Bulletin of Faculty of Pharmacy, Cairo University最新文献_第2页

QBD based Design and Characterization of Proniosomal Transdermal Delivery of Atenolol and Glibenclamide Combination: An Innovative Approach 基于QBD的阿替洛尔和格列本脲联合前体经皮给药设计和表征:一种创新方法

Bulletin of Faculty of Pharmacy, Cairo University Pub Date : 2021-12-30 DOI: 10.54634/2090-9101.1021

P. Anitha, S. Ramkanth, S. Satyanarayana

{"title":"QBD based Design and Characterization of Proniosomal Transdermal Delivery of Atenolol and Glibenclamide Combination: An Innovative Approach","authors":"P. Anitha, S. Ramkanth, S. Satyanarayana","doi":"10.54634/2090-9101.1021","DOIUrl":"https://doi.org/10.54634/2090-9101.1021","url":null,"abstract":"There are numerous circumstances where chronic disease is associated with other disorders, especially in diseases like diabetes with noncommunicable disease risk factors, such as hypertension. This study shows a novel and innovative combinational proniosomal delivery of combination to beat the reactions by complex therapeutic regimen, and to improve patient compliance after controlling combinational transdermal delivery of Glibenclamide (GLB) and Atenolol (ATN) which have not been tried actually. To achieve the above reason, proniosomes were prepared and optimized utilizing Box-Behnken design. The ideal formulation was chosen by a point prediction method and formulation showed vesicle size of 562 ± 1.223 nm, entrapment efficiency of GLB & ATN 97.037 ± 1.43% and 96.230 ± 1.62% respectively which were found in concurrence with the predicted value. The optimized combinational proniosomal gel (OCPG) formulation was additionally assessed for in vitro drug release, In vitro drug permeation, and in vivo pharmacokinetic study. The OCPG formulation shows the greatest flux over the rabbit skin (128.609 ± 2.24 mg/cm/h and 322.054 ± 1.53 mg/ cm/h) of GLB and ATN respectively. The results indicated desired release and permeation profiles. OCPG showed significantly (p < 0.001) pharmacokinetic contemplate exhibited that transdermal proniosomal formulation demonstrated improvement in bioavailability of two drugs 129.30 and 174.62 times respectively as that of the oral formulation. Overall the results show that controlled release GLB and ATN provesicles offer a useful and promising transdermal delivery system for the treatment of type II diabetes and hypertension by using design. Henceforth this may be an achievement in treating diabetic hypertensive patient.","PeriodicalId":9369,"journal":{"name":"Bulletin of Faculty of Pharmacy, Cairo University","volume":"81 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88589009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The Efficacy of Oral Ivabradine in Acute Phase in Non ST-segment Elevation Myocardial Infarction (NSTEMI) Post PCI: A Pilot Study 非st段抬高型心肌梗死(NSTEMI) PCI术后急性期口服伊伐布雷定疗效的初步研究

Bulletin of Faculty of Pharmacy, Cairo University Pub Date : 2021-12-30 DOI: 10.54634/2090-9101.1024

