Acupuncture and herbal medicine最新文献

{"title":"Comprehensive profiling of Lingzhihuang capsule by liquid chromatography coupled with mass spectrometry-based molecular networking and target prediction","authors":"Mengliang Huang, Sijia Yu, Qing Shao, Hao Liu, Yingchao Wang, Hongzhang Chen, Yansheng Huang, Yi Wang","doi":"10.1097/HM9.0000000000000012","DOIUrl":"https://doi.org/10.1097/HM9.0000000000000012","url":null,"abstract":"Abstract Objective: Lingzhihuang capsule (LZHC) is a natural product that consists of 10 commonly used medicinal plants, and it is used in traditional Chinese medicine to promote people's overall health. Previously, LZHC was successfully used as adjuvant therapy for treating patients with cancer. However, the chemical constituents of LZHC and their potential biological functions remain unclear. The aim of this study is to investigate the major bioactive compounds in LZHC and predict their pharmacological targets. Methods: The LZHC constituents were putatively identified by ultra-high performance liquid chromatography coupled with time-of-flight mass spectrometry combined with mass spectrometry-based molecular networking. The targets were predicted using SwissTargetPrediction software, and the associated gene ontology and Kyoto encyclopedia of genes and genomes pathways were analyzed using the Database for Annotation, Visualization, and Integrated Discovery. The mass spectrometry-based molecular network and compound-target-pathway network were constructed using Cytoscape 3.8.0 software. Results: We putatively identified 94 compounds of LZHC by mass spectrometry-based molecular networking, including triterpene (the main structural type) and other clusters (ie, flavonoids and organic acids). Our results suggested that multiple pivotal targets were regulated by LZHC, including tumor necrosis factor, nitric oxide synthase 2, glucocorticoid receptor, estrogen receptor, 3-oxo-5-alpha-steroid 4-dehydrogenase 2, prostaglandin e2 receptor ep4 subtype, estrogen receptor beta, phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, mitogen-activated protein kinase 3, and rac-alpha serine, which are related to signal transduction, positive regulation of transcription from RNA polymerase II promoters, oxidation-reduction processes, inflammatory responses, and other biological processes. Functional annotation of those targets suggested that several signaling pathways may be regulated by LZHC, such as cancer-related proteoglycans, the PI3K-Akt-signaling pathway, and the cAMP-signaling pathway. Conclusions: Our findings reveal the chemical constituents of LZHC and provided scientific support for the efficacy of LZHC in terms of immune regulation, anti-aging, and tumor suppression. Graphical abstract: http://links.lww.com/AHM/A12","PeriodicalId":93856,"journal":{"name":"Acupuncture and herbal medicine","volume":"28 1","pages":"58 - 67"},"PeriodicalIF":0.0,"publicationDate":"2022-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74142487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Granulation process analysis technologies and potential applications in traditional Chinese medicine","authors":"Tongcan Cui, Yizhe Hou, Huimin Feng, S. Wu, Wen-long Li, Zheng Li","doi":"10.1097/HM9.0000000000000015","DOIUrl":"https://doi.org/10.1097/HM9.0000000000000015","url":null,"abstract":"Abstract Pharmaceutical production is changing from batch production to continuous production, during which granulation is one of the most important unit operations. The quality of mass-produced products is traditionally guaranteed by conducting off-line testing, which cannot meet the demand of continuous production for real-time monitoring of critical process parameters and critical quality attributes (CQAs) of the pharmaceutical granulation technology. Since the U.S. Food and Drug Administration proposed process analytical technology (PAT) in 2004, many PAT tools have been developed to monitor the granulation process and provide information regarding the granulation operation conditions and endpoint determination. In this article, we review the recent research and application of two PAT modes in the granulation process, namely, single CQA and multi-CQA PAT, with the aim to provide references for comprehensively improving the technological level of the pharmaceutical granulation process. Furthermore, the potential applications in traditional Chinese Medicine are discussed.","PeriodicalId":93856,"journal":{"name":"Acupuncture and herbal medicine","volume":"4 1","pages":"9 - 24"},"PeriodicalIF":0.0,"publicationDate":"2022-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81035547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An inspiration to the studies on mechanisms of acupuncture and moxibustion action derived from 2021 Nobel Prize in Physiology or Medicine","authors":"Yi Guo, Yong-ming Li, Tianle Xu, M. Zhu, Zhifang Xu, Baomin Dou, Yanwei Li, Zhihan Chen","doi":"10.1097/HM9.0000000000000023","DOIUrl":"https://doi.org/10.1097/HM9.0000000000000023","url":null,"abstract":"Abstract The editorial board of Acupuncture and Herbal Medicine recently convened an academic seminar with a focus on studies regarding the mechanisms mediating acupuncture efficacy and moxibustion action inspired by the 2021 Nobel Prize in Physiology or Medicine. Specifically, Professor Bailong Xiao introduced the Nobel Prize for research on the mechanically activated Piezo ion channel, evaluating the structure of the Piezo channel and its physiological and pathological functions, and proposed a possible role for the Piezo channel in acupuncture mechanical