Journal of neurosurgery. Case lessons最新文献

A neurosurgical approach to skull metastasis from uterine leiomyosarcoma: illustrative case.

Journal of neurosurgery. Case lessons Pub Date : 2025-03-31 DOI: 10.3171/CASE24769

Arturo Alejandro Carrillo-Uzeta, Eliany Varela-Avalos, Eduardo Agustin-Godinez, José Antonio Uehara-Gonzalez, José Raymundo Medina-Romero, Ana I Velazquez-Zamarripa, Alba M Quiñones-González, Patricia Anaid Romero-García

{"title":"A neurosurgical approach to skull metastasis from uterine leiomyosarcoma: illustrative case.","authors":"Arturo Alejandro Carrillo-Uzeta, Eliany Varela-Avalos, Eduardo Agustin-Godinez, José Antonio Uehara-Gonzalez, José Raymundo Medina-Romero, Ana I Velazquez-Zamarripa, Alba M Quiñones-González, Patricia Anaid Romero-García","doi":"10.3171/CASE24769","DOIUrl":"10.3171/CASE24769","url":null,"abstract":"Background: Leiomyosarcoma (LMS), a smooth muscle-derived tumor, is associated with a poor prognosis and a high potential for metastasis to local and distal sites. Skull metastases are exceptionally rare, with few cases documented in the literature. Diagnosing and treating these lesions is challenging due to their nonspecific clinical presentation and imaging similarities to other tumors.Observations: The authors report the case of a 46-year-old female with a 4-month history of a right parietal tumor, accompanied by headaches and left hemiparesis. MRI revealed a heterogeneous, intra- and extra-axial lesion with irregular margins in the right parietal region. Resection of the tumor was performed, and histopathological findings confirmed a diagnosis of metastatic LMS involving the bone and dura. Postoperative radiotherapy was administered, and the patient showed no evidence of recurrence 1 year after initial treatment. A review of the past 30 years of existing case reports of uterine LMS (uLMS) with cranial and intracranial metastases is also provided.Lessons: This report highlights the diagnostic and therapeutic complexity of metastatic LMS to the skull. Adjuvant radiotherapy might prove advantageous in improving the prognosis of patients with uLMS, underscoring the significance of integrating clinical, radiological, histopathological, and immunohistochemical findings for accurate diagnosis and management. https://thejns.org/doi/10.3171/CASE24769.","PeriodicalId":94098,"journal":{"name":"Journal of neurosurgery. Case lessons","volume":"9 13","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11959634/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spontaneous carotid-cavernous sinus fistula with fibromuscular dysplasia: illustrative case.

Journal of neurosurgery. Case lessons Pub Date : 2025-03-31 DOI: 10.3171/CASE24622

Wen Tan, Lu Jiang, Kuangyang Yu, Yuyang Pan, Yubin Yang, Jinwei Pang, Kunyang Bao, Changren Huang, Jianhua Peng, Yong Jiang

{"title":"Spontaneous carotid-cavernous sinus fistula with fibromuscular dysplasia: illustrative case.","authors":"Wen Tan, Lu Jiang, Kuangyang Yu, Yuyang Pan, Yubin Yang, Jinwei Pang, Kunyang Bao, Changren Huang, Jianhua Peng, Yong Jiang","doi":"10.3171/CASE24622","DOIUrl":"10.3171/CASE24622","url":null,"abstract":"Background: A carotid artery cavernous sinus fistula (CCF) is an abnormal shunt of blood vessels, allowing blood to flow directly or indirectly from the carotid artery into the cavernous sinus. The most common cause of spontaneous CCF (s-CCF) is ruptured internal carotid-cavernous sinus aneurysms, while fibromuscular dysplasia (FMD) is rare. FMD is a rare, idiopathic, segmental, noninflammatory, and nonatherosclerotic disease of medium-sized arteries, characterized by abnormal cell proliferation and distortion of arterial wall architecture. The authors report the case of a patient with CCF with FMD.Observations: The authors report the case of a young woman with s-CCF who was effectively treated with coiling and balloon compression. Subsequently, she was shown to have FMD susceptibility genes using single nucleotide polymorphism (SNP) testing in the follow-up phase.Lessons: The authors report the case of s-CCF caused by FMD in a young patient. SNP testing validated the existence of FMD susceptibility genes. The patient successfully recuperated following endovascular embolization therapy. For patients with s-CCF, the possibility of FMD should be considered, especially in young women with a family history. https://thejns.org/doi/10.3171/CASE24622.","PeriodicalId":94098,"journal":{"name":"Journal of neurosurgery. Case lessons","volume":"9 13","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11959639/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The use of radiofrequency ablation for the management of refractory lower extremity pain associated with lumbar spondylosis: illustrative case.

