Acta biomaterialia最新文献

{"title":"Metformin-loaded multi-enzymatic metal-organic framework nanozyme mediates metabolic reprogramming via multiple energy blockades to boost tumor immunotherapy.","authors":"Longyue He, Tiemin Li, Liye Wang, Wei Wang, Linna Chang, Zhou Shen, Lining Zhao, Xiaoping Yin, Leyong Zeng","doi":"10.1016/j.actbio.2026.10.014","DOIUrl":"10.1016/j.actbio.2026.10.014","url":null,"abstract":"<p><p>Glycolytic metabolism of tumor cells suppresses the activity of immune cells, and multiple blocking energy supply and remodeling the metabolic microenvironment are important strategies to enhance immunotherapy. Using manganese-doped porphyrin metal-organic framework (MOF) as a carrier, by depositing ultrasmall Au nanoparticle (AuNPs), loading metformin (MET) and coating polydopamine (PDA), an integrated MOF@Au/MET@PDA nanozyme with multi-enzyme activity was constructed for enhancing antitumor immunotherapy. MOF@Au/MET@PDA nanozyme possessed glutathione peroxidase/glucose oxidase/peroxidase/catalase-like activity, by which the reactive oxygen species generation was greatly enhanced, and the mitochondrial function was damaged. Moreover, by consuming glucose and inhibiting the synthesis of adenosine triphosphate, the MOF@Au/MET@PDA nanozyme effectively blocked the energy supply and hindered glycolysis. Furthermore, the MOF@Au/MET@PDA nanozyme up-regulated the Caspase 3/7 level and down-regulated the expression of programmed death ligand-1, by which the apoptosis was induced and the immunogenic cell death was triggered. Under the combined immunotherapy, the immune response was activated, and the primary and metastatic tumors were greatly inhibited, proving the strong immune effect of MOF@Au/MET@PDA nanozyme. STATEMENT OF SIGNIFICANCE: Tumor metabolic plasticity undermines the efficacy of single-pathway immunotherapy. In this work, a multi-enzymatic MOF@Au/MET@PDA nanozyme is engineered to mediate metabolic reprogramming by blocking energy supply through glucose depletion and suppression of glycolysis/oxidative phosphorylation. It amplifies oxidative stress, triggers ICD, down-regulates PD-L1, and remodels the immunosuppressive microenvironment. This nanozyme effectively inhibits primary breast tumors and lung metastasis, providing a metabolic-reprogramming strategy to boost tumor immunotherapy.</p>","PeriodicalId":93848,"journal":{"name":"Acta biomaterialia","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149148796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acid-degradable hollow calcium-manganese nanocarriers integrate calcium stress, redox catalysis, and antitumor immunity for lung cancer therapy.","authors":"Wei Liu, Maopeng Yang, Fengjiao Wang, Hongtao Yin, Shuyi Zhai, Fucheng Zhou, Qiang Gao, Jinrui He, Yanbin Zhao, Jinfeng Ning","doi":"10.1016/j.actbio.2026.10.015","DOIUrl":"10.1016/j.actbio.2026.10.015","url":null,"abstract":"<p><p>Non-small cell lung cancer (NSCLC) remains a major cause of cancer-related mortality, while acquired resistance to EGFR-targeted therapy and an immunosuppressive tumor microenvironment continue to limit therapeutic efficacy. Here, we developed a tumor cell membrane-coated, acid-degradable hollow calcium-manganese nanoplatform loaded with gefitinib (CM@HCC-Mn/Gef) for combined redox modulation and antitumor immune activation. Under acidic and redox-active conditions, CM@HCC-Mn/Gef released gefitinib, Ca²⁺, and Mn²⁺, leading to intracellular Ca²⁺ accumulation, mitochondrial depolarization, ATP depletion, reactive oxygen species generation, glutathione consumption, GPX4 downregulation, and lipid peroxidation. These coordinated effects induced ferroptosis-associated oxidative damage and immunogenic cell death (ICD), characterized by cell-surface calreticulin exposure and HMGB1 redistribution, and subsequently promoted dendritic cell maturation and T-cell activation. In gefitinib-resistant NSCLC cells, CM@HCC-Mn/Gef produced substantially greater cytotoxicity than free gefitinib, indicating that multimechanistic stress amplification enhanced the therapeutic response of resistant tumor cells. In immunocompetent syngeneic LLC tumor models, the nanoplatform