CHEST critical care最新文献

{"title":"Physician Perspectives on Challenges in Understanding Patient Preferences for Emergency Intubation: A Qualitative Assessment of Hospital Code Status Orders","authors":"Emily J. Shearer, Jacob A. Blythe, S. Wieten, Elizabeth W. Dzeng, Miriam P. Cotler, Karin B. Porter-Williamson, Joshua B. Kayser, Stephanie M. Harman, David C. Magnus, J. Batten","doi":"10.1016/j.chstcc.2024.100053","DOIUrl":"https://doi.org/10.1016/j.chstcc.2024.100053","url":null,"abstract":"","PeriodicalId":93934,"journal":{"name":"CHEST critical care","volume":"54 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139819998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating biomarkers of endothelial dysfunction associate with ventilatory ratio and mortality in acute respiratory distress syndrome due to SARS-CoV-2 infection treated with anti-inflammatory therapies","authors":"J. Alladina, F. Giacona, Alexis M. Haring, K. Hibbert, B. Medoff, Eric P. Schmidt, Taylor Thompson, Bradley A. Maron, G. A. Alba","doi":"10.1016/j.chstcc.2024.100054","DOIUrl":"https://doi.org/10.1016/j.chstcc.2024.100054","url":null,"abstract":"","PeriodicalId":93934,"journal":{"name":"CHEST critical care","volume":"23 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139876624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Process of Withdrawal of Mechanical Ventilation at End of Life in the ICU","authors":"Ava Ferguson Bryan MD, MPH ,&nbsp;Amanda J. Reich PhD, MPH ,&nbsp;Andrea C. Norton BM ,&nbsp;Margaret L. Campbell PhD, RN ,&nbsp;Richard M. Schwartzstein MD ,&nbsp;Zara Cooper MD ,&nbsp;Douglas B. White MD ,&nbsp;Susan L. Mitchell MD, MPH ,&nbsp;Corey R. Fehnel MD, MPH","doi":"10.1016/j.chstcc.2024.100051","DOIUrl":"10.1016/j.chstcc.2024.100051","url":null,"abstract":"<div><h3>Background</h3><p>Nearly one-quarter of all Americans die in the ICU. Many of their deaths are anticipated and occur following the withdrawal of mechanical ventilation (WMV). However, there are few data on which to base best practices for interdisciplinary ICU teams to conduct WMV.</p></div><div><h3>Research Question</h3><p>What are the perceptions of current WMV practices among ICU clinicians, and what are their opinions of processes that might improve the practice of WMV at end of life in the ICU?</p></div><div><h3>Study Design and Methods</h3><p>This prospective two-center observational study conducted in Boston, Massachusetts, the Observational Study of the Withdrawal of Mechanical Ventilation (OBSERVE-WMV) was designed to better understand the perspectives of clinicians and experience of patients undergoing WMV. This report focuses on analyses of qualitative data obtained from in-person surveys administered to the ICU clinicians (nurses, respiratory therapists, and physicians) caring for these patients. Surveys assessed a broad range of clinician perspectives on planning, as well as the key processes required for WMV. This analysis used independent open, inductive coding of responses to open-ended questions. Initial codes were reconciled iteratively and then organized and interpreted using a thematic analysis approach. Opinions were assessed on how WMV could be improved for individual patients and the ICU as a whole.</p></div><div><h3>Results</h3><p>Among 456 eligible clinicians, 312 in-person surveys were completed by clinicians caring for 152 patients who underwent WMV. Qualitative analyses identified two main themes characterizing high-quality WMV processes: (1) good communication (eg, mutual understanding of family preferences) between the ICU team and family; and (2) medical management (eg, planning, availability of ICU team) that minimizes patient distress. Team member support was identified as an essential process component in both themes.</p></div><div><h3>Interpretation</h3><p>Clinician perceptions of the appropriateness or success of WMV prioritize the quality of team and family communication and patient symptom management. Both are modifiable targets of interventions aimed at optimizing overall WMV.