Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine最新文献

{"title":"Immediate reporting of Delayed donor adverse reactions: role of AI driven mobile application.","authors":"Radheshyam Meher","doi":"10.1016/j.tracli.2025.02.005","DOIUrl":"https://doi.org/10.1016/j.tracli.2025.02.005","url":null,"abstract":"","PeriodicalId":94255,"journal":{"name":"Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of quadruplet induction therapy on stem cell mobilization yields in newly diagnosed multiple myeloma.","authors":"Ryan Beechinor, Stepfanie Lam, Aaron Steele, Machelle Wilson, Jeffrey Fine, Ayman Ullah, Aaron Rosenberg","doi":"10.1016/j.tracli.2025.02.001","DOIUrl":"10.1016/j.tracli.2025.02.001","url":null,"abstract":"<p><p>Daratumumab-containing quadruplet induction regimens have recently become the standard of care for patients with newly diagnosed multiple myeloma who are candidates for autologous hematopoietic stem cell transplantation. Daratumumab is a known immunosuppressant, and previous studies have shown that it may impair stem cell mobilization yields. We report a retrospective study of 104 newly diagnosed multiple myeloma patients comparing mobilization yields between those who received quadruplet daratumumab-containing induction and those who received traditional three-drug induction. Our results demonstrated that there were no statistically significant differences in achieving the patient-specific minimally required CD34+ cell yield after the first mobilization attempt between patients in the daratumumab-containing arm and those in the non-daratumumab-containing arm (P = 0.28).However, patients who received the quadruplet induction regimen with daratumumab experienced a statistically significant longer duration of apheresis collection (median of 2 days in the daratumumab-containing arm vs. 1 day in the non-daratumumab-containing arm, P = 0.011) than those who received traditional three-drug induction.Our findings reinforce the importance of incorporating both granulocyte-colony stimulating factors and plerixafor upfront into mobilization practices. Furthermore, the findings of this study may have implications for the judicious use of apheresis machines and further inform the optimal delivery of daratumumab-containing induction therapies for newly diagnosed multiple myeloma.</p>","PeriodicalId":94255,"journal":{"name":"Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac serious adverse reactions in donors in France 2010-21.","authors":"Karim Boudjedir, Monique Carlier, Isabelle Hervé, Paul-Michel Mertes, Sophie Somme, Anne-Marine Lenzotti, Gilles Folléa","doi":"10.1016/j.tracli.2025.02.002","DOIUrl":"10.1016/j.tracli.2025.02.002","url":null,"abstract":"<p><strong>Aim: </strong>To study cardiac serious adverse reactions in blood donors (CSARD) reported in the context of whole blood donation (WBD) or apheresis donation (AD) in France. Although potentially serious, they have been poorly studied so far.</p><p><strong>Methods: </strong>Retrospective descriptive study of the 125 CSARD (myocardial infarction-MI, acute coronary syndrome-ACS, angina pectoris-AP, rhythm disorder-RD) reported between 2010 and 2021. The studied parameters were age, gender, type of donation, diagnosis, time to onset, imputability, severity (grade), cardiovascular risk factors (CVRF). They were reviewed within the reports by 5 experts, who independently recorded their opinions on each parameter (except age, gender, type of donation). The collegial analysis of the opinions then resulted in a consensus for all cases. The time between the occurrence of CSARD and donation has been extended and limited to 48 h. An additional criterion of imputability was added for the CSARD attributed to causes other than the donation (e.g., coronary atheroma) but Aggravated or Triggered by the donation: AT1 possibly (>24-48 h post-donation), AT2 probably (>12-24 h post-donation) or AT3 certainly (within 12 h or pre-donation start).