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Rhyme or reason in therapeutics 治疗学中的韵律或道理
IF 1.3
BJPsych Advances Pub Date : 2023-01-31 DOI: 10.1192/bja.2023.1
John Cookson, J. Pimm
{"title":"Rhyme or reason in therapeutics","authors":"John Cookson, J. Pimm","doi":"10.1192/bja.2023.1","DOIUrl":"https://doi.org/10.1192/bja.2023.1","url":null,"abstract":"SUMMARY This editorial introduces the BJPsych Advances special issue on biological psychiatry.","PeriodicalId":9336,"journal":{"name":"BJPsych Advances","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2023-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84340452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Partial agonists of dopamine receptors: clinical effects and dopamine receptor interactions in combining aripiprazole with a full antagonist in treating psychosis 多巴胺受体部分激动剂:阿立哌唑与完全拮抗剂联合治疗精神病的临床效果和多巴胺受体相互作用
IF 1.3
BJPsych Advances Pub Date : 2023-01-27 DOI: 10.1192/bja.2022.86
J. Cookson, J. Pimm, G. Reynolds
{"title":"Partial agonists of dopamine receptors: clinical effects and dopamine receptor interactions in combining aripiprazole with a full antagonist in treating psychosis","authors":"J. Cookson, J. Pimm, G. Reynolds","doi":"10.1192/bja.2022.86","DOIUrl":"https://doi.org/10.1192/bja.2022.86","url":null,"abstract":"SUMMARY Partial agonists of dopamine receptors are used in combination with full antagonists in treating psychosis, either to mitigate side-effects or in the hope of increasing effectiveness. We examine how combinations may affect the occupancy of D2/D3 dopamine receptors and explore how these can explain the outcomes in the light of the dopamine hypothesis of psychosis. The combinations considered here are from published studies combining aripiprazole with amisulpride, with risperidone in people with hyperprolactinaemia and with olanzapine to mitigate weight gain. We discuss possible worsening of symptoms by the addition of a partial agonist or switching. We also examine the potentially adverse interaction with a full antagonist such as haloperidol given during a subsequent relapse to control severe agitation.","PeriodicalId":9336,"journal":{"name":"BJPsych Advances","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2023-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75201298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Therapeutic monitoring of plasma clozapine and N-desmethylclozapine (norclozapine): practical considerations 血浆氯氮平和n -去甲基氯氮平(去氯氮平)的治疗监测:实际考虑
IF 1.3
BJPsych Advances Pub Date : 2023-01-27 DOI: 10.1192/bja.2022.71
R. Flanagan, S. Gee, S. Belsey, L. Couchman, J. Lally
{"title":"Therapeutic monitoring of plasma clozapine and N-desmethylclozapine (norclozapine): practical considerations","authors":"R. Flanagan, S. Gee, S. Belsey, L. Couchman, J. Lally","doi":"10.1192/bja.2022.71","DOIUrl":"https://doi.org/10.1192/bja.2022.71","url":null,"abstract":"SUMMARY Clozapine dose assessment in treatment-refractory schizophrenia is complicated. There is a narrow margin between an effective and a potentially toxic dose and wide inter-individual variation in clozapine metabolic capacity. Moreover, factors such as changes in smoking habit, infection/inflammation, co-prescription of certain drugs, notably fluvoxamine, and age alter the dose requirement within individuals. Therapeutic drug monitoring (TDM) of plasma clozapine and N-desmethylclozapine (norclozapine) can help assess adherence, guide dosage and guard against toxicity. This article gives an overview of clozapine pharmacokinetics and factors affecting clozapine dose requirements. It then outlines the procedures and processes of clozapine TDM, from taking the blood sample for laboratory assay or point-of-contact (finger-prick) testing (POCT) to interpreting and acting on the results.","PeriodicalId":9336,"journal":{"name":"BJPsych Advances","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2023-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89907255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Traumatised and on TikTok: from inside the psych ward 精神受到创伤，在抖音上:来自精神病房内部
IF 1.3
BJPsych Advances Pub Date : 2023-01-10 DOI: 10.1192/bja.2022.87
Damon Parsons
{"title":"Traumatised and on TikTok: from inside the psych ward","authors":"Damon Parsons","doi":"10.1192/bja.2022.87","DOIUrl":"https://doi.org/10.1192/bja.2022.87","url":null,"abstract":"\u0000 Faster internet speeds and ever-present mobile phones present a new challenge to psychiatric wards – the ability for patients to live stream their in-patient stays. What are the benefits and the risks to the patient streaming and the ward as a whole? This article is to help start a conversation about this unique problem and how health professionals might go about addressing it.","PeriodicalId":9336,"journal":{"name":"BJPsych Advances","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2023-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87787064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Empathy and the work of clinical psychiatrists: narrative review 同理心与临床精神科医生的工作:叙述性回顾
IF 1.3
BJPsych Advances Pub Date : 2023-01-10 DOI: 10.1192/bja.2022.80
A. Barrera, Saïk J. G. N. de La Motte de Broöns de Vauvert
