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Journal of the advanced practitioner in oncology最新文献

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Post-Transplant Cyclophosphamide for the Prevention of Graft-vs.-Host Disease in Allogeneic Hematopoietic Cell Transplantation: A Guide to Management for the Advanced Practitioner. 环磷酰胺预防移植物抗逆转录病毒的移植后预防-异基因造血细胞移植中的宿主病：高级从业者管理指南。
Journal of the advanced practitioner in oncology Pub Date : 2023-09-01 DOI: 10.6004/jadpro.2023.14.6.5
Ekaterina Kachur, Jai N Patel, Allison L Morse, Donald C Moore, Justin R Arnall
{"title":"Post-Transplant Cyclophosphamide for the Prevention of Graft-vs.-Host Disease in Allogeneic Hematopoietic Cell Transplantation: A Guide to Management for the Advanced Practitioner.","authors":"Ekaterina Kachur,&nbsp;Jai N Patel,&nbsp;Allison L Morse,&nbsp;Donald C Moore,&nbsp;Justin R Arnall","doi":"10.6004/jadpro.2023.14.6.5","DOIUrl":"10.6004/jadpro.2023.14.6.5","url":null,"abstract":"<p><p>Cyclophosphamide remains a critical component to haploidentical transplant conditioning regimens. Post-transplant cyclophosphamide (PTCy) emerged as an effective component of graft-vs.-host disease (GVHD) prophylaxis in the nonmyeloablative haploidentical bone marrow transplant setting. The relative ease of administration compared with ex vivo manipulations and efficacy in reducing GVHD has led to increasing PTCy use in transplant centers around the world. The role of PTCy has expanded to haploidentical transplantation with myeloablative conditioning regimens and peripheral blood progenitor cells as the donor source. Moreover, encouraging results in GVHD management have been shown with the use of PTCy alone or in combination with other immunosuppressives in the human leukocyte antigen-matched donor setting. The toxicity profile of cyclophosphamide varies extensively depending on dose, duration, overall drug exposure, and, potentially, pharmacogenetics. This review highlights the pharmacology, pharmacokinetics, and toxic effects of cyclophosphamide and offers practical guidance for clinical application in the post-transplant setting. We summarize data on the management of high-dose cyclophosphamide toxicities and provide insights into the pharmacogenetic implications on drug efficacy and safety data.</p>","PeriodicalId":94110,"journal":{"name":"Journal of the advanced practitioner in oncology","volume":"14 6","pages":"520-532"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e6/40/jadpro-14-520.PMC10558021.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41175071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
'My Choices, My Wishes' Program and Its Effect on Chemotherapy at the End of Life and Advance Care Directive Documentation. “我的选择，我的愿望”计划及其对临终化疗的影响和高级护理指导文件。
Journal of the advanced practitioner in oncology Pub Date : 2023-09-01 DOI: 10.6004/jadpro.2023.14.6.3
Jessica Tamar Davis
{"title":"'My Choices, My Wishes' Program and Its Effect on Chemotherapy at the End of Life and Advance Care Directive Documentation.","authors":"Jessica Tamar Davis","doi":"10.6004/jadpro.2023.14.6.3","DOIUrl":"10.6004/jadpro.2023.14.6.3","url":null,"abstract":"<p><strong>Background: </strong>Oncology patients have tremendous symptom burden both physically and emotionally. Palliative care (PC) improves quality of life and prevents suffering. Advance care planning (ACP) empowers patients to articulate goals of their care. New guidelines call for palliative care to be provided and chemotherapy avoided the last 2 weeks of life. The American Society of Clinical Oncology (ASCO) recommends integrating palliative care within the oncology setting to achieve these outcomes. However, the best mode to provide this care remains unclear. A nurse practitioner/physician assistant (NP/PA)-based model from within the oncology clinic is a potential option.</p><p><strong>Methods: </strong>A program evaluation was done to determine the effectiveness of the \"My Choices, My Wishes\" NP/PA-led program.</p><p><strong>Results: </strong>From 2012 to 2018, the number of patients receiving PC/ACP visits increased from 2.6% to 19.4%. The percentage of patients receiving chemotherapy in the last 14 days of life decreased from 12.5% to 7.14%. The number of advance care directives completed increased from 17.5% to 37.5%.</p><p><strong>Conclusion: </strong>This program was an effective way to provide PC/ACP for oncology patients. We still need to understand why patients pursue chemotherapy at the end of life. It is necessary to improve our communication techniques with patients and families in order to guarantee high-quality, high-value care.</p>","PeriodicalId":94110,"journal":{"name":"Journal of the advanced practitioner in oncology","volume":"14 6","pages":"489-497"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6b/d1/jadpro-14-489.PMC10558017.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41163614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Precautions for Patients Taking Tamoxifen or Aromatase Inhibitors. 服用三苯氧胺或芳香化酶抑制剂的患者注意事项。
