Inflammation and regeneration最新文献_第4页

Genome editing iPSC to purposing enhancement of induce CD8 killer T cell function for regenerative immunotherapy 基因组编辑 iPSC 以增强诱导 CD8 杀伤性 T 细胞功能，用于再生免疫疗法

Inflammation and regeneration Pub Date : 2024-04-18 DOI: 10.1186/s41232-024-00328-3

Sota Kurihara, A. Ishikawa, S. Kaneko

引用次数: 0

Tissue-resident memory T cells: decoding intra-organ diversity with a gut perspective 组织驻留记忆 T 细胞：从肠道角度解码器官内多样性

Inflammation and regeneration Pub Date : 2024-04-17 DOI: 10.1186/s41232-024-00333-6

Mari Murakami

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Hippo pathway in cell–cell communication: emerging roles in development and regeneration 细胞-细胞通讯中的河马通路：在发育和再生中的新作用

Inflammation and regeneration Pub Date : 2024-04-02 DOI: 10.1186/s41232-024-00331-8

Akihiro Nita, T. Moroishi

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Identification of cancer-specific cell surface targets for CAR-T cell therapy. 为 CAR-T 细胞疗法鉴定癌症特异性细胞表面靶点。

Inflammation and regeneration Pub Date : 2024-03-29 DOI: 10.1186/s41232-024-00329-2

Naoki Hosen

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Tenascin-C modulates alveolarization in bronchopulmonary dysplasia. Tenascin-C 可调节支气管肺发育不良的肺泡化。

Inflammation and regeneration Pub Date : 2024-03-28 DOI: 10.1186/s41232-024-00330-9

Wei Liu, Yu Mao, Qianru Lv, Keyu Lu, Chunyu Yin, Rui Cheng, Mingshun Zhang

引用次数: 0

Designer cell therapy for tissue regeneration. 用于组织再生的设计细胞疗法。

Inflammation and regeneration Pub Date : 2024-03-15 DOI: 10.1186/s41232-024-00327-4

Noyuri Zama, Satoshi Toda

引用次数: 0

Regulation of inflammatory diseases via the control of mRNA decay. 通过控制 mRNA 的衰变来调节炎症性疾病。

Inflammation and regeneration Pub Date : 2024-03-15 DOI: 10.1186/s41232-024-00326-5

Masanori Yoshinaga, Osamu Takeuchi

引用次数: 0

Chronological transitions of hepatocyte growth factor treatment effects in spinal cord injury tissue. 脊髓损伤组织中肝细胞生长因子治疗效果的时序转换。

Inflammation and regeneration Pub Date : 2024-03-13 DOI: 10.1186/s41232-024-00322-9

Yuji Okano, Yoshitaka Kase, Yu Suematsu, Masaya Nakamura, Hideyuki Okano

{"title":"Chronological transitions of hepatocyte growth factor treatment effects in spinal cord injury tissue.","authors":"Yuji Okano, Yoshitaka Kase, Yu Suematsu, Masaya Nakamura, Hideyuki Okano","doi":"10.1186/s41232-024-00322-9","DOIUrl":"10.1186/s41232-024-00322-9","url":null,"abstract":"Inflammatory responses are known to suppress neural regeneration in patients receiving stem cell-based regenerative therapy for spinal cord injury (SCI). Consequently, pathways involved in neurogenesis and immunomodulation, such as the hepatocyte growth factor (HGF)/MET signaling cascade, have garnered significant attention. Notably, various studies, including our own, have highlighted the enhanced recovery of locomotor functions achieved in SCI animal models by combining HGF pretreatment and human induced stem cell-derived neural stem/progenitor cell (hiPSC-NS/PC) transplantation. However, these studies implicitly hypothesized that the functionality of HGF in SCI would be time consistent and did not elucidate its dynamics. In the present article, we investigated the time-course of the effect of HGF on SCI, aiming to uncover a more precise mechanism for HGF administration, which is indispensable for developing crystallizing protocols for combination therapy. To this end, we performed a detailed investigation of the temporal variation of HGF using the RNA-seq data we obtained in our most recent study. Leveraging the time-series design of the data, which we did not fully exploit previously, we identified three components in the effects of HGF that operate at different times: early effects, continuous effects, and delayed effects. Our findings suggested a concept where the three components together contribute to the acceleration of neurogenesis and immunomodulation, which reinforce the legitimacy of empirically fine-tuned protocols for HGF administration and advocate the novel possibility that the time-inconsistent effects of HGF progressively augment the efficacy of combined therapy.","PeriodicalId":94041,"journal":{"name":"Inflammation and regeneration","volume":"44 1","pages":"10"},"PeriodicalIF":0.0,"publicationDate":"2024-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10935783/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140112532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gene editing technology to improve antitumor T-cell functions in adoptive immunotherapy. 利用基因编辑技术提高采用性免疫疗法中的抗肿瘤 T 细胞功能。

