Building Resilience at Universities: Role of Innovation and Entrepreneurship最新文献

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The impact of Risk Identification on IT Project Delivery in Qatar Public Sector 风险识别对卡塔尔公共部门IT项目交付的影响
Building Resilience at Universities: Role of Innovation and Entrepreneurship Pub Date : 2021-10-20 DOI: 10.29117/quarfe.2021.0159
Mutaz Oshi, Emad AbuShanab
{"title":"The impact of Risk Identification on IT Project Delivery in Qatar Public Sector","authors":"Mutaz Oshi, Emad AbuShanab","doi":"10.29117/quarfe.2021.0159","DOIUrl":"https://doi.org/10.29117/quarfe.2021.0159","url":null,"abstract":"Unmanaged project risks can jeopardize the project's success and outcome. To assist project managers in overcoming or reducing the impact of project risk, several risk management models and standards have been established. This study is aimed to assess the impact of identified IT project risk factors on project delivery (satisfaction) in Qatar’s public sector. A questionnaire consisting of identified risk factors was developed by reviewing related literature. Data were collected from the target sample and analyzed using SPSS and SmartPLS. The results demonstrated the impact of each of the nine identified risk factors with the dependent variable project delivery (satisfaction). The hypotheses analysis showed five hypotheses H1, H2, H5, H6, and H8 supporting the literature with a positive impact on project delivery (satisfaction). Those factors are namely, the Stakeholders, Business Process, Organizational, Technical, and Schedule with significant P-values of 0.030, 0.002, 0.028, 0.023, and 0.001, respectively. The other four hypotheses H3, H4, H7, and H9 are inconsistent with the literature, with (insignificant) high P-values resulting in a negative impact on project delivery (satisfaction). Those factors are namely, Project Management, Human resources, Budget, and External with P-values 0.164, 0.605, 0.096, 0.225, respectively. The researcher recommends that project management professionals consider the five identified risk factors with a positive impact as the most critical IT risk factors; the research findings serve as a foundation and guideline to help the project management community avoid project pitfalls commonly associated with poor risk management and project failure.","PeriodicalId":9295,"journal":{"name":"Building Resilience at Universities: Role of Innovation and Entrepreneurship","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87599819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhancing Pedestrian Safety through the Development of Advanced Operational Strategies for Crosswalks in Residential Areas 制定先进的住宅人行横道运作策略,加强行人安全
Building Resilience at Universities: Role of Innovation and Entrepreneurship Pub Date : 2021-10-20 DOI: 10.29117/quarfe.2021.0157
Q. Hussain, Wael K. M. Alhajyaseen, Mohamed Kharbeche
{"title":"Enhancing Pedestrian Safety through the Development of Advanced Operational Strategies for Crosswalks in Residential Areas","authors":"Q. Hussain, Wael K. M. Alhajyaseen, Mohamed Kharbeche","doi":"10.29117/quarfe.2021.0157","DOIUrl":"https://doi.org/10.29117/quarfe.2021.0157","url":null,"abstract":"Pedestrians are the most vulnerable group in the traffic. Every year approximately 40,000 pedestrians are killed in the world due to road traffic crashes. In the state of Qatar, the situations are even worse with around one-third of the total road traffic deaths coming from pedestrians. The main aim of this driving simulator study was to investigate the impact of different measures on driving behavior. To this end, five different treatments were tested and compared with the untreated condition. The treatment conditions included two detection-based measures (i.e., Variable Message Sign VMS and LED), two different road-marking conditions (i.e., Zigzag marking and road narrowing marking) and a physical road narrowing condition. Each condition was tested with a yield/stop controlled marked crosswalk for two situations. In the first situation (Situation PA) there was no pedestrian at the crosswalk, while the second situation was based on the presence of a pedestrian (Situation PP). The experiment was conducted using the driving simulator at Qatar University. Sixty-one volunteers