International journal of biochemistry and molecular biology最新文献

{"title":"Antimicrobial and antifungal efficacy of silver nanoparticles synthesized using <i>Xanthium strumarium</i> leaf extract.","authors":"Arun Kumar Kashyap, Lalit Kumar Sahu, Priyadarsani Mishra, Khirabdhi Tanaya, Durgeshwer Singh, Nikita Kashyap, Buddhi Prakash Jain","doi":"10.62347/SDVI7410","DOIUrl":"10.62347/SDVI7410","url":null,"abstract":"<p><strong>Introduction: </strong>Silver nanoparticles (AgNPs) are unique in their physical, chemical, and biological properties. AgNPs can be synthesized through several methods including chemical, physical, or biological. Due to eco-friendly approach and use of natural reducing agent, biological or green synthesis is more popular.</p><p><strong>Objective: </strong>The aim of the study is to synthesize silver nanoparticles (AgNPs) using <i>Xanthium strumarium</i> leaf extract, and explore their antimicrobial, and antifungal properties.</p><p><strong>Methods: </strong>UV-Visible spectroscopy and Transmission Electron Microscopy (TEM) was used for nanoparticles characterization. Antibacterial and antifungal activities of the synthesized nanoparticles were performed.</p><p><strong>Results: </strong>The bioactive compounds in the extract acted as natural reducing and stabilizing agents for AgNPs synthesis. The synthesized nanoparticles were confirmed by UV-Visible spectroscopy with a characteristic absorbance peak at 400-450 nm. Transmission Electron Microscopy (TEM) revealed spherical nanoparticles ranging from 10-100 nm with uniform size distribution. The synthesized AgNPs exhibited significant antibacterial activity against <i>Staphylococcus aureus</i> and <i>Escherichia coli</i>, as well as antifungal activity against <i>Aspergillus niger</i> and <i>Aspergillus fumigatus</i>.</p><p><strong>Conclusion: </strong>The study highlights the dual role of <i>Xanthium strumarium</i> as a synthesizing agent and a source of therapeutic potential, demonstrating its eco-friendly application in nanotechnology for biomedical and agricultural use.</p>","PeriodicalId":94044,"journal":{"name":"International journal of biochemistry and molecular biology","volume":"17 3","pages":"25-34"},"PeriodicalIF":0.0,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13601896/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149043085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolation, purification and characterization of betulinic acid derivative from the root bark of <i>Afzelia africana</i> and its antiplasmodial and antimicrobial activities.","authors":"Bright Yaw Vigbedor, Clement Osei Akoto, Ralph Kwakye, Jonathan Osei-Owusu, Francis Ofosu-Koranteng, Ebenezer Asante Donkor, Gaston Hunkpe, Pius Kwashie, David Neglo, Henyo Collins Mawutor","doi":"10.62347/INVA5312","DOIUrl":"10.62347/INVA5312","url":null,"abstract":"<p><strong>Background: </strong><i>Afzelia africana</i> is a tropical plant species with numerous documented ethnobotanical and medicinal properties.</p><p><strong>Aim/objective: </strong>The study focused on the isolation, purification, characterization and biological activity of betulinic acid from the bark of <i>A. africana</i>.</p><p><strong>Methodology: </strong>The series of methods employed include column fractionation and purification, characterization (MS, ¹H, ¹³C, DEPT-135, HSQC, COSY and HMBC), antimicrobial (Micro-broth dilution, and synergistic effects), and antiplasmodial activity (MSF assay).</p><p><strong>Results: </strong>Repeated column chromatographic fractionation of the methanol (extract eluent: <i>n</i>-hexane-ethyl acetate (75:25)) and TLC profiling afforded a 15 mg white crystal characterized as betulinic acid. The compound reported good antiplasmodial activity against 3D7 strain of <i>P. falciparum</i> (IC₅₀: 12.89 ± 0.52 µg/mL). The compound exhibited varying degrees of bactericidal activities (MBC/MIC ≤ 4) against <i>S. mutans</i>, <i>C. albicans</i> 2, <i>B. subtilis</i>, <i>K. pneumonia</i> and bacteriostatic activities (MBC/MIC ≥ 4) against <i>S. aureus, E. coli</i>, methicillin-resistant <i>S. aureus, P. aeruginosa, S. typhi</i> and C. albicans 1. The compound further reported synergistic effects (FIC ≤ 0.5) against <i>E. coli, K. pneumonia, S. aureus</i> and <i>S. mutans</i>; partial synergism (FIC > 0.5 and < 1) against <i>S. typhi</i>, methicillin-resistant <i>S. aureus, B. subtilis</i> and indifferent effects (FIC > 1 and < 4) against <i>P. aeruginosa</i> when combined with tetracycline. The compound with Ciprofloxacin showed synergistic effect against <i>Klebsiella pneumoniae, Streptococcus mutans</i>, and <i>Salmonella typhi</i>. Additionally, it demonstrated further synergism with tetracycline against <i>Escherichia coli, Klebsiella pneumoniae</i>, and <i>Staphylococcus aureus</i>. In the antifungal synergistic studies, the combination of the compound with fluconazole and nystatin, ciprofloxacin exhibited partial synergism (FIC > 0.5 and < 1) against one strain of <i>Candida albicans</i> and full synergism (FIC ≤ 0.5) against a second strain of <i>Candida albicans</i>. When combined with fluconazole and nystatin.