inhibited primary tumor growth, increased tumor-infiltrating T cells, alleviated immunosuppressive features of the tumor microenvironment, and delayed contralateral secondary tumor progression. Combination with anti-PD-1 further enhanced tumor suppression and systemic immune activation. Collectively, CM@HCC-Mn/Gef integrates targeted drug delivery, calcium-associated mitochondrial stress, redox disruption, ferroptosis-associated damage, and immune activation, providing a biomimetic nanotherapeutic strategy for NSCLC chemoimmunotherapy. STATEMENT OF SIGNIFICANCE: Conventional nanocarriers often provide drug delivery without coordinating multiple tumor-specific stresses and immune activation. This study introduces a tumor cell membrane-coated, acid-degradable hollow calcium-manganese nanoplatform that co-releases gefitinib, Ca²⁺, and Mn²⁺ in the tumor microenvironment. The material couples calcium-associated mitochondrial dysfunction with manganese-driven redox catalysis, thereby enhancing oxidative damage, lipid peroxidation, and immunogenic cell death-associated responses. It also improves tumor accumulation, promotes dendritic cell maturation and T-cell activation, and enhances anti-PD-1 therapy in immunocompetent lung cancer models. This work establishes a direct link between biomaterial composition, stimulus-responsive degradation, catalytic function, and antitumor immunity, offering a versatile design strategy for biomaterials-enabled chemoimmunotherapy.</p>","PeriodicalId":93848,"journal":{"name":"Acta biomaterialia","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149149138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial induction of mitochondrial calcification as a trigger for cancer immunotherapy.","authors":"Kaixin Zhang, Hanhui Li, Zhuoxin Wang, Hongkun Wu, Li Shi, Qingqing Feng, Hongye Guan, Ben Wang","doi":"10.1016/j.actbio.2026.10.016","DOIUrl":"10.1016/j.actbio.2026.10.016","url":null,"abstract":"<p><p>Tumor calcification shows promise as a clinical predictor of tumor response and often involves mitochondrial calcification, which provides mineral precursors for extracellular deposition. However, the methods available for regulating mitochondrial calcification in tumor calcification therapy are limited. Herein, we designed and synthesized (4-carboxybutyl) triphenylphosphonium bromide (CTPP)-functionalized calcium peroxide (CaO₂) nanoparticles (CTPP/CaO₂) to achieve selective induction of mitochondrial calcification in hepatocellular carcinoma cells. The CTPP/CaO₂-induced mitochondrial calcification sustains elevated intracellular calcium ion (Ca²⁺) and reactive oxygen species (ROS), exacerbates mitochondrial dysfunction, and triggers tumor cell death via pyroptosis. Pyroptosis further promotes the release of intracellular contents and exposure of calreticulin on the cell membrane, effectively activating the antitumor immune response in vivo. This mitochondrial calcification strategy integrates direct killing of tumor cells with subsequent activation of the antitumor immune response, thus providing a promising approach for engineering mitochondrial calcification with potential applications in cancer therapy. STATEMENT OF SIGNIFICANCE: Tumor calcification is a promising anticancer therapeutic strategy, but most existing methodologies are confined to non-specific extracellular mineralization with unsatisfactory targeting precision. We herein report a mitochondria-targeted nanoplatform that selectively initiates mitochondrial calcification against hepatocellular carcinoma. The resultant mitochondrial impairment and persistent ROS overproduction drive tumor pyroptosis, enabling direct tumor ablation and robust antitumor immune activation. Meanwhile, in situ tumor calcification augments CT/MR imaging contrast. This mitochondria-targeted calcification strategy achieves integrated theranostics and provides a potential strategy for refractory solid malignancies.