Physiologia最新文献

{"title":"Physiological Stress as Risk Factor for Hypersensitivity to Contrast Media: A Narrative Review of the Literature and a Proposal of Psychophysiological Tools for Its Detection","authors":"C. Pruneti, S. Guidotti","doi":"10.3390/physiologia2030006","DOIUrl":"https://doi.org/10.3390/physiologia2030006","url":null,"abstract":"The use of contrast media in clinical diagnostic practice has increased significantly in recent years, accompanied by an increase in adverse reactions. These are the fleeting symptoms most complained about by patients: Flushing of the face, feeling of nausea, and heat lasting a few seconds, considered side effects related to the drug. Hypersensitivity reactions are rarer but dangerous and are driven by the immune system. To ensure the optimal management of adverse reactions to iodinated contrast media, various types of health specialists, such as radiologists, are looking into how to deal with the problem. While there are many suggestions in the scientific literature on what to do in the case of important reactions during or after radiological examination, unfortunately, there are no studies on primary and secondary prevention and, in particular, on psychophysical and psychophysiological influences. Some inferences could be made by observing the studies about psychophysiological stress and immune-inflammatory processes of allergies. The few studies in the literature on the analysis of processes affecting both psychophysiological stress and allergic responses have been analyzed. Finally, stress measurement methods are proposed that can highlight “hypersensitive” people with physiological characteristics capable of exacerbating or accentuating an allergic reaction to contrast media.","PeriodicalId":93484,"journal":{"name":"Physiologia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46114651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Ingestion of Ice Slurry on the Sleep Quality of Rugby Union Players in the Summer Season","authors":"Akihisa Morito, T. Inami, Akihiro Hirata, Satoshi Yamada, Masatsugu Shimomasuda, Keita Kato, Shigeyuki Tahara, N. Kohtake","doi":"10.3390/physiologia2030005","DOIUrl":"https://doi.org/10.3390/physiologia2030005","url":null,"abstract":"The aim of this study was to investigate the effect of ingestion of ice slurry before bedtime on the sleep quality of rugby union players in the summer season. Thirteen healthy male university rugby union players volunteered for this study. The participants ingested either ice slurry or a room-temperature beverage (control) 30 min before bedtime. A wearable activity-based sleep monitor was used to analyze objective sleep parameters, and the subjective sleep scores were assessed using the Oguri–Shirakawa–Azumi Sleep Inventory, middle-aged and aged version (OSA-MA). No differences in the amount or efficiency of sleep were observed between the ice slurry/control beverage conditions. Significant shortening of the sleep latency was observed in the ice slurry condition as compared with the control beverage condition. Moreover, significant improvement of the subjective sleep score for “feeling refreshed” on the OSA-MA was observed in the ice slurry condition. There were no significant differences in the other subjective sleep scores between the two conditions. The results suggest that ice slurry ingestion before bedtime may improve the latency of sleep onset, accelerate recovery from fatigue, and be useful as a sleep improvement strategy in rugby union players engaging in exercises during the summer season.","PeriodicalId":93484,"journal":{"name":"Physiologia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49525963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Innate Immunity to Inflammation: A Primer on Multiple Facets of NF-κB Signaling in COVID-19","authors":"Ashutosh Pandey, Abhinava K. Mishra","doi":"10.3390/physiologia2020004","DOIUrl":"https://doi.org/10.3390/physiologia2020004","url":null,"abstract":"Nuclear factor-kappa B (NF-κB) induces the expression of many pro-inflammatory genes, including cytokines and chemokines. In the past decades, a wealth of clinical as well as animal model-based studies have demonstrated the association of the deregulated NF-κB signaling pathway with the progression of various inflammatory diseases, including inflammatory bowel disease (IBD), multiple sclerosis (MS), and chronic obstructive