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International journal of cardiology and cardiovascular diseases最新文献

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The functional importance of the left atrium in patients with coronary slow flow phenomenon 冠状动脉慢血流现象患者左心房功能的重要性
International journal of cardiology and cardiovascular diseases Pub Date : 2021-12-31 DOI: 10.46439/cardiology.1.011
{"title":"The functional importance of the left atrium in patients with coronary slow flow phenomenon","authors":"","doi":"10.46439/cardiology.1.011","DOIUrl":"https://doi.org/10.46439/cardiology.1.011","url":null,"abstract":"","PeriodicalId":93449,"journal":{"name":"International journal of cardiology and cardiovascular diseases","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78118325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Older women and cardiac rehabilitation: Next steps on the journey 老年妇女和心脏康复:旅程的下一步
International journal of cardiology and cardiovascular diseases Pub Date : 2021-12-31 DOI: 10.46439/cardiology.1.012
{"title":"Older women and cardiac rehabilitation: Next steps on the journey","authors":"","doi":"10.46439/cardiology.1.012","DOIUrl":"https://doi.org/10.46439/cardiology.1.012","url":null,"abstract":"","PeriodicalId":93449,"journal":{"name":"International journal of cardiology and cardiovascular diseases","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83703540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mechanisms of troponin release into serum in cardiac injury associated with COVID-19 patients. COVID-19相关心脏损伤患者肌钙蛋白向血清释放的机制
International journal of cardiology and cardiovascular diseases Pub Date : 2021-01-01 Epub Date: 2021-03-08 DOI: 10.46439/cardiology.1.006
R John Solaro, Paola C Rosas, Paulina Langa, Chad M Warren, Beata M Wolska, Paul H Goldspink
{"title":"Mechanisms of troponin release into serum in cardiac injury associated with COVID-19 patients.","authors":"R John Solaro, Paola C Rosas, Paulina Langa, Chad M Warren, Beata M Wolska, Paul H Goldspink","doi":"10.46439/cardiology.1.006","DOIUrl":"10.46439/cardiology.1.006","url":null,"abstract":"<p><p>Serum levels of thin filament proteins, cardiac troponin T (cTnT) and cardiac troponin I (cTnI) employing high sensitivity antibodies provide a state-of-the art determination of cardiac myocyte injury in COVID-19 patients. Although there is now sufficient evidence of the value of these determinations in patients infected with SARS-CoV-2, mechanisms of their release have not been considered in depth. We summarize the importance of these mechanisms with emphasis on their relation to prognosis, stratification, and treatment of COVID-19 patients. Apart from frank necrotic cell death, there are other mechanisms of myocyte injury leading to membrane fragility that provoke release of cTnT and cTnI. We discuss a rationale for understanding these mechanisms in COVID-19 patients with co-morbidities associated with myocyte injury such as heart failure, hypertension, arrythmias, diabetes, and inflammation. We describe how understanding these significant aspects of these mechanisms in the promotion of angiotensin signaling by SARS-CoV-2 can affect treatment options in the context of individualized therapies. Moreover, with likely omic data related to serum troponins and with the identification of elevations of serum troponins now more broadly detected employing high sensitivity antibodies, we think it is important to consider molecular mechanisms of elevations in serum troponin as an element in clinical decisions and as a critical aspect of development of new therapies.</p>","PeriodicalId":93449,"journal":{"name":"International journal of cardiology and cardiovascular diseases","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8562719/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39842278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High-resolution 3D fluorescent imaging of intact tissues 完整组织的高分辨率三维荧光成像
International journal of cardiology and cardiovascular diseases Pub Date : 2019-11-26 DOI: 10.46439/cardiology.1.001
Danny El-Nachef, A. Martinson, Xiulan Yang, C. Murry, W., R. Maclellan
{"title":"High-resolution 3D fluorescent imaging of intact tissues","authors":"Danny El-Nachef, A. Martinson, Xiulan Yang, C. Murry, W., R. Maclellan","doi":"10.46439/cardiology.1.001","DOIUrl":"https://doi.org/10.46439/cardiology.1.001","url":null,"abstract":"Histological analysis of fluorescently labeled tissues has been a critical tool to understand molecular organization in situ. However, assessing molecular structures within large cells and in the context of human organ anatomy has been challenging because it requires penetration of staining reagents and light deep into opaque tissues, while also conforming to the spatial constraints of high-resolution objective lenses. This methodology article describes optimized sample preparation for sub-micron resolution 3D imaging in human and rodent tissues, yielding imaging depth (>100 µm) and resolution (<0.012 µm3 voxel size) that has previously been limited to whole-mount in vitro organoid systems, embryos, and small model organisms. Confocal images of adult human and rodent organs, including heart, kidney, and liver, were generated for several chemical and antibody stains in cleared tissue sections >100 µm thick. This method can be readily adopted by any lab performing routine histology and takes 3 days from the start of tissue preparation to 3D images.","PeriodicalId":93449,"journal":{"name":"International journal of cardiology and cardiovascular diseases","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91078151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retrospective evaluation of heart failure verification and relation to readmission and all-cause mortality in a community-based cohort 以社区为基础的队列中心力衰竭验证及其与再入院和全因死亡率的关系的回顾性评估
International journal of cardiology and cardiovascular diseases Pub Date : 1900-01-01 DOI: 10.46439/cardiology.1.005
{"title":"Retrospective evaluation of heart failure verification and relation to readmission and all-cause mortality in a community-based cohort","authors":"","doi":"10.46439/cardiology.1.005","DOIUrl":"https://doi.org/10.46439/cardiology.1.005","url":null,"abstract":"","PeriodicalId":93449,"journal":{"name":"International journal of cardiology and cardiovascular diseases","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81209390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Therapeutic antibody approach for pulmonary arterial hypertension 肺动脉高压的抗体治疗方法
International journal of cardiology and cardiovascular diseases Pub Date : 1900-01-01 DOI: 10.46439/cardiology.1.002
{"title":"Therapeutic antibody approach for pulmonary arterial hypertension","authors":"","doi":"10.46439/cardiology.1.002","DOIUrl":"https://doi.org/10.46439/cardiology.1.002","url":null,"abstract":"","PeriodicalId":93449,"journal":{"name":"International journal of cardiology and cardiovascular diseases","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75845246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Risk of aerosol transmission of SARS-CoV-2 in cardiovascular care 心血管护理中SARS-CoV-2气溶胶传播的风险
International journal of cardiology and cardiovascular diseases Pub Date : 1900-01-01 DOI: 10.46439/cardiology.1.003
{"title":"Risk of aerosol transmission of SARS-CoV-2 in cardiovascular care","authors":"","doi":"10.46439/cardiology.1.003","DOIUrl":"https://doi.org/10.46439/cardiology.1.003","url":null,"abstract":"","PeriodicalId":93449,"journal":{"name":"International journal of cardiology and cardiovascular diseases","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86697003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A twin herbal formula has gained sufficient clinical and laboratory evidences to be accepted as an effective cardio-vascular protective supplement 一种双草药配方已经获得了足够的临床和实验室证据，被接受为有效的心血管保护补充剂
International journal of cardiology and cardiovascular diseases Pub Date : 1900-01-01 DOI: 10.46439/cardiology.1.004
{"title":"A twin herbal formula has gained sufficient clinical and laboratory evidences to be accepted as an effective cardio-vascular protective supplement","authors":"","doi":"10.46439/cardiology.1.004","DOIUrl":"https://doi.org/10.46439/cardiology.1.004","url":null,"abstract":"","PeriodicalId":93449,"journal":{"name":"International journal of cardiology and cardiovascular diseases","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79154173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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