</p>","PeriodicalId":93848,"journal":{"name":"Acta biomaterialia","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149148662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiscale Meniscus Mechanics under Unconfined Compression: Composite Fibril-Reinforced Biphasic Modeling across Infinitesimal to Physiological Cumulative Strain Regimes.","authors":"Sayed Shahabodin Hashemi, Manijhe Mokhtari-Dizaji, Jose Luis Martin-Rodriguez","doi":"10.1016/j.actbio.2026.10.012","DOIUrl":"https://doi.org/10.1016/j.actbio.2026.10.012","url":null,"abstract":"&lt;p&gt;&lt;p&gt;To investigate the mechanical roles of proteoglycan aggregates, interstitial fluid, and the collagen fibrillar network in meniscal mechanics, we developed and experimentally validated a composite fibril-reinforced biphasic (CFRB) model based on a heterogeneous and anisotropic structural description of the meniscus and tested whether shear wave elastography (SWE) could independently reflect matrix‑dominated and fibril‑engaged behavior. Focusing on the pars intermedia, 21+12+(6 × 5) disc specimens underwent unconfined compression across cumulative strains extending into the nonlinear regime to identify model parameters and evaluate strain-rate effects, pressurization, and interstitial fluid transport. Within classical fibril-reinforced poroelastic (FRB) theory, the equally distributed collagen fibrillar network across three orthogonal directions corresponded to linear progressive fibrillar recruitment, while dynamic stiffness amplitude exhibited heterogeneous yet systematically evolving behavior consistent with interstitial fluid transport and pressurization. With nonlinear fibrillar reinforcement, the FRB model showed substantial errors in fibril modulus, whereas the CFRB framework, incorporating frequency-time circular poroelastic analysis, identified lateral strain, biphasic parameters, and mechanical-regime thresholds, and captured the experimental curves and strain heterogeneity. These findings were supported by inverse analysis, finite element methods, meniscal tensile mechanics, and SWE measurements in the plane perpendicular to loading. Increasing strain rate increased the elastic fraction and enabled derivation of pressurization convergence equations, whereas the equilibrium modulus showed no significant rate dependence, consistent with matrix-deformation estimates from the normalized threshold curve and corresponding SWE measurements; this range is proposed as a mechanical regime suitable for evaluation of matrix-related degeneration and elastographic assessment. This framework stratifies cumulative strain, decodes elastography into matrix versus fibril responses, and advances meniscal constitutive modeling toward clinical translation. STATEMENT OF SIGNIFICANCE: Quantifying solid-phase moduli, lateral strain evolution, nonlinear fibril-recruitment thresholds, and permeability parameters can provide insights into the mechanics of porous menisci. Here, Hashemi S.S. et al. introduce a composite fibril-reinforced biphasic (CFRB) framework with poroelastic transformation equations that quantitatively resolves matrix- and fibril-dominated mechanical regimes across cumulative compressive strains from infinitesimal to physiological levels. The framework quantitatively resolved matrix and fibrillar contributions within the matrix-dominated regime, revealing that fibrillar reinforcement also modulated the matrix-deformation response, potentially contributing to anisotropic behavior. The low-strain regime provides a mechanically meaningful ran","PeriodicalId":93848,"journal":{"name":"Acta biomaterialia","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149149523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effective treatment of orthotopic liver cancer with bifunctional embolization microspheres.","authors":"Baoqu Zhang, Jianke Li, Jianmin Zhao, Yanwu Peng, Perumal Ramesh Kannan, Han Zhang, Xiangdong Kong, Rui Tang, Ruibo Zhao","doi":"10.1016/j.actbio.2026.10.017","DOIUrl":"10.1016/j.actbio.2026.10.017","url":null,"abstract":"<p><p>Transcatheter arterial chemoembolization (TACE) is a minimally invasive procedure used widely for the treatment of unresectable hepatocellular carcinoma (HCC). However, embolization-induced hypoxia upregulates VEGF, and the resulting angiogenic response contributes to tumor recurrence, further limiting the efficacy of TACE against