</p><p><strong>Conclusion: </strong>Betulinic acid has been isolated for the first time from the bark of <i>Afzelia africana</i>. It demonstrated good antiplasmodial activity against <i>P. falciparum</i>, as well as various bactericidal and bacteriostatic effects against multiple microbial strains. Additionally, betulinic acid demonstrated synergistic effects when combined with tetracycline, ciprofloxacin, fluconazole, and nystatin.</p>","PeriodicalId":94044,"journal":{"name":"International journal of biochemistry and molecular biology","volume":"17 2","pages":"10-24"},"PeriodicalIF":0.0,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13213174/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148059179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gene polymorphisms and occurrence of type 2 diabetes in a Gabonese population.","authors":"Aude S Mbang Bengone, Rosalie Nikiema-Ndong, Alvine S Batou, Edwige Nnegue Edzo, Frédéric Da Dari, Felix Ovono Abessolo","doi":"10.62347/NWNL2838","DOIUrl":"10.62347/NWNL2838","url":null,"abstract":"<p><strong>Background: </strong>Type 2 diabetes (T2DM) is a metabolic disease characterized by chronic hyperglycemia. We investigated the relationship between the polymorphisms <i>rs5219</i> of KCNJ11, <i>rs7903146</i> of TCF7L2, and <i>rs13266634</i> of SLC30A8 in a Gabonese population with T2DM.</p><p><strong>Method: </strong>This case-control study was conducted at the Endocrinology Department of the University Hospital of Libreville. We enrolled 97 patients with T2DM and, from the general population, 87 control subjects who met the inclusion criteria. Genomic DNA was extracted with the Qiagen kit, and polymorphisms were analyzed using the RFLP method.</p><p><strong>Results: </strong>For KCNJ11, the wild type (EE) genotype frequency was 62.2% in controls versus 42.6% in cases, whereas the mutant type (KK) genotype frequency was 28.7% in cases versus 21.1% in controls (P=0.0243). For TCF7L2, the wild type (CC) genotype was found in 51.7% of controls and 37.1% of cases, and the mutant type (TT) genotype was found in 22.7% of cases versus 9.2% of controls (P=0.0253). For SLC30A8, the wild type (CC) genotype occurred in 26.0% of cases and 24.6% of controls (P=0.9326). After adjustment for age and body mass index, the recessive transmission models of <i>rs5219</i> (KCNJ11) and <i>rs7903146</i> (TCF7L2) were significantly associated with T2DM (P=0.021 and P=0.026, respectively).</p><p><strong>Conclusion: </strong>The <i>rs5219</i> variant of KCNJ11 and the <i>rs7903146</i> variant of TCF7L2 were associated with the occurrence of T2DM in this population.</p>","PeriodicalId":94044,"journal":{"name":"International journal of biochemistry and molecular biology","volume":"17 1","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2026-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13009447/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147517746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paternal contributions to telomere reprogramming in fetal development.","authors":"Sadia Farrukh, Saeeda Baig, Rubina Hussain","doi":"10.62347/TSGO8987","DOIUrl":"10.62347/TSGO8987","url":null,"abstract":"<p><strong>Objectives: </strong>Telomere length, the markers of biological aging, can be influenced by risk factors that may lead to health issues like chronic non-communicable diseases. This study explored the paternal telomere length influenced by diseases like diabetes and hypertension with age and its association with newborn telomere length (TL) and the telomerase gene.</p><p><strong>Methods: </strong>In this cross-sectional study, 204 father-newborn dyads were recruited. The qPCR was used for the quantification of TL (T/S ratio), and Sanger sequencing was done for telomerase (TERT) genotype identification. Statistical Package for Social Sciences (SPSS) and GraphPad Prism Software were used for data analysis. The Spearman correlation was used to find an association between father and newborn TL. The Kruskal-Wallis and Mann-Whitney test was used to find differences among disease groups and TL. The P<0.05 was considered statistically significant.