Journal of the advanced practitioner in oncology Pub Date : 2023-09-01 DOI: 10.6004/jadpro.2023.14.6.2
Mary Heery
{"title":"Precautions for Patients Taking Tamoxifen or Aromatase Inhibitors.","authors":"Mary Heery","doi":"10.6004/jadpro.2023.14.6.2","DOIUrl":"10.6004/jadpro.2023.14.6.2","url":null,"abstract":"Tamoxifen and aromatase inhibitors are widely prescribed therapies for the treatment of breast cancer. Tamoxifen is a selective estrogen receptor modulator that treats hormone-sensitive breast cancers. Research has demonstrated that tamoxifen therapy improves survival and reduces the risk of developing recurrent invasive breast cancer by up to 40%. Aromatase inhibitors are the drug of choice for the treatment of estrogen receptor– or progesterone receptor–positive breast cancer in postmenopausal women. Research on aromatase inhibitors has demonstrated improved survival in postmenopausal women, postmenopausal women with metastasis, and premenopausal women under the age of 35 with ovarian ablation. The benefits of these agents have been clearly shown through various clinical trials, yet adherence may be challenging for some patients due to issues of drug interactions, proper education, and adverse effects. Education to prevent and treat adverse effects is of the utmost importance to promote adherence and improve the effectiveness of these medications. Advanced practitioners are in a position to prescribe these therapies, review medication interactions, educate patients, impact patients’ quality of life, improve patients’ sense of control, and increase patients’ partnerships with their oncology providers.","PeriodicalId":94110,"journal":{"name":"Journal of the advanced practitioner in oncology","volume":"14 6","pages":"478-482"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ca/ef/jadpro-14-478.PMC10558019.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41173389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Importance of Endpoints in Oncology Clinical Trials. 终点在肿瘤临床试验中的重要性。
Journal of the advanced practitioner in oncology Pub Date : 2023-09-01 DOI: 10.6004/jadpro.2023.14.6.1
Beth Faiman
{"title":"The Importance of Endpoints in Oncology Clinical Trials.","authors":"Beth Faiman","doi":"10.6004/jadpro.2023.14.6.1","DOIUrl":"10.6004/jadpro.2023.14.6.1","url":null,"abstract":"","PeriodicalId":94110,"journal":{"name":"Journal of the advanced practitioner in oncology","volume":"14 6","pages":"466-467"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/af/1e/jadpro-14-466.PMC10558020.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41144017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Posters From JADPRO Live 2022 临床海报来自JADPRO Live 2022
Journal of the advanced practitioner in oncology Pub Date : 2023-01-01 DOI: 10.6004/jadpro.2023.14.1.10
L. Kiley
{"title":"Clinical Posters From JADPRO Live 2022","authors":"L. Kiley","doi":"10.6004/jadpro.2023.14.1.10","DOIUrl":"https://doi.org/10.6004/jadpro.2023.14.1.10","url":null,"abstract":"OCTOBER 20 TO 23, 2022, IN AURORA, COLORADO The posters for the abstracts below can be found at JADPROLive.com","PeriodicalId":94110,"journal":{"name":"Journal of the advanced practitioner in oncology","volume":"14 1","pages":"1 - 28"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46447752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Introduction 介绍
Journal of the advanced practitioner in oncology Pub Date : 2022-07-01 DOI: 10.6004/jadpro.2022.13.5.9
Beth Faiman, PhD, MSN, APRN-BC, AOCN®, BMTCN, FAAN, Tiffany Richards, PhD, ANP-BC, AOCNP
{"title":"Introduction","authors":"Beth Faiman, PhD, MSN, APRN-BC, AOCN®, BMTCN, FAAN, Tiffany Richards, PhD, ANP-BC, AOCNP","doi":"10.6004/jadpro.2022.13.5.9","DOIUrl":"https://doi.org/10.6004/jadpro.2022.13.5.9","url":null,"abstract":"Advances in the diagnosis and management of multiple myeloma (MM) and other plasma cell disorders such as AL amyloidosis and Waldenström macroglobulinemia (WM) continue to evolve rapidly. Over the past several years, there have been significant gains in understanding disease biology, leading to improvements in diagnostic techniques, a shift towards targeted therapies, and a potential transition away from traditional chemotherapeutic agents as the standard of care.","PeriodicalId":94110,"journal":{"name":"Journal of the advanced practitioner in oncology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44179703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pull Up a Seat: Engaging Patients as Empowered Partners in Health Equity Transformation 拉一个座位:让患者参与卫生公平转型的授权合作伙伴