Manar M Ahmed, M. Abbassi, G. Shaaban, S. Farid

{"title":"The Efficacy of Oral Ivabradine in Acute Phase in Non ST-segment Elevation Myocardial Infarction (NSTEMI) Post PCI: A Pilot Study","authors":"Manar M Ahmed, M. Abbassi, G. Shaaban, S. Farid","doi":"10.54634/2090-9101.1024","DOIUrl":"https://doi.org/10.54634/2090-9101.1024","url":null,"abstract":"Background: An elevated heart rate is a major risk factor for cardiovascular mortality and morbidity. This study aims to evaluate the beneficial effect of heart rate reduction of oral ivabradine in patients presenting with non ST-segment elevation myocardial infarction (NSTEMI) during acute stage post percutaneous coronary intervention. Results: A total of 100 patients admitted to the emergency department, National Heart Institute, Cairo, Egypt, were randomized into two groups as follows: Group A: 50 patients with NSTEMI treated with ivabradine (5 mg twice daily) in addition to the conventional treatment; Group B: 50 patients with NSTEMI treated with the conventional treatment only. Demographic data, detailed history, clinical examination, chest pain onset, blood pressure, heart rate (HR), temperature and respiratory rate, electrocardiogram (ECG) as well as echocardiography and laboratory investigations were recorded. Patients were monitored for a period of 3e5 days (acute stage). There was a significant difference between both groups regarding reduction of heart rate on discharge in patients presenting with NSTEMI (P < 0.05). However, there was no significant differences in mortality, heart failure (HF), cardiogenic shock, arrhythmia and any mechanical complications in the acute stage. Conclusion: Ivabradine significantly reduced heart rate in patients with NSTEMI without affecting blood pressure or hemodynamics; however, this did not show a significant impact on major adverse cardiac events (MACE) during shortterm follow up in the Coronary Care Unit (CCU) (Clinicaltrials.gov NCT04285736).","PeriodicalId":9369,"journal":{"name":"Bulletin of Faculty of Pharmacy, Cairo University","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87363027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Knowledge, Attitude, Practices, and Barriers of Pharmacovigilance among Healthcare Workers: A Cross-sectional Survey from Lahore, Pakistan 卫生保健工作者的知识、态度、做法和药物警戒障碍:来自巴基斯坦拉合尔的横断面调查

Bulletin of Faculty of Pharmacy, Cairo University Pub Date : 2021-12-30 DOI: 10.54634/2090-9101.1023

Z. Mustafa, M. Salman, N. Asif, A. Z. Rao, Q. Khan, A. Nawaz, Muhammad W. Mumtaz, Athar Masood, Muhammad Farhan Ali Khan, N. Shehzadi, K. Hussain

{"title":"Knowledge, Attitude, Practices, and Barriers of Pharmacovigilance among Healthcare Workers: A Cross-sectional Survey from Lahore, Pakistan","authors":"Z. Mustafa, M. Salman, N. Asif, A. Z. Rao, Q. Khan, A. Nawaz, Muhammad W. Mumtaz, Athar Masood, Muhammad Farhan Ali Khan, N. Shehzadi, K. Hussain","doi":"10.54634/2090-9101.1023","DOIUrl":"https://doi.org/10.54634/2090-9101.1023","url":null,"abstract":"Background : Adverse drug reactions (ADRs) are associated with increased length of hospital stay, permanent disability and even death. Objectives : The purpose of this study was to assess knowledge, attitude, practice (KAP), and barriers related to Pharmacovigilance (PV) among Pakistani healthcare workers (HCWs). Methods : A cross-sectional study was conducted in the second largest metropolitan city (Lahore) of Pakistan during a period of 4 months (June e September 2018). A self-administered questionnaire was used to collect data from the doctors, pharmacists, and nurses from 8 tertiary care hospitals, recruited via convenient sampling. All data were analyzed in SPSS version 21. Results : A total of 363 participants (125 doctors, 83 pharmacists and 155 nurses) were recruited. The median [inter-quartile range (IQR)] knowledge score was 6 (3), with 44.6, 41.9, and 13.5% of participants having poor (score < 6), moderate (score 6 e 9), and good (score ≥ 10) PV related knowledge, respectively. Additionally, the median (IQR) attitude and practice score were 7 (3) and 4 (2), respectively [good attitudes 24.8% (score ≥ 8); good practices 33.9% (score ≥ 5)]. Pharmacist were found to have signi ﬁ cantly better KAP related to PV than others (p < 0.001). Moreover, male HCWs had substantially better KAP than females. Conclusion : Although pharmacist have better KAP scores than other HCWs, yet overall KAP of PV among study participants were inadequate. Thus, continuous training and teaching programs should be conducted to improve awareness and to promote ADR reporting.","PeriodicalId":9369,"journal":{"name":"Bulletin of Faculty of Pharmacy, Cairo University","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84129158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Nanocrystal based orally disintegrating tablets as a tool to improve dissolution rate of Vortioxetine 纳米晶口腔崩解片提高沃替西汀溶出度