</p><p><strong>Results: </strong>A positive correlation (r=0.39) (P<0.0001) was seen among fathers and newborn TL. The mean TL (T/S ratio) was found to be longer in healthy fathers and their newborns (1.67±1.18, 2.36±1.39), whereas significantly shorter TL (1.41±0.98, 2.02±1.58) (P=0.000) was seen in fathers suffering from diseases. The healthy fathers and their newborns TL (2.94±0.72, 3.10±0.61) were seen longer in the 15-20 (yrs) age category. Moreover, newborns of fathers (41-45 yrs) with both diabetes and hypertension had significantly longer telomere length (3.20±2.92) compared to their fathers (1.15±1.65) (P=0.006). The TERT risk genotype AC (rs2736100) was the most prevalent among the newborn girls.</p><p><strong>Conclusion: </strong>A positive association with shorter TL in newborns was found in fathers having chronic diseases such as diabetes and hypertension, highlighting the contribution of fathers in reprogramming newborns' telomere biology.</p>","PeriodicalId":94044,"journal":{"name":"International journal of biochemistry and molecular biology","volume":"16 2","pages":"16-23"},"PeriodicalIF":0.0,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12455035/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145139825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatoprotective and antioxidant effects of <i>Celosia trigyna</i> and <i>Euphorbia hirta</i> in mitigating paracetamol-induced liver toxicity: bridging ethnomedicine and modern pharmacology.","authors":"Tunbosun Emmanuel Akinboboye, Temitope Deborah Olaniyi, Gbadebo E Adeleke, Abiodun Bukunmi Aborisade, Adewale Adetutu","doi":"10.62347/CLHF2294","DOIUrl":"10.62347/CLHF2294","url":null,"abstract":"<p><strong>Background: </strong>Paracetamol is a widely used over-the-counter drug for pain relief and fever management. However, its misuse through chronic overuse or acute overdose presents significant risks to human health, primarily causing hepatotoxicity and systemic oxidative stress.</p><p><strong>Methodology: </strong>This study evaluated the hepatoprotective, antioxidant, and anti-inflammatory effects of aqueous leaf extracts of <i>Celosia trigyna</i> and <i>Euphorbia hirta</i> in mitigating paracetamol-induced liver damage in male Wistar rats.</p><p><strong>Results: </strong>Paracetamol administration (150 mg/kg) significantly elevated liver function markers (ALT, AST, ALP, and bilirubin), oxidative stress parameters (MDA), and inflammatory cytokines (IL-6 and TNF-α), while depleting antioxidant defenses (SOD and GSH). Disrupted lipid profiles were also observed in the paracetamol-only group. Pretreatment with Celosia trigyna and Euphorbia hirta extracts (125 mg/kg and 250 mg/kg) effectively ameliorated these effects by normalizing liver function markers, reducing oxidative stress and inflammation, and restoring lipid profiles. Molecular docking identified bioactive compounds such as rutin, quercetin, and kaempferol as potent inhibitors of Glutathione-S-Transferase, Tumor Necrosis Factor-alpha, and Cytochrome P450, with binding affinities of -9.3, -7.2, and -8.3 kcal/mol, respectively. These interactions underpin the antioxidant and anti-inflammatory activities observed <i>in vivo</i>.</p><p><strong>Conclusion: </strong>These findings suggest that <i>Celosia trigyna</i> and <i>Euphorbia hirta</i> have the potential to serve as natural prophylactic or therapeutic agents for mitigating paracetamol toxicity. Further research is required to isolate their active compounds and explore their synergistic potential with conventional treatments. This study bridges traditional medicine and modern pharmacology, offering innovative approaches to managing drug-induced liver.