Rejuvenation research最新文献_第2页

BICDL1 Mediates Pyroptosis to Promote Breast Cancer Cell Proliferation, Inhibition, and Migration. BICDL1介导乳腺癌细胞凋亡促进乳腺癌细胞增殖、抑制和迁移。

IF 2.6

Rejuvenation research Pub Date : 2025-09-15 DOI: 10.1177/15491684251375414

Xu Chu, Ling Xiang, Yan Zou, Xiang Li, Na Zhang, Hao Zhao

{"title":"BICDL1 Mediates Pyroptosis to Promote Breast Cancer Cell Proliferation, Inhibition, and Migration.","authors":"Xu Chu, Ling Xiang, Yan Zou, Xiang Li, Na Zhang, Hao Zhao","doi":"10.1177/15491684251375414","DOIUrl":"https://doi.org/10.1177/15491684251375414","url":null,"abstract":"Elevated levels of Bicaudal-D Family Like Cargo Adaptor 1 (BICDL1) are associated with poor prognosis in various cancers. However, the role of BICDL1 in breast cancer (BC) has not been reported. We analyzed BICDL1 expression in BC using bioinformatics and molecular experiments. Gene Set Enrichment Analysis was conducted to identify significantly enriched signaling pathways related to BICDL1. The effects of BICDL1 on BC cell proliferation, migration, invasion, and expression of epithelial-mesenchymal transition (EMT)-related proteins were assessed using colony formation assays, Transwell assays, and Western blot. The influence of BICDL1 on pyroptosis in BC cells was determined by measuring the expression of key pyroptosis proteins (NLRP3, GSDMD-N, procaspase-1, cleaved caspase-1, ASC), lactate dehydrogenase release, and cytokines (IL-1β and IL-18). We also investigated whether BICDL1 promotes BC proliferation and metastasis by regulating pyroptosis using Nigericin, an agent that induces NLRP3 inflammasome activation. The results showed that BICDL1 was significantly overexpressed in BC tissues and cells. Knockdown of BICDL1 inhibited BC cell proliferation, migration, invasion, and the EMT process, while overexpression of BICDL1 had the opposite effects. BICDL1 was enriched in the pyroptosis pathway; overexpression of BICDL1 suppressed pyroptosis, thus promoting BC cell proliferation, inhibition, and migration. Notably, the addition of Nigericin reversed the effects of BICDL1 overexpression on BC cells. These results suggested that BICDL1 promoted BC cell proliferation, inhibition, and migration by hindering pyroptosis. These findings indicate that BICDL1 is a potential biomarker for BC treatment.","PeriodicalId":94189,"journal":{"name":"Rejuvenation research","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145056456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation Between Polypharmacy and Gut Microbiota Compositional Changes in Older People Who Were Treated with Multidrug Therapy. 多药治疗与老年人肠道菌群组成变化的相关性

IF 2.6

Rejuvenation research Pub Date : 2025-08-12 DOI: 10.1177/15491684251365971

Lina Yu, Minghui Bi, Lianhong Xie

{"title":"Correlation Between Polypharmacy and Gut Microbiota Compositional Changes in Older People Who Were Treated with Multidrug Therapy.","authors":"Lina Yu, Minghui Bi, Lianhong Xie","doi":"10.1177/15491684251365971","DOIUrl":"https://doi.org/10.1177/15491684251365971","url":null,"abstract":"This study investigates the correlation between polypharmacy and gut microbiota compositional changes in older people who were treated with multidrug therapy, aiming to provide insights into the complex interplay between medication use, gut microbiota, and aging. High-throughput sequencing of the 16S rRNA gene was employed to analyze microbial diversity in older patients with multiple chronic diseases and polypharmacy, and the results were compared with a control group of older people without multiple chronic diseases and not undergoing polypharmacy. The study revealed distinct differences in gut microbiota composition between the two groups, with lower alpha-diversity observed in multidrug therapy group. Furthermore, the analysis identified several significant differences in microbiome composition at the genus and family levels between the multidrug therapy and the control group. The findings underscore the importance of understanding the impact of polypharmacy on the gut microbiota and its relationship to overall health in older people. Additionally, the study provides insights into the potential effects of specific medications, such as antihypertensive drugs, proton pump inhibitors, and antibiotics, on the gut microbiota, highlighting the need for continued research in this critical area to optimize therapeutic strategies for the older population.","PeriodicalId":94189,"journal":{"name":"Rejuvenation research","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144823573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stem Cell Aging and Rejuvenation in the Skeletal Muscle System. 骨骼肌系统中的干细胞衰老和年轻化。

