Postgraduate medicine最新文献

{"title":"The frontal QRS-T angle in predicting prognosis in acute ischemic stroke.","authors":"Umut Arda, Serdar Özdemir","doi":"10.1080/00325481.2025.2573626","DOIUrl":"10.1080/00325481.2025.2573626","url":null,"abstract":"<p><strong>Introduction and aim: </strong>Factors determining the prognosis of ischemic stroke include clinical, laboratory, and demographic variables, such as initial neurological status, brain imaging findings, blood glucose levels, inflammatory markers, and early treatment response. This study aimed to assess the prognostic value of the frontal QRS-T angle in predicting prognosis in patients with acute ischemic stroke.</p><p><strong>Materials and methods: </strong>This prospective, single-center, observational prognostic value study was conducted at the Emergency Department of the University of Health Sciences Ümraniye Training and Research Hospital. Adult patients presenting to the emergency department with stroke symptoms between 1 September 2022, and 1 September 2023, were included. The study population consisted of patients with ischemic stroke confirmed by radiological and clinical evaluations. Demographic data, comorbidities, electrocardiography parameters, laboratory results, affected arteries and hemispheres, and in-hospital mortality were recorded.</p><p><strong>Results: </strong>The study involved the evaluation of 149 patients presenting to the emergency department with stroke symptoms, of whom 40.3% were women, with a median age of 73 years. The in-hospital mortality rate was 8.7%. The most common comorbidity was hypertension (64%). The median frontal QRS-T angle was 50.5 (interquartile range [IQR]: 19.0-122.5) in the survival group and 90 (IQR: 58-133) in the mortality group (<i>p</i> = 0.069, Mann-Whitney U test). Multivariate logistic regression analysis revealed that age ( >68, odds ratio [OR]: 8.92), heart rate ( >110, OR: 19.8), RR interval ( <525 ms, OR: 38.7), P interval ( <94 ms, OR: 9.36), QTcB interval ( >467 ms, OR: 7.27), and atrial fibrillation (OR: 8.31) significantly increased the risk of mortality.</p><p><strong>Conclusion: </strong>According to the findings of this study, no significant difference was observed in the frontal QRS-T angle between survivors and non-survivors among patients with acute ischemic stroke.</p>","PeriodicalId":94176,"journal":{"name":"Postgraduate medicine","volume":" ","pages":"1-7"},"PeriodicalIF":2.8,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145254249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Left atrial Mechanical function and clinical performance in non-dilated versus dilated cardiomyopathy.","authors":"Özden Seçkin, Serkan Ünlü, Gülten Taçoy Aydoğdu","doi":"10.1080/00325481.2025.2573625","DOIUrl":"https://doi.org/10.1080/00325481.2025.2573625","url":null,"abstract":"<p><strong>Background: </strong>Non-dilated left ventricular cardiomyopathy (NDLVC) is a distinct entity characterized by impaired left ventricular ejection fraction despite normal chamber dimensions. While it may represent an earlier or less fibrotic stage of non-ischemic cardiomyopathy compared to dilated-cardiomyopathy (DCM), its clinical and structural characterization remains incomplete.</p><p><strong>Objectives: </strong>This study aimed to compare left atrial (LA) phasic strain parameters between patients with NDLVC and those with DCM, all with similarly reduced ejection fractions. Additionally, the relationship between LA function and exercise capacity was assessed using the 6-minute walk test (6MWT).</p><p><strong>Methods: </strong>In this prospective, observational study, 83 patients with non-ischemic systolic dysfunction were enrolled(NDLVC:<i>n</i> = 51; DCM:<i>n</i> = 32). All underwent comprehensive transthoracic echocardiography, including LA strain analysis (reservoir, conduit, contractile phases) using speckletracking imaging. Functional capacity was evaluated via 6MWT.</p><p><strong>Results: </strong>Patients with NDLVC exhibited significantly higher LA reservoir and conduit strain values than those with DCM. Among all echocardiographic parameters, LA conduit strain showed the strongest correlation with 6MWT distance (<i>r</i> = 0.42, <i>p</i> = 0.002) and was the only independent predictor of functional capacity in multivariable analysis.</p><p><strong>Conclusions: </strong>LA conduit strain is a promising noninvasive parameter for identifying functional and structural differences between NDLVC and DCM. Its strong association with exercise capacity and ability to differentiate phenotypes may support its integration into clinical assessment and follow up,particularly in clarifying structural and functional differences in non-ischemic remodeling patterns. These findings suggest that preserved LA conduit function in NDLVC may reflect a less hemodynamically burdened atrial profile, which is consistent with better clinical performance and functional capacity.