Microbiology & infectious diseases (Wilmington, Del.)最新文献

{"title":"How to Stop the Next Pandemic; Approach that Aims to Prevent the Emergence and Spread of Novel Pathogens","authors":"O. Nyarko, Y. Hardy, F. Ankobea-Kokroe, Gilda Opoku, S. Konadu, Edna Naa Ashiokor Mensah","doi":"10.33425/2639-9458.1113","DOIUrl":"https://doi.org/10.33425/2639-9458.1113","url":null,"abstract":"Introduction and Origin of Emerging Infections Forty (40) years ago, the World Health Organization officially declared the smallpox eradicated at the 33rd World health assembly in May 1980 [1]. The lessons learnt from that victory such as the use of new technology and international cooperation amongst others have aided in the fight against other infectious diseases and can also help us in the fight against emerging infections. Infectious diseases remain amongst the leading causes of death worldwide and particularly in sub-Saharan Africa [2]. New infections emerge periodically and contribute significantly to the global burden of disease morbidity and mortality [3,4]. Majority of these emerging infections are especially of viral but also bacterial origin [5]. About half of pathogenic microorganisms found in wildlife and livestock are zoonotic [5-7]. Most pandemics known to humans originated from animal species, wildlife, domestic animals and livestock [5]. Animal species thus serve as reservoirs of pathogens that can potentially threaten the existence of the human race [8].","PeriodicalId":93597,"journal":{"name":"Microbiology & infectious diseases (Wilmington, Del.)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69746347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Borrelia Invasion of Brain Pyramidal Neurons and Biofilm Borrelia Plaques in Neuroborreliosis Dementia with Alzheimer’s Phenotype","authors":"A. MacDONALD","doi":"10.33425/2639-9458.1111","DOIUrl":"https://doi.org/10.33425/2639-9458.1111","url":null,"abstract":"Dementia in Lyme borreliosis complex has been reported, mainly in post-mortem studies without available antemortem evidence of active borrelia infection. Blanc in 2014 studied living patients with Lyme neuroborreliosis dementia and several dementia phenotype illnesses including an Alzheimer’s Phenotype. Herein we report an additional case study of a longitudinal evolution of European neuroborreliosis over eight years from tick bite to mild cognitive disease, to advanced dementia to death with a brain Alzheimer’s disease phenotype and concurrent borrelia deposits in brain Alzheimer’s disease sites at autopsy. Intrathecal borrelia specific antibodies were detected by commercial diagnostic laboratories (antemortem). Molecular autopsy tissue imaging was completed with borrelia specific DNA probes and an immunomicroscopic detection histopathology method. Results: Autopsy showed intact spirochetes, fragmented spirochetes, deposits of borrelia-specific proteins inside plaque lesions and inside of neurons, and borrelia DNA deposits in plaque and neuronal sites. Pure Alzheimer’s disease (without Lewy bodies) was a routine neuropathological finding. CSF evidence for a brain compartment immune response is established here. Intrathecal antibodies to infection presented as oligoclonal total CSF IgG bands (n=twelve increase to n=13 bands) and separate borrelia IgG western blot band analysis in cerebrospinal fluids (seven diagnostic borrelia CSF antibody bands). Blood western blot disclosed triple borrelia species infection; burgdorferi European type (eighteen bands), garinii (twelve bands) and afzelii (eighteen bands). Total borrelia IgG antibodies in blood during life were two hundred-fold higher than normal range. Western blot of cerebrospinal fluid prior to death disclosed 7 protein bands which were not represented in simultaneous blood western blot studies, further validating the intrathecal fingerprint of a separate brain compartment immune response to neuroborreliosis infection. Conclusion: Borrelia protein antigenic stimulation of intrathecal borrelia antibodies was caused by resident deposits of spirochetal protein deposits in plaques, in diseased neurons, and in neuropil brain sites, and in intact brain spirochetes. Deposits of borrelia proteins inside neurons and brain phagocytes and in neuropil sites (invasosomes) confirm remnants of chronic brain infection.","PeriodicalId":93597,"journal":{"name":"Microbiology & infectious diseases (Wilmington, Del.