Journal of medicine and healthcare最新文献

{"title":"Clinical Significance of Color Doppler Ultrasound Applied in Patients with Peripherally Inserted Central Venous Catheters before Extubation: A Retrospective Analysis of Real-World Data","authors":"Ran An, Wen-feng Chen, Qiaomiao Zeng","doi":"10.47363/jmhc/2022(4)201","DOIUrl":"https://doi.org/10.47363/jmhc/2022(4)201","url":null,"abstract":"Aims and Objectives: By comparing peripherally inserted central venous catheter (PICC)-related complications in real-life patients, we aimed to analyze the significance of color Doppler ultrasound (CDU) applied routinely or once with symptoms of thrombosis before extubation. Methods: For this retrospective study, patient data from January to December 2020 were collected from an intelligent safe platform for infusion, which was embedded in the hospital information system (HIS). After screening by the inclusion and exclusion criteria, venous therapy liaisons were interviewed regarding the PICC procedures and complications of the enrolled patients. Then, the patient medical records were checked to verify the CDU usage and collect the CDU results. Difficulties in extubation and serious complications, including catheter fracture or pulmonary embolism during or after extubation, were also collected. This paper adheres to the RECORD checklist of EQUATOR guidelines. Results: Of the 1455 patients, 489 underwent CDU examination before extubation. Among these, thrombosis was detected in 37 (7.6%) patients and only 1 (0.2%) patient without thrombosis experienced difficulties in extubation. No serious complications were observed in the CDU group. Meanwhile, among the 966 patients in the non-CDU group, three (0.3%) faced difficulties and one patient developed symptoms of pulmonary embolism. Furthermore, among patients with thrombosis in the CDU group, the duration of catheter retention was significantly shorter than that in patients without thrombosis (76.65±42.55 vs. 121.04±45.99 days, P <0.001). Conclusions: After evaluation of their clinical symptoms, patients without symptoms could be directly removed according to conventional procedures, while patients with symptoms should undergo CDU examination before extubation. Relevance to Clinical Practice: When removing the catheter for PICC carriers, it is assessed that the patients have no discomfort symptoms and can be directly extubated without B-ultrasound examination.","PeriodicalId":93468,"journal":{"name":"Journal of medicine and healthcare","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45115913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful Management of an Oligometastatic Nsclc Patient with Multimodal Therapy","authors":"N. Ismaili","doi":"10.47363/jmhc/2022(4)199","DOIUrl":"https://doi.org/10.47363/jmhc/2022(4)199","url":null,"abstract":"Non-small cell lung cancer (NSCLC) is more often diagnosed at an advanced stage and carries a poor prognosis. Recently, according to the new version of AJCC staging system published in 2018, oligometastatic disease has been integrated as an intermediate stage between non-metastatic and metastatic forms. The prognosis of oligometastatic NSCLC was significantly improved by the use of multimodal therapy, including chemotherapy, targeted therapies, immunotherapy, surgery and stereotactic radiotherapy. However, there is little evidence regarding the optimal sequence of these modalities in the management of patients with oligometastatic disease. We describe here a case study of a patient diagnosed with metachronous oligometastatic NSCLC, successfully managed by multimodal therapy based on stereotactic radiotherapy, chemotherapy, immunotherapy and standard radiotherapy for local control. Furthermore, randomized prospective studies would be of capital interest, including multi-centre patient studies and evaluation of several treatment strategies.","PeriodicalId":93468,"journal":{"name":"Journal of medicine and healthcare","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43557589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Possible Role of Ppar-Alpha Agonist in Attenuated Cardioprotective Effects of Ischemic Postconditioning in Diabetic Rat Heart","authors":"S. Shivangi","doi":"10.47363/jmhc/2022(4)197","DOIUrl":"https://doi.org/10.47363/jmhc/2022(4)197","url":null,"abstract":"Background: It has been accounted for that infarct size reduction and cardioprotective effects of Ischemic Postconditioning (IPOC) have been abrogated in few pathological conditions including diabetes. Peroxisome Proliferator-Activated Receptor-Alpha (PPAR-Alpha) agonist is known to have cardioprotective effect. Therefore, the current examination researched the possible role of PPAR-Alpha Agonist in Attenuated Cardioprotective Effects