stimulation. Professor Michael Xi Zhu introduced the discovery of the transient receptor potential (TRP) family, reporting that the therapeutic effects of Chinese medicine and acupuncture may be achieved via the TRP family, and that information regarding associations between the meridian and lymphatic systems may have important research and medical value. In addition, Professor Tianle Xu reviewed the history of ion channel research, particularly the physiological and pharmacological effects of non-classical ion channels (eg, the acid sensing ion channel family) and pointed out that the characterization and neural circuits of acupuncture deqi manipulation are important for elucidating the mechanisms of acupuncture actions. Professor Yongming Li similarly proposed that the 2021 Nobel Prize may open the door to disclosing the histological basis of acupuncture and moxibustion and analyzing the main scientific concerns regarding the clinical translation of acupuncture and moxibustion from basic to translational research. Finally, Professor Yi Guo summarized the study progress of the acupoint microenvironment induced by acupuncture over the course of nearly 30 years and put forward the hypothesis that acupuncture may initiate the physical-chemical coupling network by activating ion channel receptors in acupoints via physical and mechanical stimulation. Therefore, we conclude that a primary achievement of the 2021 Nobel Prize in Physiology or Medicine is in helping interpret how acupuncture and moxibustion adjust homeostasis (ie, by activating mechanical and thermal sensation), which is conducive to validating and promoting the clinical efficacy of acupuncture modalities.","PeriodicalId":93856,"journal":{"name":"Acupuncture and herbal medicine","volume":"1 1","pages":"1 - 8"},"PeriodicalIF":0.0,"publicationDate":"2022-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78825131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and evaluation of Panax notoginseng saponins contained in an in situ pH-triggered gelling system for sustained ocular posterior segment drug delivery","authors":"Peng Lu, Renxing Wang, Y. Xing, Yanquan Gao, Qingqing Zhang, Bin Xing, Ying Zhang, Chang-hai Yu, Xinfu Cai, Q. Shang, D. Kebebe, Jiaxin Pi, Zhidong Liu","doi":"10.1097/HM9.0000000000000020","DOIUrl":"https://doi.org/10.1097/HM9.0000000000000020","url":null,"abstract":"Supplemental Digital Content is available in the text Abstract Objective: This study aimed to lay the foundation for the research on Panax notoginseng saponins (PNS) in pH-sensitive in situ gel and the development and improvement of related preparations. Methods: We used Carbopol®940, a commonly used pH-sensitive polymer, and the thickener hydroxypropyl methylcellulose (HPMC E4M) as an ophthalmic gel matrix to prepare an ophthalmic in situ gel of PNS. In addition, formula optimization was performed by assessing gelling capability with the results of in vitro release studies. In vitro (corneal permeation, rheological, and stability) and in vivo (ocular irritation and preliminary pharmacokinetics in the vitreous) studies were also performed. Results: The results demonstrated that the in situ gelling systems containing PNS showed a sustained release of the drug, making it an ideal ocular delivery system for improving posterior ocular bioavailability. Conclusions: This study lays the foundation for the research of PNS contained in an in situ pH-triggered gel as well as the development and improvement of related preparations. It concurrently traditional Chinese medicine with a contemporary in situ gelling approach to provide new directions for the treatment of posterior ocular diseases such as diabetic retinopathy.","PeriodicalId":93856,"journal":{"name":"Acupuncture and herbal medicine","volume":"27 1","pages":"107 - 121"},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83258945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The rationale behind the four major anti-coronavirus principles of Chinese herbal based on systems medicine.","authors":"Guanyuan Jin, Louis Lei Jin, Bonnie Xia Jin","doi":"10.1097/HM9.0000000000000019","DOIUrl":"10.1097/HM9.0000000000000019","url":null,"abstract":"<p><p>As the novel coronavirus disease 2019 (COVID-19) and its multi variants continue to rage into the second year of a global pandemic, many success stories of applying Chinese herbal medicine (CHM) to COVID-19 patients continue to emerge from China and other parts of the world. Herewith, the authors summarized those experiences from a systems medicine perspective and categorize the four major treatment principles: (1) focusing on eliminating toxins in the early stage of the disease, (2) tonifying the body against deficiency throughout the entire disease course, (3) treating affected lung and intestine simultaneously based on visceral interactions, and (4) and cooling the blood and removing blood stasis at the later stage. The rationale behind these principles is shown via a scientific interpretation. This is not only helpful in reducing the complexity of promoting the CHM applications to enhance anti-pandemic efficacy but also to ramp up the process of integrating traditional Chinese medicine with modern medical practices.</p>","PeriodicalId":93856,"journal":{"name":"Acupuncture and herbal medicine","volume":"1 2","pages":"90-98"},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f6/c5/hm9-1-90.PMC9373908.