</p><p><strong>Results: </strong>Out of 125 reports, 50 were excluded: cardiac qualification of SARD invalidated (8), lack of data (2), absence donation (1), occurrence more than 48 h after the donation (39). The 75 included CSARD (including 5 deaths) comprised 58 coronary events (38 MI, 13 ACS, 7 AP) and 17 RD, and their complementary imputability criterion (AT) was classified respectively as follows 1 (20%), 2 (24%), 3 (56%). The estimated cumulative incidence of CSARD/106 donations is 2.1, significantly higher for AD (5.3) than for WBD (1.6; p < 0.001). The male (M) and female (F) percentages are 81% vs 19%, significantly different from the ones of the standard donor population over 2010-21: 48% M vs 52% F. The median ages, 55 years (30-70) in men, and 47 years (23-68) in women, were significantly higher than the ones of standard donor population 2010-21, respectively 46 (p < 0,001) and 41 (p = 0,04). In the 58 coronary accidents, at least 3 CVRF were noted in 38 cases (66%) and at least 4 CVRF in 20 cases (34%), including 5 with 5 CVRF. In 6/75 cases (8%) pre-existing signs not detected during the pre-donation interview (PDI) would have permanently contraindicated donation.</p><p><strong>Conclusions: </strong>A complementary study should assess whether a more formalised consideration of CVRF in the PDI could reduce the frequency of CSARD of coronary type.</p>","PeriodicalId":94255,"journal":{"name":"Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143412243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A randomized controlled clinical trial to compare the clinical outcome of random-based versus formula-based blood transfusion in a tertiary care hospital setting.","authors":"Prashant Pandey, Supriya Kumari, Gyanendra Agarwal, Shalendra Goel, Divya Setya, Saikat Mandal, Arghyadeep Marik, Mukesh Kumar Singh","doi":"10.1016/j.tracli.2025.02.004","DOIUrl":"https://doi.org/10.1016/j.tracli.2025.02.004","url":null,"abstract":"<p><strong>Background and objectives: </strong>Red cell transfusion is the mainstay of therapy for anemia and it is important to transfuse adequate dosage of red cells to maintain tissue oxygen demands. Additionally, it is also important to avoid overload of red cells to prevent adverse effects. Therefore, we compared the rise in hemoglobin and hematocrit for random-Based transfusion (RBT) and formula-based blood transfusion (FBBT) among patients to get a better understanding of differences in clinical outcome between the two methods.</p><p><strong>Materials and methods: </strong>In this study 752 patients were included who were admitted in the hospital and required transfusion of a single unit of PRBC. Patients included in the study were randomized in two categories, RBT and FBBT, using stratified random sampling without any bias. In RBT category, patients received blood transfusion according to standard practice i.e. patient received the full red cell unit without any modifications in volume. All odd number request in cross-match register during the study period who fulfilled the eligibility were included in this group. In FBBT group, even numbered requests in the crossmatch register were randomized to receive FBBT. In this category, patients received transfusion according to the following formula: Volume of PRBCs to be transfused= TBV × (Desired Hct - Current Hct of patient)/ Hct of donor unit (where the desired rise of Hct is 3%) RESULTS: In our study we found that the rise in hemoglobin and hematocrit levels were significantly higher for patients receiving FBBT as compared to the patients receiving RBT. Pre-transfusion hemoglobin and hematocrit did not have a significant difference whereas the post transfusion hemoglobin and hematocrit showed a higher rise in the FBBT group as compared to the RBT group. (Welch corrected t = 2.633, p value = 0.0086).</p><p><strong>Conclusion: </strong>This study re-emphasizes the value of FBBT over the routinely used RBT. This study found that FBBT had an edge over RBT, providing significantly higher increase in post-transfusion Hb and Hct. The authors therefore are of the opinion that use of FBBT may be considered in routine clinical practice to optimize transfusions for the patients.</p>","PeriodicalId":94255,"journal":{"name":"Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Which is the best storage temperature to preserve the haemostatic quality of non-leukoreduced whole blood units collected under a military emergency protocol - Cold or room temperature?","authors":"J Degueldre, E Dessy, F T'Sas, V Deneys, M-A Van Dievoet","doi":"10.1016/j.tracli.2025.02.003","DOIUrl":"10.1016/j.tracli.2025.02.003","url":null,"abstract":"<p><strong>Objectives: </strong>Emergency collection may be the only way to access blood when an urgent need arises, such as in a military setting. However, it is important to preserve any excess whole blood donations for future transfusion needs. Cold or room temperature (RT) storage has been reported in the literature. This raises the question of which storage temperature best preserves haemostatic properties of whole blood (WB). Our study investigated this question for storage times up to 48 h.