La Revue de medecine interne最新文献

[Initial management of acute leukemia and its complications]. 急性白血病的初步处理及其并发症。

La Revue de medecine interne Pub Date : 2025-05-15 DOI: 10.1016/j.revmed.2025.04.025

Giulia Schiavini, Amandine Ségot, Gerasimos Tsilimidos, Vasiliki Papadopoulou, Sabine Blum

引用次数: 0

[Drug-induced immune thrombocytopenia: When both oxaliplatin and methylprednisolone are the culprits]. [药物性免疫性血小板减少症：当奥沙利铂和甲基强的松龙都是罪魁祸首]。

La Revue de medecine interne Pub Date : 2025-05-14 DOI: 10.1016/j.revmed.2025.03.427

François Therme, Juliette Guiraud-Chaumeil, Géraldine Perkins, Margaux Lafaurie, Julien Maquet, Marie-Léa Piel-Julian, Sophie Voisin, Gérald Bertrand, Guillaume Moulis

{"title":"[Drug-induced immune thrombocytopenia: When both oxaliplatin and methylprednisolone are the culprits].","authors":"François Therme, Juliette Guiraud-Chaumeil, Géraldine Perkins, Margaux Lafaurie, Julien Maquet, Marie-Léa Piel-Julian, Sophie Voisin, Gérald Bertrand, Guillaume Moulis","doi":"10.1016/j.revmed.2025.03.427","DOIUrl":"https://doi.org/10.1016/j.revmed.2025.03.427","url":null,"abstract":"Introduction: Drug-induced immune thrombocytopenia (DIIT) is a rare cause of immune thrombocytopenia, characterized by the formation of drug-dependent antiplatelet antibodies. DIIT can lead to life-threatening hemorrhage. The diagnosis is difficult, relying on the detection of antiplatelet antibodies in patient's serum exclusively in the presence of the implicated drug. The gold standard test is the monoclonal antibody immobilization of platelet antigens (MAIPA), although other techniques (flow cytometry and Luminex®) can be used.Patients: We report two cases of DIIT induced by both oxaliplatin and methylprednisolone.Results: The two patients were undergoing chemotherapy for colon malignancy, receiving a regimen including oxaliplatin following premedication with methylprednisolone. Thrombocytopenia occurred within hours after one infusion (both patients had received prior courses with this regimen). Immunological tests for both patients revealed antiplatelet antibodies in the presence of oxaliplatin (anti-GPIIbIIIa in the first observation, and polytypic in the second one) and methylprednisolone (anti-GPIbV in the first observation and GPIIbIIIa in the second one). After the discontinuation of the implicated drugs (and treatment with prednisone plus intravenous immunoglobulin for the first patient), both patients showed rapid improvement in a few days. Both patients continued chemotherapy without oxaliplatin and methylprednisolone. No relapse was observed during the follow up.Conclusion: DIIT are a rare cause of secondary immune thrombocytopenia. Diagnosis is complex, and the detection of drug-dependent antiplatelet antibodies in reference laboratories is essential. Oxaliplatin is a classical cause of DIIT. However, associated drugs like methylprednisolone can also be responsible for DIIT.","PeriodicalId":94122,"journal":{"name":"La Revue de medecine interne","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Epistaxis and weight loss in a 73-year-old man]. [1例73岁男性鼻出血与体重减轻]。

La Revue de medecine interne Pub Date : 2025-05-13 DOI: 10.1016/j.revmed.2025.04.028

Bahïa El Abed, Yusuf Sahin, Guillaume Bonnard, Cécile Le Boterff, Marion Leterrier-Plong, Marine Morrier, Mourad Tiab, Romain Collot, David Lebeaux

引用次数: 0

Morbi-mortality of obese patients with systemic sclerosis: A comparative study. 肥胖患者合并系统性硬化症的发病-死亡率：一项比较研究。

La Revue de medecine interne Pub Date : 2025-05-06 DOI: 10.1016/j.revmed.2025.04.026

Lucile Grange, Benjamin Chaigne, Marion Casadevall, Pascal Cohen, Bertrand Dunogue, Alexis Régent, Luc Mouthon