Journal of neurosurgery. Case lessons Pub Date : 2025-03-31 DOI: 10.3171/CASE24837

Vincent Codispoti, Matthew J Solomito

{"title":"The use of radiofrequency ablation for the management of refractory lower extremity pain associated with lumbar spondylosis: illustrative case.","authors":"Vincent Codispoti, Matthew J Solomito","doi":"10.3171/CASE24837","DOIUrl":"10.3171/CASE24837","url":null,"abstract":"Background: The lumbar spine is a common cause of referred pain to the lower extremities. Standard conservative treatments (i.e., physical therapy and pharmacotherapy) can provide only partial or temporary relief, in which case injections might be used. This often consists of epidural steroid injections to treat possible radicular pain. When symptoms still persist, radiofrequency ablation (RFA) to treat facet-mediated pain can offer a viable option before surgical intervention.Observations: In this illustrative case, a patient presenting with a complex array of worsening symptoms in the lower extremities, secondary to lumbar spondylosis, was treated using RFA. Conservative treatments resulted in partial, temporary relief. A facet-mediated source of pain was suspected, and diagnostic blocks indicated that the patient would be a candidate for bilateral RFA of the medial branches at L3, L4, and L5. Following the RFA procedure, the patient had full resolution of her lower extremity pain and paresthesias.Lessons: RFA procedures are typically performed to address low back pain rather than concomitant lower extremity pain and paresthesias. This case provides evidence indicating that, in the face of appropriate conservative management and diagnostic testing, RFA of the medial lumbar branches can address lower extremity pain secondary to lumbar spine pathology. https://thejns.org/doi/10.3171/CASE24837.","PeriodicalId":94098,"journal":{"name":"Journal of neurosurgery. Case lessons","volume":"9 13","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11959633/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Parameningeal embryonal rhabdomyosarcoma with leptomeningeal metastasis in a young adult female: illustrative case.

Journal of neurosurgery. Case lessons Pub Date : 2025-03-31 DOI: 10.3171/CASE24755

Justin Maldonado, Youssef Zohdy, Stewart Neill, Travis Atchley, Edoardo Porto, Uday Thakar, Hithardhi Duggireddy, Karen Salmeron Moreno, Sarah G Mitchell, Bree R Eaton, Tomas Garzon-Muvdi

{"title":"Parameningeal embryonal rhabdomyosarcoma with leptomeningeal metastasis in a young adult female: illustrative case.","authors":"Justin Maldonado, Youssef Zohdy, Stewart Neill, Travis Atchley, Edoardo Porto, Uday Thakar, Hithardhi Duggireddy, Karen Salmeron Moreno, Sarah G Mitchell, Bree R Eaton, Tomas Garzon-Muvdi","doi":"10.3171/CASE24755","DOIUrl":"10.3171/CASE24755","url":null,"abstract":"Background: Rhabdomyosarcoma (RMS) is a rare malignancy of undifferentiated skeletal muscle tissue and is the most common pediatric soft tissue sarcoma. Adolescent and young adult (AYA) patients (15-21 years of age) experience poorer outcomes compared with younger patients, primarily due to unfavorable histological subtypes, primary location, and tumor size. Tumors that arise from the skull base called parameningeal RMS have a poor prognosis due to anatomical complexity and the risk of leptomeningeal metastasis.Observations: The authors present the case of an 18-year-old female patient with a 4-month history of multiple progressive cranial neuropathies. MRI demonstrated a large left-sided mass centered at the foramen ovale with significant intracranial and infratemporal extension. Following near-total resection, pathology revealed embryonal RMS with anaplastic features. She subsequently began six cycles of high-dose vincristine, actinomycin, and cyclophosphamide therapy and proton radiation therapy. Two weeks after completing radiation therapy, follow-up imaging revealed a recurrence with leptomeningeal metastasis. Despite treatment with vincristine, irinotecan, and temozolomide chemotherapy, and craniospinal irradiation, the patient died of disease 5 months after spinal metastasis diagnosis.Lessons: Genomic profiling might be considered for early integration as a standard practice in this population in cases of such aggressive and rare malignancies. https://thejns.org/doi/10.3171/CASE24755.","PeriodicalId":94098,"journal":{"name":"Journal of neurosurgery. Case lessons","volume":"9 13","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11959641/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