Bulletin of Faculty of Pharmacy, Cairo University Pub Date : 2021-01-05 DOI: 10.21608/BFPC.2020.20253.1063

Eknath D. Ahire, S. Thakkar, Yogeshwari Borade, M. Misra

{"title":"Nanocrystal based orally disintegrating tablets as a tool to improve dissolution rate of Vortioxetine","authors":"Eknath D. Ahire, S. Thakkar, Yogeshwari Borade, M. Misra","doi":"10.21608/BFPC.2020.20253.1063","DOIUrl":"https://doi.org/10.21608/BFPC.2020.20253.1063","url":null,"abstract":"Major depressive disorder (MDD) or depression is a heterogeneous mental illness which have direct effect on patient’s behavior and cognition; causing constant feeling of unhappiness and loss of concern in earlier enjoyed events. Vortioxetine (VOR) is a new atypical serotonergic antidepressant reported for the treatment of major MDD and has its use in various psychological disorders. Despite its therapeutic potential, it has poor water solubility which creates problem in delivery. Nanocrystal based orally disintegrating tablets (ODTs) are proposed to enhance water solubility and dissolution rate of VOR. Nanosuspension was prepared by nanoprecipitation method after optimizing various parameters. The formulated nanosuspension was effectively converted to solid powder by the lyophilization technique with emphasis on parameters like nature/concentration of cryoprotectants. Prepared nanocrystals were characterized for solid state of drug present, morphology, size after re-dispersion and stability. The powders were then subsequently compressed into ODTs and dissolution profiles of the tablets were compared. The dissolution profile of the ODTs prepared from nanocrystals showed superior dissolution profile in comparison to ODTs prepared from untreated drug.","PeriodicalId":9369,"journal":{"name":"Bulletin of Faculty of Pharmacy, Cairo University","volume":"40 1","pages":"11-20"},"PeriodicalIF":0.0,"publicationDate":"2021-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72646953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Comparison of Combined/Carvedilol Moderate Dose Atorvastatin to Single High Dose Atorvastatin for the Prevention of Contrast-Induced Nephropathy after Cardiac Catheterization 联合/卡维地洛中剂量阿托伐他汀与单剂量阿托伐他汀预防心导管术后造影剂肾病的比较

Bulletin of Faculty of Pharmacy, Cairo University Pub Date : 2021-01-05 DOI: 10.21608/BFPC.2020.28002.1075

Rabab A EL-Gazara, M. Abbassi, N. Sabry, Mohamed Mohamed, Soad Zakaria

{"title":"Comparison of Combined/Carvedilol Moderate Dose Atorvastatin to Single High Dose Atorvastatin for the Prevention of Contrast-Induced Nephropathy after Cardiac Catheterization","authors":"Rabab A EL-Gazara, M. Abbassi, N. Sabry, Mohamed Mohamed, Soad Zakaria","doi":"10.21608/BFPC.2020.28002.1075","DOIUrl":"https://doi.org/10.21608/BFPC.2020.28002.1075","url":null,"abstract":"Background: Contrast-induced nephropathy (CIN) is associated with increased morbidity, and the need for short-term hemodialysis. Although several preventive measures have been used, the best approach to prevent CIN is still controversial. Objectives: This study is intended to evaluate the protective effect of carvedilol/ medium dose statin compared to the recommended high dose atorvastatin on the development CIN in patients undergoing elective cardiac catheterization (CC). Methods: A total of 144 patients planned for CC were randomly assigned to: • Group (A): 49 patients received atorvastatin as single high dose 80 mg 12 hours before CC and another 40 mg of atorvastatin 2 hours before PCI. • Group (B): 48 patients were prescribed carvedilol 12.5 mg twice daily for seven days before CC and continued for 24 hours post CC, plus 40 mg atorvastatin 12 hours before CC. • Group (C): 47 patients received 40 mg atorvastatin 12 hours before CC. Results: The baseline characteristics of the 3 groups were comparable. CIN incidence was the lowest in group A, but was not significantly different (p=0.420). CIN developed in 4 (8.2%), 6(12.2%), and 8(17%) patients in groups A, B, and C respectively. Median change in CrCl 48 hours, and serum NGAL 4 hours post CC was significantly lower in group A compared to group C (p=0.0330, p=0.0348 respectively). Conclusions: The present study revealed that, combined carvedilol/statin regimen was comparable to single high dose atorvastatin in CIN prevention. However, short high dose of atorvastatin might be preferable in terms of kidney function preservation.","PeriodicalId":9369,"journal":{"name":"Bulletin of Faculty of Pharmacy, Cairo University","volume":"30 1","pages":"0-0"},"PeriodicalIF":0.0,"publicationDate":"2021-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83419456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A critical review on the plants used for the treatment of ulcer in Kerala 喀拉拉邦溃疡治疗用植物综述

