Psychosocial rehabilitation journal最新文献

Alternative Oxidase Transcription Factors AOD2 and AOD5 of Neurospora crassa Control the Expression of Genes Involved in Energy Production and Metabolism. 蟋蟀神经孢子的替代氧化酶转录因子 AOD2 和 AOD5 控制参与能量生产和代谢的基因的表达。

IF 2.6

Psychosocial rehabilitation journal Pub Date : 2017-02-09 DOI: 10.1534/g3.116.035402

Zhigang Qi, Kristina M Smith, Erin L Bredeweg, Natasa Bosnjak, Michael Freitag, Frank E Nargang

{"title":"Alternative Oxidase Transcription Factors AOD2 and AOD5 of Neurospora crassa Control the Expression of Genes Involved in Energy Production and Metabolism.","authors":"Zhigang Qi, Kristina M Smith, Erin L Bredeweg, Natasa Bosnjak, Michael Freitag, Frank E Nargang","doi":"10.1534/g3.116.035402","DOIUrl":"10.1534/g3.116.035402","url":null,"abstract":"In Neurospora crassa, blocking the function of the standard mitochondrial electron transport chain results in the induction of an alternative oxidase (AOX). AOX transfers electrons directly from ubiquinol to molecular oxygen. AOX serves as a model of retrograde regulation since it is encoded by a nuclear gene that is regulated in response to signals from mitochondria. The N. crassa transcription factors AOD2 and AOD5 are necessary for the expression of the AOX gene. To gain insight into the mechanism by which these factors function, and to determine if they have roles in the expression of additional genes in N. crassa, we constructed strains expressing only tagged versions of the proteins. Cell fractionation experiments showed that both proteins are localized to the nucleus under both AOX inducing and noninducing conditions. Furthermore, chromatin immunoprecipitation and high throughput sequencing (ChIP-seq) analysis revealed that the proteins are bound to the promoter region of the AOX gene under both conditions. ChIP-seq also showed that the transcription factors bind to the upstream regions of a number of genes that are involved in energy production and metabolism. Dependence on AOD2 and AOD5 for the expression of several of these genes was verified by quantitative PCR. The majority of ChIP-seq peaks observed were enriched for both AOD2 and AOD5. However, we also observed occasional sites where one factor appeared to bind preferentially. The most striking of these was a conserved sequence that bound large amounts of AOD2 but little AOD5. This sequence was found within a 310 bp repeat unit that occurs at several locations in the genome.","PeriodicalId":93140,"journal":{"name":"Psychosocial rehabilitation journal","volume":"13 1","pages":"449-466"},"PeriodicalIF":2.6,"publicationDate":"2017-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5295593/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80453965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modulation of Cytokines in Cancer Patients by Intravenous Ascorbate Therapy. 静脉注射抗坏血酸疗法对癌症患者细胞因子的调节作用

Psychosocial rehabilitation journal Pub Date : 2016-01-03 DOI: 10.12659/msm.895368

Nina Mikirova, Neil Riordan, Joseph Casciari

{"title":"Modulation of Cytokines in Cancer Patients by Intravenous Ascorbate Therapy.","authors":"Nina Mikirova, Neil Riordan, Joseph Casciari","doi":"10.12659/msm.895368","DOIUrl":"10.12659/msm.895368","url":null,"abstract":"Background: Cytokines play an important role in tumor angiogenesis and inflammation. There is evidence in the literature that high doses of ascorbate can reduce inflammatory cytokine levels in cancer patients. The objective of this study was to investigate the effect of treatment by intravenous vitamin C (IVC) on cytokines and tumor markers.Material/methods: With the availability of protein array kits allowing assessment of many cytokines in a single sample, we measured 174 cytokines and additional 54 proteins and tumor markers in 12 cancer patients before and after a series of IVC treatments.Results: Presented results show for our 12 patients the effect of treatment resulted in normalization of many cytokine levels. Cytokines that were most consistently elevated prior to treatments included M-CSF-R, Leptin, EGF, FGF-6, TNF-α, β, TARC, MCP-1,4, MIP, IL-4, 10, IL-4, and TGF-β. Cytokine levels tended to decrease during the course of treatment. These include mitogens (EGF, Fit-3 ligand, HGF, IGF-1, IL-21R) and chemo-attractants (CTAC, Eotaxin, E-selectin, Lymphotactin, MIP-1, MCP-1, TARC, SDF-1), as well as inflammation and angiogenesis factors (FGF-6, IL-1β, TGF-1).Conclusions: We are able to show that average z-scores for several inflammatory and angiogenesis promoting cytokines are positive, indicating that they are higher than averages for healthy controls, and that their levels decreased over the course of treatment. In addition, serum concentrations of tumor markers decreased during the time period of IVC treatment and there were reductions in cMyc and Ras, 2 proteins implicated in being upregulated in cancer.","PeriodicalId":93140,"journal":{"name":"Psychosocial rehabilitation journal","volume":"7 1","pages":"14-25"},"PeriodicalIF":0.0,"publicationDate":"2016-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4756791/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80466262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Review of Nonprofit personnel forms and guidelines. 审查非营利性人员表格和指导方针。

Psychosocial rehabilitation journal Pub Date : 1995-01-01 DOI: 10.1037/H0095490

Kendra Melanson

引用次数: 0

Remains to be seen. 还有待观察。

Psychosocial rehabilitation journal Pub Date : 1995-01-01 DOI: 10.1037/H0095507

I. D. Rutman

引用次数: 22

Community and workplace supports for individuals with severe mental illness in supported employment. 社区和工作场所为受支持就业的严重精神疾病患者提供支持。

Psychosocial rehabilitation journal Pub Date : 1995-01-01 DOI: 10.1037/H0095483

M. West, W. Parent

引用次数: 19

Exercise patterns of psychiatric patients admitted to a short-term inpatient unit. 短期住院精神病患者的运动模式。

Psychosocial rehabilitation journal Pub Date : 1995-01-01 DOI: 10.1037/H0095494

M. Auchus, K. Wood, N. Kaslow

引用次数: 4

Review of Readings in psychiatric rehabilitation. 精神康复方面的阅读资料回顾。

Psychosocial rehabilitation journal Pub Date : 1995-01-01 DOI: 10.1037/H0095492

S. George

引用次数: 0

Work performance over time for people with schizophrenia. 精神分裂症患者的长期工作表现。

Psychosocial rehabilitation journal Pub Date : 1995-01-01 DOI: 10.1037/H0095493

P. Lysaker, M. Bell

引用次数: 34

Review of Credibility part I: The struggle to be human, Credibility part II: The six disciplines of credibility, and Credibility: How leaders gain and lose it, why people demand it. 《诚信回顾》第一部分:做人的奋斗;《诚信》第二部分:诚信的六门学科;《诚信:领导者如何获得和失去诚信，人们为什么需要诚信》。

Psychosocial rehabilitation journal Pub Date : 1995-01-01 DOI: 10.1037/H0095488

A. Zipple, Patricia E. Holland

引用次数: 1

Review of Women of color: Integrating ethnic and gender identities in psychotherapy. 有色人种妇女综述:在心理治疗中整合种族和性别认同。

Psychosocial rehabilitation journal Pub Date : 1995-01-01 DOI: 10.1037/h0095471

L. Washington

引用次数: 0