Acta neurologica Taiwanica最新文献_第7页

Unusual Manifestation of Bilateral Meralgia Paresthetica Following Laparoscopic Appendectomy: A Case Report. 腹腔镜阑尾切除术后双侧感觉异常痛的异常表现1例。

Acta neurologica Taiwanica Pub Date : 2025-07-01 Epub Date: 2025-09-29 DOI: 10.4103/ANT.ANT_113_0012

Sunny Chou, Poyin Huang

引用次数: 0

Seronegative but Cerebrospinal Fluid-positive NMDA Receptor Encephalitis in an Alzheimer's Dementia Patient with Good Treatment Outcome: A Case Report. 血清阴性但脑脊液阳性的NMDA受体脑炎在阿尔茨海默氏痴呆患者中治疗效果良好：1例报告

Acta neurologica Taiwanica Pub Date : 2025-07-01 Epub Date: 2025-09-29 DOI: 10.4103/ANT.ANT_113_0041

Yu-Chung Lee, Yi-Cheng Tai

{"title":"Seronegative but Cerebrospinal Fluid-positive NMDA Receptor Encephalitis in an Alzheimer's Dementia Patient with Good Treatment Outcome: A Case Report.","authors":"Yu-Chung Lee, Yi-Cheng Tai","doi":"10.4103/ANT.ANT_113_0041","DOIUrl":"10.4103/ANT.ANT_113_0041","url":null,"abstract":"We present a rare case of elderly-onset anti-N-methyl-D-aspartate (NMDA) receptor encephalitis combined with underlying Alzheimer dementia, characterized by seronegativity but cerebrospinal fluid (CSF) antibody positivity, which showed a significant improvement following intravenous immunoglobulin (IVIG) treatment. The case highlights serial electroencephalogram (EEG) changes. We focus the discussion on factors contributing to favorable recovery. A 78-year-old woman with Alzheimer's dementia and hypertension experienced rapid onset of further cognitive decline over 1 week, presenting with disorientation, irrelevant speech, and disorganized behaviors. Myoclonus of both upper limbs and focal seizures 10 days later which lead her into intensive care unit (ICU) admission. Test results revealed positive anti-NMDA antibodies in CSF but negative in serum. Serial electroencephalograms (EEG) exhibited extreme delta brush activity transitioning to excess beta activity. Initial treatment with a 5-day course of steroid pulse therapy showed limited efficacy. Subsequently, 5 days of IVIG therapy provided marked improvement in consciousness and cognitive function and also normalized the EEG. This patient presented with severe neurological dysfunction, the need for ICU management, and presence of extreme delta brush EEG pattern. Generally, the prognosis was unfavorable. However, advanced age onset and anti-NMDA antibody positivity in CSF with seronegativity in serum may imply better prognosis. Thus, testing anti-NMDA receptor antibody in both serum and CSF is mandatory and under this complicated situation, timely immunotherapy may be the influencing factors of good prognosis.","PeriodicalId":93852,"journal":{"name":"Acta neurologica Taiwanica","volume":"34 3","pages":"161-164"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145187905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stroke after Erysipelothrix Rhusiopathiae Endocarditis: A Case Report. 红唇丹毒心内膜炎并发脑卒中1例。

Acta neurologica Taiwanica Pub Date : 2025-07-01 Epub Date: 2025-07-05 DOI: 10.4103/ANT.ANT_113_0021

Arthur de Oliveira Veras, Ícaro Araújo de Sousa, Manoella Guerra de Albuquerque Bueno, Ellen Riedi Oliveira, Frederico Fernandes Alessio-Alves, Octávio Marques Pontes-Neto