Bulletin of Faculty of Pharmacy, Cairo University Pub Date : 2021-01-05 DOI: 10.21608/BFPC.2019.11432.1025

Jincy Jacob, J. Jipnomon, J. Nancy, B. Vinod

{"title":"A critical review on the plants used for the treatment of ulcer in Kerala","authors":"Jincy Jacob, J. Jipnomon, J. Nancy, B. Vinod","doi":"10.21608/BFPC.2019.11432.1025","DOIUrl":"https://doi.org/10.21608/BFPC.2019.11432.1025","url":null,"abstract":"Peptic ulcer disease and its complications remain the cause of significant morbidity worldwide, representing a major burden for health care resources. Although potent anti-ulcer drugs are available, most of them produce several side effects, thus emphasizing the need to search for new alternatives. As high as 80% of the world population depends on plant- derived medicines for the first line of primary health care, reinforcing the theory that plant extracts can be good sources of new drugs. This review focuses to consolidate the evidence-based information on antiulcer plants used in Kerala accumulated in databases (Google Scholar, PubMed, Scopus, Science Direct and Web of Science) upto January 2019. Plants like Acacia nilotica L., Achyranthes aspera Linn., Aegle marmelos L., Allium sativum L., Aloe barbadensis Miller, Annona muricata Linn., Bacopa monnieri Linn., Carica papaya Linn., Centella asiatica Linn., Curcuma longa Linn., Elettaria cardamomum Linn., Hibiscus rosa-sinensis Linn., Mangifera indica Linn., Mimosa pudica L., Moringa oleifera Linn., Ocimum sanctum Linn., Piper nigrum Linn., Phyllanthus emblica Linn., Terminalia chebula Retz., and Zingiber officinale Roscoe. are available in Kerala, reported with antiulcer activity. The secondary metabolites present in the plants like alkaloids, flavonoids, terpenoids, tannins, glycosides, terpines, and resins also have an important role in reliving ulcers due to its antisecretory, antioxidant, and cytoprotective properties. This review summarizes the botany, ethnopharmacology, phytochemistry and mechanism of action of antiulcer plants.","PeriodicalId":9369,"journal":{"name":"Bulletin of Faculty of Pharmacy, Cairo University","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80836796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Design, Synthesis and Antibacterial Studies of Some New Pyridopyrimidine Derivatives as Biotin Carboxylase Inhibitors 新型吡啶嘧啶类生物素羧化酶抑制剂的设计、合成及抗菌研究

Bulletin of Faculty of Pharmacy, Cairo University Pub Date : 2021-01-05 DOI: 10.21608/BFPC.2019.10149.1017