</p>","PeriodicalId":94044,"journal":{"name":"International journal of biochemistry and molecular biology","volume":"16 1","pages":"1-15"},"PeriodicalIF":0.0,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12089789/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adulteration in edible oil (mustard oil) and ghee; detection and their effects on human health.","authors":"Afrin Begum, Buddhi Prakash Jain","doi":"10.62347/VVCI2092","DOIUrl":"10.62347/VVCI2092","url":null,"abstract":"<p><p>Edible oils and ghee are vital parts of our daily culinary practices. In recent years, owing to heightened demand in the domestic and global markets, consistent reports regarding the adulteration of edible oils and ghee with substandard ingredients have been reported. Adulteration in edible oils is widespread, with distinctive contaminants, including cottonseed, mineral, and lower-cost oils like palm olein. In the case of ghee, it is repeatedly combined with animal fats, synthetic materials, or vanaspati. The consumption of contaminated oils and trans-fats within the human diet has resulted in adverse health effects, including cardiovascular diseases, digestive disorders, and even cancer. The review aims to summarize various adulterants found in edible oil (mustard oil) and ghee, their detection techniques, and harmful effects. This review provides an overview of the contemplation linked to the adulteration of edible oils and ghee, the compliance with relevant regulations, and the technological approaches available for detection. The detection technologies for identifying adulteration in edible oils are chromatography and spectroscopy biochemical methods and the use of high-precision analytical instruments. The presence of adulterants in edible oil and ghee undermines our societal integrity and our ethical standards. Awareness among consumers is essential for effectively combating these adulterations.</p>","PeriodicalId":94044,"journal":{"name":"International journal of biochemistry and molecular biology","volume":"15 6","pages":"141-148"},"PeriodicalIF":0.0,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11751471/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143030533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Performance prediction of polypeptide derivatives as efficient potential microbial inhibitors: a computational approach.","authors":"Abel Kolawole Oyebamiji, Sunday A Akintelu, Faith Eniola Olujinmi, Lukmon Akanni Jinadu, Oluwakemi Ebenezer, Juliana Oluwasayo Aworinde, Banjo Semire, Jonathan O Babalola","doi":"10.62347/YLVH4793","DOIUrl":"10.62347/YLVH4793","url":null,"abstract":"<p><strong>Objective: </strong>Lately, various scientists have been paying a lot of consideration to the design of operational antimicrobial agents due to the rise of multiple drug-resistant strains. Therefore, this work is aimed at discovering the biochemical behavior of the analyzed polypeptides in relation to glutamine amidotransferase GatD (pdb id: 5n9m) for gram positive bacteria and beta-lactamase class A (pdb id: 5fqq) for gram negative bacteria. Additionally, this study aims to identify the specific atoms involved in the observed biochemical interactions between the studied complexes using computational methods.</p><p><strong>Methods: </strong>In this work, five polypeptides were studied using insilico approach via Spartan 14 software, molecular operating environment, ADMETSar, and Gromacs.</p><p><strong>Results: </strong>The descriptors obtained revealed the activities of the studied compounds, the molecular interaction between the studied ligands as well as glutamine amidotransferase GatD (pdb id: 5n9m) and beta-lactamase class A (pdb id: 5fqq) which thereby exposed compound 1 and 5 to be the compounds with greatest ability to inhibit the studied targets among other studied compounds.</p><p><strong>Conclusion: </strong>Our discoveries may open door for the design of collection of proficient polypeptide-based drug-like compounds as potential anti-microbial agents.</p>","PeriodicalId":94044,"journal":{"name":"International journal of biochemistry and molecular biology","volume":"15 5","pages":"127-140"},"PeriodicalIF":0.0,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11578866/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142712012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring endocrine FGFs - structures, functions and biomedical applications.","authors":"Phuc Phan, Gaёtane Ternier, Oshadi Edirisinghe, Thallapuranam Krishnaswamy Suresh Kumar","doi":"10.62347/PALK2137","DOIUrl":"10.62347/PALK2137","url":null,"abstract":"<p><p>The family of fibroblast growth factors (FGFs) consists of 22 members with diverse biological functions in cells, from cellular development to metabolism. The family can be further categorized into three subgroups based on their three modes of action. FGF19, FGF21, and FGF23 are endocrine FGFs that act in a hormone-like/endocrine manner to regulate various metabolic activities. However, all three members of the endocrine family require both FGF receptors (FGFRs) and klotho co-receptors to elicit their functions. α-klotho and β-klotho act as scaffolds to bring endocrine FGFs closer to their receptors (FGFRs) to form active complexes. Numerous novel studies about metabolic FGFs' structures, mechanisms, and physiological insights have been published to further understand the complex molecular interactions and physiological activities of endocrine FGFs. Herein, we aim to review the structures, physiological functions, binding mechanisms to cognate receptors, and novel biomedical applications of endocrine FGFs in recent years.