{"title":"Stroke after Erysipelothrix Rhusiopathiae Endocarditis: A Case Report.","authors":"Arthur de Oliveira Veras, Ícaro Araújo de Sousa, Manoella Guerra de Albuquerque Bueno, Ellen Riedi Oliveira, Frederico Fernandes Alessio-Alves, Octávio Marques Pontes-Neto","doi":"10.4103/ANT.ANT_113_0021","DOIUrl":"10.4103/ANT.ANT_113_0021","url":null,"abstract":"Erysipelothrix rhusiopathiae is a rare cause of infective endocarditis (IE). This study aims to report the fifth known case of intracranial manifestation resulting from E. rhusiopathiae endocarditis. Moreover, we aim to address the main epidemiological and clinical aspects associated with this issue. A 62-year-old retired bird breeder presented with left-sided appendicular ataxia and hemiparesis. Diagnostic tests revealed endocarditis caused by E. rhusiopathiae . He received a 6-week antibiotic course, including ampicillin, which resulted in neurological and cardiac improvement. Follow-ups demonstrated no recurrence, and he was discharged from both neurology and cardiology 1 year later. The low virulence of the E. rhusiopathiae pathogen explains the minimal frequency of intracranial manifestations associated with the infection. However, patient's overall condition is a decisive factor in this context. This is the first reported case concerning presumed transmission by birds. Physical manifestations are more commonly found in IE involving the mitral valve compared to the aortic and tricuspid valves. Even with appropriate treatment, mortality from endocarditis associated with E. rhusiopathiae can exceed 38%. Furthermore, IE by this microorganism often causes extensive valve damage. The positive outcome of this case emphasizes the significance of prompt recognition and appropriate management. This report highlights the need for clinical awareness regarding E. rhusiopathiae as an etiological agent for IE and its potential complications, including stroke.","PeriodicalId":93852,"journal":{"name":"Acta neurologica Taiwanica","volume":" ","pages":"165-169"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144577181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vertebral Artery Dissection Following COVID-19 Infection. COVID-19感染后椎动脉夹层。

Acta neurologica Taiwanica Pub Date : 2025-07-01 Epub Date: 2025-09-29 DOI: 10.4103/ANT.ANT_113_0055

Hsin-Wei Wu, Chia-Hung Wu, Feng-Chi Chang

引用次数: 0

Middle Cerebral Artery Dissection after AstraZeneca COVID-19 Vaccination. 阿斯利康COVID-19疫苗接种后的大脑中动脉夹层。

Acta neurologica Taiwanica Pub Date : 2025-04-01 Epub Date: 2025-05-29 DOI: 10.4103/ANT.ANT_113_0031

Hsin-Wei Wu, Chia-Hung Wu, Chung-Han Yang, Te-Ming Lin, Kai-Wei Yu, Feng-Chi Chang

引用次数: 0

Ischemic Stroke Due to Septic Emboli in a 78-Year-Old Man With Portal Vein Thrombosis. 78岁男性门静脉血栓化脓性栓子致缺血性卒中一例。

Acta neurologica Taiwanica Pub Date : 2025-04-01 Epub Date: 2025-05-20 DOI: 10.4103/ANT.ANT_112_0103

Cheng-Pang Tsai, Pei-Hao Chen, Chih-Po Chang

引用次数: 0

Recent Advancement of Neurofibromatosis Type 1: A Narrative Review. 1型神经纤维瘤病的最新进展：述评。

Acta neurologica Taiwanica Pub Date : 2025-04-01 Epub Date: 2025-05-23 DOI: 10.4103/ant.ANT-D-24-00042