HCC. Herein, we present a multifunctional embolic microsphere system in which sorafenib (SRF) and calcium carbonate (CaCO₃) nanoparticles are rationally encapsulated within sodium hyaluronate microspheres (SRF-CaCO₃@SH MSs) via microfluidic technology. The microspheres exhibited a bowl-shaped morphology with tunable diameters, which enhances in vivo embolic stability through mechanical interlocking between adjacent microspheres. In an acidic tumor microenvironment (TME), pH-triggered release of Ca²⁺ (23.9%) and SRF (65.7%) far exceeded neutral conditions. SRF-CaCO₃@SH MSs maintained >85% HUVEC viability and reduced VX2 cell viability to 24.3%, showing maximal cytotoxicity under acidic conditions. After intra-arterial injection, the microspheres occluded tumor-feeding arteries; Ca²⁺ released in the acidic TME inhibited angiogenesis, and CaCO₃ neutralized TME acidity, counteracting immunosuppression. In a rabbit VX2 orthotopic HCC model, DSA-guided TACE achieved effective occlusion, slowest tumor growth, largest necrosis, and marked downregulation of CD31, Ki67, and VEGF, without systemic toxicity. Combining morphological design, pH-responsive occlusion, TME neutralization, and anti-angiogenesis, this embolic system synergistically enhances TACE and shows strong clinical potential. STATEMENT OF SIGNIFICANCE: Conventional liver cancer embolization frequently fails due to hypoxia-driven angiogenesis and subsequent tumor recurrence. We developed a dual-functional embolic microsphere (SRF-CaCO₃@SH MS) that integrates stable vascular occlusion with active modulation of the tumor microenvironment. Utilizing microfluidics, we fabricated bowl-shaped sodium hyaluronate microspheres that mechanically interlock to ensure durable embolization. Under acidic tumor conditions, calcium carbonate neutralizes pH and releases Ca²⁺, which synergizes with sorafenib to inhibit angiogenesis and induce apoptosis. In a rabbit orthotopic HCC model, this system demonstrated superior tumor control and necrosis without inducing systemic toxicity. This work presents a microenvironment-responsive embolization strategy integrating durable vascular occlusion, pH modulation, and anti-angiogenic therapy.</p>","PeriodicalId":93848,"journal":{"name":"Acta biomaterialia","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149149294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A 3D lymphatics-on-a-chip reveals matrix stiffness dependent VEGFR-2 and VEGFR-3 contributions to lymphangiogenesis.","authors":"Lauren C Richardson, Issahy Cano, Anna M Kolarzyk, Esak Lee","doi":"10.1016/j.actbio.2026.10.013","DOIUrl":"10.1016/j.actbio.2026.10.013","url":null,"abstract":"<p><p>The lymphatic system regulates fluid homeostasis and host immunity by draining interstitial fluid and immune cells and transporting them to the lymph nodes. Lymphatic capillaries, essential for capturing interstitial material, undergo lymphangiogenesis to form new lymphatic vessels from existing ones. However, the roles of the vascular endothelial growth factor (VEGF) family and their receptors in lymphangiogenesis under varying matrix stiffness conditions remain unclear. We examine lymphangiogenesis in response to VEGF-A, VEGF-C, and VEGF-C156S across different matrix stiffnesses and evaluate the effects of VEGFR-3 and VEGFR-2 inhibition in a three-dimensional (3D) lymphatics-on-a-chip model. In the model, VEGF-C induced the greatest lymphangiogenesis across all tissue stiffnesses. VEGF-A driven lymphangiogenesis was also notable in compliant and stiff matrices. VEGF-C156S-induced lymphangiogenesis was weaker than that in VEGF-A and VEGF-C conditions. Given that VEGF-C promoted the greatest sprouting across all matrix conditions and could interact with both VEGFR-3 and VEGFR-2, we examined VEGF-C driven lymphangiogenesis under VEGFR-3 and VEGFR-2 inhibition. In a soft matrix, VEGF-C driven lymphangiogenesis was significantly blocked by the VEGFR-3 inhibitor but less extensively blocked by the VEGFR-2 inhibitor; in a stiff matrix, either the VEGFR-3 or VEGFR-2 inhibitors significantly blocked lymphangiogenesis, indicating that lymphangiogenic VEGFR-3 pathways mediate VEGF-C induced