E. D. Yulian, S. S. Panigoro, Bajuadji Sudijono, W. Gautama, P. Rustamadji, Ricky Dosan
{"title":"CXCR4 and RANK Combination as a Predictor of Breast Cancer Bone Metastasis in Indonesia","authors":"E. D. Yulian, S. S. Panigoro, Bajuadji Sudijono, W. Gautama, P. Rustamadji, Ricky Dosan","doi":"10.17352/2455-2968.000130","DOIUrl":"https://doi.org/10.17352/2455-2968.000130","url":null,"abstract":"Abdominal wall reconstruction and hernia repair surgery continue to evolve with the intention to successfully repair the abdominal wall,","PeriodicalId":93785,"journal":{"name":"Journal of surgery and surgical research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48537357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"CXCR4 and RANK Combination as a Predictor of Breast Cancer Bone Metastasis in Indonesia","authors":"Yulian Erwin D, Panigoro Sonar S, Sudijono Bajuadji, Gautama Walta, Rustamadji Primariadewi, D. Ricky","doi":"10.17352/2455-3068.000130","DOIUrl":"https://doi.org/10.17352/2455-3068.000130","url":null,"abstract":"","PeriodicalId":93785,"journal":{"name":"Journal of surgery and surgical research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41798646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Painless injections: Helfer skin tap technique","authors":"Helfer Joanne Kieffer","doi":"10.17352/2455-2968.000129","DOIUrl":"https://doi.org/10.17352/2455-2968.000129","url":null,"abstract":"Abdominal wall reconstruction and hernia repair surgery continue to evolve with the intention to successfully repair the abdominal wall,","PeriodicalId":93785,"journal":{"name":"Journal of surgery and surgical research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45747405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Does Unopposed Peri-menopausal or Post-menopausal Estrogen Protect against Breast Cancer? A Systematic Review","authors":"Onwude Joseph Loze","doi":"10.17352/2455-2968.000142","DOIUrl":"https://doi.org/10.17352/2455-2968.000142","url":null,"abstract":"Globally, breast cancer is the most common incident cancer and cause of cancer deaths in women. The incidence of breast cancer suddenly increases from age 40 and continues to increase until age 84 years. These coincide with perimenopause and menopause periods. Hormone Replacement Therapy (HRT) is recognized to cause breast cancer. This causal association has become assumed with unopposed Estrogen Replacement Therapy (ERT) which is used for women who require HRT but do not require the Progestogen component. This systematic review assessed the evidence behind the belief that unopposed ERT had a causal relationship with breast cancer. Established databases were searched to August 2017 for publications that examined the relationship between unopposed ERT and breast cancer in cohort studies (prospective and retrospective), case control studies and randomized controlled studies. Unopposed ERT could be oral, transdermal patch or gel, subcutaneous or intranasal routes. All the studies were systematically assessed for the risk of bias and the measures of effect such as appropriate measures of effect [relative risk for randomized controlled studies, incidence ratio/rate for prospective cohort studies and odds ratio for retrospective cohort studies and case control studies. The quality of the evidence was assessed with GRADE methods [1]. We report on the general direction of the evidence from different types of studies over different decades in different countries using different types of unopposed Estrogens at different doses, to show whether the evidence is consistent in its direction that unopposed Estrogens do not increase the risk of Breast cancer in perimenopausal or post-menopausal women. The evidence does not support that unopposed ERT increases the risk of breast cancer. Where an association has been reported, there was methodological association because the study was either a retrospective study as case control study or cohort study which are not study designs that are valid to show cause and effect relationships. Moreover the only randomized studies in the short term and long term show no cause and effect relationship. The implication is that as unopposed ERT does not increase the risk of breast cancer, more women can consider its use and benefi ts.","PeriodicalId":93785,"journal":{"name":"Journal of surgery and surgical research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68166762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Noaman Hh, Mohamed Mohammed A, Sorour Yasser Othman