Po-Yuan Huang, Ming-Jen Lee

{"title":"Recent Advancement of Neurofibromatosis Type 1: A Narrative Review.","authors":"Po-Yuan Huang, Ming-Jen Lee","doi":"10.4103/ant.ANT-D-24-00042","DOIUrl":"10.4103/ant.ANT-D-24-00042","url":null,"abstract":"Abstract: Neurofibromatosis type 1 (NF1) is a complex autosomal dominant genetic disorder caused by mutations in the NF1 gene on chromosome 17, which encodes the tumor-suppressor protein, neurofibromin. Neurofibromin plays a critical role in regulating the RAS signaling pathway, and its loss leads to uncontrolled cell proliferation and tumor development. Clinically, NF1 presents with variable manifestations, including café-au-lait spots, neurofibromas, optic gliomas, skeletal abnormalities, and cognitive deficits. The updated diagnostic criteria now incorporate genetic testing and choroidal anomalies, facilitating earlier and more accurate diagnoses. Recent molecular insights have revealed that neurofibromin interacts with multiple cellular pathways, contributing to diverse clinical presentations such as plexiform neurofibromas, which may transform into malignant peripheral nerve sheath tumors, and developmental issues such as scoliosis and learning disabilities. Current therapeutic approaches focus on targeting specific signaling molecules involved in tumorigenesis. This review aims to summarize the recent findings on the clinical features, molecular mechanisms, and potential treatments of NF1, offering a comprehensive understanding of the disorder's complexities and highlighting future research directions.","PeriodicalId":93852,"journal":{"name":"Acta neurologica Taiwanica","volume":" ","pages":"64-75"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144129737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute Cauda Equina Syndrome Following Spinal Anesthesia During Cesarean Section: A Case Report. 剖宫产术中脊髓麻醉后急性马尾综合征1例报告。

Acta neurologica Taiwanica Pub Date : 2025-04-01 Epub Date: 2025-05-16 DOI: 10.4103/ANT.ANT_113_0032

Shin-Rung Tsai, Wei-Hao Lin

{"title":"Acute Cauda Equina Syndrome Following Spinal Anesthesia During Cesarean Section: A Case Report.","authors":"Shin-Rung Tsai, Wei-Hao Lin","doi":"10.4103/ANT.ANT_113_0032","DOIUrl":"https://doi.org/10.4103/ANT.ANT_113_0032","url":null,"abstract":"Abstract: This case report aims to discuss the prompt recognition and the possible mechanism of acute cauda equina syndrome (CES) following intrathecal bupivacaine administration for cesarean section. A 30-year-old primigravida developed sudden-onset bilateral lower-extremity weakness, numbness, and paresthesia, along with urinary and bowel incontinence, after an uncomplicated cesarean delivery under spinal anesthesia. Magnetic resonance imaging revealed engorgement and gadolinium enhancement of the cauda equina nerve roots, consistent with a diagnosis of CES. The patient was immediately started on high-dose intravenous steroids and intrathecal triamcinolone, followed by intensive inpatient rehabilitation. However, despite maximal medical treatment, the patient exhibited only minimal improvement, with persistent neurological deficits and dysfunction. This case highlights the importance of maintaining a high index of suspicion for CES following intrathecal bupivacaine administration and the need for prompt recognition and multidisciplinary management to optimize maternal outcomes. Understanding the potential mechanisms underlying bupivacaine-induced neurotoxicity, including direct nerve toxicity, vascular changes, and synergistic effects, may guide the development of targeted therapeutic strategies to mitigate this devastating complication. Early spinal imaging, high-dose steroid therapy, and a collaborative approach involving obstetrics, anesthesiology, neurology, and rehabilitation services are crucial for the successful management of acute CES.","PeriodicalId":93852,"journal":{"name":"Acta neurologica Taiwanica","volume":"34 2","pages":"98-101"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144236209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intracranial Atypical Cartilaginous Tumor (Low-grade Chondrosarcoma) Involving Temporal Bone, Clivus, Sphenoclival Synchondrosis, and Cavernous Sinus: A Rare Case Report. 颅内非典型软骨肿瘤（低级别软骨肉瘤）累及颞骨、斜坡、蝶巩膜软骨联合及海绵窦：罕见病例报告。

Acta neurologica Taiwanica Pub Date : 2025-04-01 Epub Date: 2025-05-23 DOI: 10.4103/ANT.ANT_113_0024

Marsal Risfandi, Celia Celia, Robert Shen, Andre Marolop Pangihutan Siahaan, Adeodata Lily Wibisono

