Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine最新文献

{"title":"Bridging the Evidence Chasm: Reflections on the WHO Sickle Cell Disease in Pregnancy Guideline.","authors":"Radheshyam Meher, Himanshi Devi, Raj Narayan Swain","doi":"10.1016/j.tracli.2025.06.007","DOIUrl":"https://doi.org/10.1016/j.tracli.2025.06.007","url":null,"abstract":"","PeriodicalId":94255,"journal":{"name":"Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144556362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What recent progress and proposals have been made and are to be made in blood transfusion?","authors":"Olivier Garraud","doi":"10.1016/j.tracli.2025.06.006","DOIUrl":"https://doi.org/10.1016/j.tracli.2025.06.006","url":null,"abstract":"","PeriodicalId":94255,"journal":{"name":"Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144512993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of the therapeutic efficacy of platelet-rich plasma intestinal spray in patients with ulcerative colitis.","authors":"Liyun Zheng, Yiming Ma, Hailong Zhuo, Mengyun Deng, Qun Luo, Xiaofei Li","doi":"10.1016/j.tracli.2025.06.005","DOIUrl":"10.1016/j.tracli.2025.06.005","url":null,"abstract":"","PeriodicalId":94255,"journal":{"name":"Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144478354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Donor-Reported Stress Type Affects Inflammatory Blood Markers Prior to Donation.","authors":"Fabrice Cognasse, Marco Heestermans, Charles-Antoine Arthaud, Marie-Ange Eyraud, Amelie Prier, Jacques Charioni, Bruno Danic, Pierre Tiberghien, Elisabeth Huis In 't Veld, Barbara Masser, Anne Claire Duchez, Hind Hamzeh-Cognasse","doi":"10.1016/j.tracli.2025.06.004","DOIUrl":"10.1016/j.tracli.2025.06.004","url":null,"abstract":"<p><strong>Background and objectives: </strong>Psychosocial stressors may contribute to inflammation. The aim of this study was to assess soluble inflammatory markers in blood donors' while they donated, focusing on perceived stress from family, work or from the act of donating.</p><p><strong>Materials and methods: </strong>Donors answered yes/no questions about stress (family, work, or donation-related) and rated puncture pain (0-9). Blood samples were centrifuged and analyzed by ELISA for inflammatory markers, including cortisol, RANTES, sCD40L, IL-2, IL-4, IL-6, IL-10, and serotonin, focusing on platelet-derived inflammatory factors.</p><p><strong>Results: </strong>Cortisol levels were higher in donors who experienced blood donation related stress as compared to donors who did not experience any type of stress. The molecule RANTES was only significantly higher in donors who experienced family stress. A significant increase in the concentration of sCD40L in the plasma of the whole sample and female donors is observed only in the group who only experienced stress related to blood donation, but not family or work-related stress.</p><p><strong>Conclusion: </strong>These findings suggest that stress experienced before blood donation may influence the inflammatory profile of blood components. Further research is needed to explore the impact of donors' experiences of psychosocial stressors on transfusion outcomes and on blood components characteristics.</p>","PeriodicalId":94255,"journal":{"name":"Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Designing and assessing the impact of a competency-based training program in transfusion medicine among MBBS interns.","authors":"Manish Raturi, Yashaswi Dhiman, Naveen Bansal, Basanta Khatiwada, Dushyant Singh Gaur, Poonam Rawat","doi":"10.1016/j.tracli.2025.06.003","DOIUrl":"10.1016/j.tracli.2025.06.003","url":null,"abstract":"<p><strong>Introduction: </strong>It has been widely recognized that there is a pressing need to strengthen transfusion medicine education for both undergraduate and postgraduate medical trainees across various clinical specialties to enhance patient safety. In response to this, the National Medical Commission (NMC) of India implemented a competency-based medical education (CBME) framework in 2019 for undergraduate MBBS students across all medical colleges in the country. The present study aimed to assess the impact of a training program designed for medical interns, developed in alignment with the CBME curriculum prescribed by the NMC.</p><p><strong>Materials and methods: </strong>This was a questionnaire-based cross-sectional study conducted among MBBS interns undergoing rotatory training in different departments of a tertiary care teaching hospital. A structured two-day educational program was organized, comprising six modules-three focusing on bedside transfusion practices and three addressing blood donation and laboratory-based transfusion medicine. Each module was designed to reflect the competencies outlined in the CBME curriculum and included pre- and post-training assessments to evaluate knowledge improvement. A pre-test was conducted to assess the knowledge of transfusion medicine among the participants and the post-test was conducted to assess the impact of the training program.</p><p><strong>Results: </strong>Overall, the pre-test score in the present study was 14.1 (47%) which increased to 22.3 (77.6%) in the post-test. Analysis of the pre-test scores showed that 80% of the interns had weak knowledge of blood transfusion reactions and its management. 55.6% of the interns had weak knowledge of indications of blood component therapy whereas 32.2% of the interns had weak knowledge of bedside transfusion medicine practices. 73.3% of the interns had weak knowledge of blood donor selection and counselling. 62.3% of the interns and 73.3% of the interns had weak knowledge of transfusion transmitted infections and basic blood banking including compatibility testing and storage conditions for various blood components, respectively. Post-training results showed a significant improvement across all domains. Effect size analysis using Cohen's d indicated that the training program was highly effective in five out of six domains, with moderate effectiveness observed in the domain of immunohematology.