Bojun Li, M. Heldner, M. Arnold, J. Coutinho, S. Zuurbier, J. Meijers, H. Kohler, V. Schroeder
{"title":"Coagulation Factor XIII in Cerebral Venous Thrombosis","authors":"Bojun Li, M. Heldner, M. Arnold, J. Coutinho, S. Zuurbier, J. Meijers, H. Kohler, V. Schroeder","doi":"10.1055/s-0039-1693487","DOIUrl":"https://doi.org/10.1055/s-0039-1693487","url":null,"abstract":"Coagulation factor XIII (FXIII) is activated in the last stage of the coagulation cascade in the presence of thrombin and Ca 2 þ by cleavage and release of the activation peptide (FXIII activation peptide, AP-FXIII) from the A-subunit and disso-ciation of the carrier B-subunits. Activated FXIII then cross-links fi brin fi bers and incorporates anti fi brinolytic proteins into the clot. Therefore, FXIII has a crucial role in stabilizing fi brin: it determines clot properties and fi brinolysis, and contributes to clot formation in every acute thrombotic event. 1 Consequently, FXIII is consumed during acute thrombotic events leading to a reduction in systemic circulating FXIII plasma levels which are also associated with outcome, e.g., in acute myocardial infarction, 2 stroke, 3 – 5 and venous thromboembolism. 6 – 9 In patients with acute stroke, we could detect circulating free AP-FXIII","PeriodicalId":94220,"journal":{"name":"TH open : companion journal to thrombosis and haemostasis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79200839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}