Archives of pathology & laboratory medicine最新文献_第4页

Concomitant Waldenström Macroglobulinemia/Lymphoplasmacytic Lymphoma and Non-Immunoglobulin M Plasma Cell Neoplasm. 合并Waldenström巨球蛋白血症/淋巴浆细胞性淋巴瘤和非免疫球蛋白M浆细胞肿瘤。

Archives of pathology & laboratory medicine Pub Date : 2025-01-13 DOI: 10.5858/arpa.2024-0270-OA

Yue Zhao, Philip Petersen, Sophie Stuart, Jiaqi He, Yaping Ju, Luis F Carrillo, Eric D Carlsen, Yi Xie, Alireza Ghezavati, Imran Siddiqi, Ling Zhang, Endi Wang

{"title":"Concomitant Waldenström Macroglobulinemia/Lymphoplasmacytic Lymphoma and Non-Immunoglobulin M Plasma Cell Neoplasm.","authors":"Yue Zhao, Philip Petersen, Sophie Stuart, Jiaqi He, Yaping Ju, Luis F Carrillo, Eric D Carlsen, Yi Xie, Alireza Ghezavati, Imran Siddiqi, Ling Zhang, Endi Wang","doi":"10.5858/arpa.2024-0270-OA","DOIUrl":"https://doi.org/10.5858/arpa.2024-0270-OA","url":null,"abstract":"Context.—: The co-occurrence of plasma cell neoplasm (PCN) and lymphoplasmacytic lymphoma (LPL) is rare, and their clonal relationship remains unclear.Objective.—: To evaluate the clinicopathologic characteristics of concomitant LPL/PCN.Design.—: Retrospectively analyzed clinical and laboratory data of 14 cases.Results.—: Three patients initially presented with immunoglobulin (Ig) M paraprotein, 1 with IgG paraprotein, and 10 had simultaneous diagnoses of PCN and LPL. In 13 cases, flow cytometry detected both LPL and PCN in marrow biopsies. Furthermore, immunohistochemistry highlighted the 2 neoplastic populations, demonstrating an increased proportion of plasma cells and their expression of cyclin D1, CD56, and/or a non-IgM isotype restriction. All cases exhibited discordant heavy-chain isotypes between LPL and PCN. Thirteen of the 14 cases (92.9%) had concordant light-chain restrictions between the 2 neoplasms, and the remaining case (7.1%) showed discordant light-chain restrictions. Of the 12 patients with follow-up, 5 were treated with myeloma regimens, 2 with LPL regimens, 3 with combined therapy, and 2 with observation alone. Follow-up ranged from 2 to 146 months (median, 12.5 months). One patient died of PCN progression, one died of comorbidity, and 10 patients were alive with or without disease. Survival analysis showed no significant difference from the control.Conclusions.—: The discordant heavy-chain isotype restrictions between PCN and LPL suggest biclonal B-cell neoplasms, which is supported by PCN's phenotypic distinction, such as the expression of cyclin D1 and/or CD56. However, our series exhibited a tendency toward concordant light-chain restrictions between the 2 neoplasms, raising the possibility that PCN may evolve from LPL through class switching.","PeriodicalId":93883,"journal":{"name":"Archives of pathology & laboratory medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142973866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Improved Performance on Longitudinal Knowledge Assessment in Continuing Certification: The ABPath CertLink Strategy. 持续认证中纵向知识评估的改进绩效：ABPath CertLink策略。

Archives of pathology & laboratory medicine Pub Date : 2025-01-13 DOI: 10.5858/arpa.2024-0318-OA

Gary W Procop, Tyler Sandersfeld, Ty McCarthy, Ritu Nayar

{"title":"Improved Performance on Longitudinal Knowledge Assessment in Continuing Certification: The ABPath CertLink Strategy.","authors":"Gary W Procop, Tyler Sandersfeld, Ty McCarthy, Ritu Nayar","doi":"10.5858/arpa.2024-0318-OA","DOIUrl":"https://doi.org/10.5858/arpa.2024-0318-OA","url":null,"abstract":"Context.—: All member boards of the American Board of Medical Specialties have continuing certification (ie, maintenance of certification) programs. The efficacy of these programs has been questioned and, therefore, warrants study.Objective.—: To determine if the American Board of Pathology CertLink program, as structured, is associated with an improvement in the performance of participants on the assessment of content that was previously missed (ie, inaccurately answered).Design.—: We reviewed the performance of American Board of Pathology CertLink participants from January 2022 through December 2023 on the readministration of the content from 110 036 multiple-choice items that were previously missed by the participants in a program with enhanced learning strategies and incentives.Results.—: The correct response rate upon the assessment of readministered content that was previously missed increased from 0% to 62.2% (68 394 of 110 036), which exceeds that which would be achieved by guessing (P < .001).Conclusions.—: The American Board of Pathology CertLink program, which incentivizes learning and was constructed from adult learning principles and modern educational precepts to improve knowledge retention, interrupt forgetting, and introduce practice-relevant content, is associated with an improvement in the performance of diplomates on continuing certification knowledge assessments.","PeriodicalId":93883,"journal":{"name":"Archives of pathology & laboratory medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142973347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effect of Window Size on Pathologists' Search for Rare Elements in a Digital Pathology Setting. 窗口大小对病理学家在数字病理设置中搜索稀有元素的影响。