IF 2.6

Rejuvenation research Pub Date : 2025-08-01 Epub Date: 2025-06-24 DOI: 10.1089/rej.2025.0028

Michela Libergoli, Albert E Almada

引用次数: 0

Red Blood Cell-Derived Exosomes as Mediators of Age-Related Neurodegeneration. 红细胞来源的外泌体作为年龄相关性神经变性的介质。

IF 2.6

Rejuvenation research Pub Date : 2025-08-01 Epub Date: 2025-06-04 DOI: 10.1089/rej.2025.0013

Jonalyn DeCastro, Ami Mehta-Doshi, Chao Liu, Animesh Ray, Kiana Aran

{"title":"Red Blood Cell-Derived Exosomes as Mediators of Age-Related Neurodegeneration.","authors":"Jonalyn DeCastro, Ami Mehta-Doshi, Chao Liu, Animesh Ray, Kiana Aran","doi":"10.1089/rej.2025.0013","DOIUrl":"10.1089/rej.2025.0013","url":null,"abstract":"Age-associated neurodegenerative diseases (NDDs), including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis, are marked by progressive degeneration of the nervous system. Current diagnostic approaches, such as neuroimaging and cerebrospinal fluid biomarkers, are invasive, costly, and lack early diagnostic reliability. Recent studies highlight the potential of extracellular vesicles, particularly exosomes, derived from erythrocytes or red blood cells (RBCs), as emerging indicators of aging and age-associated diseases. Exosomes carry noncoding RNA, lipid, and protein molecules, and modulate cellular pathways at distant sites, providing neuroprotective and anti-inflammatory effects. In this study, we isolated RBC-derived exosomes of young and old mice. MicroRNA sequencing analysis revealed differential expression of several miRNA species between young and old mice. We report an upregulation of miR-125a-5p and a downregulation of miR-302a-5p in old mice that are potentially linked to neurodegenerative pathways. This study underscores the potential of RBC-derived exosomes as noninvasive biomarkers for NDDs.","PeriodicalId":94189,"journal":{"name":"Rejuvenation research","volume":" ","pages":"184-194"},"PeriodicalIF":2.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12315997/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144217988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Umbilical Cord Blood Plasma Enhances Cellular Repair and Senescence Suppression in Human Dermal Fibroblasts Under Oxidative Stress. 脐带血促进氧化应激下人皮肤成纤维细胞的细胞修复和衰老抑制。

IF 2.6

Rejuvenation research Pub Date : 2025-08-01 Epub Date: 2025-05-02 DOI: 10.1089/rej.2024.0085