possessing a valid Qatari driving license participated in the study. The collected data was analyzed for drivers’ yielding rates, vehicle-pedestrian interactions, and driving speed. The results showed that the three conditions, i.e., VMS, Narrowing and Physical were effective in improving drivers’ yielding rate up to 98.2%. In addition, we found that all the treatment conditions were effective in reducing drivers’ travel speed in Situation PP. Nevertheless, in the situation with no pedestrian present, the physical road narrowing outperformed the other conditions in terms of reducing travel speed. Taking into account the results from this study, we recommend Physical condition as a potentially effective and low-cost treatment for improving safety at yield/stop controlled crosswalks.","PeriodicalId":9295,"journal":{"name":"Building Resilience at Universities: Role of Innovation and Entrepreneurship","volume":"104 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87739172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Complexity and Use in Building Evaluation (CUBE2): The Modular Case of the BCR Corridors at Qatar University 建筑评估中的复杂性和使用(CUBE2):卡塔尔大学BCR走廊的模块化案例
Building Resilience at Universities: Role of Innovation and Entrepreneurship Pub Date : 2021-10-20 DOI: 10.29117/quarfe.2021.0202
S. Al-Thani, Lolwa Al-Mohannadi, Meera Al-Khulifi, Doha Elsaman, Mark David, H. Osama
{"title":"Complexity and Use in Building Evaluation (CUBE2): The Modular Case of the BCR Corridors at Qatar University","authors":"S. Al-Thani, Lolwa Al-Mohannadi, Meera Al-Khulifi, Doha Elsaman, Mark David, H. Osama","doi":"10.29117/quarfe.2021.0202","DOIUrl":"https://doi.org/10.29117/quarfe.2021.0202","url":null,"abstract":"The BCR Corridors at QU are notorious for wayfinding difficulties of end-users in the building complex. These navigation problems appear to arise due to the repetitive similarity of individual parts in its modular design, highly localized impediments to readability and visibility such as shading device screens and temporary installations, and the relationship of those different parts composing the collective whole of the BCR Corridors to the immediate surrounding context of the QU campus (Figure 1). The purpose of the “Complexity and Use in Building Evaluation” research project (CUBE2: QUST-2-CENG-2019-12) is to build on the research success of the post-occupancy cluster in the first demonstration project (CUBE1: QUST-2-CENG-2018-9). It includes continuing to develop a detailed post-occupancy dataset of movement and space use in buildings at QU. The goal is to contribute positively to future design refinements, alterations, and design of new university buildings at QU. We want to help create a world-class center of education and research where space use, interaction, and innovation are tactically ‘woven’ into the design and planning of the campus at various scales of the built environment. In the CUBE1 study, Major et al. (2019) were able to graphically illustrate building program/use and movement/space use patterns. It included quantifying the relationship between movement and spatial layout, and the significance of other end-user activities such as sitting and interacting in the common areas of the QU Women’s Engineering Building. It also included identifying adaptive re-use of classrooms and storage spaces for laboratory and office uses, leading to a shortage of storage spaces in the building. There was a consistent relationship (R^2=0.68, p < 0.001) between sitting and interacting unrelated to accessibility or metric area, i.e., the availability of seating was the dominant factor for casual encounter, mostly of students. Finally, there was a weak but consistent relationship (R^2=0.38, p < 0.001) between spatial layout and movement flows using space syntax modeling when allowing for the strongly programmatic differences (classrooms versus faculty offices) in different wings of the building (Major et al., 2019) (Figure 2). The post-occupancy evaluation findings in the CUBE1 project were largely consistent with previous results of space syntax research over the last 30 years for generative layouts such as office buildings, colleges, and research laboratories. Those results include the generative role of spatial layout for