Archives of pathology & laboratory medicine Pub Date : 2025-01-02 DOI: 10.5858/arpa.2024-0378-OA

Alana Lopes, Sean Rasmussen, Bojana Djordjevic, Jose A Gomez, Maria Florencia Mora, Anurag Sharma, Joanna C Walsh, Bret Wehrli, Aaron D Ward, Matthew J Cecchini

{"title":"The Effect of Window Size on Pathologists' Search for Rare Elements in a Digital Pathology Setting.","authors":"Alana Lopes, Sean Rasmussen, Bojana Djordjevic, Jose A Gomez, Maria Florencia Mora, Anurag Sharma, Joanna C Walsh, Bret Wehrli, Aaron D Ward, Matthew J Cecchini","doi":"10.5858/arpa.2024-0378-OA","DOIUrl":"https://doi.org/10.5858/arpa.2024-0378-OA","url":null,"abstract":"Context.—: Digital pathology requires pathologists to assess tissue digitally rather than on an analog microscope, which has been the mainstay tool for tissue assessment for more than a century. The impact of different digital interaction configurations on pathologists' performance is not well understood. This work focuses on the impact of the display window size for diagnostic assessment.Objective.—: To determine the effect of digital image viewer window size on pathologists' diagnostic performance when searching for tumors in lymph nodes while under a time limit.Design.—: Six pathologists assessed 8 breast lymph node whole slide images using 4 digital image viewer window sizes (8, 14, 24, and 32 inches) for tumors in lymph nodes while under a time limit. Eye-gaze data were collected. Pathologists were subsequently asked to rate their preference of window sizes.Results.—: The fraction of window not covered with foveated vision was significantly associated with window size ranging from 43% for 32 inches to 5% for 8 inches (P < .001). There was no statistically significant relationship between the number of false negatives or assessment time and window size (P = .21 and P = .28, respectively). The distance traversed per panning instance ranged from 301 pixels for 32-inch to 193 pixels for 8-inch windows (P = .002). All pathologists preferred the largest window size as it provided more context for diagnostic assessment.Conclusions.—: Window size does not significantly affect pathologists' diagnostic performance when searching for tumors in lymph nodes. However, pathologists adapted their slide navigation approach to accommodate the amount of context the window size permitted.","PeriodicalId":93883,"journal":{"name":"Archives of pathology & laboratory medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142924170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plexiform Fibromyxoma. Plexiform Fibromyxoma .

Archives of pathology & laboratory medicine Pub Date : 2025-01-02 DOI: 10.5858/arpa.2024-0254-RA

Julianne Szczepanski, Maria Westerhoff, Shula Schechter

引用次数: 0

Age- and Sex-Dynamic Fluctuations and Reference Intervals for Alkaline Phosphatase Among the Spanish Population. 西班牙人口碱性磷酸酶的年龄和性别动态波动及参考区间。

Archives of pathology & laboratory medicine Pub Date : 2025-01-01 DOI: 10.5858/arpa.2023-0335-OA

Laura Castells Vilella, Paula Sánchez-Pintos, José Félix Muñiz Llama, Matías Gámez Martínez, María Luz Couce, Jordi Antón