Journal of the advanced practitioner in oncology Pub Date : 2022-04-01 DOI: 10.6004/jadpro.2022.13.3.3
Maimah Karmo, A. Pierre
{"title":"Pull Up a Seat: Engaging Patients as Empowered Partners in Health Equity Transformation","authors":"Maimah Karmo, A. Pierre","doi":"10.6004/jadpro.2022.13.3.3","DOIUrl":"https://doi.org/10.6004/jadpro.2022.13.3.3","url":null,"abstract":"At the JADPRO Live Virtual 2021 keynote interview, Maimah Karmo, CEO and Founder of the Tigerlily Foundation, spoke with Amy Pierre, MSN, ANP-BC, on her breast cancer experience and drive to establish an organization that educates, advocates for, and empowers young women of color at every stage of their breast cancer journey. Ms. Karmo and Ms. Pierre also discussed the role of the advanced practitioner in furthering patient-centered, equitable care.","PeriodicalId":94110,"journal":{"name":"Journal of the advanced practitioner in oncology","volume":"13 1","pages":"202 - 204"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44651275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mental Health in the Oncology Setting: General Considerations and Treatment Tips. 肿瘤环境下的心理健康：一般注意事项和治疗技巧。
Journal of the advanced practitioner in oncology Pub Date : 2022-04-01 Epub Date: 2022-05-23 DOI: 10.6004/jadpro.2022.13.3.12
Lisa W Goldstone
{"title":"Mental Health in the Oncology Setting: General Considerations and Treatment Tips.","authors":"Lisa W Goldstone","doi":"10.6004/jadpro.2022.13.3.12","DOIUrl":"https://doi.org/10.6004/jadpro.2022.13.3.12","url":null,"abstract":"<p><p>Patients with comorbid mental health and substance use disorders are at greater risk for mortality and have higher cancer care costs. At JADPRO Live Virtual 2021, Lisa W. Goldstone, MS, PharmD, BCPS, BCPP, talked through general considerations in the oncology setting for persons with comorbid mental health or substance use disorders, strategies for recognizing when patients with new or preexisting mental health symptoms or disorders may benefit from treatment and/or referral, and first and second-line pharmacotherapy options.</p>","PeriodicalId":94110,"journal":{"name":"Journal of the advanced practitioner in oncology","volume":"13 3","pages":"243-246"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9126327/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71490604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cardio-Oncology Considerations in Oncologic Treatment Decisions. 肿瘤治疗决策中的心脏肿瘤学考虑。
Journal of the advanced practitioner in oncology Pub Date : 2022-04-01 Epub Date: 2022-05-23 DOI: 10.6004/jadpro.2022.13.3.11
Anecita P Fadol
{"title":"Cardio-Oncology Considerations in Oncologic Treatment Decisions.","authors":"Anecita P Fadol","doi":"10.6004/jadpro.2022.13.3.11","DOIUrl":"https://doi.org/10.6004/jadpro.2022.13.3.11","url":null,"abstract":"<p><p>At JADPRO Live Virtual 2021, presenter Anecita P. Fadol, PhD, FNP-BC, FAANP, FAAN, emphasized the critical role advanced practitioners play in the identification, monitoring, and management of the cardiac complications of cancer therapy. Dr. Fadol's presentation discussed identification of the most common cardiotoxicities associated with cancer therapy, clinical considerations related to common oncologic treatments with potential cardiotoxicity that may impact cancer treatment decisions, and the management of common cardiovascular issues in patients with cancer.</p>","PeriodicalId":94110,"journal":{"name":"Journal of the advanced practitioner in oncology","volume":"13 3","pages":"237-242"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9126328/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142928944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular Testing in Hematologic Malignancies 血液恶性肿瘤的分子检测
Journal of the advanced practitioner in oncology Pub Date : 2022-04-01 DOI: 10.6004/jadpro.2022.13.3.29
L. Zitella
{"title":"Molecular Testing in Hematologic Malignancies","authors":"L. Zitella","doi":"10.6004/jadpro.2022.13.3.29","DOIUrl":"https://doi.org/10.6004/jadpro.2022.13.3.29","url":null,"abstract":"Molecular testing technologies have been increasingly integrated into clinical research and are essential tools in the care of patients with hematologic malignancies. During this session at JADPRO Live Virtual 2021, Laura J. Zitella, MS, RN, ACNP-BC, AOCN®, reviewed key concepts for diagnostic testing with a focus on molecular testing (including cytogenetics, FISH, PCR, and next-generation sequencing) and discussed how to interpret the results for hematologic malignancies to inform prognosis as well as treatment.","PeriodicalId":94110,"journal":{"name":"Journal of the advanced practitioner in oncology","volume":"13 1","pages":"324 - 327"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45830307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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