movement and casual encounter in buildings, the prescriptive effects of strong programmatic aspects (in this case, classroom location and course schedules) in causing some spaces to over-perform/underperform for some types of uses, most usually movement, and the singular importance for the provision of seating to facilitate consistent and robust use of spaces whether at the building or urban level (Hillier and Penn, 1991; Hilli","PeriodicalId":9295,"journal":{"name":"Building Resilience at Universities: Role of Innovation and Entrepreneurship","volume":"69 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86144952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development and In Vivo Testing of Smart Nanoparticles for Enhanced Anti-Cancer Activity and Reduced Cardiotoxicity Associated with Tyrosine Kinase Inhibitors 智能纳米颗粒的开发和体内测试增强抗癌活性和降低与酪氨酸激酶抑制剂相关的心脏毒性
Building Resilience at Universities: Role of Innovation and Entrepreneurship Pub Date : 2021-10-20 DOI: 10.29117/quarfe.2021.0088
H. Yalcin, Hissa F. Al-Thani, S. Shurbaji
{"title":"Development and In Vivo Testing of Smart Nanoparticles for Enhanced Anti-Cancer Activity and Reduced Cardiotoxicity Associated with Tyrosine Kinase Inhibitors","authors":"H. Yalcin, Hissa F. Al-Thani, S. Shurbaji","doi":"10.29117/quarfe.2021.0088","DOIUrl":"https://doi.org/10.29117/quarfe.2021.0088","url":null,"abstract":"Tyrosine kinase inhibitors (TKIs) are new generation of anti-cancer drugs with very high efficiency against cancer cells. However, TKIs are associated with severe cardiotoxicity limiting their clinical benefits. One TKI that has been developed recently but not explored much is Ponatinib. The use of nanoparticles as a better therapeutic agent to deliver anti-cancer drugs and reduce their cardiotoxicity has been recently considered. In this study, PLGA-PEG-PLGA nanoparticles were synthesized to deliver Ponatinib while reducing its cardiotoxicity for treatment of chronic myeloid leukemia. Shape, size, surface charge and drug uptake ability of these nanoparticles were assessed using transmission electron microscopy (TEM), ZetaSIZER NANO and high-performance liquid chromatography (HPLC). Cardiotoxicity of Ponatinib, unloaded and loaded PLGA-PEG-PLGA nanoparticles were studied on zebrafish model through measuring the survival rate and cardiac function parameters, to optimize efficient drug concentrations in an in vivo setting. These particles were tested on zebrafish cancer xenograft model in which, K562 cell line, was transplanted into zebrafish embryos. We showed that, at an optimal concentration (0.0025mg/ml), Ponatinib loaded PLGA-PEG-PLGA particles are non-toxic/non-cardio-toxic and are very efficient against cancer growth and metastasis. Zebrafish is a good animal model for investigating the cardiotoxicity associated with the anti-cancer drugs such as TKIs, to determine the optimum concentration of smart nanoparticles with the least side effects and to generate xenograft model of several cancer types. Also, PLGA-PEG-PLGA NPs could be good candidate for CML treatment, but their cellular internalization should be enhanced. This could be achieved by coating and labeling the surface of PLGA-PEG-PLGA NPs with specific ligands that are unique to CML cells.","PeriodicalId":9295,"journal":{"name":"Building Resilience at Universities: Role of Innovation and Entrepreneurship","volume":"176 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86224409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Influence of Critical Success Factors over the Performance of Infrastructure Projects in Qatar 关键成功因素对卡塔尔基础设施项目绩效的影响
Building Resilience at Universities: Role of Innovation and Entrepreneurship Pub Date : 2021-10-20 DOI: 10.29117/quarfe.2021.0187
Maryam Hussain Abal-Seqan, S. Pokharel, K. Naji