{"title":"Age- and Sex-Dynamic Fluctuations and Reference Intervals for Alkaline Phosphatase Among the Spanish Population.","authors":"Laura Castells Vilella, Paula Sánchez-Pintos, José Félix Muñiz Llama, Matías Gámez Martínez, María Luz Couce, Jordi Antón","doi":"10.5858/arpa.2023-0335-OA","DOIUrl":"10.5858/arpa.2023-0335-OA","url":null,"abstract":"Context.—: Interpretation of alkaline phosphatase (ALP) activity is essential for the diagnosis of certain diseases. ALP changes during life and may vary between different populations.Objective.—: To establish reference intervals (RIs) and percentile charts for ALP activity in the Spanish population through a multicentric observational study and to compare the RIs to those defined in other countries.Design.—: A total of 662 350 ALP measurements from individuals ages 0 to 99 years from 9 Spanish tertiary care centers collected between 2020 and 2022 were analyzed. This study is the largest published on this topic in the literature to date.Results.—: Continuous percentile charts for ALP according to sex and age were established which can be used as RIs. Higher levels are reached during the first weeks of life. In puberty, a differential evolution is observed in both sexes, reaching a peak at 10 to 13 years of age in boys and remaining stable in girls at this age. Significant differences were also observed in adults, higher in men between ages 20 and 49 years and between ages 50 and 79 years in women, as reported in some countries.Conclusions.—: ALP activity follows an age- and sex-dependent fluctuation with geographic differences. It is important to have appropriate reference values for each population in order to allow for a correct diagnostic interpretation and early diagnosis of diseases related to ALP abnormalities.","PeriodicalId":93883,"journal":{"name":"Archives of pathology & laboratory medicine","volume":" ","pages":"e19-e25"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141155940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tissue Prior to the Initial Hematoxylin-Eosin Section Demonstrates Value as an Alternative Source of DNA for Molecular Testing. 在初始苏木精-伊红切片之前的组织证明了作为分子测试DNA的替代来源的价值。

Archives of pathology & laboratory medicine Pub Date : 2024-12-31 DOI: 10.5858/arpa.2024-0222-OA

Peter Sabatini, Robert Ta, Melanie Peralta, Melanie Anderson, Shehnaz Khan, Rosetta Belcastro, Andrea Arruda, Mark David Minden, Michael Cabanero, Anca Prica, Tong Zhang, Robert Kridel, Tracy Stockley, Daniel Xia

{"title":"Tissue Prior to the Initial Hematoxylin-Eosin Section Demonstrates Value as an Alternative Source of DNA for Molecular Testing.","authors":"Peter Sabatini, Robert Ta, Melanie Peralta, Melanie Anderson, Shehnaz Khan, Rosetta Belcastro, Andrea Arruda, Mark David Minden, Michael Cabanero, Anca Prica, Tong Zhang, Robert Kridel, Tracy Stockley, Daniel Xia","doi":"10.5858/arpa.2024-0222-OA","DOIUrl":"https://doi.org/10.5858/arpa.2024-0222-OA","url":null,"abstract":"Context.—: Small biopsies are used for histologic, immunophenotypic, cytogenetic, molecular genetic, and other ancillary studies. Occasionally, this diagnostic tissue is exhausted before molecular testing can be performed.Objective.—: To investigate a simple banking protocol for currently discarded tissues trimmed off prior to the initial hematoxylin-eosin section, as an alternative source of DNA for molecular studies.Design.—: Mock biopsies of lung adenocarcinomas, benign testes, and B-cell lymphomas were constructed from biobank blocks; these simulated biopsies were assessed via epidermal growth factor receptor (EGFR) p.L858R droplet digital polymerase chain reaction (PCR), Biomed B-cell clonality testing by PCR, or a custom next-generation sequencing panel for lymphomas. For each cancer mock biopsy, DNA amounts and molecular test results from the \"trimmings\" samples were compared to data from corresponding molecular samples acquired via a \"standard\" clinical protocol.Results.—: The data show that although trimmings samples usually contained less DNA than standard samples, both sample classes generally had sufficient DNA for testing and produced essentially identical molecular results. A single sample showed low-level carryover contamination on droplet digital PCR testing.Conclusions.—: Tissue trimmings banked by using the studied protocol demonstrated value as a potential alternative sample for molecular testing.","PeriodicalId":93883,"journal":{"name":"Archives of pathology & laboratory medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142960251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic Implications of the Bethesda System in Fine-Needle Aspiration for Follicular Thyroid Carcinoma. Bethesda系统细针穿刺治疗滤泡性甲状腺癌的预后意义。

Archives of pathology & laboratory medicine Pub Date : 2024-12-30 DOI: 10.5858/arpa.2024-0304-OA

Hyunju Park, Young Lyun Oh, Myoung Kyoung Kim, Soo Yeon Hahn, Jun-Ho Choe, Man Ki Chung, Bogyeong Han, Sun Wook Kim, Jae Hoon Chung, Tae Hyuk Kim