</p></div>","PeriodicalId":93934,"journal":{"name":"CHEST critical care","volume":"2 2","pages":"Article 100051"},"PeriodicalIF":0.0,"publicationDate":"2024-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949788424000054/pdfft?md5=6f57aac2781996dcaadec16f7775d7cd&pid=1-s2.0-S2949788424000054-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139632635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterizing Cardiac Function in ICU Survivors of Sepsis","authors":"Kevin Garrity MBChB ,&nbsp;Christie Docherty MBChB ,&nbsp;Kenneth Mangion PhD ,&nbsp;Rosie Woodward BSc ,&nbsp;Martin Shaw PhD ,&nbsp;Giles Roditi MBChB ,&nbsp;Benjamin Shelley MD ,&nbsp;Tara Quasim MD ,&nbsp;Philip McCall MD ,&nbsp;Joanne McPeake PhD","doi":"10.1016/j.chstcc.2024.100050","DOIUrl":"10.1016/j.chstcc.2024.100050","url":null,"abstract":"<div><h3>Background</h3><p>Sepsis is one of the most common reasons for ICU admission and a leading cause of mortality worldwide. More than one-half of survivors experience significant physical, psychological, or cognitive impairments, often termed post-intensive care syndrome (PICS). Sepsis is recognized increasingly as being associated with a risk of adverse cardiovascular events that is comparable with other major cardiovascular risk factors. It is plausible that sepsis survivors may be at risk of unidentified cardiovascular disease, and this may play a role in functional impairments seen after ICU discharge.</p></div><div><h3>Research Question</h3><p>What is the prevalence of myocardial dysfunction after an ICU admission with sepsis and to what extent might it be associated with physical impairments in PICS?</p></div><div><h3>Study Design and Methods</h3><p>Characterisation of Cardiovascular Function in ICU Survivors of Sepsis (CONDUCT-ICU) is a prospective, multicenter, pilot study characterizing cardiovascular function and functional impairments in survivors of sepsis taking place in the west of Scotland. Survivors of sepsis will be recruited at ICU discharge and followed up 6 to 10 weeks after hospital discharge. Biomarkers of myocardial injury or dysfunction (high sensitivity troponin and N-terminal pro B-type natriuretic peptide) and systemic inflammation (C-reactive protein, IL-1β, IL-6, IL-10, and tumor necrosis factor alpha) will be measured in 69 patients at recruitment and at follow-up. In addition, a cardiovascular magnetic resonance substudy will be performed at follow-up in 35 patients. We will explore associations between cardiovascular magenetic resonance indexes of cardiac function, biomarkers of cardiac dysfunction and inflammation, and patient-reported outcome measures.</p></div><div><h3>Interpretation</h3><p>CONDUCT-ICU will provide data regarding the cause and prevalence of cardiac dysfunction in survivors of sepsis and will explore associations with functional impairment. It will provide feasibility data and operational learning for larger studies investigating mechanisms of functional impairment after ICU admission and the association between sepsis and adverse cardiovascular events.</p></div><div><h3>Trial Registry</h3><p>ClinicalTrials.gov; No.: NCT05633290; URL: <span>www.clinicaltrials.gov</span><svg><path></path></svg></p></div>","PeriodicalId":93934,"journal":{"name":"CHEST critical care","volume":"2 1","pages":"Article 100050"},"PeriodicalIF":0.0,"publicationDate":"2024-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949788424000042/pdfft?md5=4a94f2c031a2d39c9cf534d196f702f2&pid=1-s2.0-S2949788424000042-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139635011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of SARS-CoV-2 IgG Seroconversion After Convalescent Plasma Transfusion on Hospital Outcomes in COVID-19","authors":"Sonal R. Pannu MD ,&nbsp;Michael Cardone MD ,&nbsp;Mohankumar Doraiswamy MD ,&nbsp;Jing Peng PhD ,&nbsp;Ma Jianing MS ,&nbsp;Michael Para MD ,&nbsp;Shan-Lu Liu MD, PhD ,&nbsp;Gerald Lozanski MD ,&nbsp;Scott Scrape MD ,&nbsp;Rama K. Mallampalli MD ,&nbsp;Matthew Exline MD ,&nbsp;Jeffrey C. Horowitz MD","doi":"10.1016/j.chstcc.2024.100048","DOIUrl":"10.1016/j.chstcc.2024.100048","url":null,"abstract":"<div><h3>Background</h3><p>Convalescent plasma increases SARS-CoV-2 clearance in COVID-19, especially in patients lacking preexisting antibodies.