</p><p><strong>Conclusion: </strong>Although transfusion medicine knowledge is essential for routine practice in core medical and surgical specialties, a substantial knowledge gap exists among medical interns. This study demonstrates that a structured, CBME program is an effective strategy to improve transfusion medicine knowledge among MBBS interns.</p>","PeriodicalId":94255,"journal":{"name":"Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serological profiling and molecular characterization of D variants in Chengdu blood donors.","authors":"Jue Hou, Yu Xia, Jian Li, Xue Chen, Meng Li, Yuwei Zhao, Xuemei Fu","doi":"10.1016/j.tracli.2025.06.002","DOIUrl":"10.1016/j.tracli.2025.06.002","url":null,"abstract":"<p><strong>Background: </strong>Some D variant individuals are at risk of developing anti-D immunization when exposed to RhD-positive red cells. Therefore, accurate typing of D variants is essential to ensure the safety of clinical blood transfusion practices. The aim of this study was to investigate the serological profiles and molecular characteristics of D variants among Chengdu blood donors and to establish a more cost-effective RHD genotyping strategy tailored for the Chinese population.</p><p><strong>Methods: </strong>During the period from 2019 to 2022, samples from Chengdu blood donors typed as RhD-negative with IgM anti-D using the microplate method underwent additional RhD typing with a panel of monoclonal anti-D reagents using both the micro-column gel card technique and the saline tube method. Samples that could not be classified as either RhD-positive or RhD-negative were genotyped using the PCR-SSP assay and Sanger sequencing. RHD zygosity status was determined by assessing the presence or absence of hybrid Rhesus boxes. Alloantibody screening was conducted to evaluate the risk of anti-D immunization.</p><p><strong>Results: </strong>Three variants RHD*15, RHD*DEL1, and RHD*06.03.01 accounted for 61% of D variants identified in our study. Each of these were studied for distinct reaction patterns with a panel of anti-Ds. Additionally, eight previously reported D variant alleles, including RHD*01W.95, RHD*01W.72, RHD*01W.12, RHD*01W.18, RHD*01W.39, RHD*01W.67, RHD*01W.71, and RHD*01W.960A were observed sporadically. Furthermore, two novel alleles characterized by a nucleotide change (c.283G>T) and a nucleotide change (c.84C>G) respectively were identified. No cases of anti-D formation were detected in the D variant samples.</p><p><strong>Conclusions: </strong>The spectrum of D variants identified in this study highlights the genetic diversity in the Chengdu blood donors, underscoring the need to incorporate these D variants into RHD genotyping strategy tailored specifically for the Chinese population. Comprehensive analysis of serological reaction patterns across these D variants would help guide molecular testing strategies and enhance genotyping cost-efficiency.</p>","PeriodicalId":94255,"journal":{"name":"Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transfusion strategy and allo-immunization to red blood cell antigens after allogeneic hematopoietic stem cell transplantation with partial donor/recipient Rh matching.","authors":"Jeromine Beaufort, Alienor Xhaard, Aline Floch, Marie Robin, Flore Sicre de Fontbrune, David Michonneau, Florian Chevillon, Nathalie Dhedin, Matthieu Jestin, Eleonore Kaphan, Pedro Henrique de Lima Prata, Mathilde Ruggiu, Richard Traineau, Candice Cavalie, Gerard Socie, Regis Peffault de Latour, Anne-Claire Lepretre","doi":"10.1016/j.tracli.2025.06.001","DOIUrl":"10.1016/j.tracli.2025.06.001","url":null,"abstract":"<p><strong>Background: </strong>After allogeneic hematopoietic stem cell transplantation (alloHSCT), the HAS recommends transfusing red blood cells (RBCs) matched for Rh (\"Rhesus\") phenotypes, and the EFS recommends respecting both donor and recipient Rh phenotypes. We previously reported a 10.3% allo-immunization rate in 58 Rh-incompatible alloHSCT recipients transfused in the donor phenotype: none was directed against the mismatched donor Rh antigens.</p><p><strong>Study design and methods: </strong>In this single-center retrospective study, we investigated the incidence of allo-immunization to RBC antigens during the first year after alloHSCT in 264 patients with partial donor/recipient Rh matching, and transfused from alloHSCT with RBCs expressing at least one donor Rh antigen absent from the recipient.</p><p><strong>Results: </strong>Six patients had a positive RBC antibody screening test (allo-immunization rate: 2.3%). In five cases, the antibodies were unrelated to the transfusion strategy. One patient presented a temporary anti-C, possibly related to the transfusion strategy, occurring in a context of immune hemolytic anemia.</p><p><strong>Discussion: </strong>Our findings indicate that the transfusion of RBC in the donor Rh phenotype is associated with a low rate of immunization to RBC antigens. These results question the current transfusion guidelines in alloHSCT recipients, aiming to limit the use of short-supply RBCs phenotypes.</p>","PeriodicalId":94255,"journal":{"name":"Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144251700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Red blood cell exchange in Hemoglobin Evans: A novel therapeutic avenue for a rare hemoglobinopathy.","authors":"Radheshyam Meher","doi":"10.1016/j.tracli.2025.05.005","DOIUrl":"10.1016/j.tracli.2025.05.005","url":null,"abstract":"","PeriodicalId":94255,"journal":{"name":"Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144145356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic plasma exchange in treatment of autoimmune retinopathy.","authors":"Yigit Baykara, Muharrem Yunce","doi":"10.1016/j.tracli.2025.05.003","DOIUrl":"10.1016/j.tracli.2025.05.003","url":null,"abstract":"","PeriodicalId":94255,"journal":{"name":"Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144087171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From 'Aww to Wow': emerging role of transfusion medicine in fecal microbiota transplantation.","authors":"Radheshyam Meher","doi":"10.1016/j.tracli.2025.05.004","DOIUrl":"10.1016/j.tracli.2025.05.004","url":null,"abstract":"","PeriodicalId":94255,"journal":{"name":"Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}