FET-CREB fusion-positive extra-axial myxoid mesenchymal tumor in the cerebellum: illustrative case.

Journal of neurosurgery. Case lessons Pub Date : 2025-03-31 DOI: 10.3171/CASE24872

Zhaohui Jin, Lei Tian, Yangyang Li, Dong Wang, Lei Tang, Ran Wang, Feiyu Ding, Chengyuan Huang, Kun Yang

{"title":"FET-CREB fusion-positive extra-axial myxoid mesenchymal tumor in the cerebellum: illustrative case.","authors":"Zhaohui Jin, Lei Tian, Yangyang Li, Dong Wang, Lei Tang, Ran Wang, Feiyu Ding, Chengyuan Huang, Kun Yang","doi":"10.3171/CASE24872","DOIUrl":"10.3171/CASE24872","url":null,"abstract":"Background: Myxoid mesenchymal tumor (MMT) is an exceptionally rare central nervous system (CNS) tumor, with even fewer reported cases in the cerebellum. Its complex histopathological features and nonspecific clinical presentation pose considerable challenges in diagnosis. The rarity of the tumor, coupled with its poorly characterized clinical and radiological features, complicates early detection and effective treatment.Observations: xsThe authors present the case of an 18-year-old female who presented with persistent headaches and intermittent diplopia. MRI revealed a hypervascular mass in the right cerebellum, showing marked contrast enhancement. The patient underwent total tumor resection, and histopathological examination revealed lobulated tumor cells that were positive for the FET-CREB fusion gene. Immunohistochemical staining was positive for epithelial membrane antigen, vimentin, and H3K27me3, with a Ki-67 proliferation index of 8%, confirming the diagnosis of MMT. The patient had an uneventful recovery and remained recurrence free during a 6-month follow-up.Lessons: This case highlights the critical role of the FET-CREB fusion gene in diagnosing cerebellar MMT. It emphasizes the importance of early recognition, comprehensive pathological evaluation, and genetic analysis in managing this rare tumor. A thorough, multidisciplinary diagnostic approach is essential for determining the optimal treatment and improving patient outcomes. https://thejns.org/doi/10.3171/CASE24872.","PeriodicalId":94098,"journal":{"name":"Journal of neurosurgery. Case lessons","volume":"9 13","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11959636/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Giant pediatric brainstem cavernoma: illustrative case.

Journal of neurosurgery. Case lessons Pub Date : 2025-03-31 DOI: 10.3171/CASE24814

Andrew L DeGroot, Randall W Treffy, Omar Hussain, Peter Palmer, Elsa Arocho-Quinones, Hirad Hedayat