Miso Jeong, Hyangju Lee, Tae-Hyun Ko, Soo Jin Choi, Wonil Oh, Sangwoo Kim

{"title":"Umbilical Cord Blood Plasma Enhances Cellular Repair and Senescence Suppression in Human Dermal Fibroblasts Under Oxidative Stress.","authors":"Miso Jeong, Hyangju Lee, Tae-Hyun Ko, Soo Jin Choi, Wonil Oh, Sangwoo Kim","doi":"10.1089/rej.2024.0085","DOIUrl":"10.1089/rej.2024.0085","url":null,"abstract":"Aging is associated with a gradual decline in cellular function, largely driven by oxidative stress, which leads to cellular senescence. These processes contribute to tissue degeneration and age-related dysfunction. Human dermal fibroblasts (HDFs), critical for maintaining skin structure, are highly vulnerable to oxidative damage, making them key contributors to skin aging. Umbilical cord blood plasma (UCBP), rich in growth factors and regenerative molecules, has shown potential in preventing cellular senescence and addressing key mechanisms of tissue aging. Based on findings from heterochronic parabiosis experiments that demonstrated the rejuvenating effect of young blood, we investigated the effects of UCBP on hydrogen peroxide (H2O2) induced oxidative stress in HDFs and compared its efficacy with adult blood plasma (ABP). Our results indicate that although both UCBP and ABP reduce reactive oxygen species (ROS), UCBP is more effective in suppressing cellular senescence and maintaining fibroblast proliferation. These findings suggest that UCBP's protective effects extend beyond ROS reduction, potentially by modulating the senescence-associated secretory phenotype and the enhancement of tissue repair mechanisms.","PeriodicalId":94189,"journal":{"name":"Rejuvenation research","volume":" ","pages":"195-204"},"PeriodicalIF":2.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plasmapheresis as a Potential Generalizable Therapy for Myocardial Infarction. 血浆置换作为一种潜在的可推广治疗心肌梗死的方法。

IF 2.6

Rejuvenation research Pub Date : 2025-08-01 Epub Date: 2025-06-04 DOI: 10.1089/rej.2025.0015

Joana Marie C Cruz, Javier Lozano-Gerona, Al James A Manua, Mariel Lizbeth Joy S Agsaoay, Jana Victoria San Pedro, Irina M Conboy, Ahmad Reza Mazahery, Jose B Nevado

{"title":"Plasmapheresis as a Potential Generalizable Therapy for Myocardial Infarction.","authors":"Joana Marie C Cruz, Javier Lozano-Gerona, Al James A Manua, Mariel Lizbeth Joy S Agsaoay, Jana Victoria San Pedro, Irina M Conboy, Ahmad Reza Mazahery, Jose B Nevado","doi":"10.1089/rej.2025.0015","DOIUrl":"10.1089/rej.2025.0015","url":null,"abstract":"Myocardial infarction (MI) remains the leading cause of mortality and morbidity worldwide. It is caused by a thrombotic occlusion of coronary vessel/s that leads to cardiomyocyte death. As a response, inflammatory and fibrotic responses are initiated to replace the necrotic tissue and remodel the heart. However, in most cases, these responses are excessively activated, which accentuates the injury and causes adverse cardiac remodeling, often leading to heart failure. This is highly attributed to the dysregulated repair mechanism brought by reduced regenerative capacity of the adult heart, chronic inflammation, and other patient factors, such as comorbidities, diet, and lifestyle. Because of the negative consequences of excessive inflammation and fibrosis in post-MI responses, inhibiting factors associated with these processes are one of the major approaches in MI management. Several therapies have been developed to broadly and/or selectively inhibit inflammation- and fibrosis-associated proteins over the past decades and have shown promise in addressing post-MI complications. However, challenges (e.g., off-targets, problems with drug delivery, dosage, route, and cost) and efficacy of these interventions in the clinical setting remain. Hence, alternative approaches to optimally alleviate these post-MI processes are still much needed. In this review, we discuss the possible use of plasmapheresis, a technique that involves extracorporeal replacement of blood plasma, as a treatment for MI. We provide an overview of the inflammatory and fibrotic responses after MI and focus on how plasmapheresis can be an approach to target these pathways.","PeriodicalId":94189,"journal":{"name":"Rejuvenation research","volume":" ","pages":"172-183"},"PeriodicalIF":2.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12315998/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144217987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aging and Rejuvenation Are Systemic, and So Is the Bipartisan Interest in Meaningful Longevity Therapeutics. 衰老和返老还老是系统性的，两党对有意义的长寿疗法的兴趣也是如此。

