Kaku igaku. The Japanese journal of nuclear medicine最新文献

{"title":"","authors":"","doi":"10.18893/kakuigaku.rgr.2633","DOIUrl":"https://doi.org/10.18893/kakuigaku.rgr.2633","url":null,"abstract":"","PeriodicalId":94120,"journal":{"name":"Kaku igaku. The Japanese journal of nuclear medicine","volume":"63 1","pages":"17-20"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147358274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"10.18893/kakuigaku.arm.2637","DOIUrl":"https://doi.org/10.18893/kakuigaku.arm.2637","url":null,"abstract":"","PeriodicalId":94120,"journal":{"name":"Kaku igaku. The Japanese journal of nuclear medicine","volume":"63 1","pages":"41-47"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148901782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The 47th Report on Survey of the Adverse Reaction to Radiopharmaceuticals (The 50th Survey in 2024)].","authors":"Hidehiko Okazawa, Tomoya Uehara, Daiki Kayano, Ichiei Kuji, Tatsuya Higashi, Mana Yoshimura","doi":"10.18893/kakuigaku.rp.2631","DOIUrl":"10.18893/kakuigaku.rp.2631","url":null,"abstract":"<p><p>This survey was performed in order to investigate the incidence of adverse reactions to radiopharmaceuticals in FY2024 in Japan. It was based on responses to questionnaires sent to nuclear medicine institutions. Replies were obtained from 989 institutions out of 1,176 to which the questionnaire had been sent. A total of 925,315 radiopharmaceutical administrations were reported. Nine cases of adverse reactions were reported. The incidence of adverse reactions per 100,000 cases was 1.0. No case of defective products was reported.</p>","PeriodicalId":94120,"journal":{"name":"Kaku igaku. The Japanese journal of nuclear medicine","volume":"63 1","pages":"1-11"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146121531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Advances in Cardiac Sympathetic PET Imaging: Development and Clinical Translation of ¹⁸F-fluproxadine (¹⁸F-AF78)].","authors":"Naoko Nose, Takahiro Higuchi","doi":"10.18893/kakuigaku.ra.2602","DOIUrl":"https://doi.org/10.18893/kakuigaku.ra.2602","url":null,"abstract":"<p><p>The cardiac sympathetic nervous system plays an important role in the pathophysiology and prognosis of heart failure, ischemic heart disease, and arrhythmias. Cardiac sympathetic innervation has traditionally been assessed using ¹²³I-meta-iodobenzylguanidine (¹²³I-MIBG) SPECT and ¹¹C-hydroxyephedrine (¹¹C-HED) PET. However, these approaches have limitations related to spatial resolution, quantitative capability, physical half-life, and dependence on specialized facilities. ¹⁸F-fluproxadine, formerly known as ¹⁸F-AF78, is a novel PET tracer targeting the norepinephrine transporter (NET) at sympathetic nerve terminals. Preclinical studies have demonstrated its high NET affinity, favorable myocardial uptake, and potential to reflect intravesicular neuronal dynamics. In addition, structure-activity relationship analyses, investigations of interactions with organic cation transporters (OCTs), development of a clinical radiosynthesis method, and First-in-Human evaluation have provided a foundation for clinical translation. This review summarizes the development of ¹⁸F-fluproxadine PET and discusses future perspectives for cardiac sympathetic nerve imaging.</p>","PeriodicalId":94120,"journal":{"name":"Kaku igaku. The Japanese journal of nuclear medicine","volume":"63 1","pages":"61-68"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149240941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Prognostic Value of Myocardial Flow Reserve Derived from ¹³N-ammonia PET in Patients with Ischemic Heart Disease in Japan].","authors":"Atsushi Yamamoto, Masao Miyagawa, Takashi Kudo, Michinobu Nagao, Kenji Fukushima, Hideki Okayama, Naoto Kawaguchi, Masateru Kawakubo","doi":"10.18893/kakuigaku.rgr.2632","DOIUrl":"https://doi.org/10.18893/kakuigaku.rgr.2632","url":null,"abstract":"<p><p>Myocardial flow reserve (MFR) measured by 13N-ammonia PET is a well-established indicator of adverse outcomes in patients with ischemic heart disease (IHD), with a low MFR (<2.0) indicating a poor prognosis. Furthermore, MFR can be used to non-invasively diagnose ischemia with non-obstructive coronary arteries. However, most of the evidence originates from Western populations, and studies in Japan are limited to small sample sizes. Therefore, we aimed to investigate the utility of MFR for risk stratification of cardiovascular events in a Japanese cohort.Between January 2016 to December 2023, consecutive 413 Japanese patients who underwent NH₃-PET because of known or suspected IHD at multiple facilities in Japan were analyzed. We evaluated myocardial blood flow (MBF) at rest and during adenosine-induced hyperemic stress, and calculated MFR from the ratio of stress to rest