{"title":"Influence of Critical Success Factors over the Performance of Infrastructure Projects in Qatar","authors":"Maryam Hussain Abal-Seqan, S. Pokharel, K. Naji","doi":"10.29117/quarfe.2021.0187","DOIUrl":"https://doi.org/10.29117/quarfe.2021.0187","url":null,"abstract":"This thesis focuses on developing an understanding of factors that can help in increasing the project performance in Qatar and elsewhere. The understanding leads to focus on factors in the design, development and operation of the project. This research identifies 23 critical success factors in four different groups: top management support, project manager’s skills, project team’s skills, and stakeholder management knowledge. The work also identifies four main project success criteria: project delivery on time, within the budget, with the expected quality, and meeting stakeholder's satisfaction.","PeriodicalId":9295,"journal":{"name":"Building Resilience at Universities: Role of Innovation and Entrepreneurship","volume":"455 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82942614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Magnetorheological Elastomer (MRE) based Torsional Vibration Isolator for application in a Prototype Drilling Shaft 基于磁流变弹性体(MRE)的扭振隔振器在钻杆样机中的应用
Building Resilience at Universities: Role of Innovation and Entrepreneurship Pub Date : 2021-10-20 DOI: 10.29117/quarfe.2021.0047
Thaer M. I. Syam, Asan Gani Bin Abdul Muthalif
{"title":"Magnetorheological Elastomer (MRE) based Torsional Vibration Isolator for application in a Prototype Drilling Shaft","authors":"Thaer M. I. Syam, Asan Gani Bin Abdul Muthalif","doi":"10.29117/quarfe.2021.0047","DOIUrl":"https://doi.org/10.29117/quarfe.2021.0047","url":null,"abstract":"Magnetorheological Elastomer (MRE) is a type of smart composite material consisting of a polymer matrix embedded with ferromagnetic particles. In the presence of an external magnetic field, its mechanical properties, such as stiffness, changes make it attractive in vibration isolation applications. Unwanted vibration in machines can cause severe damage and machine breakdown. In Qatar, the extraction of the natural gas from the ground requires sophisticated drilling machines. In this work, a semi-active vibration isolator using MRE is proposed for a potential application in a drilling system to isolate the torsional vibration. MRE was fabricated with a 35% mass fraction (MF) consisting of silicon rubber and iron particles. It was fitted with aluminum couplers and attached to the shaft (drill string) to study its efficiency in vibration isolation under a magnetic field. Two tests were conducted on the drilling prototype setup used in this work; the first test was a hammer impact test. The torsional transfer function TTF analysis showed that the system's natural frequency has shifted from 13.9 Hz to 17.5 Hz by the influence of increasing magnetic field around the MRE. The results showed that the continuous rotational vibration amplitude of the prototype is attenuated by more than 40%.","PeriodicalId":9295,"journal":{"name":"Building Resilience at Universities: Role of Innovation and Entrepreneurship","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82915640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of SnO2 Nanoparticles’ Impact on local Pichoclorum Atomus Growth Performance, Cell Morphology and Metabolites Content SnO2纳米颗粒对局部皮藻生长性能、细胞形态和代谢物含量影响的评价
Building Resilience at Universities: Role of Innovation and Entrepreneurship Pub Date : 2021-10-20 DOI: 10.29117/quarfe.2021.0034
Touria Bounnit, I. Saadaoui, R. Rasheed, Hareb Al jabri, S. Sayadi, A. Ayesh
{"title":"Assessment of SnO2 Nanoparticles’ Impact on local Pichoclorum Atomus Growth Performance, Cell Morphology and Metabolites Content","authors":"Touria Bounnit, I. Saadaoui, R. Rasheed, Hareb Al jabri, S. Sayadi, A. Ayesh","doi":"10.29117/quarfe.2021.0034","DOIUrl":"https://doi.org/10.29117/quarfe.2021.0034","url":null,"abstract":"Oxide nanoparticles are among the most used nanomaterials and have received considerable attention over their potential ecological effects. Increasing investigations report toxicity of certain oxide nanoparticles, however, there are also studies showing opposite results, highlighting the fact that these nanoparticles may differ in their toxicological effects, which depend on particle variety and size, test organism species, and test method. The current study investigates the ecotoxicity of SnO2 nanoparticles on a local marine algae isolate. Five different concentrations (1, 5, 25, 50 and 100mg/L) were tested and the culture was followed for 72h. Algae growth, morphology and metabolites were followed each 24h. The obtained data showed that the SnO2 presented a toxicity on the algae growth that was decreasing with the