of Ischemic Postconditioning in Diabetic Rat Heart. Materials and Methods: Rats were injected Alloxan Monohydrate (150/mg/kg/i.p) single dose to produced diabetes. Isolated Langendorff ’s perfused normal and diabetic rat hearts were subjected to global ischemia for 30 min followed by reperfusion for 120 min. Coronary effluent was analyzed for Lactatedehydogenase (LDH) and Creatine Kinase (CK) release to evaluate the extent of cardiac injury. The oxidative stress in heart was evaluated by measuring Thiobarbituric Acid Reactive Substances (TBARS), superoxide dismutase (SOD) generation and reduced form of glutathione. Result: In the current investigation, Ischemia-reperfusion (I/R) induced oxidative stress by increasing TBARS, superoxide anion generation and the decreased form of glutathione in normal and diabetic rat heart. Moreover, I/R induced myocardial injury, was evaluated in terms of increase in, LDH and CK release in coronary effluent, and reduction in coronary flow rate in normal and diabetic rat heart. The diabetic rat heart showed enhanced I/R induced myocardial injury with high extent of oxidative stress as compared with normal rat heart subjected to I/R Six episodes of IPOC afforded cardioprotection against I/R induced myocardial injury in normal rat heart as assessed in terms of improvement of coronary flow rate and decrease of LDH, CK and oxidative stress. On other hand, IPOC mediated myocardial protection against I/R injury was nullified in diabetic rat heart. Fenofibrate (5µM), a selective agonist of PPAR alpha, its administration markedly restored the Cardioprotective potential of IPOC in diabetic rat heart. Conclusion: The current investigation presumed that, the high degree of oxidative stress produced in diabetic rat heart during reperfusion and resulting inactivation of PPAR alpha receptor might be responsible for abolishing the Cardioprotective potential of IPOC against I/R induced myocardial injury","PeriodicalId":93468,"journal":{"name":"Journal of medicine and healthcare","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44767322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic Inflammatory Demyelinating Polyneuropathy Incidence in Covid-19 and Covid-19 Vaccines","authors":"Simranjit Singh","doi":"10.47363/jmhc/2022(4)193","DOIUrl":"https://doi.org/10.47363/jmhc/2022(4)193","url":null,"abstract":"","PeriodicalId":93468,"journal":{"name":"Journal of medicine and healthcare","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47449235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute Pancreatitis in Children","authors":"R. Muthiah","doi":"10.47363/jmhc/2022(4)190","DOIUrl":"https://doi.org/10.47363/jmhc/2022(4)190","url":null,"abstract":"","PeriodicalId":93468,"journal":{"name":"Journal of medicine and healthcare","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70825904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the Multidimensional Comorbidity of ObsessiveCompulsive Disorder, Body Dysmorphic Disorders, and Eating Disorders: Theoretical and Practical Approaches to Treatment","authors":"E. Gorbis","doi":"10.47363/jmhc/2022(4)200","DOIUrl":"https://doi.org/10.47363/jmhc/2022(4)200","url":null,"abstract":"Research on obsessive-compulsive disorder (OCD), body dysmorphic disorder (BDD), and eating disorders (EDs), including anorexia and bulimia, has shown appreciable two-way comorbidity between these conditions, especially OCD and BDD. There are few, if any, however, assessments of the multidimensional comorbidity of OCD, BDD, and EDs. Here, we review the literature on prevalence and comorbidity of these disorders and estimate their three-way comorbidity. We calculate that multidimensional comorbidity of OCD, BDD, and EDs is present in about 1.5% of cases of primary OCD, 3.7% of cases of primary BDD and 9.8% of cases of primary EDs. We further provide recommendations for treatment of cases in which all three disorders appear together, beginning with the advice to treat that disorder first which poses the highest danger to the patient upon check in. for LVM.","PeriodicalId":93468,"journal":{"name":"Journal of medicine and healthcare","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47137184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distinction between Guillain-Barre Syndrome and Chronic Inflammatory Demyelinating Polyneuropathy","authors":"Simranjit Singh","doi":"10.47363/jmhc/2022(4)194","DOIUrl":"https://doi.org/10.47363/jmhc/2022(4)194","url":null,"abstract":"","PeriodicalId":93468,"journal":{"name":"Journal of medicine and healthcare","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48656279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cell Communication in Brain for Memory and