Kansas journal of medicine最新文献

{"title":"Elevated Circulating Fibroblast Growth Factor 21 in Lean Type 2 Diabetes: Evidence of Metabolic Dysregulation in the Absence of Adiposity.","authors":"Sarah Nafea, Nasir Siddique, Seemal Abdulqadir, Hsu Myat Noe, Nidhi Reji, Rameeqa Ejaz, Idrees Mohamed Idrees Abubaker","doi":"10.17161/kjm.vol19.25552","DOIUrl":"10.17161/kjm.vol19.25552","url":null,"abstract":"<p><strong>Introduction: </strong>Lean type 2 diabetes mellitus (T2DM) is a form of diabetes that develops in persons with normal Body Mass Index (BMI) and considerable metabolic impairment. High levels of Fibroblast Growth Factor-21 (FGF21) can indicate disrupted metabolic signaling in this group. The study aimed to assess circulating FGF21 levels in lean T2DM and to examine their association with insulin resistance and hepatic steatosis, both biomarkers of metabolic dysregulation.</p><p><strong>Methods: </strong>This cross-sectional study included 425 lean adults (body mass index 18.5-22.9 kg/m²), comprising 200 lean T2DM patients and 225 non-diabetic controls. An enzyme-linked immunosorbent assay (ELISA) was used to measure serum FGF21 levels. Insulin resistance was assessed using the Homeostatic Model Assessment of Insulin Resistance (HOMA-IR), and ultrasonography was used to evaluate hepatic steatosis.</p><p><strong>Results: </strong>Lean T2DM patients had significantly higher levels of glycated hemoglobin (HbA1c), homeostatic model assessment of insulin resistance (HOMA-IR), fasting glucose, fasting insulin, low-density lipoprotein (LDL) cholesterol, aspartate aminotransferase (AST), and total cholesterol, while high-density lipoprotein (HDL) cholesterol was lower than non-diabetic controls (all p <0.001). In multivariable analyses of the lean T2DM cohort, serum FGF21 was independently associated with HOMA-IR (β = 0.775, p <0.001) and hepatic steatosis (OR, 1.02; 95% CI, 1.01-1.03).</p><p><strong>Conclusions: </strong>Circulating FGF21 levels are elevated in lean T2DM and may reflect compensatory upregulation or altered FGF21 signaling rather than confirmed tissue-level resistance. FGF21 was an independent predictor of insulin resistance and hepatic steatosis, suggesting its potential as a biomarker of metabolic dysfunction in the normal-BMI group.</p>","PeriodicalId":94121,"journal":{"name":"Kansas journal of medicine","volume":"19 4","pages":"102-109"},"PeriodicalIF":0.0,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13502511/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148815313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolated, Unilateral Lower Eyelid Mass Presenting as a Delayed Ocular Complication of Dermal Filler.","authors":"Diana N Le, Jennifer K Burgoyne","doi":"10.17161/kjm.vol19.25671","DOIUrl":"10.17161/kjm.vol19.25671","url":null,"abstract":"","PeriodicalId":94121,"journal":{"name":"Kansas journal of medicine","volume":"19 4","pages":"119-121"},"PeriodicalIF":0.0,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13502510/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148815266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrent Hypoglycemia Secondary to Pancreatic Insulinoma.","authors":"Grace Keirn, Chao Wu, Sarah Cain, Ravindra Chuda","doi":"10.17161/kjm.vol19.25440","DOIUrl":"10.17161/kjm.vol19.25440","url":null,"abstract":"","PeriodicalId":94121,"journal":{"name":"Kansas journal of medicine","volume":"19 4","pages":"113-118"},"PeriodicalIF":0.0,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13502508/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148815361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of Physical Activity and Sleep with Depression, Anxiety, and Loneliness Among U.S. Adults: A Population-Based Cross-Sectional Study.","authors":"Samuel Ofei-Dodoo, Yousaf Khan, Ibrahim Touffaha, Divya Natesan, Hayrettin Okut, Claire Richardson, Isabelle Bevis, Mark White","doi":"10.17161/kjm.vol19.25605","DOIUrl":"10.17161/kjm.vol19.25605","url":null,"abstract":"<p><strong>Introduction: </strong>Physical activity, strength training, and sleep are important determinants of mental health. The authors of this study examined the associations of these lifestyle behaviors with emotional health outcomes among U.S. adults.