</p>","PeriodicalId":94044,"journal":{"name":"International journal of biochemistry and molecular biology","volume":"15 4","pages":"68-99"},"PeriodicalIF":0.0,"publicationDate":"2024-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11411148/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142304864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Marine bioactive peptides with anticancer potential, a narrative review.","authors":"Diana Rafieezadeh, Goli Esfandyari","doi":"10.62347/TUVQ7468","DOIUrl":"10.62347/TUVQ7468","url":null,"abstract":"<p><p>In this paper, we explore marine bioactive peptides with anticancer potential sourced from various marine organisms, including tunicates, sea sponges, and mollusks. Peptides like Stylisin and Papuamides have been isolated, identified, and modified to enhance their activity, with many advancing to clinical trials due to their diverse biological activities, promising prospects in medicine. Enzymatic hydrolysis is a favored method for extracting peptides from marine proteins, particularly from sponges known for their rich bioactive compounds. Compounds such as Jaspamide and Homophymins exhibit potent cytotoxic activity against cancer cells, underscoring their therapeutic potential. Additionally, peptides from ascidians and mollusks, such as Aplidine and Kahalalide F, demonstrate significant anticancer properties. This study also explores peptides influencing apoptosis, microtubule dynamics, and angiogenesis, providing insights into potential mechanisms for cancer treatment. While peptides like Neovastat and mycothiazole target known pathways, others such as patellamides act through unknown mechanisms, highlighting the intricate interactions of marine peptides with cancer cells. Overall, marine-derived peptides show promise as valuable candidates for developing novel anticancer therapies.</p>","PeriodicalId":94044,"journal":{"name":"International journal of biochemistry and molecular biology","volume":"15 4","pages":"118-126"},"PeriodicalIF":0.0,"publicationDate":"2024-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11411149/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142304866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the seas for cancer cures: the promise of marine-derived bioactive peptide.","authors":"Diana Rafieezadeh, Mohammadjavad Abbaspour","doi":"10.62347/JGQA3746","DOIUrl":"10.62347/JGQA3746","url":null,"abstract":"<p><p>Marine environments harbor a wealth of bioactive peptides with potential anticancer properties, sourced from diverse organisms like tunicates, sea sponges, and mollusks. Through isolation, identification, and modification, peptides such as Stylisin and Papuamides have shown enhanced activity and progressed to clinical trials, underscoring their therapeutic promise. Enzymatic hydrolysis emerges as a favored method for peptide extraction from marine proteins, with sponges identified as particularly rich sources. Compounds like Jaspamide and Homophymins exhibit potent cytotoxic activity against cancer cells, highlighting their therapeutic potential. Additionally, peptides from ascidians and mollusks, including Aplidine and Kahalalide F, demonstrate significant anticancer properties. The study delves into peptides affecting apoptosis, microtubule dynamics, and angiogenesis inhibition, offering insights into potential cancer treatment mechanisms. Marine-derived peptides hold great promise as valuable candidates for novel anticancer therapies, with ongoing research aimed at unlocking their full therapeutic benefits.</p>","PeriodicalId":94044,"journal":{"name":"International journal of biochemistry and molecular biology","volume":"15 4","pages":"100-106"},"PeriodicalIF":0.0,"publicationDate":"2024-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11411150/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142304865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}