dose, with lower doses presenting more negative impacts than the higher doses. In parallel, the slow growth observed at 1-5 mg/L was explained by the dramatic damages caused by the SnO2 on the cell morphology, which was detected using the scanning electronic microscopy. Indeed, this low negative impact of higher concentrations of SnO2 (50-100mg/L) is explained by the high agglomeration of ten particles leading to reduced effect on the cell morphology and health. Furthermore, and in accordance with the morphological data, the metabolites analysis data revealed that SnO2 nanoparticles induced stress, which was manifested by an increase in the lipid content and decrease in the proteins, a metabolite that is involved in the algal growth.","PeriodicalId":9295,"journal":{"name":"Building Resilience at Universities: Role of Innovation and Entrepreneurship","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88823456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spectrophotometric Determination of the Honey Bee Quality 用分光光度法测定蜜蜂品质
Building Resilience at Universities: Role of Innovation and Entrepreneurship Pub Date : 2021-10-20 DOI: 10.29117/quarfe.2021.0002
Mohammed Alsafran, Mohammed Akkbik, A. Ahmadi, Mohammad I. Ahmad
{"title":"Spectrophotometric Determination of the Honey Bee Quality","authors":"Mohammed Alsafran, Mohammed Akkbik, A. Ahmadi, Mohammad I. Ahmad","doi":"10.29117/quarfe.2021.0002","DOIUrl":"https://doi.org/10.29117/quarfe.2021.0002","url":null,"abstract":"Honey produced by bees from nectar in flowers and plants, is an aqueous supersaturated sugar solution, mainly monosaccharide (fructose and glucose) (70%–80%) and water (10%–20%). 5-Hydroxymethylfurfural (5-HMF) content in honey bee is an indicator of the purity. High concentration of 5-HMF in honey bee indicates overheating and poor storage conditions (The chemical properties of honey, free acids and total acids) significantly in correlation with the HMF content and provides parameters that are used to make quick assessments of honey quality (Khalil et al., 2010). The recommended value of 5-HMF (Alinorm 01/25, 2000) and the European Union (Directive 110/2001) in honey usually should not exceed 80 or 40 mg/kg, respectively. This work aims to examine the concentration of 5-Hydroxymethylfurfural (5-HMF) content in different Qatari honey bee samples as an indicator of the honey bee quality by using the reference White Method.","PeriodicalId":9295,"journal":{"name":"Building Resilience at Universities: Role of Innovation and Entrepreneurship","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83018118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anticancer Activity of Neosetophomone B, An Aquatic Fungal Secondary Metabolite, Against Hematological Malignancie S 水生真菌次级代谢物Neosetophomone B对血液恶性肿瘤的抗癌作用
Building Resilience at Universities: Role of Innovation and Entrepreneurship Pub Date : 2021-10-20 DOI: 10.29117/quarfe.2021.0106
S. Kuttikrishnan, K. Prabhu, T. Elimat, Ashraf Khalil, N. Oberlies, F. Alali, S. Uddin
{"title":"Anticancer Activity of Neosetophomone B, An Aquatic Fungal Secondary Metabolite, Against Hematological Malignancie S","authors":"S. Kuttikrishnan, K. Prabhu, T. Elimat, Ashraf Khalil, N. Oberlies, F. Alali, S. Uddin","doi":"10.29117/quarfe.2021.0106","DOIUrl":"https://doi.org/10.29117/quarfe.2021.0106","url":null,"abstract":"Cancer is one of the most life threatening diseases, causing nearly 13% death in the worldwide. Leukemia, cancer of the hematopoetic cells is the main cause of cancer death in adults and children. Therapeutic agents used in treatment of cancer are known to have narrow therapeutic window and tendency to develop resistance against some cancer cell lines thus, proposing a need to discover some novel agents to treat cancer. In the present study we investigated the anticancer activity of Neosetophomone B(NSP-B), an aquatic fungal metabolite isolated from Neosetophoma sp against leukemic cells (K562 and U937). MTT results demonstrated a dose dependent inhibition of cell proliferation in K562 and U937 cell lines. Annexin staining using flow cytometry indicated that NSP-B treatment cause a dose dependent apoptosis in leukemic cells.Western blot analysis showed that NSP-B mediated apoptosis involves sequential activation