Journal of dermatological science最新文献

{"title":"50th JSID","authors":"","doi":"10.1016/S0923-1811(25)00201-4","DOIUrl":"10.1016/S0923-1811(25)00201-4","url":null,"abstract":"","PeriodicalId":94076,"journal":{"name":"Journal of dermatological science","volume":"120 2","pages":"Page 80"},"PeriodicalIF":4.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145493231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of metastatic breast carcinoma to the skin expressing SARS-CoV-2 spike protein possibly derived from mRNA vaccine","authors":"Shigetoshi Sano","doi":"10.1016/j.jdermsci.2025.09.007","DOIUrl":"10.1016/j.jdermsci.2025.09.007","url":null,"abstract":"","PeriodicalId":94076,"journal":{"name":"Journal of dermatological science","volume":"120 2","pages":"Pages 71-73"},"PeriodicalIF":4.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145277080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Foxp3-ablation/melanoma-induced vitiligo: An enhanced mouse model","authors":"Shiyu Jin , Sheng Wan , Xiuzu Song , Cuiping Guan","doi":"10.1016/j.jdermsci.2025.09.002","DOIUrl":"10.1016/j.jdermsci.2025.09.002","url":null,"abstract":"","PeriodicalId":94076,"journal":{"name":"Journal of dermatological science","volume":"120 2","pages":"Pages 74-76"},"PeriodicalIF":4.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145228691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regulation of melanogenesis via ubiquitin-proteasome system and autophagy by 3,3,5-trimethylcyclohexyl succinate dimethylamide and tranexamic acid","authors":"Jing Wang ,&nbsp;Fanglan Zha ,&nbsp;Simin Lin ,&nbsp;Yun Wei ,&nbsp;Lingling Xuan ,&nbsp;Zhangying Ye ,&nbsp;Hu Huang","doi":"10.1016/j.jdermsci.2025.09.004","DOIUrl":"10.1016/j.jdermsci.2025.09.004","url":null,"abstract":"<div><h3>Background</h3><div>Excessive melanogenesis in skin melanocytes results in hyperpigmentation disorders.</div></div><div><h3>Objective</h3><div>This study investigates the combined effects and mechanisms of 3,3,5-trimethylcyclohexanol succinate dimethylamide (335, a succinic acid derivative) and tranexamic acid (TXA) on melanogenesis.</div></div><div><h3>Methods</h3><div>Skin penetration of 335 was assessed via Raman spectroscopy. Interactions between 335 and TXA were predicted by molecular docking. The anti-melanogenic effect was evaluated by measuring melanin content in human keratinocytes (HaCaT) and mouse melanoma cells (B16). Transcriptome sequencing was performed to identify key pathways by which 335 regulates melanogenesis. Melanosomes were isolated from human melanoma cells (MNT-1) and co-cultured with keratinocytes to validate the specific mechanisms. A 3D melanin skin model was established to evaluate the anti-pigmentation effect of 335 and TXA by analyzing apparent chroma, lightness (L*), and melanin content and distribution.</div></div><div><h3>Results</h3><div>The skin penetration of 335 was enhanced by the addition of TXA, and the two compounds exhibited hydrogen bonding and hydrophobic interactions. The combination of 335 and TXA (1:10) significantly reduced the melanin content in B16 cells compared to individual treatments. Transcriptomics revealed 335 modulates the ubiquitin-proteasome system (UPS) and autophagy. Experimental validation confirmed that 335 and TXA combination inhibited melanin production by promoting ubiquitination degradation of tyrosinase and autophagic degradation of melanosomes. In the 3D skin model, the combination enhanced skin brightness (apparent chroma and L* value) and reduced melanin deposition.</div></div><div><h3>Conclusion</h3><div>The combination of 335 and TXA inhibits melanogenesis by UPS-mediated tyrosinase degradation and autophagy-driven melanosome degradation, offering a promising strategy for hyperpigmentation treatment.</div></div>","PeriodicalId":94076,"journal":{"name":"Journal of dermatological science","volume":"120 2","pages":"Pages 61-70"},"PeriodicalIF":4.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145228639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Welcome Message","authors":"","doi":"10.1016/S0923-1811(25)00204-X","DOIUrl":"10.1016/S0923-1811(25)00204-X","url":null,"abstract":"","PeriodicalId":94076,"journal":{"name":"Journal of dermatological science","volume":"120 2","pages":"Page I"},"PeriodicalIF":4.