Journal of experimental nephrology最新文献

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Toll-like receptor 3 signaling and human glomerular endothelial cells toll样受体3信号传导与人肾小球内皮细胞的关系
Journal of experimental nephrology Pub Date : 2020-12-31 DOI: 10.46439/nephrology.1.002
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引用次数: 0
In vitro analysis and cadaver feasibility study of a peritoneal dialysis catheter tungsten weighted anchor 腹膜透析置管钨重锚的体外分析及尸体可行性研究
Journal of experimental nephrology Pub Date : 2020-12-31 DOI: 10.46439/nephrology.1.005
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引用次数: 0
Usefulness to assess the disease progression and mortality risk profiles, in a population of chronic kidney disease patients followed by general practitioners and nephrologists 在全科医生和肾病学家随访的慢性肾病患者人群中评估疾病进展和死亡风险概况的有效性
Journal of experimental nephrology Pub Date : 2020-12-31 DOI: 10.46439/nephrology.1.003
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引用次数: 0
Beneficial effects of nicotinamide on hypertensive mice with impaired endothelial nitric oxide function 烟酰胺对内皮细胞一氧化氮功能受损的高血压小鼠的有益作用
Journal of experimental nephrology Pub Date : 2020-08-26 DOI: 10.46439/nephrology.1.001
Phillip K Huynh, Jennifer C. Wilder, S. Hiller, J. Hagaman, N. Takahashi, Nobuyo Maeda-Smithies, Feng Li
{"title":"Beneficial effects of nicotinamide on hypertensive mice with impaired endothelial nitric oxide function","authors":"Phillip K Huynh, Jennifer C. Wilder, S. Hiller, J. Hagaman, N. Takahashi, Nobuyo Maeda-Smithies, Feng Li","doi":"10.46439/nephrology.1.001","DOIUrl":"https://doi.org/10.46439/nephrology.1.001","url":null,"abstract":"Nicotinamide (Nam, amide form of niacin acid or nicotinate), a precursor for nicotinamide adenine dinucleotide (NAD+), is important for normal physiological function of organisms. Nam also suppresses mobilization of Ca2+ from sarcoplasmic reticulum into cytoplasm through inhibiting ADP-ribose cyclase. Previously, we have demonstrated that a pharmacological dose of Nam normalizes maternal blood pressure in mouse models of preeclampsia, a pregnancy related hypertensive disorder. We hypothesized that Nam could decrease blood pressure in hypertensive conditions unrelated to pregnancy. Nam at a dose of 500 mg/kg/day was given to wild type (WT) mice treated with L-NAME, endothelial nitric oxide synthase (eNOS)-null and renin transgenic (Renin-Tg) mice via drinking water. Blood pressure was measured by tail-cuff at different stages of treatment. The function and structure of kidneys of WT mice with L-NAME were determined at the end of the study. The gene expression of markers of inflammation and fibrosis in the kidneys of WT mice with L-NAME was also measured. Nam effectively prevented increase in blood pressure in L-NAME treated mice and decreased elevated blood pressure in eNOS-null mice. However, it did not alter high blood pressure in Renin-Tg mice. Nam prevented increase in urinary albumin excretion and collagen deposit in kidneys of WT mice treated with L-NAME. In addition, Nam significantly decreased the mRNA levels of the markers of inflammation and fibrosis in the kidneys of WT mice treated with L-NAME. Nam may execute beneficial effects on hypertensive conditions associated with eNOS dysfunction via suppressing inflammation. Because Nam is generally regarded as safe in humans, it merits further evaluation for the tailored treatment for the subgroup of hypertensive cases associated with impaired eNOS system.","PeriodicalId":93117,"journal":{"name":"Journal of experimental nephrology","volume":"54 56 1","pages":"1 - 8"},"PeriodicalIF":0.0,"publicationDate":"2020-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75924390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Beneficial effects of nicotinamide on hypertensive mice with impaired endothelial nitric oxide function. 烟酰胺对内皮细胞一氧化氮功能受损的高血压小鼠的有益作用。
Journal of experimental nephrology Pub Date : 2020-01-01
Phillip K Huynh, Jen Wilder, Sylvia Hiller, John Hagaman, Nobuyuki Takahashi, Nobuyo Maeda-Smithies, Feng Li
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引用次数: 0
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