Cirugia espanola最新文献_第5页

Omic analysis of the protein profile in digestive tumours, from proteomics to clinical practice 从蛋白质组学到临床实践的消化肿瘤蛋白质谱的组学分析。

Cirugia espanola Pub Date : 2026-09-01 Epub Date: 2026-02-12 DOI: 10.1016/j.cireng.2026.800303

Florina I. Bura, Rafaela Pezzopane, Melissa Granados, Lidia Rodríguez-Ortiz, Blanca Rufián-Andújar, Ana Martínez-López, María del Carmen Vázquez-Borrego, Antonio Romero-Ruiz, Alvaro Arjona-Sánchez

{"title":"Omic analysis of the protein profile in digestive tumours, from proteomics to clinical practice","authors":"Florina I. Bura, Rafaela Pezzopane, Melissa Granados, Lidia Rodríguez-Ortiz, Blanca Rufián-Andújar, Ana Martínez-López, María del Carmen Vázquez-Borrego, Antonio Romero-Ruiz, Alvaro Arjona-Sánchez","doi":"10.1016/j.cireng.2026.800303","DOIUrl":"10.1016/j.cireng.2026.800303","url":null,"abstract":"<div><div>Proteomics has emerged as a key tool in precision medicine, enabling in-depth molecular characterization of digestive tumours. This article outlines a standardised workflow, encompassing sample collection, protein extraction, and unbiased proteomic analysis using high-resolution liquid chromatography coupled with mass spectrometry. These approaches allow for the identification of biomarkers for early diagnosis, prognosis, and the development of targeted therapies. The review also highlights the value of single-cell proteomics to dissect tumour heterogeneity and discusses the use of in vitro and in vivo models to validate therapeutic targets. Additionally, it explores the potential of intraoperative molecular indicators to improve surgical outcomes. Altogether, the integration of proteomics with bioinformatics and artificial intelligence offers new opportunities to translate molecular discoveries into clinical practice, ultimately improving the management and quality of life of patients with digestive tumours.</div></div>","PeriodicalId":93935,"journal":{"name":"Cirugia espanola","volume":"104 9","pages":"Article 800303"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146198364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Response — Human factors in surgical practice: A national study 反应-手术实践中的人为因素：一项全国性研究。

Cirugia espanola Pub Date : 2026-09-01 Epub Date: 2026-05-14 DOI: 10.1016/j.cireng.2026.800343

Antonio Ríos

引用次数: 0

Reply: Human factors in surgical practice: A national study 答复：外科实践中的人为因素：一项全国性研究。

Cirugia espanola Pub Date : 2026-09-01 Epub Date: 2026-05-14 DOI: 10.1016/j.cireng.2026.800346

Mireia Verdaguer-Tremolosa, Víctor Rodrigues-Gonçalves, Pilar Martínez-López, Manuel López-Cano

引用次数: 0

Resection of liver metastases from gastric cancer: Remenecor project. 胃癌肝转移灶切除术：Remenecor项目。

Cirugia espanola Pub Date : 2026-08-31 DOI: 10.1016/j.cireng.2026.800377

José M Ramia, Nuria Blanco-Asensio, Juan Jesús Rubio, Silvia Carbonell-Morote, Margarida Casellas, Manuel Abradelo de Usera, Fernando Rotellar, Mario Serradilla-Martín

