Adaptive medicine最新文献_第3页

Complexity and Diversity of Polycomb Group Proteins: How Do They Work? 多梳蛋白的复杂性和多样性:它们是如何工作的?

Adaptive medicine Pub Date : 2018-06-30 DOI: 10.4247/AM.2018.ABI204

Yi‐Chung Chien

引用次数: 0

Tumor Biomarkers in Nipple Discharge of Breast Cancer: Current Status and Future Perspectives 乳腺癌乳头溢液中的肿瘤生物标志物:现状和未来展望

Adaptive medicine Pub Date : 2018-06-30 DOI: 10.4247/AM.2018.ABI206

Yawen Wang

引用次数: 0

Evolving Vertebral Compression Fracture 发展中的椎体压缩性骨折

Adaptive medicine Pub Date : 2018-06-30 DOI: 10.4247/AM.2018.ABI208

Hung-Chieh Wu

引用次数: 0

Changes of Serum NO, IL-6 and TNF-α in the Qinghai-Tibet Plateau with High Altitude Alcoholic Liver Disease and Their Clinical Significances 青藏高原高原酒精性肝病患者血清NO、IL-6、TNF-α的变化及其临床意义

Adaptive medicine Pub Date : 2018-06-30 DOI: 10.4247/AM.2018.ABI200

Zhao Wu

引用次数: 0

Exacerbation of Mild Hypoxia on Acute Radiation Syndrome and Subsequent Mortality. 轻度缺氧对急性放射综合征的加重及随后的死亡率。

Adaptive medicine Pub Date : 2017-01-01 Epub Date: 2017-03-31 DOI: 10.4247/am.2017.abg170

Juliann G Kiang

{"title":"Exacerbation of Mild Hypoxia on Acute Radiation Syndrome and Subsequent Mortality.","authors":"Juliann G Kiang","doi":"10.4247/am.2017.abg170","DOIUrl":"10.4247/am.2017.abg170","url":null,"abstract":"Mild hypoxia induced by 20% hemorrhage results in increases in few cytokine concentrations and sclerostin levels in blood, but shows no changes in bone formation, bone marrow cellularity, and gastrointestinal (GI) integrity and no systemic bacterial infection as well as no subsequent mortality. On the other hand, severe hypoxia induced by 40% hemorrhage causes significant increases in most cytokine concentrations, GI injury, lung injury, systemic bacterial infection, cellular ATP reduction and subsequent mortality. The severe hypoxia drastically damages GI and lung morphology, elevates cytokine concentrations in blood and increases inducible nitric oxide synthase (iNOS) expression in cells that is mediated by transcription factors NF-κB/NF-IL6, subsequently producing free radicals that disrupt mitochondria. ATP depletion, p53 phosphorylation, and caspase-3 activation are found, suggesting cell apoptosis. As a result, mortality occurs. However, when mild hypoxia follows ionizing radiation, the mild hypoxia significantly enhances radiation-induced mortality and acute radiation syndrome, including injury of bone marrow, GI, kidney, and lung. The synergism also occurs at the molecular level, resulting in alteration of microRNAs, amplification of iNOS expression, cytokine increases, sepsis, and ATP depletion. This is the first demonstration of synergistic effects between mild hypoxia and ionizing radiation.","PeriodicalId":93243,"journal":{"name":"Adaptive medicine","volume":"9 1","pages":"28-33"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8491646/pdf/nihms-1737221.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39492016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Radiation Combined Injury: DNA Damage, Apoptosis, and Autophagy. 辐射复合损伤:DNA损伤、细胞凋亡和自噬。

Adaptive medicine Pub Date : 2010-04-30 DOI: 10.4247/AM.2010.ABA004

Juliann G Kiang, Bradley R Garrison, Nikolai V Gorbunov

{"title":"Radiation Combined Injury: DNA Damage, Apoptosis, and Autophagy.","authors":"Juliann G Kiang, Bradley R Garrison, Nikolai V Gorbunov","doi":"10.4247/AM.2010.ABA004","DOIUrl":"https://doi.org/10.4247/AM.2010.ABA004","url":null,"abstract":"Radiation combined injury is defined as an ionizing radiation exposure received in combination with other trauma or physiological insults. The range of radiation threats we face today includes everything from individual radiation exposures to mass casualties resulting from a terrorist nuclear incident, and many of these exposure scenarios include the likelihood of additional traumatic injury. Radiation combined injury sensitizes target organs and cells and exacerbates acute radiation syndrome. Organs and cells with high sensitivity to combined injury are the skin, the hematopoietic system, the gastrointestinal tract, spermatogenic cells, and the vascular system. Among its many effects, radiation combined injury results in decreases in lymphocytes, macrophages, neutrophils, platelets, stem cells, and tissue integrity; activation of the iNOS/NF-κB/NF-IL6 and p53/Bax pathways; and increases in DNA single and double strand breaks, TLR signaling, cytokine concentrations, bacterial infection, and cytochrome c release from mitochondria to cytoplasm. These alterations lead to apoptosis and autophagy and, as a result, increased mortality. There is a pressing need to understand more about the body's response to combined injury in order to be able to develop effective countermeasures, since few currently exist. In this review, we summarize what is known about how combined injury modifies the radiation response, with a special emphasis on DNA damage/repair, signal transduction pathways, apoptosis, and autophagy. We also describe current and prospective countermeasures relevant to the treatment and prevention of combined injury.","PeriodicalId":93243,"journal":{"name":"Adaptive medicine","volume":"2 1","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2010-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8491956/pdf/nihms-1739722.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39492015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 38