MBF. The patients were divided into two groups according to MFR as defined by receiver-operating characteristic (ROC) analysis. The frequency of major adverse cardiovascular events (MACE), including acute coronary syndrome, revascularization after three months, heart failure hospitalization, and all-cause mortality, was compared by Kaplan-Meier and log-rank test. For imaging and clinical parameters, hazard ratios (HR) and 95% confidence intervals (CI) were calculated using the Cox proportional hazards regression model.The ROC curve analysis of MFR for MACE showed the optimal cutoff value of 2.1. The incidence of MACE in the group with reduced MFR was significantly higher than that with preserved MFR (p < 0.0001). MFR and summed stress score were significant factors in univariate analysis. Multivariate analysis indicated that MFR was an independent prognostic factor of MACE (HR: 0.50, 95% CI: 0.36-0.70, p < 0.0001).In Japan, MFR derived from NH₃-PET was also a useful prognostic factor. The cutoff value for MFR was comparable to that reported in previous studies involving patients in the West.</p>","PeriodicalId":94120,"journal":{"name":"Kaku igaku. The Japanese journal of nuclear medicine","volume":"63 1","pages":"13-16"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147313812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"10.18893/kakuigaku.arm.2634","DOIUrl":"https://doi.org/10.18893/kakuigaku.arm.2634","url":null,"abstract":"","PeriodicalId":94120,"journal":{"name":"Kaku igaku. The Japanese journal of nuclear medicine","volume":"63 1","pages":"21-25"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147358290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Prevention of Radiation Detection Issues at International Airports Following Nuclear Medicine Procedures: The Role of Pre-travel Screening].","authors":"Aya Kashima, Hiroshi Higashino, Rika Nishihara, Kimie Akiyama, Miku Saeki, Kanami Hirata, Asumi Takeuchi, Masayuki Tanaka, Fumitaka Kawajo, Akihiko Ikemizu, Kou Matsushita, Katsunori Ida, Hiroyuki Fujieda, Mitsunori Abe","doi":"10.18893/kakuigaku.tr.2601","DOIUrl":"https://doi.org/10.18893/kakuigaku.tr.2601","url":null,"abstract":"<p><p>To prevent potential radiation detection issues at international airports following nuclear medicine procedures, our hospital conducts screenings regarding international travel plans both at the time of booking and on the day of the examination. We evaluated the results and clinical utility of these screenings conducted for 6,132 cases over a seven-year period from April 2019 to March 2026. Overall, 1.29% (79 cases) of patients reported planned international travel; however, excluding the COVID-19 pandemic period (April 2020 to March 2022), the rate was 2.24% (77 out of 3,437 cases). Regarding the timing of disclosure, 62.03% (49/79 cases) identified their travel plans during the booking process, while 37.98% (30/79 cases) did not disclose them until the day of the examination. For cases identified at booking, we adjusted the examination schedules for 11 patients and changed the radiopharmaceutical for one patient. For those identified on the day of the procedure, emergency certificates were issued for three patients to proceed with the examination. No examinations were canceled, and there were no reports of post-procedural airport complications. We concluded that screening at the time of booking is essential to enable flexible interventions, such as rescheduling and modifying protocols, to ensure patient safety and convenience.</p>","PeriodicalId":94120,"journal":{"name":"Kaku igaku. The Japanese journal of nuclear medicine","volume":"63 1","pages":"31-34"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148681655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"10.18893/kakuigaku.rp.2637","DOIUrl":"https://doi.org/10.18893/kakuigaku.rp.2637","url":null,"abstract":"","PeriodicalId":94120,"journal":{"name":"Kaku igaku. The Japanese journal of nuclear medicine","volume":"63 1","pages":"49-59"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149120999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"10.18893/kakuigaku.arm.2635","DOIUrl":"https://doi.org/10.18893/kakuigaku.arm.2635","url":null,"abstract":"","PeriodicalId":94120,"journal":{"name":"Kaku igaku. The Japanese journal of nuclear medicine","volume":"63 1","pages":"27-29"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148564284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"10.18893/kakuigaku.arm.2636","DOIUrl":"https://doi.org/10.18893/kakuigaku.arm.2636","url":null,"abstract":"","PeriodicalId":94120,"journal":{"name":"Kaku igaku. The Japanese journal of nuclear medicine","volume":"63 1","pages":"35-39"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148881996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}