Cognition","authors":"S. Phadnis","doi":"10.47363/jmhc/2022(4)191","DOIUrl":"https://doi.org/10.47363/jmhc/2022(4)191","url":null,"abstract":"Memory retention is the important topic of study in terms of Neurobiology. Cellular circuits involved in the nervous system is seen to be cordially communicating and establishing a network to transfer and store the data. The most extraordinary property of this cellular community is its ability to undergo adaptive modifications in response to environment, originating from inside or outside the body. Such ability, known as neuronal plasticity, allows long-lasting modifications of the strength, composition and efficacy of the connections between neurons, which constitutes the biochemical base for learning and memory. Neuronal and Non- neuronal cells both are involved in the process of memory. Cellular communication can be through release of chemical or a component or by releasing some biological structures like Extracellular vesicles. Also certain hormones are released by cells as a mean of communication and these hormones or cytokine like factors also assist in memory building process. We will further also see the action of these non- neuronal cells when implanted into a mice to check its memory retention.","PeriodicalId":93468,"journal":{"name":"Journal of medicine and healthcare","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46319849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic Inflammatory Demyelinating Polyneuropathy [CIDP]","authors":"Simranjit Singh","doi":"10.47363/jmhc/2022(4)196","DOIUrl":"https://doi.org/10.47363/jmhc/2022(4)196","url":null,"abstract":"","PeriodicalId":93468,"journal":{"name":"Journal of medicine and healthcare","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44588130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Prevalence of Work Related Wound and Associated Risk Factors in Working Equines","authors":"Alamne Hunegnaw Mekete","doi":"10.47363/jmhc/2022(4)192","DOIUrl":"https://doi.org/10.47363/jmhc/2022(4)192","url":null,"abstract":"Across-sectional study was conducted in Hawasssa town, the capital city of Southern Nations and Nationalities People Regional state; to estimate the prevalence of work related wound and associated risk factors in working equines. The study animals were selected randomly. A total of 309 equines were included in the study comprising 164 (53.1%) of donkey, 95(30.74%) of horses, and 50(16.18%) of mules. The risk factors sex, age, body condition scores, purpose of the animals were assessed through questionnaire survey and physical clinical examination of animals. The study shows that an overall prevalence of external injuries in working equines was 84.1%. The prevalence of external injuries by the species was 25.89%, 45.95% and 12.3% for horse, donkey and mule respectively. Statistically significant difference (p<0.05) in the occurrence of external injuries was noted among working equines of different sex groups, different functions, and different causes. Higher prevalence of external injuries was recorded in male animals (79.93%) than female (4.6%). Moreover, the occurrence of external injuries was higher in equines used for cart pool (40.77%) than those used for fetching of water (14.28%). In addition to this the distribution rate of external injuries between animals of different body condition showed that the highest rate was recorded in animals with medium body condition (31.39%) followed by those with good condition (27.18%).The major causes of external injury was inappropriate use of harness materials (33.7%) followed by over load and falling (12.3%). The prevalence of distribution of wounds on various body parts, was (23.46%) on the back which was relatively highest than shoulder, multiple body parts and wither which represent 11.5%, 10.77% and 8.1% respectively. The occurrence of external injuries in horses were 18.75% multiple wounds, 17.5% on the back and 15% on the shoulder while 23.24% on the back, 9.86 on wither and 8.45% multiple wounds, were found in donkeys. The occurrence of 36.86% of external injuries in the back of mule was observed in the study which was higher than other parts of the body. The study showed that working equine owners practice different approaches (70.4%) to manage wounds while 29.6% owners left their animals without any follow up. Hence, greater proportion of the owners (40%) have taken their animals to nearby health centers, while treated with medicine purchased from local markets 11.5% and 9.6% with medical plants. Relatively horse owners seek veterinarian services (43.5%).","PeriodicalId":93468,"journal":{"name":"Journal of medicine and healthcare","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43290508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}