (mean Hb 8.6 ± 1.3 g/dL) and showed the highest risk of adverse outcome (adjusted OR 4.3, 95 % CI 2.7-6.8, p < 0.001). Cluster 3-seronegative women with preserved Hb (≥12 g/dL) but neonatal depression (1-min Apgar < 7 in 100 % of cases)-represented an unexpected high-risk phenotype. Cluster 5 (antibody-negative, Hb ≥ 12 g/dL, 1-min Apgar ≥ 7) served as the low-risk reference.</p><p><strong>Conclusion: </strong>Unsupervised clustering of simple antenatal parameters reveals hidden risk profiles that outperform single-threshold screening. This data-driven phenotyping could refine surveillance intensity and transfusion strategies in sensitised pregnancies.</p>","PeriodicalId":94255,"journal":{"name":"Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144994920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Closing the iron gap: practical solutions to retain valued donors.","authors":"RishiRaj Sinha, Devanshi Khare","doi":"10.1016/j.tracli.2025.08.006","DOIUrl":"10.1016/j.tracli.2025.08.006","url":null,"abstract":"","PeriodicalId":94255,"journal":{"name":"Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144994881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}