</p></div><div><h3>Research Question</h3><p>In hospitalized patients with COVID-19 receiving convalescent plasma, does conversion to a positive SARS-CoV-2 IgG status provide mortality benefit in patients who lacked SARS-CoV-2 IgG?</p></div><div><h3>Study Design and Methods</h3><p>This observational study included consecutive hospitalized patients with COVID-19 who received convalescent plasma under the Expanded Access Program from April through August 2020. SARS-CoV-2 N-based IgG antibody enzyme-linked immunosorbent assay measurements before and after transfusion were recorded. Outcomes of patients without preexisting antibodies who demonstrated seroconversion immediately after receipt of convalescent plasma were compared with those who did not show seroconversion. Hospital mortality was the primary outcome.</p></div><div><h3>Results</h3><p>Two hundred seventy-five hospitalized patients received convalescent plasma during the study period. SARS-CoV-2 IgG was collected from 234 patients. One hundred ten patients (47%) showed seropositive findings and 124 patients (53%) showed seronegative findings before transfusion. Among the seronegative group, 63 patients (50.8%) demonstrated seroconversion after plasma transfusion, whereas 61 patients (49.2%) continued to show seronegative findings despite transfusion. Age, sex, BMI, Sequential Organ Failure Assessment score, and receipt of high-titer plasma were similar across all subgroups. Seroconversion after transfusion was not associated with survival at hospital discharge (OR, 1.9; 95% CI, 0.7-4.9; <em>P</em> = .17).</p></div><div><h3>Interpretation</h3><p>Serologic response after transfusion of convalescent plasma was not shown to be associated with hospital survival in patients with COVID-19 without preexisting SARS-CoV2 IgG antibodies.</p></div>","PeriodicalId":93934,"journal":{"name":"CHEST critical care","volume":"2 2","pages":"Article 100048"},"PeriodicalIF":0.0,"publicationDate":"2024-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949788424000029/pdfft?md5=c4534f01664c91fbef24ac3d4315a920&pid=1-s2.0-S2949788424000029-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139636742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Venous Air Embolism","authors":"Hamza Alzghoul MD ,&nbsp;Omar Obeidat MD ,&nbsp;Saeed Abughazaleh MD ,&nbsp;Abdallah Al-Ani MD ,&nbsp;Ahmad Al-Jabali ,&nbsp;Mohammad Z. Khrais MD ,&nbsp;Mohammed Tarawneh MD ,&nbsp;Hashim Al-Ani MD ,&nbsp;Mohamed F. Ismail MD ,&nbsp;Ariel Ruiz De villa MD ,&nbsp;Asad Haider MD ,&nbsp;Bashar N. Alzghoul MD, FCCP ,&nbsp;Bilal F. Samhouri MD","doi":"10.1016/j.chstcc.2024.100049","DOIUrl":"10.1016/j.chstcc.2024.100049","url":null,"abstract":"<div><h3>Background</h3><p>Venous air embolism (VAE) is an understudied entity. Herein, we summarize VAE case reports and small case series reported in the literature.</p></div><div><h3>Research Question</h3><p>What are the clinical features, diagnostic approaches, and clinical outcomes of VAE and how do surgery-related VAEs compare with non-surgery-related VAEs?</p></div><div><h3>Study Design and Methods</h3><p>Using the search terms <em>air</em>, <em>gas</em>, <em>venous</em>, and <em>embolism</em>, 437 articles were identified. After applying predetermined exclusion criteria, we included the 164 articles describing cases of isolated VAE. We extracted data pertaining to patient demographics and clinical presentations; VAE characteristics, for example, cause and clinical context; diagnostic testing and time to diagnosis; and clinical management and outcomes. We used the Shapiro-Wilk test to assess data distribution (ie, normally vs nonnormally distributed), the Pearson χ² test for categorical variables, and the Mann-Whitney <em>U</em> test and <em>t</em> test for continuous variables.