of caspase 9, 3 and poly (ADP-ribose) polymerase (PARP) cleavage. Furthermore NSP-B treatment of leukemic cells resulted in upregulation of pro-apoptotic proteins (Bax) with downregulation of anti-apoptotic proteins ( Bcl-2 ).Thus, present study focuses on exploring the mechanism of anticancer activity of NSP-B on leukemic cells, raising the possibility of its use as a novel therapeutic agent for hematological malignancies. Results: We sought to determine whether NSP-B suppresses the growth of leukemic cell lines. We tested a panel of leukemic cell lines with different doses of NSP-B. Cell viability decreased in a concentration-dependent manner in K562 and U937 cell lines. NSP-B induced apoptosis in K562 and U937 cell lines via downregulation of anti-apoptotic proteins and enhancement of pro-apoptotic proteins. NSP-B induced the activation of caspase cascade signaling pathway. Altogether our results suggest that the NSP-B plays an important role in apoptosis in leukemic cell lines .Conclusions: Our data provides insight on anticancer activities of NSP-B in leukemic cell lines (K562 and U937). NSP-B inhibit cell viability via inducing apoptosis. The NSP-B mediated apoptosis occurs via downregulation of anti-apoptotic proteins and enhancement of pro-apototic proteins, thereby activating the caspase-cascade signaling. Further studies are required to elicit role of NSP-B in regulating molecular pathway involved in the progression of cancer. Taken together, above results suggest that NSP-B may have a future therapeutic role in leukemia and possibly other hematological malignancies.","PeriodicalId":9295,"journal":{"name":"Building Resilience at Universities: Role of Innovation and Entrepreneurship","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80665860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Types and Severity of Medication-Errors with Automated Systems within Medication-Use Process: Systematic-Review 用药过程中自动化系统用药错误的类型和严重程度:系统综述
Building Resilience at Universities: Role of Innovation and Entrepreneurship Pub Date : 2021-10-20 DOI: 10.29117/quarfe.2021.0124
M. Mustafa, Najlaa Al-Qahtani, K. Yusuff
{"title":"Types and Severity of Medication-Errors with Automated Systems within Medication-Use Process: Systematic-Review","authors":"M. Mustafa, Najlaa Al-Qahtani, K. Yusuff","doi":"10.29117/quarfe.2021.0124","DOIUrl":"https://doi.org/10.29117/quarfe.2021.0124","url":null,"abstract":"Automated systems have been crucial to reducing medication errors and improving patient safety. However, their use has increased medication-errors associated with other factors:socio-technical interactions, automation bias, workarounds, and overrides. This comprehensive systematic review was conducted to identify types and severity of medication-errors associated with the use of automated system in all stages of the medication use process. This provides new perspectives that contribute significantly to global knowledge in the research area. Three databases were searched to include English-language observational and experimental studies(from 2000-2019) focused on types and severity of medication errors. A data-extraction form was developed, and quality was assessed using Hoy-et-al tool. The search yielded 860 articles after deduplication and thirteen were eligible. The bias risk was low for eight studies(62%) and moderate for five(38%). The medication-error types, and prevalence were omitted information(4-61%), wrong dose(4-30%), incorrect medication(1-18%), incorrect administration time(3-18%), and incorrect frequency(0.6%-21%) and occurred in the prescribing(62%) and administration(69%) stage. The error severity assessment used was NCC-MERP-index(46%), other(23%), or not conducted(31%). Omitted information and incorrect dose were the most common errors associated with automated systems in the prescribing and administration stages. However, the error severity and classification was inconclusive due to differences in study design and assessment criteria.","PeriodicalId":9295,"journal":{"name":"Building Resilience at Universities: Role of Innovation and Entrepreneurship","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86960546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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