IF 2.6

Rejuvenation research Pub Date : 2025-08-01 Epub Date: 2025-07-16 DOI: 10.1177/15491684251360989

Irina Conboy

引用次数: 0

Association Between Successful Aging and Mortality: Evidence from the Chinese Longitudinal Healthy Longevity Survey (2011-2018). 成功老龄化与死亡率的关系：来自中国健康寿命纵向调查（2011-2018）的证据。

Rejuvenation research Pub Date : 2025-07-07 DOI: 10.1089/rej.2025.0014

Wen Li, Xiangrui Fu, Wenbo Xiao, Guanghan Zhu, Yurong Liu, Xuan Zhang, Wenli Lu, Yuan Wang

{"title":"Association Between Successful Aging and Mortality: Evidence from the Chinese Longitudinal Healthy Longevity Survey (2011-2018).","authors":"Wen Li, Xiangrui Fu, Wenbo Xiao, Guanghan Zhu, Yurong Liu, Xuan Zhang, Wenli Lu, Yuan Wang","doi":"10.1089/rej.2025.0014","DOIUrl":"https://doi.org/10.1089/rej.2025.0014","url":null,"abstract":"Successful aging is essential for health, particularly as the global population of older adults rises. It assesses whether older adults maintain a healthy lifestyle and enjoy quality in their later years. This study explores the relationship between successful aging and mortality, focusing on how its components relate to mortality across different genders. We conducted a longitudinal analysis of 9633 older adults (aged 65+) from the Chinese Longitudinal Healthy Longevity Survey (2011-2018). This study used two definitions of successful aging: SA I includes five dimensions (the absence of major diseases, no subthreshold depression, freedom from disability, high cognitive function, and active social participation); SA II consists of four dimensions and excludes the absence of major diseases. Both genders exhibited lower mortality rates among those achieving successful aging (males: hazard ratio [HR] = 0.62 for SA I, HR = 0.65 for SA II; females: HR = 0.57 for SA I, HR = 0.58 for SA II). All successful aging dimensions correlated with reduced death risk, except for subthreshold depression in females. In males, significant reductions in mortality were linked to freedom from disability (HR = 0.49) and active social participation (HR = 0.60). In females, these were notable for freedom from disability (HR = 0.46) and high cognitive function (HR = 0.47). SA I, which includes the absence of major diseases, is more relevant for Chinese younger old. The influence of successful aging components on mortality risk varies by gender, emphasizing the importance of addressing functional daily living challenges to enhance the health of older adults in China.","PeriodicalId":94189,"journal":{"name":"Rejuvenation research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144577483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Epigenetic Landscape: From Molecular Mechanisms to Biological Aging. 表观遗传景观：从分子机制到生物衰老。

Rejuvenation research Pub Date : 2025-06-01 Epub Date: 2025-03-17 DOI: 10.1089/rej.2024.0102