</p>","PeriodicalId":94176,"journal":{"name":"Postgraduate medicine","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145260053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of a new mobile application developed for tuberculosis patients: a prospective observational study from Turkey.","authors":"Derya Oztomurcuk, Sule Ozturk, Ozlem Tosuner, Yasemin Dinc","doi":"10.1080/00325481.2025.2571932","DOIUrl":"10.1080/00325481.2025.2571932","url":null,"abstract":"<p><strong>Objective: </strong>A new mobile application for video directly observed treatment (vDOT) was developed and implemented for tuberculosis (TB) patients in Turkey in 2023. This study evaluated its features and analyzed one-year user data.</p><p><strong>Methods: </strong>A prospective observational study was conducted between 1 February 2023, and 31 January 2024, with 115 voluntary TB patients who met the inclusion criteria. Additionally, a satisfaction/adherence questionnaire prepared by the researchers was administered via telephone to 95 individuals who voluntarily used vDOT through the mobile application.</p><p><strong>Findings: </strong>During the study period, a total of 12,839 videos were approved, with an average of 111.6 videos uploaded per patient. The average duration of vDOT use was 15.7 weeks. The median number of vDOT use days was 23.0, and in the last six months of the study, the number of vDOT use days was equal to or above the median. According to the satisfaction/adherence questionnaire, 72.6% of patients perceived the mobile application to be easy to use, and 94.7% stated that vDOT protected their privacy better than face-to-face monitoring. Patients with higher education levels, those living in city centers, and those owning a personal smartphone were significantly more likely to find the mobile application easy to use (<i>p</i> < 0.05).</p><p><strong>Conclusion: </strong>This study revealed high usage rates for the mobile application, which was developed for vDOT and implemented as a telemedicine solution for the first time in Turkey. Additionally, the results on ease of use and satisfaction/adherence suggest that the mobile application can be used positively by the majority of patients.</p>","PeriodicalId":94176,"journal":{"name":"Postgraduate medicine","volume":" ","pages":"1-10"},"PeriodicalIF":2.8,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145234891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of systemic and nervous system factors in patients with shoulder pain: a perspective review.","authors":"Michel Gcam Mertens, Mira Meeus, Kim G Ingwersen, David H Christiansen, Filip Struyf","doi":"10.1080/00325481.2025.2571943","DOIUrl":"10.1080/00325481.2025.2571943","url":null,"abstract":"<p><strong>Background: </strong>Persistent shoulder pain is often driven by inflammatory conditions, including tendinopathy, bursitis, and frozen shoulder. Treatment remains uncertain, but targeting underlying mechanisms like inflammation, metabolic factors, and nervous system disturbances may be more effective.</p><p><strong>Objective: </strong>This perspective review summarizes these underlying mechanisms' roles in patients with inflammatory-driven shoulder pain and potential effective treatments for these mechanisms.</p><p><strong>Results: </strong>Literature links inflammatory-driven shoulder pain to low-grade inflammation, obesity, hypertension, diabetes mellitus, and/or autonomic and central nervous system disturbances, which are interconnected. Both acute and chronic inflammation are evident in tissue around the shoulder joint, potentially compromising treatment outcomes and predisposing tissue to hyperresponsiveness. Persistent inflammation can disrupt endocrine and nervous system functions, leading to additional health issues. Metabolic factors, characterized by low-grade inflammation, increase the risk for developing inflammatory-driven shoulder pain. Patients with inflammatory-driven shoulder pain often exhibit autonomic and somatosensory dysregulation. The autonomic nervous system's involvement in the inflammatory pathway can be influenced by or influence inflammation when dysregulation precedes shoulder pain development. Its pathways overlap with pain processing, potentially affecting each other. Prolonged stress (mental or biological) can lead to a maladaptive state and trigger somatosensory dysregulation. Interventions targeting these mechanisms go beyond the joint and include pain neuroscience education, exercise therapy, graded motor imagery, stress management, lifestyle interventions, and combinations of these. However, evidence specific to shoulder pain is limited.</p><p><strong>Conclusion: </strong>Future research should prioritize understanding these underlying mechanisms in patients with inflammatory-driven musculoskeletal shoulder pain and evaluating targeted interventions' effects on shoulder disabilities.