pulmonary disease (COPD). Given the conserved role of the NF-κB pathway as the pivotal regulator of pro-inflammatory gene expression, different components of the NF-κB pathway are proposed as major therapeutic targets against these diseases. The ongoing coronavirus disease of 2019 (COVID-19) has posed a significant public health crisis regarding inflammation-related diseases. A robust inflammatory response is associated with COVID-19-infection-related complications, including muti-organ failure and death. This review summarizes the past and current state of knowledge on the role of the NF-κB signaling pathway in the innate immune response and inflammatory diseases with the objective of potential therapeutic use in developing effective treatment options for COVID-19.","PeriodicalId":93484,"journal":{"name":"Physiologia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45621682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Note from the Editor-in-Chief of Physiologia","authors":"P. Atherton","doi":"10.3390/physiologia2020003","DOIUrl":"https://doi.org/10.3390/physiologia2020003","url":null,"abstract":"I am proud to call myself a physiologist, and, as such, it was my pleasure and honour (over a year ago now) to take on the role of founding Editor-in-Chief of Physiologia [...]","PeriodicalId":93484,"journal":{"name":"Physiologia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45628904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhance Trial: Effects of NAD3® on Hallmarks of Aging and Clinical Endpoints of Health in Middle Aged Adults: A Subset Analysis Focused on Blood Cell NAD+ Concentrations and Lipid Metabolism","authors":"M. Roberts, Shelby C. Osburn, Joshua S. Godwin, Bradley A. Ruple, Michael B. La Monica, B. Raub, J. Sandrock, T. Ziegenfuss, H. Lopez","doi":"10.3390/physiologia2010002","DOIUrl":"https://doi.org/10.3390/physiologia2010002","url":null,"abstract":"Limited pre-clinical and clinical data suggest theacrine or theacrine-based supplements modulate biological processes associated with lipid metabolism and aging. Herein, we sought to examine if 12 weeks of daily supplementation with a theacrine-based supplement (termed NAD3®; 312 mg of combined Wasabia japonica freeze-dried rhizome standardized for isothicyantes, theacrine, and copper (I)niacin chelate) altered serum lipids as well as select nicotinamide adenine dinucleotide (NAD+)-associated metabolites in peripheral blood mononuclear cells (PBMCs). Twenty-eight participants (12 males, 16 females) were randomly assigned to receive either NAD3 (n = 13; age: 52 ± 7 years old, body mass index: 29.0 ± 5.0 kg/m2) or a cellulose placebo (n = 15; age: 51 ± 5 years old, body mass index: 28.3 ± 3.9 kg/m2). Blood samples were obtained in mornings following overnight fasts prior to supplementation (Pre) and following the 12-week intervention (Post). PBMCs were freshly isolated and prepared for targeted NAD+ metabolomics, and serum as well as whole blood was assayed for blood lipids and other safety markers through a commercial laboratory. Significant interactions (p < 0.05) were observed for total cholesterol, LDL cholesterol, and LDL: HDL ratio and post hoc analyses indicated these biomarkers significantly decreased with NAD3 supplementation (Pre-to-Post percent decreases were 11.1, 15.2, and −18.9%, respectively). A significant interaction was also observed for PBMC NAD+: NADH values, where levels trended downward from Pre to Post in the CTL group (p = 0.081) and values at Post were greater in NAD3 versus CTL (p = 0.023). No interactions were observed for systolic/diastolic blood pressure, body mass, or blood markers indicative of clinical safety. Although participant numbers were limited, these first-in-human data demonstrate a theacrine-based NAD3 supplement can favorably alter biomarkers of lipid metabolism and cellular NAD+ status. However, the latter data are limited to targeted NAD+ metabolites, and the effects of supplementation on other cellular metabolites or mechanisms related to the observed outcomes need to be further explored.","PeriodicalId":93484,"journal":{"name":"Physiologia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43726404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hematological Parameters and Iron Status in Adult Men and Women Using Altitude Adjusted and Unadjusted Hemoglobin Values for Anemia Diagnosis in Cusco, Peru (3400 