lymphangiogenesis the most in a soft matrix. VEGFR-2 can similarly contribute to lymphangiogenesis in a stiff matrix, showing VEGF-C mediated sprouting loses stiffness resilience under VEGFR-2 inhibition. Ultimately, VEGF-C/VEGFR-3 signaling has a greater impact on lymphangiogenesis in a compliant matrix, but VEGF-C/VEGFR-2 signaling mediates stiffness-resistant lymphangiogenesis in a stiff matrix. STATEMENT OF SIGNIFICANCE: The lymphatic system preserves fluid homeostasis by draining interstitial fluid. Lymphatic capillaries form new vessels through lymphangiogenesis across tissues spanning soft to stiff environments, yet how VEGF signaling functions under varying matrix stiffness remains unclear. Using a 3D lymphatics-on-a-chip model, we investigated lymphangiogenesis induced by VEGF-A, VEGF-C, and VEGF-C156S and assessed VEGFR-3 and VEGFR-2 inhibition. VEGF-C produced the strongest sprouting across all stiffness conditions; VEGF-A elicited weaker responses, and VEGF-C156S was effective only in soft matrices. In compliant matrices, VEGF-C-driven sprouting depended primarily on VEGFR-3. In stiff matrices, inhibition of either VEGFR-3 or VEGFR-2 significantly reduced lymphangiogenesis, revealing stiffness-dependent receptor contributions to VEGF-C-mediated sprouting, suggesting distinct therapeutic strategies for varying ECM stiffness in different organs and diseases.</p>","PeriodicalId":93848,"journal":{"name":"Acta biomaterialia","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13671825/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149139819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A pH-sensitive and ROS-responsive hydrogel enhanced by arginine-derived carbon dots for the diagnosis and treatment of infected wounds.","authors":"Xianli Wang, Jiajing Qiu, Zhengbin Dai, Jiacheng Li, Xiaoyu Li, Feiyue He, Jiaqi Dong, Huan Liu, Cheng Wang, Yi Shao, Chenglin Chu, Feng Xue, Li Tao, Liqu Huang, Jing Bai","doi":"10.1016/j.actbio.2026.10.009","DOIUrl":"10.1016/j.actbio.2026.10.009","url":null,"abstract":"<p><p>Effective repair of infected wounds requires both precise elimination of bacteria in the host and accelerated healing, yet strategies that integrate real-time diagnosis with targeted therapy remain scarce. Here, we synthesize L-arginine-derived carbon quantum dots (Arg‑CQDs) and incorporate them into a poly(ethylene glycol) diacrylate/carboxymethyl chitosan (PEGDA/CMCS) double-network hydrogel via free-radical polymerization. The resulting Arg‑CQDs-enhanced hydrogel functions as a sensitive pH-responsive optical sensor. Density functional theory (DFT) calculations reveal that under acidic conditions, Arg‑CQDs possess a smaller HOMO-LUMO gap and a larger oscillator intensity, favoring intense radiative electronic transitions. Under alkaline conditions, a larger gap and a smaller oscillator intensity promote dominant non‑radiative transitions. Consequently, the ultraviolet (UV)-excited luminescence intensity of the composite hydrogel decreases as pH increases, enabling visual assessment of infection via smartphone-based RGB color channel analysis. Moreover, the hydrogel exhibits microenvironment-selective pro-oxidant and antioxidant behavior. In bacterial environments, the positively charged Arg‑CQDs disrupt the electron transport chain and elevate reactive oxygen species (ROS) levels, achieving potent bactericidal activity. In cellular environments, they scavenge excess ROS through the up-regulation of GGT5 and Aldo-Keto reductase, thereby activating JAK2-STAT3/IL‑10 signaling to promote macrophage anti-inflammatory responses. In a rat model of infected wounds, this hydrogel achieves re‑epithelialization and vascularized wound closure within 14 days, outperforming commercial Ag⁺ dressings. This \"sense‑and‑act\" smart hydrogel represents a promising platform for the simultaneous diagnosis and treatment of infected wounds. STATEMENT OF SIGNIFICANCE: This work reports an Arg-CQDs-enhanced PEGDA/CMCS composite hydrogel that functions as a pH-responsive optical sensor, enabling smartphone‑based visual assessment of infection. DFT calculations reveal that acidic conditions promote intense