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41761736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ivermectin as Prophylaxis Against COVID-19 Retrospective Cases Evaluation","authors":"H. Sch, R. Roberto, C. Allo, E. Héctor","doi":"10.33425/2639-9458.1103","DOIUrl":"https://doi.org/10.33425/2639-9458.1103","url":null,"abstract":"","PeriodicalId":93597,"journal":{"name":"Microbiology & infectious diseases (Wilmington, Del.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49090371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology of Gardnerella vaginalis Infections at Thies Regional Hospital Center (Senegal)","authors":"D. Rokhaya, Moussa Naimatou, K. Roughyatou, Diop Halimatou, Diop Oumar, D. Amadou, S. Habibou, Niang Aissatou Ahmet, D. Baidy, Sow Ahmad Iyane","doi":"10.33425/2639-9458.1104","DOIUrl":"https://doi.org/10.33425/2639-9458.1104","url":null,"abstract":"Introduction: Bacterial vaginosis is a very common infection in women, and is the most common form of genital infection. It results from the imbalance of the vaginal flora by the replacement of lactobacilli by anaerobic bacteria, mycoplasmas and Gardnerella vaginalis. Materials and Method: This is a two-year retro prospective study between July 31, 2017 and July 31, 2019 in women for whom a vaginal swab was performed. We performed a macroscopic and microscopic examination of the vaginal secretions. These are collected from the vaginal walls or from the posterior cul-de-sac with a sterile swab, trying to bring back as many secretions as possible. Results: We collected a total of 2376 vaginal swabs from the Thiès RHC (Regional Hospital Center). We observed 608 cases of Gardnerella vaginalis vaginosis, a frequency of 25.5%. The average age of the patients was 32.7 years. The age group [25-34] years represents 40.9%, [35-44] 25.65% and the age group [15-24] years 17.26%. Married women represented 54.77% and single women 3%. Nulligest patients accounted for 28.78%, paucigests 40.62% and multigestates 28.94%. The frequency of carriage was 40% in nulliparous women, 42.1% in paucigests and 16.77% in multigestates. Conclusion: Gardnerella vaginalis vaginosis is a common condition especially in women of childbearing age. It can lead to severe gynecological and obstetrical complications. For a more accurate diagnosis, it is necessary to reinforce the laboratory diagnosis. *Correspondence: Rokhaya Diagne, Microbiologist, Teacherresearcher, Thies university, UFR des Sciences de la Santé, BP 967, Thies, Senegal. Received: 30 October 2020; Accepted: 16 November 2020 Microbiology & Infectious Diseases ISSN 2639-9458","PeriodicalId":93597,"journal":{"name":"Microbiology & infectious diseases (Wilmington, Del.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46845521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Salmonella arizonae Bacteremia in a 16-Year-Old Male Patient with Cavernoma: A Case Report","authors":"Georgios Bonanos, P. Xaplanteri, Odyssefs Dimitrakopoulos, A. Lekkou, Fotios N Tzortzidis","doi":"10.33425/2639-9458.1105","DOIUrl":"https://doi.org/10.33425/2639-9458.1105","url":null,"abstract":"Bacteremia due to Salmonella enterica subsp. arizonae is extremely rare and most commonly involves immunocompromised patients. Herein we present a 16-year-old Greek male with bacteremia after craniotomy due to cavernoma. The patient kept turtles as companion animals. In our case we suggest that the turtles our patient kept as companion animals were the source of infection. S. arizonae nested in the brain lesion and bacteremia was due to perioperative manipulations. *Correspondence: Panagiota Xaplanteri, Senior Assistant, Department of Microbiology, University Campus, University General Hospital of Patras, Patras, 26504, Greece, Tel: +306932914660, Fax: +302610992618. Received: 28 October 2020; Accepted: 12 November 2020 Microbiology & Infectious Diseases ISSN 2639-9458","PeriodicalId":93597,"journal":{"name":"Microbiology & infectious diseases (Wilmington, Del.