{"title":"Giant pediatric brainstem cavernoma: illustrative case.","authors":"Andrew L DeGroot, Randall W Treffy, Omar Hussain, Peter Palmer, Elsa Arocho-Quinones, Hirad Hedayat","doi":"10.3171/CASE24814","DOIUrl":"10.3171/CASE24814","url":null,"abstract":"Background: Cerebral cavernous malformations are low-flow vascular lesions and the most common of all vascular pathologies encountered by neurosurgeons. The location of these lesions is critically important in determining the symptomatology and whether intervention is indicated. Cavernous malformations localized to the brainstem are often the most complex of these to manage given the density of critical structures and tracts found within the brainstem.Observations: Here, the authors present the case of a 3-year-old male who presented with hemiparesis and eventually developed hydrocephalus from a giant brainstem cavernous malformation. The patient initially did well on steroids but had a recurrent hemorrhage that led to worsening hemiparesis and hydrocephalus. The authors then elected to resect the cavernous malformation via a supracerebellar infratentorial approach utilizing intraoperative MRI to ensure complete resection. Postoperatively, the patient returned to near baseline neurological function.Lessons: The authors describe an uncommon approach to the management of a pediatric patient with a giant brainstem cavernous malformation by carefully examining the potential approaches and utilizing available technologies to ensure an excellent outcome for the patient. https://thejns.org/doi/10.3171/CASE24814.","PeriodicalId":94098,"journal":{"name":"Journal of neurosurgery. Case lessons","volume":"9 13","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11959640/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A retroclival endodermal cyst mimicking an arachnoid cyst: illustrative case.

Journal of neurosurgery. Case lessons Pub Date : 2025-03-31 DOI: 10.3171/CASE24826

Akihiro Okada, Yukinori Terada, Takeshi Kawauchi, Kenji Hashimoto

{"title":"A retroclival endodermal cyst mimicking an arachnoid cyst: illustrative case.","authors":"Akihiro Okada, Yukinori Terada, Takeshi Kawauchi, Kenji Hashimoto","doi":"10.3171/CASE24826","DOIUrl":"10.3171/CASE24826","url":null,"abstract":"Background: It is important to differentiate arachnoid cysts from endodermal cysts in the posterior cranial fossa because they require different surgical treatments. Arachnoid cysts generally require fenestration. Meanwhile, in endodermal cysts, complete cyst resection is preferred to prevent recurrence. Despite the use of MRI and intraoperative findings, misdiagnosis can occur. Herein, the authors report a retroclival endodermal cyst that was initially suspected to be an arachnoid cyst based on pre- and intraoperative findings but was pathologically diagnosed as an endodermal cyst postoperatively.Observations: A 23-year-old female patient presented with a cystic lesion on the anterior brainstem. MRI showed that the cystic contents and CSF were similar in terms of signal. The cyst was suspected to be an arachnoid cyst. However, it continued to increase in size. Craniotomy and fenestration were performed, and the intraoperative findings were consistent with an arachnoid cyst. Therefore, intraoperative pathological examination was not performed, and the cyst wall was partially resected. The diagnosis of an endodermal cyst was confirmed via postoperative pathological examination.Lessons: This case underscores the importance of considering endodermal cysts in the differential diagnosis of retroclival lesions even if the imaging and intraoperative findings are indicative of an arachnoid cyst. https://thejns.org/doi/10.3171/CASE24826.","PeriodicalId":94098,"journal":{"name":"Journal of neurosurgery. Case lessons","volume":"9 13","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11959647/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Compressive optic neuropathy caused by a nonectatic internal carotid artery: illustrative case.

Journal of neurosurgery. Case lessons Pub Date : 2025-03-31 DOI: 10.3171/CASE24623

Jennifer R Lischynski, Samuel Molot-Toker, Behzad Mansouri, Anthony M Kaufmann

{"title":"Compressive optic neuropathy caused by a nonectatic internal carotid artery: illustrative case.","authors":"Jennifer R Lischynski, Samuel Molot-Toker, Behzad Mansouri, Anthony M Kaufmann","doi":"10.3171/CASE24623","DOIUrl":"10.3171/CASE24623","url":null,"abstract":"Background: Optic nerve compression from direct contact with the internal carotid artery (ICA) is a rarely described cause of monocular vision loss. Thus, little is known about the incidence, optimal management, and outcomes of this particular type of compressive optic neuropathy.Observations: The authors present the case of a 52-year-old female with progressive monocular vision loss. After an extensive workup, including a formal neuro-ophthalmology assessment, her symptoms were attributed to a neurovascular conflict between the optic nerve and a nonectatic supraclinoid ICA. She underwent a pterional craniotomy for optic nerve decompression, including bony unroofing of the optic canal and fenestration of the dural sheath. On follow-up, there was improvement in both her radiographic and clinical findings.Lessons: This case highlights a unique indication for optic nerve decompression in the setting of monocular vision loss caused by nonectatic vascular compression. https://thejns.org/doi/10.3171/CASE24623.","PeriodicalId":94098,"journal":{"name":"Journal of neurosurgery. Case lessons","volume":"9 13","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11959642/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Schwannoma with uncharacteristic rapid growth and high Ki-67 index: illustrative case.