radiative electronic transitions, whereas alkaline conditions favor weak non-radiative transitions, accounting for the pH‑dependent luminescence. Furthermore, the hydrogel exhibits microenvironment‑selective behavior. In bacterial niches, it elevates ROS levels to achieve potent sterilization. In cellular environments, it scavenges excess ROS and up-regulates GGT5 and Aldo‑Keto reductase, thereby activating JAK2-STAT3/IL-10 signaling to orchestrate anti-inflammatory responses. In a rat model of infected wounds, this \"sense‑and‑act\" hydrogel accomplishes complete re-epithelialization and vascularized closure within 14 days, outperforming commercial Ag⁺ dressings. Collectively, these findings establish a promising platform for the simultaneous diagnosis and treatment of infected wounds.</p>","PeriodicalId":93848,"journal":{"name":"Acta biomaterialia","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149119972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disorder-engineered thermoelectric Cu₂Se/SnSe₂ heterojunctions embedded in glycyrrhizic acid hydrogels for pyro-photo-ultrasonic therapy of periodontitis.","authors":"Boyu Zeng, Maoxin Ren, Meng Chen, Qiyao Zheng, Congyang Mao, Yuan Li, Chaofeng Wang, Talante Juma, Xiangmei Liu, Yongping Cao, Yufeng Zheng, Shuilin Wu","doi":"10.1016/j.actbio.2026.09.052","DOIUrl":"10.1016/j.actbio.2026.09.052","url":null,"abstract":"<p><p>Periodontitis treatment is severely hampered by rapid electron-hole recombination and hypoxic microenvironment, which fundamentally limit reactive oxygen species (ROS) yields in conventional photo/sonodynamic therapies. Herein, we propose a disorder-engineered thermoelectric heterojunction strategy that couples pyro-photo-ultrasonic effects to overcome these bottlenecks. Thermoelectric Cu₂Se(CuSe)/SnSe₂ heterojunctions, synthesized by mechanochemical ball milling, introduce dense CuSe nanodomains and interfacial defects that serve simultaneously as phonon-scattering centers (minimizing thermal conductivity of κ_tot = 0.09 W/(m·K)) and non-radiative relaxation channels, enabling efficient photo-to-thermal conversion. A pronounced built-in electric field, arising from the large work function difference between Cu₂Se (7.17 eV) and SnSe₂ (6.52 eV), synergizes with the thermoelectric field induced by photo-ultrasonic thermal gradients, yielding sustained carrier separation (ZT = 0.08 at 450 K) and robust ROS generation under hypoxic conditions. The resultant heterojunction achieves unprecedented antibacterial efficacy (>98.37% against Staphylococcus aureus and >99.54% against Porphyromonas gingivalis) under 808 nm NIR/ultrasound co-activation. Integration of glycyrrhizic acid hydrogel provides a biocompatible matrix (97.8% cell viability, <5% hemolysis) that substantially downregulates TNF-α, reduces osteoclastogenesis significantly, and markedly restores alveolar bone height. This work establishes a \"disorder-engineering for biocatalysis\" strategy, demonstrating that controllable lattice imperfections can be harnessed to drive multi-physical coupling for high-efficacy therapy of infected bone tissues. STATEMENT OF SIGNIFICANCE: Conventional mechanical/antibiotic treatment and prevailing exogenous stimulus-responsive strategies face significant problems in the treatment of periodontitis, mainly in rising bacterial resistance, insufficient deep pathogen elimination and limited antibacterial ability. In this work, we constructed a Cu₂Se(CuSe)/SnSe₂ thermoelectric heterojunction based on disorder-engineering strategy. Under near-infrared and ultrasonic co-stimulation, the synergy between built-in electric field and thermoelectromotive force effectively suppresses carrier recombination, enabling remarkably enhanced ROS generation and bactericidal efficacy under periodontal hypoxic microenvironment. Integrated with glycyrrhizic acid hydrogel, the system achieves favorable biocompatibility, anti-inflammatory activity, and alveolar bone repair capacity, offering a meaningful paradigm for multi-physical field synergistic antibacterial therapy.