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41159852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcome measures in clinical trials of traditional Chinese medicine for stable angina pectoris","authors":"D. Xing, Mingjun Zhu, Chunxiang Liu, Hui Wang","doi":"10.1097/HM9.0000000000000014","DOIUrl":"https://doi.org/10.1097/HM9.0000000000000014","url":null,"abstract":"Abstract Objective: This work aimed to present a descriptive analysis of the outcome measures used in clinical trials of traditional Chinese medicine (TCM) for patients with stable angina pectoris, and to provide baseline data for the development of core outcome sets (COSs) for relevant clinical trials. Methods: Medical databases were searched to identify randomized trials of the effects of TCM for the treatment of stable angina pectoris. Outcome measures of each trial were extracted. Descriptive statistics were used to analyze the baseline characteristics of outcomes in clinical trials of TCM. Results: 94 randomized trials (with 9,111 participants) involving 79 different outcomes were identified. The mean number of outcomes was 5 (1–21 per trial). The 5 most commonly reported outcomes were efficacy rate of electrocardiogram, efficacy rate of angina pectoris, efficacy rate of TCM syndrome, fasting lipid indices, and withdrawal rate of nitroglycerin. Several challenges were identified: (1) significant heterogeneity of outcomes and differences in the technique and timing of the measurement of the same outcome; (2) transformation of continuous data into categorical data and presented as such in >90% of trials; (3) few trials on the outcomes associated with the advantages and characteristics of TCM; and (4) selective reporting of outcomes. Conclusions: The outcomes used are excessively heterogenous, and the choice of some outcomes (timing and techniques) for measurement is confusing or inappropriate. Hence, developing and implementing a COS is necessary for greater consistency.","PeriodicalId":93856,"journal":{"name":"Acupuncture and herbal medicine","volume":"13 1","pages":"99 - 106"},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74842766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trigger points and sensitized acupoints: same book, different covers?","authors":"Mingsheng Sun, Mingxiao Yang, Jing Rong, Xingsha Ma, Hui Zheng, Dingjun Cai, Ling Zhao, F. Liang","doi":"10.1097/hm9.0000000000000018","DOIUrl":"https://doi.org/10.1097/hm9.0000000000000018","url":null,"abstract":"","PeriodicalId":93856,"journal":{"name":"Acupuncture and herbal medicine","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73373450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupuncture – a national heritage of China to the world: international clinical research advances from the past decade","authors":"Baoyan Liu, Bo Chen, Yi Guo, Lixin Tian","doi":"10.1097/hm9.0000000000000017","DOIUrl":"https://doi.org/10.1097/hm9.0000000000000017","url":null,"abstract":"","PeriodicalId":93856,"journal":{"name":"Acupuncture and herbal medicine","volume":"301 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77185409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The inhibitory effect of lotus leaf extract on hyperuricemia and its potential mechanism","authors":"Yating An, Jia Hao, Jian Li, Wei He, Lei Wang, Yi Zhang","doi":"10.1097/HM9.0000000000000001","DOIUrl":"https://doi.org/10.1097/HM9.0000000000000001","url":null,"abstract":"Abstract Objective: Lotus leaf is a traditional Chinese herb that has been used successfully for centuries for relieving edema by inducing diuresis. Based on its good clinical evidence and anti-hypertensive effectiveness, this study aimed to investigate the potential mechanism of the hyperuricemic inhibitory effects of lotus leaf crude extract (LL) and lotus leaf total alkaloids fraction (LA). Methods: The xanthine oxidase (XOD) inhibitory effect of LL and LA was analyzed in vitro by determining mRNA expression and protein expression levels of hepatic XOD. The hyperuricemic inhibitory effect of the lotus leaf was analyzed in vivo in a potassium oxonate (PO)-induced rat model by determining mRNA expression for renal urate transporters. Results: At a concentration of 40 μg/mL, LL and LA suppressed XOD enzymatic activity by 37.35% ± 9.50% and 47.73% ± 8.32%, respectively. Both LL and LA administration significantly reduced the concentration of uric acid in the serum and liver of PO-induced hyperuricemic rats. Both LL and LA administration could inhibit XOD mRNA and protein expression, activate renal organic anion transporter 1/3 mRNA expression, and inhibit renal urate reabsorption by decreasing renal GLUT9 and renal urate transporter 1. Conclusions: Insight was gained into the mechanism behind the hyperuricemic inhibitory effects of LL and LA. Our results suggest that they act on two targets: decreasing the production of uric acid by inhibiting mRNA and protein expression of XOD in the liver, and regulating the mRNA expression of renal urate transporters in the kidneys.","PeriodicalId":93856,"journal":{"name":"Acupuncture and herbal medicine","volume":"5 1","pages":"122 - 129"},"PeriodicalIF":0.0,"publicationDate":"2021-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82973152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carbon quantum dot preparation and application to detecting active ingredients in traditional Chinese medicine","authors":"Bo Liu, Shangxin Guo, Xiaohui Fan, Xingchu Gong","doi":"10.1097/hm9.0000000000000002","DOIUrl":"https://doi.org/10.1097/hm9.0000000000000002","url":null,"abstract":"","PeriodicalId":93856,"journal":{"name":"Acupuncture and herbal medicine","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76957868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}