</p>","PeriodicalId":94176,"journal":{"name":"Postgraduate medicine","volume":" ","pages":"1-12"},"PeriodicalIF":2.8,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145234883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A narrative review of drugs targeting inflammation in vascular disease.","authors":"Jenna Kristan, Mark A Malesker, James M Backes, Daniel E Hilleman","doi":"10.1080/00325481.2025.2571944","DOIUrl":"10.1080/00325481.2025.2571944","url":null,"abstract":"<p><p>Inflammation is recognized as an important component of atherosclerosis resulting in an increased risk of myocardial infarction and stroke. Studies, conducted as early as the 1960s, involving drugs targeting different pathways of inflammation linked to cardiovascular (CV) disease have produced inconsistent results. Drugs such as the statins with mechanisms of action beyond an anti-inflammatory effect have clear benefit in reducing CV risk. Other drugs such as the broad-spectrum anti-inflammatory agents (corticosteroids, lipoprotein-associated phospholipase A2 inhibitors, methotrexate) have been found to have no benefit in reducing CV risk. More specific anti-inflammatory agents which target the NLRP3 inflammasome, interleukin (IL)-1β and/or IL-6, and high-sensitivity C-reactive protein have been associated with therapeutic benefit. Despite favorable outcome data and FDA-approval for one of these agents (colchicine), a recent study has created uncertainty concerning the routine use of this agent for CV risk reduction. Multiple studies with a variety of anti-cytokine related agents are on-going in efforts to further reduce residual CV risk. Compared to other common CV risk factors such as hypertension and dyslipidemia, our understanding and management of inflammation is poorly understood. Due to the complexities of the inflammatory process, targeted approaches that can markedly reduce inflammatory markers are likely needed to demonstrate clinically relevant reductions in major adverse cardiovascular events.</p>","PeriodicalId":94176,"journal":{"name":"Postgraduate medicine","volume":" ","pages":"1-10"},"PeriodicalIF":2.8,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145234876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of health literacy on colchicine adherence in adolescents with familial Mediterranean fever.","authors":"Emine Özçelik, Elif Çelikel, Zahide Ekici Tekin, Cüneyt Karagöl, Şeyma Ertem, Merve Cansu Polat, Didem Öztürk, Mehveş Işıklar Ekici, Yasemin Uğur Es, Sultan Nilay Yoğun, Şeyma Erdem Torun, Mehmet Alperen Özçelik, Banu Çelikel Acar","doi":"10.1080/00325481.2025.2571393","DOIUrl":"10.1080/00325481.2025.2571393","url":null,"abstract":"<p><strong>Objective: </strong>Familial Mediterranean fever (FMF) is the most common monogenic autoinflammatory disease for which colchicine is regularly used every day. Health literacy (HL) is the ability of individuals to acquire, understand and use health information. The aim of this study was to evaluate medication adherence and HL levels in adolescents with FMF and to investigate the impact of HL on colchicine adherence.</p><p><strong>Methods: </strong>A cross-sectional, prospective study was conducted with FMF patients aged 12-18 years at the Pediatric Rheumatology Department. Medication adherence was measured using the Medication Adherence Scale in FMF Patients, with scores ≥60 indicating adherence. HL was assessed using the Health Literacy Scale for School-Age Children, categorizing scores as low (10-25), moderate (26-35), or high (36-40).</p><p><strong>Results: </strong>Among 87 FMF patients, 53 (60.9%) were female. The mean age of the patients was 14.89 ± 1.69 years. HL levels were moderate in 64 (73.6%), high in 17 (19.5%) and low in 6 (6.9%) patients. Patients were divided into 2 groups according to medication adherence. Nineteen (21.8%) patients were colchicine adherent and 68 (78.2%) were colchicine non-adherent. A significant difference was observed between the groups in terms of HL levels (<i>p</i> < 0.05). None of the patients with low HL were adherent to colchicine treatment. Higher HL levels were associated with increased medication adherence (<i>p</i> < 0.05). There was no statistically significant difference between adherent and non-adherent patients in terms of gender, age, educational status, reminder methods, school absenteeism, frequency attacks at the last year, colchicine dose, number of colchicine tablets per day (<i>p</i> > 0.05).</p><p><strong>Conclusion: </strong>Adolescents with FMF were generally found to have moderate levels of HL. Colchicine adherence was found to be higher as HL levels increased.