</p>","PeriodicalId":93848,"journal":{"name":"Acta biomaterialia","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149120104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Setd2 is associated with strontium-induced bone regeneration\" [Acta Biomaterialia 2017;53:495-505].","authors":"Xiaoshi Jia, Qiaoyun Long, Richard J Miron, Chengcheng Yin, Yan Wei, Yufeng Zhang, Min Wu","doi":"10.1016/j.actbio.2026.09.043","DOIUrl":"https://doi.org/10.1016/j.actbio.2026.09.043","url":null,"abstract":"","PeriodicalId":93848,"journal":{"name":"Acta biomaterialia","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149119983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An NIR-triggered self-propelled janus nanomotor-integrated hydrogel with enzymatic cascade reactions and photothermal-enhanced drug release for the treatment of gouty arthritis.","authors":"Lingzi Feng, Yun Li, Cong Ding, Yifan Li, Juntao Jiang, Qiang Zhang, Manqi Yan, Fei Cao, Ting Wu, Yong Hu","doi":"10.1016/j.actbio.2026.10.005","DOIUrl":"10.1016/j.actbio.2026.10.005","url":null,"abstract":"<p><p>Gouty arthritis is characterized by monosodium urate (MSU) crystal deposition, persistent joint inflammation, oxidative stress, and limited drug penetration. Here, we report an injectable hydrogel system embedding asymmetric Janus nanomotors (Col-PLGA@Au-CU) that integrates enzymatic cascade reaction, photothermal propulsion, and on-demand drug release for active gout therapy. The nanomotors consist of colchicine-loaded PLGA cores partially coated with gold nanoshells and functionalized with uricase (UOx) and catalase (CAT), which are encapsulated in a chitosan-based hydrogel for intra-articular retention. Under near-infrared (NIR) irradiation, the gold nanoshells generate localized heat, which accelerates the release of the nanomotors from the hydrogel. The elevated temperature also enhances the UOx/CAT cascade reaction, resulting in increased oxygen generation and enhanced active motion of the nanomotors. Meanwhile, the photothermal effect accelerates the release of colchicine from the hydrogel. The enzymatic cascade not only depletes uric acid but also decomposes H₂O₂ into O₂ and H₂O, relieving oxidative stress and hypoxia. In vitro, the NIR-triggered nanomotors exhibited significantly enhanced cellular uptake, ROS scavenging, HIF-1α suppression, and M2 macrophage polarization. In a murine MSU-induced gout model, intra-articular injection of Col-PLGA@Au-CU@CS hydrogel followed by NIR irradiation effectively reduced joint swelling, restored gait patterns, decreased synovial inflammation, protected cartilage integrity, and downregulated TNF-α and IL-6 expression, without systemic toxicity. This enzyme-powered, photothermal-activatable Janus nanomotor hydrogel represents a controlled-release platform that combines enhanced active transport, microenvironment modulation, and triggered drug delivery, offering a promising strategy for precision therapy of gouty arthritis. STATEMENT OF SIGNIFICANCE: This study presents a novel injectable Janus nanomotor-integrated hydrogel (Col-PLGA@Au-CU@CS) for the treatment of gouty arthritis. By combining an enzymatic cascade (uricase and catalase) with a photothermal gold nanoshell, the system achieves simultaneous uric acid depletion, hydrogen peroxide decomposition, and NIR-triggered self-propulsion. The asymmetric nanomotors overcome poor drug penetration into avascular cartilage, while the hydrogel ensures intra-articular retention. Under NIR irradiation, enhanced directional motion, on-demand colchicine release, and reactive oxygen species scavenging lead to marked suppression of synovial inflammation, M2 macrophage polarization, and cartilage protection in a murine gout model. This work establishes an enzyme-powered, photothermal-activatable platform that integrates active tissue penetration, microenvironment modulation, and triggered drug delivery, offering a promising precision therapy strategy for gouty arthritis and potentially other inflammatory joint diseases.</p>","PeriodicalId":93848,"journal":{"name":"Acta biomaterialia","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2026-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149120010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}