</p><p><strong>Methods: </strong>This comparison study used 30 bags of WB collected from eligible military personnel. WB bags were randomly stored at either 22 °C or 4 °C. Samples from each bag were taken immediately after blood collection and analysed again after 48 h storage. Analyses included: metabolic and haematological parameters, coagulation factors, thrombin generation potential and platelet function (platelet activity, clotting capacity and aggregometry).</p><p><strong>Results: </strong>The overall quality of both storage conditions at 48 h was adequate according to metabolic parameters. Aggregometry was significantly affected in both groups. Clot stiffness was better preserved in WB stored at RT, however coagulation time was extended compared to storage at 4 °C. The platelet count was reduced in 4 °C. The thrombin generation potential was maintained irrespective of storage conditions.</p><p><strong>Conclusion: </strong>The storage at RT offers encouraging in vitro results to promote its use to recover haemostatic functions. As both conservation temperature is acceptable, this will offer greater flexibility to access blood in a resource-limited environment. The choice of either temperature should depend on the frequency of patient admissions.</p>","PeriodicalId":94255,"journal":{"name":"Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study of clinical manifestations and etiologies of megaloblastic anemia in children.","authors":"Rim Belhaj, Ines Maaloul, Roeya Kolsi, Taicir Rekik, Imen Chabchoub, Hajer Aloulou, Thouraya Kamoun","doi":"10.1016/j.tracli.2025.01.006","DOIUrl":"10.1016/j.tracli.2025.01.006","url":null,"abstract":"<p><strong>Background and aim: </strong>Megaloblastic anemia (MA) is a rare pathology in childhood due, in the majority of cases, to a deficiency of folic acid and/or vitamin B12 (cobalamin). This study aims to determine the epidemiological, clinical, and paraclinical profiles of MA in children and to specify its etiologies, therapeutic modalities, and treatment responses.</p><p><strong>Methods: </strong>This is a retrospective descriptive study of MA cases in children carried out in the General Pediatrics Department of the Hedi Chaker University Hospital of Sfax over a period of 42 years, from January 1979 to December 2021. We included all the patients under 16 years old with a myelogram showing megaloblastosis. The selected patients' demographic characteristics, physical signs, laboratory findings, and treatment responses were recorded.</p><p><strong>Results: </strong>Twenty cases of MA were collected, including 11 boys and 9 girls. The incidence of MA in children was 0.014%. The median age at diagnosis was 3.37 years. The clinical presentation was anemic syndrome with pallor and asthenia in all the cases. Neurological manifestations were noted in 2 cases and digestive disorders in 10 cases. Seven infants had psychomotor delays. On admission, all our patients had anemia with an average value of 5.6 g/dl. It was macrocytic in 19 cases. The blood count also revealed leukopenia (7 cases), thrombocytopenia (10 cases), and pancytopenia (5 cases). The myelogram showed megaloblastosis in all the cases and sideroblasts in one. A brain MRI was performed on five patients, and it showed abnormalities in three cases. The etiological investigations revealed a vitamin B12 deficiency secondary to a maternal Biermer's disease (6 cases), malnutrition (3 cases), Imerslund's disease (3 cases), congenital deficiency in transcobalamin II (3 cases), Biermer's disease (1 case), giardiasis (1 case), folic acid deficiency secondary to a poor dietary intake (1 case), mitochondrial cytopathy with vitamin B12-Folic acid deficiency (1 case), and Pearson syndrome (1 case). Our treatment included symptomatic measures, replacement therapy, and etiological treatment. Favorable evolution was noted in 11 cases. Five patients had neurological sequelae, and one patient died.