</p>","PeriodicalId":94176,"journal":{"name":"Postgraduate medicine","volume":" ","pages":"1-7"},"PeriodicalIF":2.8,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145228713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of low-dose growth hormone treatment on obesity: a meta-analysis of randomized controlled trials.","authors":"Fei Sun, Aili Yang, Yuxin Jin, Li Tian, Xinwen Yu, Shengru Liang, Wencheng Zhang, Guohong Zhao, Bin Gao","doi":"10.1080/00325481.2025.2570106","DOIUrl":"10.1080/00325481.2025.2570106","url":null,"abstract":"<p><strong>Background: </strong>Growth hormone (GH) reduces visceral adiposity, increases lean body mass, and improves the lipid profile in obese adults. However, high-dose GH regimens have been associated with frequent adverse effects. The efficacy and safety of low-dose GH treatment in obese individuals without GH deficiency remain unclear. This study aims to evaluate the effects of recombinant human growth hormone (rhGH) on body composition, lipid profile, glucose metabolism, and adverse events in this population.</p><p><strong>Methods: </strong>A systematic review and meta-analysis were conducted in accordance with the PRISMA statement. PubMed, Cochrane Library, and EMBASE databases were systematically searched up to December 2024. Eligible studies included randomized controlled trials (RCTs) involving obese individuals without GH deficiency, with at least one endpoint related to body composition, lipid profile, or glucose metabolism. The study protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO, #CRD42023464234).</p><p><strong>Results: </strong>A total of 10 RCTs involving 420 participants were included. The mean age of participants ranged from 18 to 65 years, and treatment durations varied from 4 to 72 weeks. Low-dose rhGH therapy resulted in a significant reduction in visceral adipose tissue (SMD: -0.34, 95%CI: -0.57 to -0.12, <i>p</i> = 0.003) and a significant increase in thigh muscle area (MD: 6.33 cm², 95%CI: 1.72 to 10.95, <i>p</i> = 0.007) compared to placebo. Additionally, fasting glucose levels were modestly elevated (MD: 4.18 mg/dL, 95%CI: 0.68 to 7.67, <i>p</i> = 0.02). No serious adverse events were reported in association with low-dose rhGH treatment across the included studies.</p><p><strong>Conclusions: </strong>Low-dose rhGH therapy significantly reduces visceral fat and enhances thigh muscle mass in obese individuals without GH deficiency. These findings suggest that low-dose rhGH may offer therapeutic potential for sarcopenic obesity, warranting further investigation in larger, longer-term studies.</p>","PeriodicalId":94176,"journal":{"name":"Postgraduate medicine","volume":" ","pages":"1-11"},"PeriodicalIF":2.8,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145208944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of linezolid in treating upper-extremity arteriovenous graft infection in maintenance hemodialysis patients.","authors":"Long Cui, Hai Yuan, Zhao Gao","doi":"10.1080/00325481.2025.2567228","DOIUrl":"10.1080/00325481.2025.2567228","url":null,"abstract":"<p><strong>Objective: </strong>Arteriovenous graft (AVG) infection is a severe and potentially life-threatening complication that frequently leads to graft dysfunction in patients undergoing maintenance hemodialysis (MHD). However, antimicrobial resistance are becoming increasingly common.This study investigated the efficacy of linezolid in treating graft infections and to compare the effectiveness and safety of linezolid against teicoplanin among MHD patients.</p><p><strong>Method: </strong>This retrospective cohort study was conducted at a single center. A total of 53 cases of AVG infections occurring between June 2016 and June 2023 were included in this study. The AVG infections were divided into two groups: the control group (teicoplanin 200 mg/day iv) and the linezolid group (600 mg/day iv). The antimicrobial treatment period for AVG infection depended on whether the symptoms completely disappeared.Clinical data, operative records, duration of hospital stays, and costs were collected from the Hospital Information System (HIS) and analyzed between the two groups.</p><p><strong>Results: </strong>Out of the 53 patients, 30 (56.6%) were women, and their median age was 64 years. The most common clinical presentations of graft infection were purulent drainage, abscesses, pain, and swelling. Among the 53 patients, 9 (17.0%) had positive blood or wound cultures. Gram-positive cocci were the most common organisms identified. The proportion of salvaged grafts in the linezolid group was significantly higher (24 out of 28) compared to the control group (15 out of 25) (<i>p</i> = 0.034). The duration of hospital stays was shorter for patients in the linezolid group compared to the control group (9.6 ± 1.0 versus 16.1 ± 1.9, <i>p</i> = 0.012). Additionally, the average cost in the linezolid group was significantly lower than that in the control group (CNY 15,050 ± 1,611 versus 23,920 ± 4,097, <i>p</i> = 0.039).</p><p><strong>Conclusions: </strong>Linezolid was found to effectively control most cases of AVG infections, resulting in shorter hospital stays and significantly reducing the clinical burden on MHD patients especially when the blood or wound cultures were negative.