{"title":"[Non pharmacological intervention: A critical analysis of the concept].","authors":"Fabrice Berna, François Paille, Laurence Verneuil","doi":"10.1016/j.revmed.2025.06.018","DOIUrl":"https://doi.org/10.1016/j.revmed.2025.06.018","url":null,"abstract":"","PeriodicalId":94122,"journal":{"name":"La Revue de medecine interne","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144692868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[How can we help female patients with genital mutilation in their health care pathway?]","authors":"Mama Aissata Yattara, Olivier Lidove","doi":"10.1016/j.revmed.2025.06.010","DOIUrl":"https://doi.org/10.1016/j.revmed.2025.06.010","url":null,"abstract":"","PeriodicalId":94122,"journal":{"name":"La Revue de medecine interne","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144669207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hadi Faiz, Elise Reyal, Benjamin Subran, Jonathan London, Emmanuel Le Guen, Mailys Cohu, Olivier Lidove
{"title":"[Catatonia - About four clinical cases and literature review].","authors":"Hadi Faiz, Elise Reyal, Benjamin Subran, Jonathan London, Emmanuel Le Guen, Mailys Cohu, Olivier Lidove","doi":"10.1016/j.revmed.2025.06.006","DOIUrl":"https://doi.org/10.1016/j.revmed.2025.06.006","url":null,"abstract":"<p><strong>Introduction: </strong>Catatonia is a neuropsychiatric syndrome characterized by the presence of at least three out of the twelve following signs: stupor, catalepsy, waxy flexibility, mutism, negativism, posturing, mannerisms, stereotypies, agitation, grimacing, echolalia, and echopraxia. We will describe four cases of catatonia that occurred over one year in a single medicine department.</p><p><strong>Clinical cases: </strong>All four patients were over 60 years old. The causes of catatonia were diverse: hemorrhagic shock occurring in the context of mixed dementia, schizoaffective disorder, a severe major depressive episode, and a depressive syndrome associated with Lewy body disease. Three out of four patients were treated with electroconvulsive therapy (ECT), and all evolved towards remission. The diagnoses were consistently established by a liaison psychiatrist.</p><p><strong>Discussion: </strong>Before the recruitment of liaison psychiatrists in the institution, this diagnosis had not been considered in the department. The cause of catatonia can be psychiatric (75 to 80% of cases) and/or non-psychiatric (20 to 25% of cases). In two thirds of organic cases, it is a condition of the central nervous system. Symptomatic treatment with benzodiazepine allows for remission of symptoms in more than two thirds of cases. In the absence of response to benzodiazepines, treatment with electroconvulsive therapy is indicated. Catatonia can progress to death, following possible complications or in cases of severe dysautonomia (malignant catatonia).</p><p><strong>Conclusion: </strong>Catatonia is underdiagnosed and undertreated. Despite a relatively high prevalence, well-defined diagnostic criteria, and a symptomatic treatment that is often very effective, the prognosis of catatonia can be poor in the absence of treatment. Psychiatrists should be consulted whenever there is doubt regarding a clinical presentation.</p>","PeriodicalId":94122,"journal":{"name":"La Revue de medecine interne","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144610754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Patrick Mercié, Visal Keo, Anne Contis, Étienne Rivière, Noémie Gensous, Guillaume Vial, Vivien Guillotin, Estibaliz Lazaro, Valérie Aurillac, Pierre Duffau, Emmanuel Richard, Emmanuel Ribeiro
{"title":"[Place of chitotriosidase as a serum biomarker of sarcoidosis: A narrative review of the literature].","authors":"Patrick Mercié, Visal Keo, Anne Contis, Étienne Rivière, Noémie Gensous, Guillaume Vial, Vivien Guillotin, Estibaliz Lazaro, Valérie Aurillac, Pierre Duffau, Emmanuel Richard, Emmanuel Ribeiro","doi":"10.1016/j.revmed.2025.06.014","DOIUrl":"https://doi.org/10.1016/j.revmed.2025.06.014","url":null,"abstract":"<p><p>Sarcoidosis is an inflammatory systemic disease characterized by epithelio-gigantocellular granulomatosis without cell necrosis. The diagnosis is pathologic. There are many biomarkers of sarcoidosis. The oldest and most widely used in routine medical practice is angiotensin-converting enzyme (ACE) since 1975. However, it is a marker of low diagnostic value. The other most frequently studied biomarkers of interest are chitotriosidase (CTO), soluble IL-2 receptor (rsIL-2), neopterin, lysozyme, and SAA protein. In this work, we propose a review of the serum biomarkers of sarcoidosis. The studies are heterogeneous, and the results are difficult to conclude. Pathology remains the gold standard for the definitive diagnosis. In the context of evolutionary follow-up and