MASL)","authors":"Dulce E. Alarcón-Yaquetto, Ramón Figueroa-Mujica, V. Valverde-Bruffau, Cinthya Vásquez-Velásquez, Juan José Sánchez-Huamán, Luis Jimenez-Troncoso, Rodrigo E. Rozas-Gamarra, G. Gonzales","doi":"10.3390/physiologia2010001","DOIUrl":"https://doi.org/10.3390/physiologia2010001","url":null,"abstract":"(1) Background: Current diagnosis of anemia in high altitude populations uses an adjustment of observed hemoglobin (Hb) values. Such an approach has been challenged by findings in different populations in Tibet, Ethiopia and the Andes as inappropriate, as it might incorrectly classify an individual with complete iron stores as anemic. We aimed to assess the suitability of this approach in adult men and women from Cusco, Peru (3400 m); (2) Methods: Complete blood count and iron status biomarkers were measured in 345 subjects (189 females and 156 males), iron status biomarkers were quantified with enzyme-linked immunoassays; (3) Results: Anemia prevalence was overestimated when the altitude-adjustment factor was applied. Hematological parameters were better correlated to iron status biomarkers in the non-adjusted anemia category. When stratified by sex, only women showed a significant association between Hb and other hematological parameters with iron storage and availability (Hepcidin and TFR-F); (4) Conclusion: The prevalence of anemia is overestimated with current guidelines. The rate of anemia using non-adjusted Hb values is more closely related to the rates of anemia or iron deficiency when used hematological parameters, markers of iron status, and measurements of hepcidin and erythropoietin. Sex differences related to iron status were observed, suggesting that men are at a higher risk of iron overload than women at high altitudes. It could be highlighted that a personalized approach is important when assessing a subject, taking in to account hematological parameters as well as origin (Southern Andean or other).","PeriodicalId":93484,"journal":{"name":"Physiologia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45100240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proteasome- and Calpain-Mediated Proteolysis, but Not Autophagy, Is Required for Leucine-Induced Protein Synthesis in C2C12 Myotubes.","authors":"Shelby C Osburn,&nbsp;Christopher G Vann,&nbsp;David D Church,&nbsp;Arny A Ferrando,&nbsp;Michael D Roberts","doi":"10.3390/physiologia1010005","DOIUrl":"https://doi.org/10.3390/physiologia1010005","url":null,"abstract":"<p><p>Muscle protein synthesis and proteolysis are tightly coupled processes. Given that muscle growth is promoted by increases in net protein balance, it stands to reason that bolstering protein synthesis through amino acids while reducing or inhibiting proteolysis could be a synergistic strategy in enhancing anabolism. However, there is contradictory evidence suggesting that the proper functioning of proteolytic systems in muscle is required for homeostasis. To add clarity to this issue, we sought to determine if inhibiting different proteolytic systems in C2C12 myotubes in conjunction with acute and chronic leucine treatments affected markers of anabolism. In Experiment 1, myotubes underwent 1-h, 6-h, and 24-h treatments with serum and leucine-free DMEM containing the following compounds (<i>n</i> = 6 wells per treatment): (i) DMSO vehicle (CTL), (ii) 2 mM leucine + vehicle (Leu-only), (iii) 2 mM leucine + 40 μM MG132 (20S proteasome inhibitor) (Leu + MG132), (iv) 2 mM leucine + 50 μM calpeptin (calpain inhibitor) (Leu + CALP), and (v) 2 mM leucine + 1 μM 3-methyladenine (autophagy inhibitor) (Leu + 3MA). Protein synthesis levels significantly increased (<i>p</i> < 0.05) in the Leu-only and Leu + 3MA 6-h treatments compared to CTL, and levels were significantly lower in Leu + MG132 and Leu + CALP versus Leu-only and CTL. With 24-h treatments, total protein yield was significantly lower in Leu + MG132 cells versus other treatments. Additionally, the intracellular essential amino acid (EAA) pool was significantly greater in 24-h Leu + MG132 treatments versus other treatments. In a follow-up experiment, myotubes were treated for 48 h with CTL, Leu-only, and Leu + MG132 for morphological assessments. Results indicated Leu + MG132 yielded significantly smaller myotubes compared to CTL and Leu-only. Our data are limited in scope due to the utilization of select proteolysis inhibitors. However, this is the first evidence to suggest proteasome and calpain inhibition with MG132 and CALP, respectively, abrogate leucine-induced protein synthesis in myotubes. Additionally, longer-term Leu + MG132 treatments translated to an atrophy phenotype. Whether or not proteasome inhibition in vivo reduces leucine- or EAA-induced anabolism remains to be determined.