{"title":"Intracranial Atypical Cartilaginous Tumor (Low-grade Chondrosarcoma) Involving Temporal Bone, Clivus, Sphenoclival Synchondrosis, and Cavernous Sinus: A Rare Case Report.","authors":"Marsal Risfandi, Celia Celia, Robert Shen, Andre Marolop Pangihutan Siahaan, Adeodata Lily Wibisono","doi":"10.4103/ANT.ANT_113_0024","DOIUrl":"10.4103/ANT.ANT_113_0024","url":null,"abstract":"Abstract: Intracranial atypical cartilaginous tumors (ACTs) or low-grade chondrosarcoma are rare among all skull base and intracranial tumors. Late diagnosis leads to higher morbidity and worsened neurological deficits caused by neurovascular compression. Intracranial ACTs have a higher mortality rate than other ACTs due to their location, difficulty of surgical management, local invasiveness, and recurrence rate. This report aims to highlight the challenges of diagnosing and managing intracranial ACTs, which can present with symptoms mimicking other cranial base tumors. It also aims to raise awareness about the possibility of misdiagnosis, which can lead to futile pharmacological treatment. To the best of the authors' knowledge, no published cases of intracranial ACTs from Indonesia have been reported. A 43-year-old female with complaints of chronic left facial numbness and paralysis, diplopia, tinnitus, and posture and exertion-related headache with worsening symptoms for the last 2 months, especially after waking up in the morning, with a disturbance of the left cranial nerves V-2, V-3, VI, VII, and VIII. The patient had been receiving symptomatic treatment repeatedly with several differential diagnoses for one-prior-year due to an underdiagnosis. Magnetic resonance imaging showed a mass with bone destruction located on the left temporal bone involving sphenoclival synchondrosis, clivus, and cavernous sinus with a ring-and-arch-forming calcification with the lytic pattern. After total gross resection, the diagnosis of ACTs was confirmed by a histopathological specimen that shows an abundant lobulated mass composed of uniform hyaline cartilage matrix, increased cellularity, and myxoid changes. Continuous follow-up is necessary because ACTs have a mild recurrence rate despite a high postsurgical survival rate.","PeriodicalId":93852,"journal":{"name":"Acta neurologica Taiwanica","volume":" ","pages":"93-97"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144129731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Subacute Subdural Hematoma Following Ventriculoperitoneal Shunt Procedure: A Case Report. 脑室腹腔分流术后亚急性硬膜下血肿1例报告。

Acta neurologica Taiwanica Pub Date : 2025-04-01 Epub Date: 2025-05-29 DOI: 10.4103/ANT.ANT_113_0015

Rizaldy Taslim Pinzon, Nunki Puspita Utomo

{"title":"Subacute Subdural Hematoma Following Ventriculoperitoneal Shunt Procedure: A Case Report.","authors":"Rizaldy Taslim Pinzon, Nunki Puspita Utomo","doi":"10.4103/ANT.ANT_113_0015","DOIUrl":"10.4103/ANT.ANT_113_0015","url":null,"abstract":"Abstract: The ventriculoperitoneal shunt (VPS) procedure is known to be a risk factor for subdural hematoma (SDH), although it is uncommon. The development after possible cerebrospinal fluid overdrainage and stretching of bridging veins facilitates the further expansion of the hematoma, thus provoking intracranial symptoms and often necessitates surgical treatment. However, in the case of complications, the incidence of SDH post-VPS insertion is not well documented, especially in Indonesia. We reported a case of a 59-year-old previously healthy Indonesian male with sudden right-side extremity weakness and dysarthria 2 months post-VPS procedure as the treatment for long-standing overt ventriculomegaly in adults. History of head trauma and oral anticoagulant consumption was denied. As his mental state deteriorated, he also presented with a high fever; therefore, suspicion of cerebritis was raised and was later confirmed to be subacute SDH after a second radiology scan, prompting further surgical intervention. Burr-hole drainage was done, and the patient was discharged from the hospital with a favorable outcome. This case demonstrated that subdural accumulation of the blood may occur following VPS insertion, most likely caused by a sudden pressure release following the procedure. The near-misdiagnosis of subacute SDH proves a challenging diagnosis in such an underreported case.","PeriodicalId":93852,"journal":{"name":"Acta neurologica Taiwanica","volume":" ","pages":"113-117"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144176240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0