{"title":"[Critical appraisal of the literature in systematic review].","authors":"Kazunori Miyake","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Critical appraisal of a literature is an important part of Systematic Review(SR) of laboratory tests. In this process, the quality of the clinical study is evaluated by using knowledge of clinical epidemiology and biostatistics. In the critical appraisal of articles of diagnostic tests, estimation of the design related bias, such as selection bias, spectrum bias, work-up bias, and referral bias, is extremely important. This article introduces the checklist for a diagnostic test proposed by the EBD collaboration in Japan. The proposed checklist consists of 23 items which effect on quality and external validity of the clinical studies. It will become a useful tool for systematic review in laboratory medicine.</p>","PeriodicalId":94202,"journal":{"name":"Rinsho byori. The Japanese journal of clinical pathology","volume":"51 7","pages":"691-5"},"PeriodicalIF":0.0,"publicationDate":"2003-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41176117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[A systematic review for the diagnostic accuracy o serum C-reactive protein measurement in neonatal infants with infection].","authors":"H Ishida, Y Takemura, T Kawai","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We presented an example of systematic review regarding diagnostic test accuracy. We compared the diagnostic accuracy of serum C-reactive protein (CRP) concentrations measured by the highly sensitive methods for neonatal infection with that by the conventional-sensitivity methods in the literatures available. Our results with the summary ROC curve indicated that the high sensitivity CRP is likely to provide a better diagnostic accuracy than the conventional methods, even though there was a heterogeneity in the specificity among studies. In the reviewing process of the literatures, we found several critical problems, such as the publishing bias and insufficient quality of primary articles. These problems may have had a substantial influence on the summary estimates. Systematic reviewing of the related articles uncovered the defects in the primary studies, requiring more prudent study designs for future clinical trials.</p>","PeriodicalId":94202,"journal":{"name":"Rinsho byori. The Japanese journal of clinical pathology","volume":"49 10","pages":"1020-9"},"PeriodicalIF":0.0,"publicationDate":"2001-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144370022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Conference of morphological analysis].","authors":"K Higashi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>To date, hematological malignancies have been diagnosed and classified by morphological analysis following ordinary and special staining such as Wright's and Giemsa's double staining. The FAB classification, which is applied for acute leukemia, is a typical classification system used worldwide. Recently, various reference techniques have been developed for the diagnosis of hematological malignancies and are useful for diagnosing hematological diseases, but morphological analysis still remains the basic reference technique. Therefore, expertise in morphological analysis is extremely important, and full training in this field is necessary.</p>","PeriodicalId":94202,"journal":{"name":"Rinsho byori. The Japanese journal of clinical pathology","volume":"Suppl 115 ","pages":"7-13"},"PeriodicalIF":0.0,"publicationDate":"2001-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142305230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}