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47252698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nontuberculous Mycobacterial Diseases among People Living with HIV (PLHIV) at the Philippine General Hospital","authors":"Christopher S Delos Santos, Rowena Nacionales Virrey, M. Mendoza, Concepcion F Ang Rmt, M. Cajucom, Sang-Nae Cho","doi":"10.33425/2639-9458.1100","DOIUrl":"https://doi.org/10.33425/2639-9458.1100","url":null,"abstract":"","PeriodicalId":93597,"journal":{"name":"Microbiology & infectious diseases (Wilmington, Del.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49222738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of A Loop-Mediated Isothermal Amplification Assay for Rapid Detection of Human Fasciola in Vietnam","authors":"T. Hải, Nguyen Thi Bich Ngoc, T. T. Dương, Nguyễn Thị Hương Bình, N. Hường","doi":"10.33425/2639-9458.1101","DOIUrl":"https://doi.org/10.33425/2639-9458.1101","url":null,"abstract":"","PeriodicalId":93597,"journal":{"name":"Microbiology & infectious diseases (Wilmington, Del.)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45316552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biofilms in Rheumatoid Arthritis Nodules: A Novel Clue Relating to Microbial Origin","authors":"H. Allen, Zixuan Yi Bs, A. Roberts, R. Allen","doi":"10.33425/2639-9458.1075","DOIUrl":"https://doi.org/10.33425/2639-9458.1075","url":null,"abstract":"A ABSTRACT Biofilms have been found in many cutaneous diseases and play an important role in disease pathogenesis of atopic dermatitis, psoriasis, and tinea versicolor. Recently, necrobiotic granulomas in granuloma annulare were shown to contain biofilms, which led us to investigate whether biofilms are also present in the necrobiotic granulomas of rheumatoid arthritis (RA). In this brief report, we evaluated eight skin nodules from five patients with known rheumatoid arthritis. We used pathology staining to identify two key components of biofilms: polysaccharides (using periodic acid Schiff [PAS] and colloidal iron [CFe]) and amyloid (using Congo Red). We also used the immune histochemical stain CD 282 to evaluate whether Toll-like receptor 2 was present. The PAS, CFe, and Congo red stains were positive, indicating biofilms were present. CFe positivity is an indicator that the biofilms have an acidic matrix; gram negative organisms are known to thrive in that milieu. CD 282 was negative except in one lesion that was penetrating through the epidermis and one which was weakly positive. Since microbes are responsible for creating biofilms, our findings suggest that microbes, especially gram negatives, are involved in RA pathogenesis.","PeriodicalId":93597,"journal":{"name":"Microbiology & infectious diseases (Wilmington, Del.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46437705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe Adult Malaria at Brazzaville University Hospital: Prevalence and Associated Factors","authors":"Sékangué Obili G, O. Br, Adoua Doukaga T, Ekat Martin, Angonga Pabota E, Ellenga Mbolla BF","doi":"10.33425/2639-9458.1066","DOIUrl":"https://doi.org/10.33425/2639-9458.1066","url":null,"abstract":"","PeriodicalId":93597,"journal":{"name":"Microbiology & infectious diseases (Wilmington, Del.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49103544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge and Awareness of Bell's Palsy Among Dentists and Dental Students in Riyadh City, Kingdom of Saudi Arabia","authors":"Asma Al Meslet, Shaima Aldhafeeri, Atheer Alzahrani, Ashwaq Alshehri, Kawther Al gahtani, Marwa Abdul Majeed, Munnera Alanizi","doi":"10.33425/2639-9458.1067","DOIUrl":"https://doi.org/10.33425/2639-9458.1067","url":null,"abstract":"","PeriodicalId":93597,"journal":{"name":"Microbiology & infectious diseases (Wilmington, Del.)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42615858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}