</p></div><div><h3>Results</h3><p>We collated 174 patients; 108 patients (62.1%) were male. Most VAE episodes (n = 160 [92%]) were iatrogenic. Eighty-two patients (47%) experienced respiratory, cardiac, or neurologic symptoms, or a combination thereof, whereas 15 patients (8.6%) were asymptomatic; the remaining patients (n = 77 [44.3%]) had collapsed or been intubated before VAE diagnosis. Most patients (56.9%) were hemodynamically unstable on presentation. Diagnostic and management approaches varied considerably across reports. Of management strategies, oxygen supplementation (F<span>io</span>₂ = 1.0) and body repositioning were implemented most frequently. Seventy-nine patients (45%) received ICU level of care, 13 patients (7.5%) underwent endotracheal intubation, 39 patients (22.4%) received inotropic support, and 32 patients (18.4%) died. Compared with patients with non-surgery-related VAEs, those with surgery-related VAEs underwent end-tidal CO₂ measurement more frequently (50% vs 3%; <em>P</em> &lt; .001) and showed lower all-cause mortality (11.2% vs 24.5%; <em>P</em> = .01). Time to diagnosis was nonsignificantly shorter in surgery-related episodes. Publication bias is one of our study's limitations.</p></div><div><h3>Interpretation</h3><p>Approximately one-half of VAEs are nonsurgical. Diagnostic and management strategies varied widely across reports, reflecting disease heterogeneity and inconsistent clinical approach. All-cause mortality was higher for non-surgery-related episodes than for surgery-related episodes. Considering the comparable age, sex distribution, and comorbidities between these two groups, this finding deserves further study.</p></div>","PeriodicalId":93934,"journal":{"name":"CHEST critical care","volume":"2 1","pages":"Article 100049"},"PeriodicalIF":0.0,"publicationDate":"2024-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949788424000030/pdfft?md5=356eb2505075a56a169fdcb5a9f7383a&pid=1-s2.0-S2949788424000030-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139631654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Variation in Sedative and Analgesic Use During the COVID-19 Pandemic and Associated Outcomes","authors":"Justin M. Rucci MD ,&nbsp;Anica C. Law MD ,&nbsp;Scott Bolesta PharmD ,&nbsp;Emily K. Quinn MA ,&nbsp;Michael A. Garcia MD ,&nbsp;Ognjen Gajic MD ,&nbsp;Karen Boman ,&nbsp;Santiago Yus MD ,&nbsp;Valerie M. Goodspeed MPH ,&nbsp;Vishakha Kumar MD, MBA ,&nbsp;Rahul Kashyap MD, MBA ,&nbsp;Allan J. Walkey MD","doi":"10.1016/j.chstcc.2024.100047","DOIUrl":"10.1016/j.chstcc.2024.100047","url":null,"abstract":"<div><h3>Background</h3><p>Providing analgesia and sedation is an essential component of caring for many mechanically ventilated patients. The selection of analgesic and sedative medications during the COVID-19 pandemic, and the impact of these sedation practices on patient outcomes, remain incompletely characterized.</p></div><div><h3>Research Question</h3><p>What were the hospital patterns of analgesic and sedative use for patients with COVID-19 who received mechanical ventilation (MV), and what differences in clinical patient outcomes were observed across prevailing sedation practices?</p></div><div><h3>Study Design and Methods</h3><p>We conducted an observational cohort study of hospitalized adults who received MV for COVID-19 from February 2020 through April 2021 within the Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS) COVID-19 Registry. To describe common sedation practices, we used hierarchical clustering to group hospitals based on the percentage of patients who received various analgesic and sedative medications. We then used multivariable regression models to evaluate the association between hospital analgesia and sedation cluster and duration of MV (with a placement of death [POD] approach to account for competing risks).</p></div><div><h3>Results</h3><p>We identified 1,313 adults across 35 hospitals admitted with COVID-19 who received MV. Two clusters of analgesia and sedation practices were identified. Cluster 1 hospitals generally administered opioids and propofol with occasional use of additional sedatives (eg, benzodiazepines, alpha-agonists, and ketamine); cluster 2 hospitals predominantly used opioids and benzodiazepines without other sedatives. As compared with patients in cluster 2, patients admitted to cluster 1 hospitals underwent a shorter adjusted median duration of MV with POD (β-estimate, –5.9; 95% CI, –11.2 to –0.6; <em>P</em> = .03).