{"title":"Resection of liver metastases from gastric cancer: Remenecor project.","authors":"José M Ramia, Nuria Blanco-Asensio, Juan Jesús Rubio, Silvia Carbonell-Morote, Margarida Casellas, Manuel Abradelo de Usera, Fernando Rotellar, Mario Serradilla-Martín","doi":"10.1016/j.cireng.2026.800377","DOIUrl":"https://doi.org/10.1016/j.cireng.2026.800377","url":null,"abstract":"Introduction: The liver is one of the most frequent sites of metastatic spread in gastric cancer (GC). Although systemic chemotherapy remains the standard of care, surgical resection of liver metastases has demonstrated promising outcomes in carefully selected patients.Methods: A retrospective, observational, multicentre study including all adult patients who underwent surgical treatment for GC liver metastases between January 2010 and December 2022 in Hepatobiliopancreatic Surgery units across Spain.Results: A total of 37 patients were analysed, predominantly male (73%), with a mean age of 64.1 years (SD: 13.2). Metachronous metastases were present in 73% of cases. Most procedures consisted of non-anatomical liver resections, performed via an open approach in 75.7% of patients. Negative surgical margins were achieved in 91.9% of resections. The rate of major postoperative complications was 29.6%, with an operative mortality of 2.7% and a mean postoperative hospital stay of 7.5 days. During follow-up, 64.9% of patients developed disease recurrence, predominantly within the liver. Median disease-free survival (DFS) was 14 months, and median overall survival (OS) was 40 months. The 1-, 3-, and 5-year DFS rates were 54.1%, 29.7%, and 24.3%, respectively, while the corresponding OS rates were 89.2%, 54.1%, and 37.8%. On multivariable Cox proportional hazards analysis, age, lymph node involvement, and metachronous resection were independently associated with an increased risk of death.Conclusions: Hepatectomy in selected patients with liver metastases from GC may be associated with favourable long-term survival. These findings support a potential role for surgical resection within a multidisciplinary treatment strategy; however, well-defined selection criteria are essential to optimize patient outcomes.","PeriodicalId":93935,"journal":{"name":"Cirugia espanola","volume":" ","pages":"800377"},"PeriodicalIF":0.0,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148868341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Solitary fibrous tumour of the liver, a rare entity. 肝脏单发纤维性肿瘤，罕见。

Cirugia espanola Pub Date : 2026-08-31 DOI: 10.1016/j.cireng.2026.800375

Serrablo Leyre, Cuadal Javier, Bernad Ansó Alba, Izagirre June, Serrablo Requejo Alejandro

引用次数: 0

McKittrick-Wheelock syndrome due to giant gastric villous adenoma. 巨大胃绒毛腺瘤所致McKittrick-Wheelock综合征。

Cirugia espanola Pub Date : 2026-08-31 DOI: 10.1016/j.cireng.2026.800374

Sara Peidro Parres, Mª de Las Nieves Pérez Climent, Nuria Rita Espinosa Asencio, Tatiana Belda Ibáñez

引用次数: 0

Teamwork and the Systematisation of Evidence-Based Clinical Practice: How Can We Reduce Variability. 团队合作和循证临床实践的系统化：我们如何减少可变性。

Cirugia espanola Pub Date : 2026-08-31 DOI: 10.1016/j.cireng.2026.800373

Raquel Bravo, Miguel Pera

引用次数: 0

Implementation of a robotic single-staple technique for colorectal anastomosis: Technical description and initial institutional experience 机器人单钉结直肠吻合术的实现：技术描述和初步机构经验。

Cirugia espanola Pub Date : 2026-08-01 Epub Date: 2026-05-20 DOI: 10.1016/j.cireng.2026.800349

Alba García Chiloeches, Marcos Gómez Ruiz, Isabel Cifrián Canales, Carmen Cagigas Fernández

引用次数: 0

Marjolin's ulcer: A rare case of malignancy of a fistulous tract in chronic hidradenitis suppurativa 马卓林溃疡：慢性化脓性汗腺炎致瘘管恶性肿瘤的罕见病例。

Cirugia espanola Pub Date : 2026-08-01 Epub Date: 2026-05-19 DOI: 10.1016/j.cireng.2026.800357

José Luis Maestro de Castro, Vicent Primo-Romaguera, Jorge Sancho Muriel, Blas Flor Lorente

引用次数: 0

Professor Dr Cristóbal Pera Blanco-Morales (1927–2026) Cristobal Pera Blanco-Morales教授（1927 - 2026）

Cirugia espanola Pub Date : 2026-08-01 Epub Date: 2026-06-20 DOI: 10.1016/j.cireng.2026.800360

Luis Grande

引用次数: 0