{"title":"Empathy and the work of clinical psychiatrists: narrative review","authors":"A. Barrera, Saïk J. G. N. de La Motte de Broöns de Vauvert","doi":"10.1192/bja.2022.80","DOIUrl":"https://doi.org/10.1192/bja.2022.80","url":null,"abstract":"\u0000 Clinical research suggests that empathy is associated with better clinical outcomes in various areas of medical care, raising the question of whether a similar effect occurs in psychiatry. The aim of this review is to explore philosophical, neuroscientific and psychological perspectives on the concept of empathy in the context of the day-to-day work of clinical psychiatrists. The definition of empathy is outlined and sociodemographic factors, working conditions and psychiatrists’ beliefs that can potentially affect empathy in clinical encounters are explored; educational and training aspects are also reviewed. The review concludes suggesting that research on empathy is needed to understand contextual, training and relational factors that could benefit mental healthcare as well as the working conditions of clinical psychiatrists, both inextricably linked.","PeriodicalId":9336,"journal":{"name":"BJPsych Advances","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2023-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76498431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
The devil is in the detail: a critique of nine editorials published by the International Task Force on Benzodiazepines 细节决定成败:对苯二氮卓类药物国际工作组发表的九篇社论的评论
IF 1.3
BJPsych Advances Pub Date : 2023-01-09 DOI: 10.1192/bja.2022.62
Jaden Brandt
{"title":"The devil is in the detail: a critique of nine editorials published by the International Task Force on Benzodiazepines","authors":"Jaden Brandt","doi":"10.1192/bja.2022.62","DOIUrl":"https://doi.org/10.1192/bja.2022.62","url":null,"abstract":"\u0000 Since 2018, the International Task Force on Benzodiazepines (ITFB), a group of academic psychiatrists and academic psychologists, has advocated that clinical guidelines should change to promote benzodiazepines from second- to first-line treatment for anxiety disorders, accept their use as maintenance treatment for anxiety conditions (in particular, panic disorder) and increase their use in gastrointestinal disorders. There is merit in much of what the ITFB argues, but in this article I analyse four major claims it has made in opinion editorials that I believe are not fully supported by the available evidence.","PeriodicalId":9336,"journal":{"name":"BJPsych Advances","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2023-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73372791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Re-evaluating benzodiazepines for anxiety disorders – déjà-vu all over again? 重新评估苯二氮卓类药物治疗焦虑症的效果- déjà-vu再来一次?
IF 1.3
BJPsych Advances Pub Date : 2023-01-09 DOI: 10.1192/bja.2022.85
I. Anderson
{"title":"Re-evaluating benzodiazepines for anxiety disorders – déjà-vu all over again?","authors":"I. Anderson","doi":"10.1192/bja.2022.85","DOIUrl":"https://doi.org/10.1192/bja.2022.85","url":null,"abstract":"\u0000 Benzodiazepines have attracted controversy from shortly after their introduction. They have been subject to periodic calls for their use to be re-evaluated on the basis that their risks have been overstated and their benefits underappreciated. Claims made in recent editorials from the International Task Force on Benzodiazepines in support of their wider use are critiqued in this issue. I examine here whether there is a case to change the conclusions of previous reconsiderations of the question.","PeriodicalId":9336,"journal":{"name":"BJPsych Advances","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2023-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77943101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New from CPD eLearning CPD在线学习的新内容
IF 1.3
BJPsych Advances Pub Date : 2022-12-19 DOI: 10.1192/bja.2022.79
{"title":"New from CPD eLearning","authors":"","doi":"10.1192/bja.2022.79","DOIUrl":"https://doi.org/10.1192/bja.2022.79","url":null,"abstract":"","PeriodicalId":9336,"journal":{"name":"BJPsych Advances","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2022-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74920903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
BJA volume 29 issue 1 Cover and Back matter BJA第29卷第1期封面和封底
IF 1.3
BJPsych Advances Pub Date : 2022-12-19 DOI: 10.1192/bja.2022.84
{"title":"BJA volume 29 issue 1 Cover and Back matter","authors":"","doi":"10.1192/bja.2022.84","DOIUrl":"https://doi.org/10.1192/bja.2022.84","url":null,"abstract":"","PeriodicalId":9336,"journal":{"name":"BJPsych Advances","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2022-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79444700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Integrated care systems: can they deliver? 综合护理系统:它们能做到吗?
IF 1.3
BJPsych Advances Pub Date : 2022-12-19 DOI: 10.1192/bja.2022.78
R. Rao
{"title":"Integrated care systems: can they deliver?","authors":"R. Rao","doi":"10.1192/bja.2022.78","DOIUrl":"https://doi.org/10.1192/bja.2022.78","url":null,"abstract":"SUMMARY This commentary is a response to three articles on integrated care systems in this journal. It explores some aspects of the latest transformation of England's National Health Service (NHS) and raises some questions on the extent to which the proposed NHS Long Term Plan can deliver on the current challenges.","PeriodicalId":9336,"journal":{"name":"BJPsych Advances","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2022-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75662674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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