</p></div><div><h3>Interpretation</h3><p>Patients who received MV for COVID-19 in hospitals that prioritized opioids and propofol for analgesia and sedation experienced shorter adjusted median duration of MV with POD as compared with patients who received MV in hospitals that primarily used opioids and benzodiazepines.</p></div>","PeriodicalId":93934,"journal":{"name":"CHEST critical care","volume":"2 1","pages":"Article 100047"},"PeriodicalIF":0.0,"publicationDate":"2024-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949788424000017/pdfft?md5=8e895c8170db059b221ca8fb8c0902c1&pid=1-s2.0-S2949788424000017-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139455698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Alcohol Use Characterized by Phosphatidylethanol in Patients With Respiratory Failure Before and During the COVID-19 Pandemic","authors":"Ellen L. Burnham MD ,&nbsp;Raymond Pomponio BS ,&nbsp;Grace Perry BS ,&nbsp;Patrick J. Offner BS ,&nbsp;Ryen Ormesher MD ,&nbsp;Ryan A. Peterson PhD ,&nbsp;Sarah E. Jolley MD","doi":"10.1016/j.chstcc.2023.100045","DOIUrl":"10.1016/j.chstcc.2023.100045","url":null,"abstract":"<div><h3>Background</h3><p>Alcohol misuse is overlooked frequently in hospitalized patients, but is common among patients with pneumonia and acute hypoxic respiratory failure. Investigations in hospitalized patients rely heavily on self-report surveys or chart abstraction, which lack sensitivity. Therefore, our understanding of the prevalence of alcohol misuse before and during the COVID-19 pandemic is limited.</p></div><div><h3>Research Question</h3><p>In critically ill patients with respiratory failure, did the proportion of patients with alcohol misuse, defined by the direct biomarker phosphatidylethanol, vary over a period including the COVID-19 pandemic?</p></div><div><h3>Study Design and Methods</h3><p>Patients with acute hypoxic respiratory failure receiving mechanical ventilation were enrolled prospectively from 2015 through 2019 (before the pandemic) and from 2020 through 2022 (during the pandemic). Alcohol use data, including Alcohol Use Disorders Identification Test (AUDIT)-C scores, were collected from electronic health records, and phosphatidylethanol presence was assessed at ICU admission. The relationship between clinical variables and phosphatidylethanol values was examined using multivariable ordinal regression. Dichotomized phosphatidylethanol values (≥ 25 ng/mL) defining alcohol misuse were compared with AUDIT-C scores signifying misuse before and during the pandemic, and correlations between log-transformed phosphatidylethanol levels and AUDIT-C scores were evaluated and compared by era. Multiple imputation by chained equations was used to handle missing phosphatidylethanol data.</p></div><div><h3>Results</h3><p>Compared with patients enrolled before the pandemic (n = 144), patients in the pandemic cohort (n = 92) included a substantially higher proportion with phosphatidylethanol-defined alcohol misuse (38% vs 90%; <em>P</em> &lt; .001). In adjusted models, absence of diabetes, positive results for COVID-19, and enrollment during the pandemic each were associated with higher phosphatidylethanol values. The correlation between health care worker-recorded AUDIT-C score and phosphatidylethanol level was significantly lower during the pandemic.</p></div><div><h3>Interpretation</h3><p>The higher prevalence of phosphatidylethanol-defined alcohol misuse during the pandemic suggests that alcohol consumption increased during this period, identifying alcohol misuse as a potential risk factor for severe COVID-19-associated respiratory failure. Results also suggest that AUDIT-C score may be less useful in characterizing alcohol consumption during high clinical capacity.