{"title":"Morbi-mortality of obese patients with systemic sclerosis: A comparative study.","authors":"Lucile Grange, Benjamin Chaigne, Marion Casadevall, Pascal Cohen, Bertrand Dunogue, Alexis Régent, Luc Mouthon","doi":"10.1016/j.revmed.2025.04.026","DOIUrl":"https://doi.org/10.1016/j.revmed.2025.04.026","url":null,"abstract":"Introduction: The prevalence of systemic sclerosis (SSc), as well as obesity, has significantly increased in recent decades. To address the lack of data on obese SSc patients, we conducted a retrospective comparative study to assess the prevalence, clinical characteristics, and long-term consequences of obesity in SSc patients.Methods: We conducted a retrospective comparative study at the Cochin University Hospital's Department of Internal Medicine (Paris) from 2000 to 2019.Results: Of the 911 SSc patients included, 90 (9.9%) were obese, comprising 79 females and 11 males. The median weight for obese patients was 90 [82-98] kg, compared to 60 [53-67] kg for non-obese patients, corresponding to a median body mass index of 33 [31-37] kg/m2 and 23 [20-25] kg/m2, respectively. Obese patients exhibited a higher prevalence of cardiovascular risk factors. The median modified Rodnan skin score was significantly higher in non-obese patients than in obese patients (6 [2-16] vs 3 [2-7]; P<0.05). Organ involvement did not differ significantly between obese and non-obese patients. We observed a lower number of deaths in obese SSc patients compared to non-obese SSc patients (6 [11%] vs. 26 deaths [25%], P=0.06). Analysis of 30-year Kaplan Meier survival curves did not show significant survival difference between obese and non-obese SSc patients.Conclusions: This study of obese ScS patients reveals that they have a higher prevalence of cardiovascular risk factors, lower mRSS, less calcinosis, and similar rates of organ damage and mortality compared to non-obese ScS patients.","PeriodicalId":94122,"journal":{"name":"La Revue de medecine interne","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144045437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Internal medicine: A core discipline in healthcare establishments for the care of complex patients]. [内科：医疗机构中治疗复杂病人的核心学科]。

La Revue de medecine interne Pub Date : 2025-05-06 DOI: 10.1016/j.revmed.2025.04.024

Quitterie Reynaud, Mathias Gernez, Natacha Grienay-Poletto, Pascal Sève, Arnaud Hot, Mael Richard, Yoann Roubertou, Yvan Jamilloux, Thomas Barba, Céline Piegay, Isabelle Durieu

{"title":"[Internal medicine: A core discipline in healthcare establishments for the care of complex patients].","authors":"Quitterie Reynaud, Mathias Gernez, Natacha Grienay-Poletto, Pascal Sève, Arnaud Hot, Mael Richard, Yoann Roubertou, Yvan Jamilloux, Thomas Barba, Céline Piegay, Isabelle Durieu","doi":"10.1016/j.revmed.2025.04.024","DOIUrl":"https://doi.org/10.1016/j.revmed.2025.04.024","url":null,"abstract":"Introduction: The role of internal medicine departments in the management of chronic diseases in older patients with more comorbidities is a topical issue.Methods: For each internal medicine department of the Lyon University Hospital (North, Centre and South Hospices Civils de Lyon Hospital Group), Programme de médicalisation des systèmes d'information (PMSI) activity report data were used, with the number of medical unit summary (RUM) and standardised discharge summary (RSS) stays for 4 consecutive years from 2018 to 2022.Results: Activity increased in the three internal medicine departments in outpatient day hospital activity, the rest of the activity remained stable. The rate of admissions via emergency units was multiplied by 3, with an increase in discharges to rehabilitation services. The death rate doubled. The average age increased to 68, with an increase in the Charlson score comorbidity index to 2, independently of age, and in the percentage of stays with severity 3 and 4.Conclusion: Analysis of data on conventional inpatient care in internal medicine at Lyon University Hospital shows a major qualitative change, with older patients with more comorbidities and higher severity stay profiles, leading to an increase in the number of inpatient deaths, and greater use of rehabilitation units.","PeriodicalId":94122,"journal":{"name":"La Revue de medecine interne","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144063746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Non-pharmacological interventions: A new paradigm and opportunities for internists]. [非药物干预：内科医生的新范式和机遇]。

La Revue de medecine interne Pub Date : 2025-04-26 DOI: 10.1016/j.revmed.2025.04.004