{"title":"Prognostic Implications of the Bethesda System in Fine-Needle Aspiration for Follicular Thyroid Carcinoma.","authors":"Hyunju Park, Young Lyun Oh, Myoung Kyoung Kim, Soo Yeon Hahn, Jun-Ho Choe, Man Ki Chung, Bogyeong Han, Sun Wook Kim, Jae Hoon Chung, Tae Hyuk Kim","doi":"10.5858/arpa.2024-0304-OA","DOIUrl":"https://doi.org/10.5858/arpa.2024-0304-OA","url":null,"abstract":"Context.—: Fine-needle aspiration is an effective tool for sampling thyroid nodules; its results are classified according to the Bethesda System for Reporting Thyroid Cytopathology (BSRTC), whose categories define malignancy risks.Objective.—: To compare the histologic outcomes and disease-free survival (DFS) with the preceding BSRTC categories, we hypothesized that the initial cytologic categories may reflect long-term outcomes in follicular thyroid carcinoma (FTC), similar to those observed in papillary thyroid carcinoma.Design.—: This retrospective study enrolled 134 patients with FTC who underwent preoperative cytology between April 2011 and December 2020. Results were classified into 6 categories according to the BSRTC: nondiagnostic, benign, atypia of uncertain significance (AUS), follicular neoplasm (FN), suspicious for malignancy, or malignant.Results.—: Overall, 8 of 134 patients (6.0%) were categorized as having a nondiagnostic FTC, 35 of 134 (26.1%) as benign, 51 of 134 (38.1%) as AUS, and 40 of 134 (29.9%) as FN. No lesions were classified as suspicious for malignancy or malignant. The nondiagnostic, AUS, and FN categories were associated with a progressively higher risk of vascular invasion, disease recurrence, and high-risk FTC, based on the 2022 World Health Organization classification (P for trend = .01, .01, and .01, respectively). Disease-free survival was lower in the FN group (log-rank P = .01).Conclusions.—: The initial BSRTC results may reflect not only the risk of malignancy but also the presence of vascular invasion and poor prognosis when the thyroid nodule is diagnosed as FTC. These results may provide prognostic information for therapeutic decision-making and clinical management of FTC.","PeriodicalId":93883,"journal":{"name":"Archives of pathology & laboratory medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142904308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Molecular Testing for Clonal Relatedness of Second Melanoma Tumors. 第二代黑色素瘤克隆相关性的临床分子检测。

Archives of pathology & laboratory medicine Pub Date : 2024-12-26 DOI: 10.5858/arpa.2024-0267-OA

Jaclyn M Plotzke, David Manthei, Douglas R Fullen, May P Chan, Scott C Bresler, Hong Xiao, Aleodor A Andea, Paul W Harms

{"title":"Clinical Molecular Testing for Clonal Relatedness of Second Melanoma Tumors.","authors":"Jaclyn M Plotzke, David Manthei, Douglas R Fullen, May P Chan, Scott C Bresler, Hong Xiao, Aleodor A Andea, Paul W Harms","doi":"10.5858/arpa.2024-0267-OA","DOIUrl":"https://doi.org/10.5858/arpa.2024-0267-OA","url":null,"abstract":"Context.—: Patients with melanoma can develop second tumors representing either metastases or new primary melanoma. This distinction has profound implications for management. Although clinicopathologic features are often sufficient, molecular assays can support the presence or absence of clonal relatedness in challenging cases. However, the potential for false-positive and false-negative results in this context is not well described.Objective.—: To evaluate clinical molecular assays used to determine whether melanoma tumors represent primary-metastasis pairs or unrelated tumors.Design.—: We identified clinical cases at our institution in which paired melanocytic tumors were analyzed for clonal relatedness by molecular assays. Results were compared against data sets and/or controls to establish the likelihood that paired tumors were clonally related.Results.—: In total, 12 pairs were evaluated by single-nucleotide polymorphism (SNP) array, targeted next-generation sequencing (NGS), or both. SNP array predicted relatedness in 5 of 9 cases and unrelatedness in 4 cases. In SNP comparisons, whole-chromosomal and arm-level changes were often nonspecific (coincidentally similar between unrelated tumors). Targeted NGS predicted relatedness in 2 of 4 cases and unrelatedness in 1 case, and was equivocal/noncontributory in 1 case. For targeted NGS, nonspecific (coincidentally similar) results were related to recurrent oncogenic drivers or pairs lacking detected oncogene mutations.Conclusions.—: The genome-wide analysis provided by SNP array was optimal for assessment of clonality. Targeted NGS can be informative but may be equivocal in some cases. The choice of assay may rely upon considerations including the amount of DNA, likelihood of distinctive mutations, and need for therapeutic target identification.","PeriodicalId":93883,"journal":{"name":"Archives of pathology & laboratory medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142901096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Online Portal Use of Pathology Reports in Patients With Solid Tumors. 实体肿瘤患者病理报告的在线门户使用。