</p></div>","PeriodicalId":93934,"journal":{"name":"CHEST critical care","volume":"2 1","pages":"Article 100045"},"PeriodicalIF":0.0,"publicationDate":"2024-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S294978842300045X/pdfft?md5=b396034044d113187c79e671012a8719&pid=1-s2.0-S294978842300045X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139454122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Standardization and Standards in Extracorporeal Membrane Oxygenation Education","authors":"David Furfaro MD ,&nbsp;Rebecca M. Sternschein MD","doi":"10.1016/j.chstcc.2023.100046","DOIUrl":"10.1016/j.chstcc.2023.100046","url":null,"abstract":"","PeriodicalId":93934,"journal":{"name":"CHEST critical care","volume":"2 1","pages":"Article 100046"},"PeriodicalIF":0.0,"publicationDate":"2024-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949788423000461/pdfft?md5=0e780a921595d8915349fb424408ba3a&pid=1-s2.0-S2949788423000461-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139394775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Center of Admission on Receipt of Extracorporeal Membrane Oxygenation Among Patients With Hypoxemic Respiratory Failure","authors":"Bourke W. Tillmann MD, PhD ,&nbsp;Tai Pham MD, PhD ,&nbsp;Damon C. Scales MD, PhD ,&nbsp;Eddy Fan MD, PhD ,&nbsp;Ruxandra Pinto PhD ,&nbsp;Gordon Rubenfeld MD ,&nbsp;Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure (LUNG SAFE) Investigators and Réseau Européen de Recherche en Ventilation Artificielle (REVA) Registry","doi":"10.1016/j.chstcc.2023.100040","DOIUrl":"https://doi.org/10.1016/j.chstcc.2023.100040","url":null,"abstract":"<div><h3>Background</h3><p>Given the resources and specialized training required to deliver extracorporeal membrane oxygenation (ECMO), the provision of ECMO often is centralized within expert centers. Spurred by recent evidence, the use of ECMO has increased dramatically. However, given the centralized nature of ECMO, it is possible that inequities in access exist.</p></div><div><h3>Research Question</h3><p>Does center of admission impact the likelihood of receiving ECMO among adults with moderate or severe acute hypoxemic respiratory failure (Pa<span>o</span>₂ to F<span>io</span>₂ ratio ≤ 200 mm Hg within 48 h of ventilation).</p></div><div><h3>Study Design and Methods</h3><p>We performed a retrospective cohort study using data from the Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure (LUNG SAFE) and Reseau Europeen de Recherche en Ventilation Artificielle (REVA) Influenza A(H1N1) Registry databases. Using modified log-Poisson analysis, we estimated the likelihood of receiving extracorporeal membrane oxygenation (ECMO) (initiation at the admitting hospital or transfer for initiation), adjusting for disease severity over time. To explore unmeasured confounding, we evaluated the association between center of admission on three negative controls: neuromuscular blockade, prone positioning, and dialysis.</p></div><div><h3>Results</h3><p>Among 1,581 patients (37.7% female patients; mean age, 60.7 years), 76 patients (4.8%) received ECMO. Longitudinal analysis, adjusted for trends in disease severity, demonstrated that patients admitted to ECMO centers were two times more likely to receive ECMO than those admitted to non-ECMO centers (relative risk [RR], 2.00; 95% CI, 1.17-3.41). Patients at ECMO centers received ECMO 2 days earlier than those at non-ECMO centers: median time to initiation was 1 day (interquartile range, 1-5 days) vs 3 days (interquartile range, 2-5 days; <em>P</em> = .04). Center of admission was not associated with neuromuscular blockade (RR, 1.08; 95% CI, 0.90-1.30), prone positioning (RR, 0.93; 95% CI, 0.68-1.28), or dialysis (RR, 1.04; 95% CI, 0.84-1.27).</p></div><div><h3>Interpretation</h3><p>Adults with hypoxemic respiratory failure admitted to ECMO centers were twice as likely to receive ECMO as those admitted to non-ECMO centers. These finding raise concerns regarding equity in access to care and suggest a potential lower threshold among clinicians at ECMO centers for initiation of ECMO.</p></div>","PeriodicalId":93934,"journal":{"name":"CHEST critical care","volume":"2 1","pages":"Article 100040"},"PeriodicalIF":0.0,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949788423000400/pdfft?md5=815f0e741b486b8c696ae4939e54c5d9&pid=1-s2.0-S2949788423000400-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139975857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}