{"title":"Functional outcomes of ulnar nerve neurotization by anterior interosseous nerve in high level injury","authors":"Noaman Hh, Mohamed Mohammed A, Sorour Yasser Othman","doi":"10.17352/2455-2968.000141","DOIUrl":"https://doi.org/10.17352/2455-2968.000141","url":null,"abstract":"Background: The ulnar nerve injury induce sever hand malfunction due to intrinsic muscle paralysis. The ulnar nerve repair in proximal area (high ulnar nerve injury) seldom leads to intrinsic muscle function because of long distance of nerve return. Therefore, the best techniques to restore intrinsic hand function in patient with high ulnar nerve injury is distal nerve transfer to minimize the regeneration time and distance. Objective: The aim of this study is to describe the surgical results obtained with the transfer of the motor branch of the anterior interosseous nerve destined to the pronator quadrates muscle to the motor division of the ulnar nerve (the deep branch of ulnar nerve). Methods: It is a retrospective study of thirty elderly patients with high ulnar nerve injury underwent a transfer of distal branch of anterior interosseous nerve to deep branch of ulnar nerve, and end to end suture of the ulnar nerve at the site of injury in Sohag microsurgery unit. Results: The mean postoperative follow-up period was 22 months (range from 12 to 38 months). At the fi nal follow-up, twenty-seven (90%) patients showed good results according to the Highet-Zachary scheme (M3 or M4, S3+, and negative Froment’s sign). The other three patient (10%) showed a poor result (M1, S2, positive Froment’s sign). Conclusion: This technique of transfer of distal branch of anterior interosseous nerve to deep motor branch of ulnar nerve and primary repair of ulnar nerve at site of injury is effective for motor and sensory recovery of distal ulnar innervated side of the hand.","PeriodicalId":93785,"journal":{"name":"Journal of surgery and surgical research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68165181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Historical medicine: Biblical and talmudic surgery and surgical practice","authors":"Dvorjetski Estee","doi":"10.17352/2455-2968.000127","DOIUrl":"https://doi.org/10.17352/2455-2968.000127","url":null,"abstract":"The legacy of surgery in ancient Jews included those who cared for the wounds and injuries. In light of this they were awarded the title of experts, ummanim. The aim of the paper is to introduce the history of the craft of surgery from biblical times throughout the talmudic period focusing on historical and medical perspectives. Along the way, the surgical progress made a creative advancement of anatomical studies.","PeriodicalId":93785,"journal":{"name":"Journal of surgery and surgical research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47608406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Montserrat Alemany, Jens Sorensen, C. Trampal, T. Hansen
{"title":"Detection of potentially clinically relevant lung nodules with breath-hold CT compared to free-breathing CT in PET-CT in oncology patients and the value of MIP reconstructions","authors":"Montserrat Alemany, Jens Sorensen, C. Trampal, T. Hansen","doi":"10.17352/2455-2968.000126","DOIUrl":"https://doi.org/10.17352/2455-2968.000126","url":null,"abstract":"Background: The value of an additional thoracic breath-hold (BH) CT in PET-CT for detecting small nodules is controversial. Purpose: To determine the value of a BH-CT compared to the routinely used free-breathing (FB) CT, and the value of maximum intensity projection (MIP) technique in these two CT series for detection and its potential clinical relevance in staging of small lung nodules in oncology patients. Material and methods: This retrospective study included 200 patients from February to September 2016 who were referred for oncological FDG PET-CT. Thin slice (1.25 mm) and MIP (10 mm) images were analyzed for detection of small lung nodules (1-10 mm). Binominal test and descriptive statistics were analyzed. Results: It was possible to evaluate 186 patients, with a mean age of 70.0 yrs ± 11.1 yrs, range 27-96 yrs, consisting of 84 females (mean age 68.5 yrs ± 12.2, 27-90 yrs) and 102 men (71.3 yrs ± 10.1, 27-96 yrs). In FB-CT, 393 nodules were detected in thin slice CT images, with MIP in 578. In BH-CT, 534 nodules were detected and 905 with MIP (p< 0,001). The extra detected nodules were considered as having a potential clinical relevance in 4.8% (9 of 186) of the patients. The total radiation dose from the routine PET-CT, including FB-CT, was 26 mSv and an additional 4 mSv from the BH-CT. Conclusion: An additional BH-CT in deep inspiration compared with FB-CT detects more small lung nodules, which potentially could alter the TNM stage.","PeriodicalId":93785,"journal":{"name":"Journal of surgery and surgical research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46107112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Magill, M. Ibrahim, Foad Y Mohamed, S. Grant, B. Rudran, W. Radford
{"title":"A more accurate method to determine the magnification of radiographs when templating for hip arthroplasty?","authors":"H. Magill, M. Ibrahim, Foad Y Mohamed, S. Grant, B. Rudran, W. Radford","doi":"10.17352/2455-2968.000121","DOIUrl":"https://doi.org/10.17352/2455-2968.000121","url":null,"abstract":"The use of digital templating for Total Hip Arthroplasty (THA) is now the standard approach for pre-operative planning. Digital templating holds potential to reduce operative time and post-op complications however, this often relies on imprecise assumptions. The relationship between the X-ray source, subject and detector alters the perceived magnification. We therefore determine if Body Mass Index (BMI) is positively correlated with true magnification and if a predictive model based these parameters exists. A single surgeon series (n=107) was included in this study. Two independent