</p><p><strong>Conclusion: </strong>Our study highlights the rarity and heterogeneity of the etiological contexts of MA in children. Early diagnosis and therapeutic support can improve the long-term neurological prognosis.</p>","PeriodicalId":94255,"journal":{"name":"Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143026255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Turning the tide of viral hepatitis-induced acute liver failure: The role of standard volume plasma exchange in adults and children.","authors":"Yashaswi Dhiman, Rolika Nautiyal, Anant Kumar, Saurabh Singh, Nitika Sarvesh Agrawal, Ashish Kumar Simalti, Veena Boswal, Sourabh Kumar, Manish Raturi, Dushyant Singh Gaur","doi":"10.1016/j.tracli.2025.01.007","DOIUrl":"10.1016/j.tracli.2025.01.007","url":null,"abstract":"","PeriodicalId":94255,"journal":{"name":"Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simple method to predict lymphocyte collection for chimeric antigen receptor T-cell engineering.","authors":"O Hequet, V Mialou, F Cognasse, S Mazet, Y Chelghoum, D Revesz, C Candido, J F Nicolas, M Vocanson, F Bérard, A Guironnet-Paquet, Q H Le, P Sesques, E Bachy, H Ghesquieres","doi":"10.1016/j.tracli.2025.01.005","DOIUrl":"10.1016/j.tracli.2025.01.005","url":null,"abstract":"<p><strong>Introduction: </strong>T lymphocyte collection is essential for CAR T-cell engineering in refractory hematologic malignancies but needs to be optimised. No guidelines have been established for predicting the amount of T lymphocytes to be collected. The quantity of lymphocytes and especially T cells collected depends on the pre-cytapheresis lymphocyte blood level (pcLBL) and the number of blood volumes (BVs) processed. Our aim was to define and standardise a simple method for predicting the number of T lymphocytes collected, taking into account the number of BVs processed and the pcLBL regardless of the procedures defined by different companies.</p><p><strong>Methods: </strong>We used data from our large retrospective series, which included 407 collection sessions using the same cytapheresis method in 400 patients mainly being followed up for non-Hodgkin's lymphoma (NHL) or multiple myeloma (MM). We initially analysed the performance of lymphocyte collections using collection efficiencies (CE1 and CE2), which are indices that determine the ability to collect as many cells as possible, and also assessed the percentage of neutrophils collected. Finally, we evaluated whether the number of T cells collected could be easily predicted by multiplying the pcLBL and number of BVs by an average factor.</p><p><strong>Results: </strong>In our series, CE1 and CE2 for total lymphocytes and T cells were between 76 ± 15% and 69 ± 15%, thus confirming adequate cell collection. A low percentage of neutrophils was collected (9 ± 12%). Confirmation of adequate cell collection led us to consider the relationship between pcLBL and T-cell collection. We then demonstrated that the amount of T cells collected correlated with pcLBL, and could be predicted by multiplying pcLBL by 2.5 for each BV processed.</p><p><strong>Conclusion: </strong>Easy prediction of T-cell collection is an important tool that can help apheresis and haematology teams monitor collection sessions, regardless of the companies involved and CAR T-cell technology.</p>","PeriodicalId":94255,"journal":{"name":"Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence in medical information retrieval: A word of caution.","authors":"Paramjit Kaur, Ravneet Kaur, Gagandeep Kaur, Kshitija Mittal","doi":"10.1016/j.tracli.2024.11.003","DOIUrl":"10.1016/j.tracli.2024.11.003","url":null,"abstract":"","PeriodicalId":94255,"journal":{"name":"Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142640538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Prospective Observational Study To Compare Transfusion Outcomes In Abo Identical Versus Abo Non-Identical Single Donor Platelet Concentrates: An Experience From A Tertiary Healthcare Center In India.","authors":"P. Pandey, Supriya Kumari, S. Mandal, D. Setya, Praveen Kumar","doi":"10.1016/j.tracli.2022.05.001","DOIUrl":"https://doi.org/10.1016/j.tracli.2022.05.001","url":null,"abstract":"","PeriodicalId":94255,"journal":{"name":"Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine","volume":"1986 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90333593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}