Grégory Ninot, Mathilde Minet, Jérôme Larché, Jean Ribstein, Laurent Chiche

{"title":"[Non-pharmacological interventions: A new paradigm and opportunities for internists].","authors":"Grégory Ninot, Mathilde Minet, Jérôme Larché, Jean Ribstein, Laurent Chiche","doi":"10.1016/j.revmed.2025.04.004","DOIUrl":"https://doi.org/10.1016/j.revmed.2025.04.004","url":null,"abstract":"The notion of non-pharmacological interventions (NPI) has been used by healthcare researchers since 1975, and is cited in numerous reports by French, European and international healthcare authorities, such as the WHO since 2003 and the HAS since 2011. However, it was only recently that a collaborative initiative of consensus was launched to address the lack of consensus on how to define and evaluate these health practices, amplified by the media controversy surrounding these practices during the COVID-19 episode. Indeed, in 2021, the launch of a collaborative and open research program responding to international scientific expectations in the healthcare field and to the specificities of these immaterial, personalized and targeted healthcare solutions has finally been initiated. The first part of this article, intended for specialists in internal medicine, describes the consensus-building work carried out under the guidance of a multidisciplinary committee, with the support of Inserm and the logistics of the international Non-Pharmacological Intervention Society (NPIS). Over a period of three years, this work, involving more than 1000 participants, established a definition, a characterization and an evaluative framework including 77 ethical and methodological recommendations for these practices. This NPIS Model framework has received the support of 30 French scientific and medical societies, two European societies and three French health authorities. The second part of the article presents the collaborative tools that have emerged from this work. Finally, the third part of the article looks at the implications of NPI for research and practice in the field of internal medicine.","PeriodicalId":94122,"journal":{"name":"La Revue de medecine interne","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144063748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Brain lesion]. (大脑病变)。

La Revue de medecine interne Pub Date : 2025-04-26 DOI: 10.1016/j.revmed.2025.04.009

Sihame Es-Qalli, Olivier Fain, Amir Adedjouma, Galith Kalmi

引用次数: 0

[Management of febrile neutropenia]. [发热性中性粒细胞减少症的处理]。

La Revue de medecine interne Pub Date : 2025-04-24 DOI: 10.1016/j.revmed.2025.04.005

Xavier Jannot, Jean-Édouard Terrade, Manuel Méndez-Bailón, María Belén Alonso-Ortiz, Emmanuel Andrès, Noel Lorenzo-Villalba

引用次数: 0

[In patients with asymptomatic severe aortic stenosis, does a transcatheter aortic-valve replacement improve prognosis, and is it safe?] 对于无症状的严重主动脉瓣狭窄患者，经导管主动脉瓣置换术是否能改善预后，是否安全？］

La Revue de medecine interne Pub Date : 2025-04-22 DOI: 10.1016/j.revmed.2025.03.428

Luc Lanthier, Alexandre Mutchmore, Marc-Émile Plourde, Michel Cauchon

引用次数: 0

[Erdheim-Chester disease associated with Langerhans cell histiocytosis: A case of a mixed form]. [Erdheim-Chester病合并朗格汉斯细胞组织细胞增多症：混合型1例]。

La Revue de medecine interne Pub Date : 2025-04-03 DOI: 10.1016/j.revmed.2025.02.012

Houria Sahel, Billel Merrouche, Souad Bellaifa, Nacima Djennane, Zine Charef Amir, Abdelkrim Talbi, Ammar Maireche, Radhia Ait Chalal, Amine Habouchi

{"title":"[Erdheim-Chester disease associated with Langerhans cell histiocytosis: A case of a mixed form].","authors":"Houria Sahel, Billel Merrouche, Souad Bellaifa, Nacima Djennane, Zine Charef Amir, Abdelkrim Talbi, Ammar Maireche, Radhia Ait Chalal, Amine Habouchi","doi":"10.1016/j.revmed.2025.02.012","DOIUrl":"https://doi.org/10.1016/j.revmed.2025.02.012","url":null,"abstract":"Introduction: Langerhans cell histiocytosis and Erdheim-Chester disease are rare inflammatory myeloid neoplasms. They present characteristic clinical, histological and radiological signs. Their association is exceptional. We report a new observation.Observation: A 47-year-old man presented with lesions of seborrheic dermatitis-like, intracranial hypertension, paralysis of the sixth cranial nerve, and central diabetes insipidus. The skin biopsy concluded that there was Langerhans cell histiocytosis. The bone scan showed metaphyseal-diaphyseal osteosclerotic lesions of the femur, tibia and humerus. The thoraco-abdomino-pelvic CT scan showed an aortic sheathing, suggesting Erdheim-Chester disease. The search for the BRAFV600E mutation was negative. The patient was treated with oral corticosteroid therapy then with cladribine which allowed a good evolution.Conclusion: We report an observation of a mixed form of histiocytosis associating Langerhans cell histiocytosis and Erdheim-Chester disease, with a diagnostic delay of ten years, and having responded well to treatment with cladribine.","PeriodicalId":94122,"journal":{"name":"La Revue de medecine interne","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0