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145493232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular profile of interleukin-17RA blockade by brodalumab in Japanese patients with psoriasis: Results from the ESPRIT study","authors":"James G. Krueger ,&nbsp;Akimichi Morita ,&nbsp;Mona Uchida-Yamada ,&nbsp;Chiharu Tateishi ,&nbsp;Eisaku Ogawa ,&nbsp;Koji Masuda ,&nbsp;Yukie Yamaguchi ,&nbsp;Hong Beom Hur ,&nbsp;Sandra Garcet ,&nbsp;Naomi Shishido-Takahashi ,&nbsp;Yasumasa Kanai","doi":"10.1016/j.jdermsci.2025.09.005","DOIUrl":"10.1016/j.jdermsci.2025.09.005","url":null,"abstract":"<div><h3>Background</h3><div>Brodalumab, an anti-interleukin-17 receptor A antibody, is effective in psoriasis via action on the IL-17 pathway.</div></div><div><h3>Objective</h3><div>This analysis of an exploratory intervention study (ESPRIT) in Japanese patients with moderate to severe plaque psoriasis examined the brodalumab efficacy by clinical changes, and modulation of skin inflammation via changes in skin gene expression and blood sample protein expression.</div></div><div><h3>Methods</h3><div>Primary clinical endpoints were changes in PASI score and PASI score 0 achievement rate at Week 12. For molecular endpoints, biopsies of lesional, non-lesional and healthy volunteer skin were examined by RNA sequencing and RT-PCR. Blood sample serum was analyzed by Olink high-throughput proteomics.</div></div><div><h3>Results</h3><div>Twenty healthy volunteers and 40 patients were enrolled; 37 underwent molecular profiling. Clinical assessment showed that the median baseline PASI score (19.0) significantly decreased to 0.4 at Week 12 (<em>P</em> &lt; 0.0001), with more rapid decline in higher PASI responders. Molecular assessment demonstrated that differential expressed genes in lesional skin were suppressed equivalently to non-lesional skin, establishing the molecular improvement with brodalumab. The transcriptomes of Japanese and Western patients were similar, and top-upregulated genes included IL-17-inducible and cardiovascular disease-related genes, which were suppressed by brodalumab. Serum protein analysis identified 22 proteins elevated by psoriasis. Several inflammatory and cardiovascular risk proteins correlated with psoriasis severity and BMI, but at lower rates than in Western patients.</div></div><div><h3>Conclusions</h3><div>In summary, the transcriptome and the proteome characteristics of Japanese and Western psoriasis patients were similar. Brodalumab rapidly improved skin and serum molecular levels and reduced cardiovascular disease risk factor expression.</div></div>","PeriodicalId":94076,"journal":{"name":"Journal of dermatological science","volume":"120 2","pages":"Pages 52-60"},"PeriodicalIF":4.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145282235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep intronic variant in TYR causes OCA1A in Japanese families through pseudoexon activation","authors":"Ken Okamura ,&nbsp;Toru Saito ,&nbsp;Sachiko Ohori ,&nbsp;Fumio Takada ,&nbsp;Toshifumi Nomura ,&nbsp;Etsuko Oba ,&nbsp;Yutaka Hozumi ,&nbsp;Tamio Suzuki","doi":"10.1016/j.jdermsci.2025.09.003","DOIUrl":"10.1016/j.jdermsci.2025.09.003","url":null,"abstract":"","PeriodicalId":94076,"journal":{"name":"Journal of dermatological science","volume":"120 2","pages":"Pages 77-79"},"PeriodicalIF":4.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145214844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel ATP2C1 genetic variants in a Dutch cohort of patients with Hailey-Hailey disease","authors":"Marie-Eline P.H. Debeuf ,&nbsp;Valerie L.R.M. Verstraeten ,&nbsp;Peter C. van den Akker ,&nbsp;Ruud G.L. Nellen ,&nbsp;Henny H. Lemmink ,&nbsp;Antoni H. Gostyński ,&nbsp;Peter M. Steijlen ,&nbsp;Marieke C. Bolling ,&nbsp;Michel van Geel","doi":"10.1016/j.jdermsci.2025.07.004","DOIUrl":"10.1016/j.jdermsci.2025.07.004","url":null,"abstract":"","PeriodicalId":94076,"journal":{"name":"Journal of dermatological science","volume":"120 1","pages":"Pages 43-44"},"PeriodicalIF":4.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144857209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ketoconazole alleviates UVB-induced photoaging by suppressing ROS generation and mitochondrial dysfunction in dermal fibroblasts and ex vivo porcine skin models","authors":"Hye Yeon Kim ,&nbsp;Seungmi Lee ,&nbsp;Kyung-Min Lim","doi":"10.1016/j.jdermsci.2025.07.001","DOIUrl":"10.1016/j.jdermsci.2025.07.001","url":null,"abstract":"<div><h3>Background</h3><div>Ultraviolet (UV) radiation is a major contributor to skin damage<span> and photoaging, primarily through the generation of reactive oxygen species<span> (ROS), which disrupt cellular functions and degrade extracellular matrix. Demand for effective agents to counteract these effects is increasing.