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Best practice & research. Clinical obstetrics & gynaecology最新文献

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The road to hormonal male contraception: End in sight? 男性荷尔蒙避孕之路：终结在望？
Best practice & research. Clinical obstetrics & gynaecology Pub Date : 2024-09-24 DOI: 10.1016/j.bpobgyn.2024.102559
R A Anderson, J J Reynolds-Wright
{"title":"The road to hormonal male contraception: End in sight?","authors":"R A Anderson, J J Reynolds-Wright","doi":"10.1016/j.bpobgyn.2024.102559","DOIUrl":"https://doi.org/10.1016/j.bpobgyn.2024.102559","url":null,"abstract":"<p><p>The concept of a hormonal approach that sufficiently and reversibly suppresses spermatogenesis to the level required for effective contraception has been developed and tested over several decades. The reality of achieving this has been confirmed using both testosterone alone and combination methods using a progestogen with a physiological dose of testosterone, necessary to replace the lack of endogenous testosterone production by the suppressed testes. A range of both long-acting and self-administered combination methods are effective, including injection, implant and gel methods of administration, with up to 95% of men achieving sufficient spermatogenic suppression. New steroids are also being trialled. Surveys show the widespread willingness of men and their female partners to use novel male methods, suggesting the potential of this approach to contribute to global family planning and sustainable development goals. This approach to contraception can clearly be effective, and needs to move from relatively small scale testing to large scale pre-marketing trials: only then can information about long-term safety and real-world acceptability be obtained.</p>","PeriodicalId":93895,"journal":{"name":"Best practice & research. Clinical obstetrics & gynaecology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142334263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genome sequencing in the prenatal diagnosis of structural malformations in the fetus. 基因组测序在胎儿结构畸形产前诊断中的应用。
Best practice & research. Clinical obstetrics & gynaecology Pub Date : 2024-09-13 DOI: 10.1016/j.bpobgyn.2024.102539
Matthew Hoi Kin Chau, Mahesh Choolani, Zirui Dong, Ye Cao, Kwong Wai Choy
{"title":"Genome sequencing in the prenatal diagnosis of structural malformations in the fetus.","authors":"Matthew Hoi Kin Chau, Mahesh Choolani, Zirui Dong, Ye Cao, Kwong Wai Choy","doi":"10.1016/j.bpobgyn.2024.102539","DOIUrl":"https://doi.org/10.1016/j.bpobgyn.2024.102539","url":null,"abstract":"<p><p>Prenatal genetic diagnosis has undergone two pivotal paradigm shifts, initially with the introduction of chromosomal microarray and subsequently with the advent of next-generation sequencing technologies (NGS). NGS technology has given rise to a multitude of applications, with gene panels, exome sequencing (ES), and genome sequencing (GS) emerging as highly promising tests for prenatal genetic investigations. These advanced approaches have demonstrated superior diagnostic rates when compared to conventional testing methods, showcasing the evolution and enhancement of prenatal genetic screening and diagnostic capabilities. With these ground-breaking innovations, NGS technologies have the potential to replace current standard practice in prenatal diagnosis. With the increasing use of prenatal sequencing, the need for better education and guidance on their applications grows. This chapter aims to illustrate the detection scope and feasibility of various NGS-based methods that are currently used in prenatal diagnosis.</p>","PeriodicalId":93895,"journal":{"name":"Best practice & research. Clinical obstetrics & gynaecology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142334262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Beyond the surface: Does stage I-II endometriosis impact fertility? Exploring the challenges of mild disease. 超越表面：I-II 期子宫内膜异位症会影响生育吗？探索轻度疾病的挑战。
Best practice & research. Clinical obstetrics & gynaecology Pub Date : 2024-09-01 Epub Date: 2024-05-09 DOI: 10.1016/j.bpobgyn.2024.102501
Begum Aydogan Mathyk, Esra Cetin, Youssef Youssef, Anthony N Imudia, Diana Encalada Soto, Emad Mikhail, Gaby Moawad
{"title":"Beyond the surface: Does stage I-II endometriosis impact fertility? Exploring the challenges of mild disease.","authors":"Begum Aydogan Mathyk, Esra Cetin, Youssef Youssef, Anthony N Imudia, Diana Encalada Soto, Emad Mikhail, Gaby Moawad","doi":"10.1016/j.bpobgyn.2024.102501","DOIUrl":"10.1016/j.bpobgyn.2024.102501","url":null,"abstract":"<p><p>Endometriosis is one of the most common gynecologic conditions that women face throughout their lives. Despite advances in technology, diagnosis and treatment of this relapsing and remitting condition is still challenging for many women. This review focuses on literature pertaining to minimal/mild (stage I/II) endometriosis and its impact on fertility. The effectiveness of medical interventions to improve infertility and obstetric outcomes in both natural and assisted reproductive technologies cycles remains debated. The recent ESHRE guidelines suggests that operative laparoscopy could be considered for rASRM stage I/II endometriosis as it improves ongoing pregnancy rates.</p>","PeriodicalId":93895,"journal":{"name":"Best practice & research. Clinical obstetrics & gynaecology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140960722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endometriosis related infertility. 与子宫内膜异位症有关的不孕症。
Best practice & research. Clinical obstetrics & gynaecology Pub Date : 2024-05-01 DOI: 10.1016/j.bpobgyn.2024.102504
Simone Ferrero
{"title":"Endometriosis related infertility.","authors":"Simone Ferrero","doi":"10.1016/j.bpobgyn.2024.102504","DOIUrl":"https://doi.org/10.1016/j.bpobgyn.2024.102504","url":null,"abstract":"","PeriodicalId":93895,"journal":{"name":"Best practice & research. Clinical obstetrics & gynaecology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141045643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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