observers assessed both pre- and post-operative AP pelvis radiographs using TraumaCad™. Post-operative radiographs were assessed to calculate the true magnification by calibrating from a known femoral head prosthesis size. Finally, a scatter plot with regression was used to determine if a predictive model of magnification existed using the Body Mass Index. The mean pre-operative magnification using a scaling marker was 124.2 ± 8.90%. The mean post-operative magnification using a known femoral head prosthesis size (true magnification) was 123.7 ± 3.98%. Significant variability exists in pre-operative marker data. Regression modelling showed no significant correlation between BMI and true magnification (post-op magnification). This study’s suggests that the precision and reliability of the radiographic marker in daily practice is poor. Regression modelling showed no significant correlation between BMI and the true magnification factor. Therefore, a pre-op predictive model cannot be reliably used. The data from this study suggest that a fixed magnification factor of 124% remains the most reliable and accurate method.","PeriodicalId":93785,"journal":{"name":"Journal of surgery and surgical research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42707042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
B. Dickinson, Monica B Vu, Nikkie Vu-Huynh, Alexander Shadid, Todd S Harris, R. Selby, Larry Perl, Kristina Mori, Peter Wang, S. Beanes, Alberto Mendivil, M. Hurwitz
{"title":"A load sharing principle in abdominal wall reconstruction: Communication and collaboration among plastic & reconstructive surgeons, oncologic surgeons and general surgeons","authors":"B. Dickinson, Monica B Vu, Nikkie Vu-Huynh, Alexander Shadid, Todd S Harris, R. Selby, Larry Perl, Kristina Mori, Peter Wang, S. Beanes, Alberto Mendivil, M. Hurwitz","doi":"10.21203/rs.3.rs-58066/v1","DOIUrl":"https://doi.org/10.21203/rs.3.rs-58066/v1","url":null,"abstract":"\u0000 Background: Abdominal wall reconstruction of ventral hernias can be challenging. Patients have undergone successful treatment of cancer or other intra-abdominal processes and have worked hard to get back to a “normal” life. Successful repair of abdominal wall hernias can be difficult as many comorbidities persist. Previous radiation, ongoing smoking, or overall protein malnutrition may affect wound healing and overall outcome. Surgical teams need to communicate to maximize repair success and decrease recurrence. Purpose: To create a systematic approach from our current method of abdominal wall reconstruction that facilitates communication between general surgeons and plastic and reconstructive surgeons for optimizing hernia repair outcomes. Methods: A retrospective chart review was done on patients who underwent abdominal wall reconstruction of ventral hernias and recurrent hernias with component separation and placement of strattice acellular dermal matrix or synthetic mesh over a 10 year period. Pre-op imaging consisted of an abdominal/pelvic CT-scan. A surgical flight plan was created to determine a plane of Strattice insertion and abdominal wall exposure. Pre/post-operative CT-scans were compared as well as before and after photographs. Patient satisfaction was assessed subjectively in follow-up appointments. Results: The most commonly encountered clinical scenarios were placed into a pictorial essay and a step by step approach to abdominal wall reconstruction was then created. Strattice or synthetic mesh were placed using a “load-sharing” principle and restoration of a dynamic abdominal wall was associated with high patient satisfaction, a more functional repair, and a lower incidence of recurrence. Conclusions: Successful repair of primary and recurrent abdominal wall hernias requires communication between general surgeons and plastic & reconstructive surgeons. Incision placement is important for adequate exposure and the ability to place transfascial sutures. T-junction skin breakdown and seroma formation can be minimized by maintaining blood supply and minimizing dead space. High protein nutritional stores are important for expeditious healing.","PeriodicalId":93785,"journal":{"name":"Journal of surgery and surgical research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47187133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Beyzadeoglu Murat, Sager Omer, Dincoglan Ferrat, D. Selcuk, Uysal Bora, Gamsiz Hakan, O. Fatih, Colak Onurhan, Dirican Bahar
{"title":"Single Fraction Stereotactic Radiosurgery (SRS) versus Fractionated Stereotactic Radiotherapy (FSRT) for Vestibular Schwannoma (VS)","authors":"Beyzadeoglu Murat, Sager Omer, Dincoglan Ferrat, D. Selcuk, Uysal Bora, Gamsiz Hakan, O. Fatih, Colak Onurhan, Dirican Bahar","doi":"10.17352/2455-2968.000099","DOIUrl":"https://doi.org/10.17352/2455-2968.000099","url":null,"abstract":"Vestibular schwannoma (VS), also referred to as acoustic neuroma, is one of the common benign intracranial tumors with rising incidence due to improved and more frequent neuroimaging.","PeriodicalId":93785,"journal":{"name":"Journal of surgery and surgical research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44983325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}