V. Panchabhai, P. Ingole, S. Butle

{"title":"Design, Synthesis and Antibacterial Studies of Some New Pyridopyrimidine Derivatives as Biotin Carboxylase Inhibitors","authors":"V. Panchabhai, P. Ingole, S. Butle","doi":"10.21608/BFPC.2019.10149.1017","DOIUrl":"https://doi.org/10.21608/BFPC.2019.10149.1017","url":null,"abstract":"Present study reports the development of novel pyridopyrimidine derivatives as biotin carboxylase inhibitors with potent antibacterial activity. These compounds were designed to avoid possibility of resistance development. Accordingly eighteen compounds were synthesised and characterized on the basis of spectral data. These compounds were tested for their antibacterial potential by the enzyme kinetic assay against the biotin carboxylase. The minimum inhibitory concentration (MIC) and single step resistance studies were also performed. Compound 2-((2-Phenylpyrido[2,3-d]pyrimidin-4-yl)amino)phenol (6o) showed promising activity in biotin carboxylase inhibition with low MIC. It showed molecular docking score of -7.96, this compound showed formation of hydrogen bonds with the active site residues and van Der Walls intractions. The MIC of compounds under investigation was in the rage of 2-5µg/mL over most of the strains studied. It also showed the mutant selection windows of around five which is better than the reference compound rifampin. This compound 6o can be studied further and developed into a potential antibacterial lead molecule.","PeriodicalId":9369,"journal":{"name":"Bulletin of Faculty of Pharmacy, Cairo University","volume":"68 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81684873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Determination of Spiramycin and Oxytetracycline in binary mixtures by novel spectrophotometric methods with and without regression equation 新分光光度法测定螺旋霉素和土霉素二元混合物中的含量

Bulletin of Faculty of Pharmacy, Cairo University Pub Date : 2021-01-05 DOI: 10.21608/BFPC.2019.15054.1045

Neven Ahmed, H. Saleh, Magda El Henawee, E. Hussien

{"title":"Determination of Spiramycin and Oxytetracycline in binary mixtures by novel spectrophotometric methods with and without regression equation","authors":"Neven Ahmed, H. Saleh, Magda El Henawee, E. Hussien","doi":"10.21608/BFPC.2019.15054.1045","DOIUrl":"https://doi.org/10.21608/BFPC.2019.15054.1045","url":null,"abstract":"Spiramycin (SPI) and oxytetracycline (OTC) are widely used antibacterial drugs. Thus, a great attention has been focusing on the development of a simple and selective analytical procedure for fast analysis of these compounds in a binary pharmaceutical mixture. Herein, we report four simple and reproducible spectrophotometric methods for determination of SPI and OTC in a binary mixture and in veterinary pharmaceutical formulations. A ratio difference (RD) based on the difference in the amplitude of the ratio spectra and dual wavelength methods were proposed for sensitive and selective determination of SPI in presence of OTC. Furthermore, Constant Value and Concentration Value based spectrophotometric methods were suggested for simultaneous determination of SPI and OTC in a binary mixture. The methods were successfully applied for the determination of SPI and OTC over the concentration range from 4.0 to 36.0 µg mL -1 and from 2.0 to 32.0 µg mL -1 , respectively. The proposed methods were validated according to the International Conference on Harmonization (ICH) guidelines. The methods are accurate (100±1%), precise (%RSD ≤1.5) and cost-effective for determination of SPI and OTC in binary mixtures.","PeriodicalId":9369,"journal":{"name":"Bulletin of Faculty of Pharmacy, Cairo University","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85174195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development and validation of stability indicating rp-uplc assay method for the determination of lacosamide and quetiapine fumarate in bulk and tablet dosage forms 拉科沙胺和富马酸喹硫平原料药和片剂稳定性指示rp-uplc测定方法的建立和验证

Bulletin of Faculty of Pharmacy, Cairo University Pub Date : 2019-12-01 DOI: 10.21608/bfpc.2019.101878

T. Sivaganesh, T. Rao, K. Ramasrinivas, U. SeshamRaju, Y. Shasikiran, G. Raja

引用次数: 1

Diabetic Nephropathy: Review of Novel Experimental and Clinical Strategies 糖尿病肾病:新的实验和临床策略综述

Bulletin of Faculty of Pharmacy, Cairo University Pub Date : 2019-12-01 DOI: 10.21608/bfpc.2019.101869

A. Mahfoz, N. Hassanein, A. Shoka, H. A. Latif

引用次数: 1