Rachel Evangelina, Subhashree Ganesan, Melvin George

{"title":"The Epigenetic Landscape: From Molecular Mechanisms to Biological Aging.","authors":"Rachel Evangelina, Subhashree Ganesan, Melvin George","doi":"10.1089/rej.2024.0102","DOIUrl":"10.1089/rej.2024.0102","url":null,"abstract":"Epigenetics, the study of heritable changes in gene expression that do not involve alterations to the deoxyribonucleic acid (DNA) sequence, plays a pivotal role in cellular function, development, and aging. This review explores key epigenetic mechanisms, including DNA methylation (DNAm), histone modifications, chromatin remodeling, RNA-based regulation, and long-distance chromosomal interactions. These modifications contribute to cellular differentiation and function, mediating the dynamic interplay between the genome and environmental factors. Epigenetic clocks, biomarkers based on DNAm patterns, have emerged as powerful tools to measure biological age and predict health span. This article highlights the evolution of epigenetic clocks, from first-generation models such as Horvath's multi-tissue clock to advanced second- and third-generation clocks such as DNAGrimAge and DunedinPACE, which incorporate biological parameters and clinical biomarkers for precise age estimation. Moreover, the role of epigenetics in aging and age-related diseases is discussed, emphasizing its impact on genomic stability, transcriptional regulation, and cellular senescence. Epigenetic dysregulation is implicated in cancer, genetic disorders, and neurodegenerative diseases, making it a promising target for therapeutic interventions. The reversibility of epigenetic modifications offers hope for mitigating age acceleration and enhancing health span through lifestyle changes and pharmacological approaches.","PeriodicalId":94189,"journal":{"name":"Rejuvenation research","volume":" ","pages":"93-112"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Causal Association of Sleep Traits with All-Cause and Cause-Specific Mortality: A Prospective Cohort and Mendelian Randomization Study. 睡眠特征与全因和特定原因死亡率的因果关系：一项前瞻性队列和孟德尔随机化研究。

Rejuvenation research Pub Date : 2025-06-01 Epub Date: 2025-01-30 DOI: 10.1089/rej.2024.0058

Jinjin Zhang, Hao Yu, Lirui Jiao, Di Wang, Yeqing Gu, Ge Meng, Hongmei Wu, Xuehui Wu, Dandan Zhu, Yinxiao Chen, Dongli Wang, Yaxiao Wang, Hao Geng, Tao Huang, Kaijun Niu

{"title":"Causal Association of Sleep Traits with All-Cause and Cause-Specific Mortality: A Prospective Cohort and Mendelian Randomization Study.","authors":"Jinjin Zhang, Hao Yu, Lirui Jiao, Di Wang, Yeqing Gu, Ge Meng, Hongmei Wu, Xuehui Wu, Dandan Zhu, Yinxiao Chen, Dongli Wang, Yaxiao Wang, Hao Geng, Tao Huang, Kaijun Niu","doi":"10.1089/rej.2024.0058","DOIUrl":"10.1089/rej.2024.0058","url":null,"abstract":"The study aimed to explore the association between different sleep traits and all-cause mortality as well as to validate causality in the association through mendelian randomization (MR). We analyzed 451,420 European ancestry participants from the UK Biobank. Multivariable-adjusted Cox proportional hazards model was conducted to evaluate the association between sleep traits and all-cause mortality. In MR analysis, the inverse variance weighting (IVW) method was applied as the primary analysis to investigate the causal association between sleep traits and mortality. During a median follow-up period of 12.68 years, 34,397 individuals died. Observational analyses showed the multivariate-adjusted hazard ratio (HR) and 95% confidence intervals (CIs) for short sleep, long sleep, early chronotype, daytime sleepiness, daytime napping, and insomnia with mortality, 1.246 (1.195, 1.298), 1.735 (1.643, 1.831), 0.931 (0.909, 0.953), 1.276 (1.212, 1.344), 1.299 (1.254, 1.346), and 1.117 (1.091, 1.142) (All p < 0.0001). Based on UK Biobank, MR analysis indicated the association between daytime napping and an increased risk of all-cause mortality (odd ratio [OR]: 1.219, 95% CI: 1.071-1.387, p = 0.003), which may be largely attributable to cancer disease mortality (OR: 1.188, 95% CI: 1.009-1.399, p = 0.039). We found no causal association between sleep duration, short sleep, long sleep, chronotype, daytime sleepiness, insomnia, and mortality risk. The causal associations between sleep traits and all-cause mortality risk were directionally replicated in FinnGen. Our findings suggest a potential causal association between daytime napping and increased risk of all-cause mortality in middle-aged and older persons. The finding could have important implications for evaluating daytime napping habits to decrease the risk of mortality.","PeriodicalId":94189,"journal":{"name":"Rejuvenation research","volume":" ","pages":"136-145"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143070579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0