Archives of pathology & laboratory medicine Pub Date : 2024-12-26 DOI: 10.5858/arpa.2024-0327-OA

Amber Y Bo, Yee Chung Cheng, Ben George, Deepak Kilari, Jonathan R Thompson, Julie M Jorns

{"title":"Online Portal Use of Pathology Reports in Patients With Solid Tumors.","authors":"Amber Y Bo, Yee Chung Cheng, Ben George, Deepak Kilari, Jonathan R Thompson, Julie M Jorns","doi":"10.5858/arpa.2024-0327-OA","DOIUrl":"https://doi.org/10.5858/arpa.2024-0327-OA","url":null,"abstract":"Context.—: Patients can now immediately review pathology reports via online health portals.Objective.—: To better characterize patient perceptions of pathology report helpfulness and preferences for access of pathology reports via a patient portal.Design.—: Semistructured interviews were conducted with oncology patients with breast, endocrine, gastrointestinal, genitourinary, and thoracic malignancies. Patient demographic information, cancer type, question responses, and thematically grouped comments were statistically analyzed.Results.—: Among 230 patients, there was equal sex distribution (116 of 230, 50.4% female; 114 of 230, 49.6% male). Patients who viewed or had a support member view their reports in the portal (172 of 230; 74.8%) differed from those who did not (58 of 230; 25.2%) only in perception of helpfulness (P < .001) of the report. Difficulty understanding medical terminology was the most frequently cited challenge among both those who found the reports helpful (30 of 160; 18.75%) and not helpful (31 of 46; 67.4%). Most patients (196 of 230; 85.2%) preferred immediate release of results, even if the news was bad, whereas some (34 of 230; 14.7%) would opt out of immediate release for fear of misunderstanding (11 of 34; 32.4%) or receiving distressing information from reading the report (23 of 34; 67.6%).Conclusions.—: Options for portal flexibility (ie, patient choice of opting for immediate release of some, but not all, results), patient-centered pathology reports, educational materials, clinician preparation of patients, and tailored patient support are strategies that can help more patients benefit from reviewing pathology report information.","PeriodicalId":93883,"journal":{"name":"Archives of pathology & laboratory medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142901097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Technical Competency Assessment of Peripheral Blood Smears: Tools and Trends Learned From 2 College of American Pathologists Q-Probes Studies. 外周血涂片的技术能力评估：从美国病理学家q探针研究学会的工具和趋势。

Archives of pathology & laboratory medicine Pub Date : 2024-12-24 DOI: 10.5858/arpa.2024-0259-CP

Jeffrey A Vos, Girish Venkataraman, Liuyan Jennifer Jiang, Barbara J Blond, Suzanne Coulter, Rhona J Souers

{"title":"Technical Competency Assessment of Peripheral Blood Smears: Tools and Trends Learned From 2 College of American Pathologists Q-Probes Studies.","authors":"Jeffrey A Vos, Girish Venkataraman, Liuyan Jennifer Jiang, Barbara J Blond, Suzanne Coulter, Rhona J Souers","doi":"10.5858/arpa.2024-0259-CP","DOIUrl":"https://doi.org/10.5858/arpa.2024-0259-CP","url":null,"abstract":"Context.—: Morphologic evaluation of peripheral blood smears provides valuable information to diagnose and manage a variety of hematologic disorders.Objective.—: To measure the competency of the technical staff in the morphologic evaluation of peripheral blood smears and provide performance trends.Design.—: Participating technologists accessed 10 whole slide-imaged peripheral blood smears through a web-based imaging tool in 2 separate studies. Participants performed a 100-cell differential and morphologic evaluation for each slide image. Grading criteria, determined by 3 hematopathologists, were weighted according to their clinical significance (score range, 0-100 for each case). Each institution and participant answered a questionnaire to assess the impact of current practices and educational programs on competency scores.Results.—: A total of 776 technologists from 92 institutions participated in study 1 and 1495 technologists from 179 institutions participated in study 2. Median performance scores for institutions were 78.9 and 87.6 for studies 1 and 2, respectively, encompassing a range of hematologic disorders. Based on results of the questionnaire for study 1, higher performance scores were seen when institutions required a specific number of continuing education credits per year through an agency (P = .005). In study 2, institutions with remediation procedures following a failed competency demonstrated higher performance scores (P = .03).Conclusions.—: Medical technologist competency of peripheral blood smears improves with level of experience and is positively impacted through attending educational programs. Whole slide images offer a convenient means of assessing technical competence and provide data to allow institutions to appropriately focus their procedures and educational efforts.","PeriodicalId":93883,"journal":{"name":"Archives of pathology & laboratory medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142883862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0