</p>","PeriodicalId":94176,"journal":{"name":"Postgraduate medicine","volume":" ","pages":"1-5"},"PeriodicalIF":2.8,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145152562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The silent connection: anxiety, depression, and thyroid nodules explored.","authors":"Hui Xu, Jingxian Fan, Yi Chen, Fangzhen Xia, Yanbo Chen, Jiao Yu","doi":"10.1080/00325481.2025.2566629","DOIUrl":"10.1080/00325481.2025.2566629","url":null,"abstract":"<p><strong>Objective: </strong>This research investigates the prevalence of thyroid nodules and their association with anxiety and depression disorders in Eastern China. It also investigates the potential factors influencing this relationship, focusing on demographics and thyroid function.</p><p><strong>Methods: </strong>As part of the SPECT-China project, a cross-sectional survey was conducted with 5497 participants from both urban and rural regions in Shanghai, Zhejiang, and Jiangxi provinces. Participants received thyroid ultrasonography and laboratory tests for thyroid function, while their mental health was evaluated using the Zung Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS). Data analysis employed descriptive statistics, Student's T-test, Chi-square test, and logistic regression.</p><p><strong>Results: </strong>The study found a high prevalence of TNs (57.5%) among participants, with a higher incidence in females, older individuals, and those with lower education levels. Anxiety and depression disorders were diagnosed in 4.8% and 5.2% of participants, respectively, with higher rates in females and older individuals. Logistic regression analysis, controlling for age and gender, showed no significant link between TNs and anxiety or depression disorders in the general population. However, a significant association was observed in females. No significant correlation was identified between thyroid function (as measured by TSH levels) and the presence of TNs or mental disorders.</p><p><strong>Conclusion: </strong>Thyroid nodules are prevalent in Eastern China, particularly among females, older individuals, and those with lower education. TNs show a significant correlation with anxiety and depression disorders in females, although not in the general population. This study emphasizes the significance of examining gender differences in the link between thyroid nodules and mental health, and calls for additional research in this domain.</p>","PeriodicalId":94176,"journal":{"name":"Postgraduate medicine","volume":" ","pages":"1-10"},"PeriodicalIF":2.8,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145133197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between lipid profile components and health-related quality of life among hospitalized patients with cirrhosis.","authors":"Binxin Cui, Xuqian Zhang, Gaoyue Guo, Wentian Liu, Chao Sun","doi":"10.1080/00325481.2025.2567229","DOIUrl":"10.1080/00325481.2025.2567229","url":null,"abstract":"<p><strong>Objective: </strong>The relationship between lipid profile components and health-related quality of life (HRQoL) has gained attention in general populations along with disease conditions; however, scant data is clarifying these connections in cirrhosis. We sought to identify which lipid profile component was associated with HRQoL in hospitalized cirrhotics and delineate the relationship by performing multiple linear regression and generalized additive model (GAM) analyses.</p><p><strong>Methods: </strong>This cross-sectional study recruited 344 patients with lipid profile data, which comprised total cholesterol, low-density lipoprotein cholesterol, triglyceride, and high-density lipoprotein cholesterol (HDL-C). HRQoL was defined by the EuroQol Group 5 Dimension (EQ-5D) utility index.</p><p><strong>Results: </strong>The levels of HDL-C were positively correlated with the utility index (r: 0.159, <i>p</i> = 0.003). Multiple linear regression analysis showed an increase in HDL-C was independently associated with better EQ-5D-defined HRQoL (β: 0.088 [0.015, 0.161], <i>p</i> = 0.018). Moreover, sex disparities concerning the dose-response relationship between male <i>versus</i> female patients existed via GAM analysis. In males, GAM indicated a non-linear correlation between HDL-C and EQ-5D utility index, whilst a linear correlation was observed in females.</p><p><strong>Conclusions: </strong>We disentangled the association between increased HDL-C levels and better EQ-5D-defined HRQoL in hospitalized cirrhotics. Furthermore, the dose-response relationship between HDL-C and EQ-5D utility index differed between males and females, suggesting sex-dimorphic mechanisms linking HDL-C to HRQoL. If validated in interventional studies, sex-specific HDL-C pathway modulation might inform future adjunctive approaches.</p>","PeriodicalId":94176,"journal":{"name":"Postgraduate medicine","volume":" ","pages":"1-11"},"PeriodicalIF":2.8,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145139949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}