Inflammation and regeneration Pub Date : 2024-03-11 DOI: 10.1186/s41232-024-00324-7

Yusuke Ito, Satoshi Inoue, Yuki Kagoya

{"title":"Gene editing technology to improve antitumor T-cell functions in adoptive immunotherapy.","authors":"Yusuke Ito, Satoshi Inoue, Yuki Kagoya","doi":"10.1186/s41232-024-00324-7","DOIUrl":"10.1186/s41232-024-00324-7","url":null,"abstract":"Adoptive immunotherapy, in which tumor-reactive T cells are prepared in vitro for adoptive transfer to the patient, can induce an objective clinical response in specific types of cancer. In particular, chimeric antigen receptor (CAR)-redirected T-cell therapy has shown robust responses in hematologic malignancies. However, its efficacy against most of the other tumors is still insufficient, which remains an unmet medical need. Accumulating evidence suggests that modifying specific genes can enhance antitumor T-cell properties. Epigenetic factors have been particularly implicated in the remodeling of T-cell functions, including changes to dysfunctional states such as terminal differentiation and exhaustion. Genetic ablation of key epigenetic molecules prevents the dysfunctional reprogramming of T cells and preserves their functional properties.Clustered, regularly interspaced, short palindromic repeats (CRISPR)/CRISPR-associated protein (Cas)-based gene editing is a valuable tool to enable efficient and specific gene editing in cultured T cells. A number of studies have already identified promising targets to improve the therapeutic efficacy of CAR-T cells using genome-wide or focused CRISPR screening. In this review, we will present recent representative findings on molecular insights into T-cell dysfunction and how genetic modification contributes to overcoming it. We will also discuss several technical advances to achieve efficient gene modification using the CRISPR and other novel platforms.","PeriodicalId":94041,"journal":{"name":"Inflammation and regeneration","volume":"44 1","pages":"13"},"PeriodicalIF":0.0,"publicationDate":"2024-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10926667/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140103062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The gateway reflex regulates tissue-specific autoimmune diseases. 网关反射调节组织特异性自身免疫疾病。

Inflammation and regeneration Pub Date : 2024-03-07 DOI: 10.1186/s41232-024-00325-6

Yuki Tanaka, Izuru Ohki, Kaoru Murakami, Satoshi Ozawa, Yaze Wang, Masaaki Murakami

{"title":"The gateway reflex regulates tissue-specific autoimmune diseases.","authors":"Yuki Tanaka, Izuru Ohki, Kaoru Murakami, Satoshi Ozawa, Yaze Wang, Masaaki Murakami","doi":"10.1186/s41232-024-00325-6","DOIUrl":"10.1186/s41232-024-00325-6","url":null,"abstract":"The dynamic interaction and movement of substances and cells between the central nervous system (CNS) and peripheral organs are meticulously controlled by a specialized vascular structure, the blood-brain barrier (BBB). Experimental and clinical research has shown that disruptions in the BBB are characteristic of various neuroinflammatory disorders, including multiple sclerosis. We have been elucidating a mechanism termed the \"gateway reflex\" that details the entry of immune cells, notably autoreactive T cells, into the CNS at the onset of such diseases. This process is initiated through local neural responses to a range of environmental stimuli, such as gravity, electricity, pain, stress, light, and joint inflammation. These stimuli specifically activate neural pathways to open gateways at targeted blood vessels for blood immune cell entry. The gateway reflex is pivotal in managing tissue-specific inflammatory diseases, and its improper activation is linked to disease progression. In this review, we present a comprehensive examination of the gateway reflex mechanism.","PeriodicalId":94041,"journal":{"name":"Inflammation and regeneration","volume":"44 1","pages":"12"},"PeriodicalIF":0.0,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10919025/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140051362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0