Southern African journal of HIV medicine最新文献

{"title":"Switching at Low HIV-1 RNA into Fixed Dose Combinations: TDF/FTC/RPV is non-inferior to TDF/FTC/EFV in first-line suppressed patients living with HIV.","authors":"Paula Munderi,&nbsp;Edwin Were,&nbsp;Anchalee Avihingsanon,&nbsp;Pascale A M Mbida,&nbsp;Lerato Mohapi,&nbsp;Samba B Moussa,&nbsp;Marjolein Jansen,&nbsp;Ceyhun Bicer,&nbsp;Perry Mohammed,&nbsp;Yvon van Delft","doi":"10.4102/sajhivmed.v20i1.949","DOIUrl":"https://doi.org/10.4102/sajhivmed.v20i1.949","url":null,"abstract":"<p><strong>Background: </strong>In low- and middle-income countries (LMICs), a substantial unmet need for affordable single-tablet regimen (STR) options remains. Rilpivirine (RPV, TMC278) is formulated in a low-cost STR with tenofovir disoproxil fumarate (TDF) and emtricitabine (FTC).</p><p><strong>Objectives: </strong>Switching at Low HIV-1 RNA into Fixed Dose Combinations (SALIF) compared RPV with efavirenz (EFV), both as STRs with TDF and FTC, in maintaining virologic suppression.</p><p><strong>Methods: </strong>SALIF was a phase 3b, randomised, open-label, non-inferiority study in virologically suppressed adults (HIV-1 RNA < 50 copies/mL) on non-nucleoside reverse transcriptase inhibitor (NNRTI)-based first-line antiretroviral therapy (ART) in Cameroon, Kenya, Senegal, South Africa, Uganda and Thailand. Patients (<i>N</i> = 426), stratified by NNRTI use, were randomised 1:1 to receive TDF/FTC/RPV (300/200/25 mg qd) or TDF/FTC/EFV (300/200/600 mg qd). Primary endpoint was proportion of patients with virologic suppression (HIV-1 RNA < 400 copies/mL) at week 48 (intent-to-treat, modified Food and Drug Administration Snapshot, 10% non-inferiority margin).</p><p><strong>Results: </strong>Patients received TDF/FTC/RPV (<i>n</i> = 213) or TDF/FTC/EFV (<i>n</i> = 211). At week 48, virologic suppression was maintained in 200/213 (93.9%) patients in the RPV arm and 203/211 (96.2%) in the EFV arm (difference -2.3%; 95% confidence interval: -6.4, +1.8), demonstrating non-inferiority of TDF/FTC/RPV. One patient in each arm experienced virologic failure without treatment-emergent resistance. Twenty-seven patients discontinued prematurely (8.0% RPV vs. 4.7% EFV), the most frequent reasons being adverse events (3.3% vs. 0.5%, respectively), site closure (1.9% vs. 0.5%), loss to follow-up (0.9% vs. 1.4%) and consent withdrawal (0.9% vs. 1.4%).</p><p><strong>Conclusion: </strong>In adults with suppressed viral load on first-line NNRTI-based ART in LMICs, switching to an STR of TDF/FTC/RPV was non-inferior to TDF/FTC/EFV in maintaining high rates of viral suppression with a comparable tolerability profile.</p>","PeriodicalId":94212,"journal":{"name":"Southern African journal of HIV medicine","volume":"20 1","pages":"949"},"PeriodicalIF":0.0,"publicationDate":"2019-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6676968/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41224423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum: Prevention of mother-to-child transmission of HIV guidelines: Nurses' views at four primary healthcare facilities in the Limpopo Province.","authors":"Barbara A Hanrahan, Adri Williams","doi":"10.4102/sajhivmed.v18i1.821","DOIUrl":"https://doi.org/10.4102/sajhivmed.v18i1.821","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.4102/sajhivmed.v18i1.690.].</p>","PeriodicalId":94212,"journal":{"name":"Southern African journal of HIV medicine","volume":"18 1","pages":"821"},"PeriodicalIF":0.0,"publicationDate":"2017-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11878044/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143560446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}