relapse, we can select a priori 3 markers of interest: ACE (sensitivity [Se]: from 22 to 77% and specificity [Sp]: from 54 to 99%), CTO (Se: from 45 to 89% and Sp from 70 to 100%), and rsIL-2 (Se: from 52 to 82% and Sp: from 57 to 94%). The most rational association for a particular disease phenotype has yet to be determined. Future advances will come from an in-depth knowledge of granuloma, its mechanisms of formation, growth, and regression in the context of a still partially unknown inflammatory and immune response. Recent substantial progress has been made through radiological examinations. Multi-omics technologies will undoubtedly complement the arsenal of physiopathological and diagnostic research that will make it possible to move away from pathological examination and ensure better monitoring of the disease.</p>","PeriodicalId":94122,"journal":{"name":"La Revue de medecine interne","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144610755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Luc Lanthier, Geneviève Le Templier, Alexandre Mutchmore, Marc-Émile Plourde, Michel Cauchon
{"title":"[In patients with active cancer and venous thromboembolism who have been anticoagulated for at least 6 months, is extended treatment with a reduced dose of apixaban effective in preventing recurrences and reducing the risk of bleeding, compared to a full dose?]","authors":"Luc Lanthier, Geneviève Le Templier, Alexandre Mutchmore, Marc-Émile Plourde, Michel Cauchon","doi":"10.1016/j.revmed.2025.06.011","DOIUrl":"https://doi.org/10.1016/j.revmed.2025.06.011","url":null,"abstract":"","PeriodicalId":94122,"journal":{"name":"La Revue de medecine interne","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144513025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Luc Mouthon, Pascal Sève, Christian Agard, Marc André, Emmanuel Andrès, Achille Aouba, Ygal Benhamou, Bernard Bonnotte, Laurence Bouillet, Pascal Cathébras, Fleur Cohen-Aubart, Christophe Deligny, Gilles Kaplanski, Pierre Duhaut, David Launay, Christian Lavigne, Estibaliz Lazaro, Emmanuelle Le Moigne, Alain Lescoat, Kim Ly, Nadine Magy-Bertrand, François Maillot, Mickael Martin, Nihal Martis, Thomas Moulinet, Gregory Pugnet, Loïc Raffray, Camille Roubille, Amélie Servettaz, Odile Rauzy
{"title":"[Assessment of internship sites in Internal Medicine and Clinical Immunology, 7 years after the Residency Training Program Reform: Findings from a 2024 year-end survey in France].","authors":"Luc Mouthon, Pascal Sève, Christian Agard, Marc André, Emmanuel Andrès, Achille Aouba, Ygal Benhamou, Bernard Bonnotte, Laurence Bouillet, Pascal Cathébras, Fleur Cohen-Aubart, Christophe Deligny, Gilles Kaplanski, Pierre Duhaut, David Launay, Christian Lavigne, Estibaliz Lazaro, Emmanuelle Le Moigne, Alain Lescoat, Kim Ly, Nadine Magy-Bertrand, François Maillot, Mickael Martin, Nihal Martis, Thomas Moulinet, Gregory Pugnet, Loïc Raffray, Camille Roubille, Amélie Servettaz, Odile Rauzy","doi":"10.1016/j.revmed.2025.06.008","DOIUrl":"https://doi.org/10.1016/j.revmed.2025.06.008","url":null,"abstract":"<p><strong>Objective: </strong>To compile a list of approved training sites for the Residency Training Program [Diplôme d'Études Spécialisées] in Internal Medicine and Clinical Immunology (DES-MIIC) in France.</p><p><strong>Method: </strong>All local coordinators of the DES-MIIC were contacted to establish the list of approved internship sites for the MIIC DES within their geographical subdivision.</p><p><strong>Results: </strong>We listed 244 approved training sites, of which 87 (35.7%) were in university hospitals. Depending on the region/subdivision, the number of approved training sites varied significantly. Internship sites within and outside of university hospitals were approved for the core-phase in 85% (74/87) and 63.7% (100/157) of cases, for the \"development phase\" in 94.3% (82/87) and 84.1% (132/157) of cases and for the consolidation phase 80.5% (70/87) and 52.2% (82/157) of cases, respectively. The vacancy rate for selection was lower in university hospitals than in general hospitals with ratios of 1.5 (89.3% vs. 61%), 1.8 (88.8% vs. 48.9%) and 1.6 (88,5% vs. 55.4%) - for respectively the core, development and consolidation phases.</p><p><strong>Conclusion: </strong>Thirty-five percent of internship sites were located in University hospitals. Depending on the region/subdivision, the number of approved training sites for the DES-MIIC varies greatly. Half of internship positions are vacant outside of University hospitals, just as nearly half of training sites in these same hospitals lack approval for the \"consolidation phase\".</p>","PeriodicalId":94122,"journal":{"name":"La Revue de medecine interne","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144510119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}