</p><p><strong>Methods: </strong>Authors conducted a cross-sectional analysis of data from the 2024 Health Information National Trends Survey^® 7, a nationally representative survey of U.S. adults aged ≥18 years (N = 7278). Outcomes included depression (PHQ-2), anxiety (GAD-2), overall loneliness (PROMIS Social Isolation Short Form), social loneliness, and emotional loneliness. Predictors included moderate-intensity physical activity (≥150 min/week), strength training (≥2 days/week), and weekday and weekend sleep duration. Survey-weighted logistic and multinomial logistic regression analyses were performed, adjusting for sociodemographic and health-related covariates.</p><p><strong>Results: </strong>Most respondents screened negative for depression (79.4%) and anxiety (78.4%), and 61.6% reported low loneliness. Most respondents did not meet the recommended levels of moderate-intensity physical activity (56.6%) or strength training (55.4%). In adjusted analyses, meeting strength-training guidelines was associated with lower odds of depression (adjusted odds ratio [aOR], 0.71; 95% confidence interval [CI], 0.53-0.95) and loneliness (aOR, 0.65; 95% CI, 0.43-0.98). Moderate-intensity physical activity was not independently associated with emotional health outcomes. Obtaining the recommended 7-9 hours of weekend sleep was associated with lower odds of depression, anxiety, and loneliness, whereas obtaining the recommended weekday sleep duration was associated with lower social and emotional loneliness.</p><p><strong>Conclusions: </strong>Strength training and adequate sleep were independently associated with better emotional health among U.S. adults. These findings support muscle-strengthening activities and healthy sleep habits as potential targets for mental health promotion.</p>","PeriodicalId":94121,"journal":{"name":"Kansas journal of medicine","volume":"19 4","pages":"84-101"},"PeriodicalIF":0.0,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13502507/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148815120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Analysis of Reported Adverse Events with Nirsevimab and Palivizumab in the FAERS Database.","authors":"Ibrahim Touffaha, Elizabeth Ablah, Hayrettin Okut, Gretchen Homan","doi":"10.17161/kjm.vol19.25544","DOIUrl":"10.17161/kjm.vol19.25544","url":null,"abstract":"<p><strong>Introduction: </strong>Respiratory syncytial virus (RSV) remains a leading cause of hospitalization among infants. Palivizumab has long been used for RSV prophylaxis in high-risk infants, whereas nirsevimab is a newer long-acting monoclonal antibody approved for broader use. Although clinical trials have demonstrated comparable safety profiles, comparative post-marketing safety data remain limited. Authors of this study compared reported adverse events associated with palivizumab and nirsevimab using the FDA Adverse Event Reporting System (FAERS).</p><p><strong>Methods: </strong>A retrospective cross-sectional pharmacovigilance study was conducted using FAERS reports. Adverse events were classified according to the Medical Dictionary for Regulatory Activities (Med-DRA) System Organ Classes. Comparative analyses were performed using chi-square tests and binary logistic regression, with palivizumab as the reference group. Odds ratios (ORs) and 95% confidence intervals (CIs) were reported.</p><p><strong>Results: </strong>A total of 2,021 reports met the inclusion criteria, including 1,380 for palivizumab and 641 for nirsevimab. Compared with palivizumab reports, nirsevimab reports had higher odds of including injury, poisoning, and procedural complications (OR, 7.55; 95% CI, 5.57-10.35) and skin and subcutaneous tissue disorders (OR, 2.55; 95% CI, 1.51-4.33). Nirsevimab reports had lower odds of including infections and infestations (OR, 0.51; 95% CI, 0.40-0.65), gastrointestinal disorders (OR, 0.29; 95% CI, 0.15-0.52), investigations (OR, 0.37; 95% CI, 0.18-0.68), and respiratory, thoracic, and mediastinal disorders (OR, 0.64; 95% CI, 0.51-0.80).</p><p><strong>Conclusions: </strong>Nirsevimab and palivizumab demonstrated distinct post-marketing adverse event reporting patterns. Continued post-marketing surveillance is warranted to further characterize the safety profiles of both agents.