</p>","PeriodicalId":93484,"journal":{"name":"Physiologia","volume":"1 1","pages":"22-33"},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8681867/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39741548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute CrossFit® Workout Session Impacts Blood Redox Marker Modulation","authors":"Manoel Rios, T. Macan, Jelena Stevanović-Silva, Kamonrat Nhusawi, R. Fernandes, J. Beleza, A. Ascensão, J. Magalhães","doi":"10.3390/physiologia1010004","DOIUrl":"https://doi.org/10.3390/physiologia1010004","url":null,"abstract":"We aimed to analyze the impact of a single CrossFit® session “workout of the day” (WOD) on plasma redox. Ten CrossFit®-experienced subjects volunteered to participate. Oxygen uptake (VO2) during WOD and treadmill running (TR), performed at the same VO2 and time as WOD, were continuously monitored. Venous blood samples were collected before (baseline—BL) and after both exercises, for lactate concentration, total antioxidant capacity, thiol content, and DNA damage measurements. Total antioxidant capacity decreased after both exercises (WOD and TR) vs. BL, with no differences between exercises. Thiol content increased after WOD; however, no differences between exercises were observed. DNA damage increased after both WOD and TR, although more exuberantly after WOD than TR. Much higher lactate levels were detected in WOD compared to TR. Our findings suggest that WOD induces an increased condition of oxidative injury and affects total antioxidant capacity in experienced CrossFit® performers.","PeriodicalId":93484,"journal":{"name":"Physiologia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48723231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Publisher’s Note: Physiologia—A New Open Access Journal","authors":"Agata Kolomanska","doi":"10.3390/physiologia1010003","DOIUrl":"https://doi.org/10.3390/physiologia1010003","url":null,"abstract":"One of the top four scholarly journal publishers in the world [...]","PeriodicalId":93484,"journal":{"name":"Physiologia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44014015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Ergogenic Effects of Caffeine and Nitrate Supplementation on Speed, Power and Repeated Sprint Performance of Soccer Players","authors":"Dimitris Karampelas, Konstantinos Antonopoulos, Y. Michailidis, Michalis Mitrotasios, A. Mandroukas, T. Metaxas","doi":"10.3390/physiologia1010002","DOIUrl":"https://doi.org/10.3390/physiologia1010002","url":null,"abstract":"Caffeine and nitrates have both been reported to enhance performance in power efforts; however, it is not clear which supplement is most effective. The aim of this study was to compare the effects of caffeine and nitrates on the performance of semi-professional soccer players during different fitness tests. Ten male soccer players in a randomized crossover design were assigned to receive caffeine (5 mg/kg body mass) (CG), nitrate ((250 mL/150 mg of NO3−) (NG), or a placebo (PG) on three different occasions. In each treatment, the participants performed the following tests: 10 m and 30 m sprints, the Illinois agility test, a countermovement jump test, a squat jump test, and a repeated sprint test (6 × 40 m). Caffeine boosted performance in jumps (CMJ: CGvsPG, p = 0.018; SJ: CGvsPG, p = 0.045 and CGvsNG, p = 0.001) and limited the decrease in performance in the RSA test (CGvsPG, p = 0.012). Nitrates limited the decrease in performance in the RSA test (NGvsPG, p = 0.035). In conclusion, the two supplements limited the decrease in performance in the test of repeated sprints, with caffeine showing a greater effect. Among the other tests, only caffeine improved performance, and only in the jumps. Thus, we can conclude that supplementation with caffeine 1 h before these kinds of activities at a dosage of 5 mg/kg of body weight can enhance performance.","PeriodicalId":93484,"journal":{"name":"Physiologia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43232994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}