</span></span></div></div><div><h3>Objective</h3><div><span>This study investigated the protective effects of ketoconazole (KCZ), a well-known antifungal agent, against UVB-induced photoaging using human dermal fibroblasts (Hs68) and an </span><span><em>ex vivo</em></span> porcine skin model.</div></div><div><h3>Methods</h3><div>Hs68 cells and <em>ex vivo</em><span> porcine skin were exposed to UVB radiation and subsequently treated with KCZ. We assessed cell viability<span>, collagen production, MMP-1 expression, ROS levels, mitochondrial function, and the activation of the MAPK-AP-1 signaling pathway.</span></span></div></div><div><h3>Results</h3><div><span><span>KCZ alleviated UVB-induced reductions in cell viability, suppressed MMP-1 expression, and prevented </span>collagen degradation in Hs68 cells. In the </span><em>ex vivo</em><span><span> porcine skin model, KCZ reduced UVB-induced skin damage and collagen breakdown. Additionally, KCZ significantly inhibited UVB-induced ROS generation and rescued mitochondrial dysfunction, as evidenced by recovery of </span>mitochondrial membrane potential<span> and respiratory capacity. KCZ also blocked activation of the UV-stimulated MAPK-AP-1 signaling pathway.</span></span></div></div><div><h3>Conclusion</h3><div>KCZ exhibits significant anti-photoaging effects by reducing UV-induced oxidative stress, preserving mitochondrial function, and preventing degradation of the extracellular matrix. These findings suggest that KCZ may be a potential anti-photoaging agent.</div></div>","PeriodicalId":94076,"journal":{"name":"Journal of dermatological science","volume":"120 1","pages":"Pages 11-20"},"PeriodicalIF":4.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144621614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risankizumab differentially modulates circulating T-cell populations in psoriasis according to autoreactivity status","authors":"Rebecca Favaro ,&nbsp;Paola Facheris ,&nbsp;Alessandra Formai ,&nbsp;Luigi Gargiulo ,&nbsp;Luciano Ibba ,&nbsp;Giovanni Fiorillo ,&nbsp;Roberta Valeria Latorre ,&nbsp;Jessica Avagliano ,&nbsp;Alessandra Narcisi ,&nbsp;Giampiero Girolomoni ,&nbsp;Santo Raffaele Mercuri ,&nbsp;Antonio Costanzo","doi":"10.1016/j.jdermsci.2025.08.002","DOIUrl":"10.1016/j.jdermsci.2025.08.002","url":null,"abstract":"<div><h3>Background</h3><div>In a recent paper, our group described that the presence of double autoreactivity to both LL37 and ADAMTSL5 autoantigens in psoriatic patients decreased the clinical responses to risankizumab, but how this influences the changes in the peripheral inflammatory T-cell populations is still unknown.</div></div><div><h3>Objective</h3><div>This study aims to evaluate how risankizumab modulates the circulating inflammatory T-cell populations in psoriatic patients and, specifically, in autoreactive subjects.</div></div><div><h3>Methods</h3><div>The presence of LL37- and ADAMTSL5-reactive circulating T-cells was assessed in a cohort of 142 psoriatic patients, and 87 demonstrated autoreactivity at baseline. Patients were treated with risankizumab for 52 weeks, and specific T-cell populations were analyzed at different timepoints.</div></div><div><h3>Results</h3><div>The frequency of Ki67⁺CD4⁺, Ki67⁺CD8⁺ T-cells, CD8⁺IL-17⁺ and CD8⁺IL-22⁺ T-cells showed a positive correlation with baseline PASI and decreased with treatment. Notably, CD8⁺IL-17⁺ T-cells decreased both in single-LL37 and single-ADAMTSL5-reactive subjects, but not in subjects that showed autoreactivity to both autoantigens. LL37 autoreactivity of CD4⁺ and CD8⁺ T-cells decreased with treatment, but not for CD4⁺ in double-reactive subjects. While Treg frequency negatively correlated with baseline PASI and increased within 16 weeks of treatment, significantly decreasing the IL-17⁺CD4⁺/Treg ratio over time, Treg modulation was not evident in double-reactive subjects.</div><div>Interestingly, the subpopulations of CD8⁺MAIT IL-17⁺ and CD3⁺MAIT IL-22⁺ cells, involved also in psoriatic arthritis, decreased in treated subjects following IL-23 inhibition.</div></div><div><h3>Conclusion</h3><div>Rizankizumab efficiently decreases the circulating inflammatory T-cell populations and modulates Tregs’ plasticity in single-LL37- or single-ADAMTSL5-reactive subjects, but not in double-reactive subjects.</div></div>","PeriodicalId":94076,"journal":{"name":"Journal of dermatological science","volume":"120 1","pages":"Pages 1-10"},"PeriodicalIF":4.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144983922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}