</p>","PeriodicalId":94121,"journal":{"name":"Kansas journal of medicine","volume":"19 4","pages":"76-83"},"PeriodicalIF":0.0,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13502506/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148815236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Widespread Skin Lesions in an Adult Patient.","authors":"Jason R Sakizadeh, Jessica R Newman","doi":"10.17161/kjm.vol19.25303","DOIUrl":"10.17161/kjm.vol19.25303","url":null,"abstract":"","PeriodicalId":94121,"journal":{"name":"Kansas journal of medicine","volume":"19 4","pages":"110-112"},"PeriodicalIF":0.0,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13502509/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148815343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Presenting Research During Residency Interviews: A Framework for Explaining the <i>Why</i>, <i>How</i>, <i>What</i>, <i>So What</i>, and <i>Your Role</i>.","authors":"Samuel Ofei-Dodoo","doi":"10.17161/kjm.vol19.25851","DOIUrl":"10.17161/kjm.vol19.25851","url":null,"abstract":"","PeriodicalId":94121,"journal":{"name":"Kansas journal of medicine","volume":"19 4","pages":"122-124"},"PeriodicalIF":0.0,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13502505/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148815318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Unusual Case of Bandl's Ring in a Dichorionic Diamniotic Twin Gestation.","authors":"Fernanda Reyes, Briana Gomez, Jennifer Keomany, Alexandra Meloccaro","doi":"10.17161/kjm.vol19.25142","DOIUrl":"10.17161/kjm.vol19.25142","url":null,"abstract":"","PeriodicalId":94121,"journal":{"name":"Kansas journal of medicine","volume":"19 3","pages":"61-63"},"PeriodicalIF":0.0,"publicationDate":"2026-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13336652/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148440406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbial Characteristics and Etiologic Patterns of Endophthalmitis at a Tertiary Referral Center: A Retrospective Cohort Study.","authors":"Shamir Khan, Robert Boyle, Maram El-Geneidy, Amin Karadaghy, Nathaniel Cameron, Maggie Malmberg, Vivek Velagapudi, Dante Pennipede, Radwan S Ajlan","doi":"10.17161/kjm.vol19.24297","DOIUrl":"10.17161/kjm.vol19.24297","url":null,"abstract":"<p><strong>Introduction: </strong>Endophthalmitis is a serious vision-threatening intraocular infection. Its etiology, microbiologic profile, and anti-microbial resistance patterns vary by region. Understanding local patterns is essential for guiding empiric therapy and improving patient outcomes. Authors of this study aimed to identify the most common etiologies, causative organisms, and resistance patterns of endophthalmitis at a Midwestern tertiary referral center.</p><p><strong>Methods: </strong>Authors conducted a retrospective chart review of patients diagnosed and treated for infectious endophthalmitis at the University of Kansas between 2008 and 2022. Adult patients with infectious endophthalmitis who underwent vitreous biopsy with microbiologic testing were included. Clinical findings, microbiology results, anti-microbial resistance patterns, empiric treatment regimens, and patient characteristics were collected and analyzed.</p><p><strong>Results: </strong>A total of 149 patients met the inclusion criteria, of whom 52 had positive microbiologic cultures, yielding 64 microbial isolates. The most common etiologies were endogenous infection (n = 43), postoperative infection (n = 32), infection secondary to corneal ulcer (n = 19), and trauma (n = 14). Among culture-positive cases, most isolates were bacterial (61/64). <i>Staphylococcus epidermidis</i> and <i>Staphylococcus aureus</i> were the most frequently isolated organisms, accounting for 12 and 8 isolates, respectively. Resistance was most commonly observed to erythromycin (58%) and clindamycin (33%), whereas vancomycin resistance was rare (3%).</p><p><strong>Conclusions: </strong>Endogenous infection was the most common cause of endophthalmitis in this Midwestern cohort. Regional variation in causative organisms and antimicrobial resistance patterns highlights the importance of local surveillance and tailored empiric treatment strategies to optimize patient outcomes.</p>","PeriodicalId":94121,"journal":{"name":"Kansas journal of medicine","volume":"19 3","pages":"55-60"},"PeriodicalIF":0.0,"publicationDate":"2026-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13336557/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148440620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Potential of NRX-101 for Pediatric Bipolar Depression: A Call for Research and Equity.","authors":"Muhammad Yusuf, Maryam Tariq, Ann Genovese","doi":"10.17161/kjm.vol19.24939","DOIUrl":"10.17161/kjm.vol19.24939","url":null,"abstract":"","PeriodicalId":94121,"journal":{"name":"Kansas journal of medicine","volume":"19 3","pages":"74-75"},"PeriodicalIF":0.0,"publicationDate":"2026-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13336555/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148440602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}