Journal of neurosurgery. Case lessons Pub Date : 2025-03-31 DOI: 10.3171/CASE24529

Sho Nishii, Daisuke Umebayashi, Kazuaki Kamata, Satoshi Hisaoka, Toshiki Nagai, Yukiko Shishido-Hara, Kentaro Akazawa, Naoya Hashimoto

{"title":"Schwannoma with uncharacteristic rapid growth and high Ki-67 index: illustrative case.","authors":"Sho Nishii, Daisuke Umebayashi, Kazuaki Kamata, Satoshi Hisaoka, Toshiki Nagai, Yukiko Shishido-Hara, Kentaro Akazawa, Naoya Hashimoto","doi":"10.3171/CASE24529","DOIUrl":"10.3171/CASE24529","url":null,"abstract":"Background: Schwannomas typically show slow growth and a low risk of recurrence. The authors report a rare case of a 56-year-old woman with a spinal schwannoma that exhibited rapid recurrence and an atypically high Ki-67 index (8.9%), suggesting a more aggressive behavior than usually observed in benign schwannomas.Observations: The patient initially presented with worsening low back and right sciatic nerve pain, resulting in difficulty walking independently. MRI revealed a dumbbell-shaped tumor compressing the cauda equina. A partial resection was performed to preserve nerve function, and pathology showed typical schwannoma features but with a Ki-67 index of 8.9%. The tumor rapidly regrew within 2 months, necessitating a second surgery and additional radiotherapy. Although MRI at 11 months after radiotherapy showed a tendency for tumor growth, subsequent MRI scans at 20 months after radiotherapy demonstrated a reduction in tumor size, indicating effective tumor control by the radiotherapy.Lessons: Among pathologically classified conventional schwannomas, those with a high Ki-67 index can have an atypical course that would not be considered benign. Adjuvant radiotherapy can be effective in controlling tumor growth in such atypical cases. Further research is recommended for managing such atypical cases. https://thejns.org/doi/10.3171/CASE24529.","PeriodicalId":94098,"journal":{"name":"Journal of neurosurgery. Case lessons","volume":"9 13","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11959645/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143757009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stem cell therapy for peripheral nerve injury: illustrative cases.

Journal of neurosurgery. Case lessons Pub Date : 2025-03-31 DOI: 10.3171/CASE24878

Andres A Maldonado, Ellen Y Lee, Alexander Y Shin, Robert J Spinner

{"title":"Stem cell therapy for peripheral nerve injury: illustrative cases.","authors":"Andres A Maldonado, Ellen Y Lee, Alexander Y Shin, Robert J Spinner","doi":"10.3171/CASE24878","DOIUrl":"10.3171/CASE24878","url":null,"abstract":"Background: Stem cell therapy is undergoing rapid evolution, as evidenced by preclinical studies showcasing the successful promotion of peripheral nerve regeneration using various stem cell types. Despite the absence of clinical studies that demonstrate both efficacy and safety, there has been a notable increase in the number of commercial entities marketing and promoting stem cell therapies for peripheral nerve injury (PNI) directly to patients.Observations: The authors present the cases of 5 patients who sustained traumatic PNIs and received stem cell therapy via various routes of delivery (including intramuscular, perineural, intrathecal, and intravenous administration) prior to presenting to the authors for evaluation. No objective functional improvement was noted in any of these patients at long-term follow-up.Lessons: High-quality studies and greater involvement of academic surgeons on social media platforms are essential in today's landscape to promote education, provide leadership, and foster meaningful engagement, ultimately ensuring the best possible treatment outcomes for patients regarding the role of stem cell therapies in PNIs. https://thejns.org/doi/10.3171/CASE24878.","PeriodicalId":94098,"journal":{"name":"Journal of neurosurgery. Case lessons","volume":"9 13","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11959632/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0