Seminars in virology最新文献

Pythagorean fuzzy entropy measure-based complex proportional assessment technique for solving multi-criteria healthcare waste treatment problem. 基于毕达哥拉斯模糊熵度量的复杂比例评估技术，用于解决多标准医疗废物处理问题。

Seminars in virology Pub Date : 2022-01-01 Epub Date: 2022-01-04 DOI: 10.1007/s41066-021-00304-z

Rishikesh Chaurasiya, Divya Jain

{"title":"Pythagorean fuzzy entropy measure-based complex proportional assessment technique for solving multi-criteria healthcare waste treatment problem.","authors":"Rishikesh Chaurasiya, Divya Jain","doi":"10.1007/s41066-021-00304-z","DOIUrl":"10.1007/s41066-021-00304-z","url":null,"abstract":"With the increasing risk to human health and environmental issues, the selection of appropriate management and treatment of healthcare waste has become a major problem, especially in developing countries. There are various alternatives to dispose of health care waste. The important is to assess the best alternative among them. The assessment of each alternative should be done based on public health, psychological, economic, environmental, technological, and operational aspect. The selection of the best health care waste treatment (HCWT) alternative is a complicated, multi-criteria decision-making (MCDM) problem involving numerous disparate qualitative and quantitative features. Hence, in this research article, the MCDM method is presented for estimating and choosing the best alternative of HCWT by COPRAS technique in a Pythagorean fuzzy set (PFS). Here, in this paper, first of all, a new entropy measure on PFSs is proposed and its validity is studied. Thereafter, the MCDM technique Complex Proportional Assessment (COPRAS) is discussed in which the criteria weights are assessed by the proposed entropy measure and score function to enhance an efficacy and efficiency of the proposed technique. Furthermore, the above-defined technique is employed to resolve the real-life problem to obtain the best treatment alternative to disposal of the health care waste. Finally, sensitivity analysis is presented to rationale the proposed viewpoint for prioritizing HCWT alternatives.","PeriodicalId":92955,"journal":{"name":"Seminars in virology","volume":"7 1","pages":"917-930"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8723817/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72749570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cell Type-specific Gene Expression Profiling in the Mouse Liver. 小鼠肝脏细胞特异性基因表达谱分析

IF 1.2

Seminars in virology Pub Date : 2019-09-17 DOI: 10.3791/60242

Amber W Wang, Adam M Zahm, Kirk J Wangensteen

{"title":"Cell Type-specific Gene Expression Profiling in the Mouse Liver.","authors":"Amber W Wang, Adam M Zahm, Kirk J Wangensteen","doi":"10.3791/60242","DOIUrl":"10.3791/60242","url":null,"abstract":"Liver repopulation after injury is a crucial feature of mammals which prevents immediate organ failure and death after exposure of environmental toxins. A deeper understanding of the changes in gene expression that occur during repopulation could help identify therapeutic targets to promote the restoration of liver function in the setting of injuries. Nonetheless, methods to isolate specifically the repopulating hepatocytes are inhibited by a lack of cell markers, limited cell numbers, and the fragility of these cells. The development of translating ribosome affinity purification (TRAP) technology in conjunction with the Fah-/- mouse model to recapitulate repopulation in the setting of liver injury allows gene expression profiling of the repopulating hepatocytes. With TRAP, cell type-specific translating mRNA is rapidly and efficiently isolated. We developed a method that utilizes TRAP with affinity-based isolation of translating mRNA from hepatocytes that selectively express the green fluorescent protein (GFP)-tagged ribosomal protein (RP), GFP:RPL10A. TRAP circumvents the long time period required for fluorescence-activated cell sorting that could change the gene expression profile. Furthermore, since only the repopulating hepatocytes express the GFP:RPL10A fusion protein, the isolated mRNA is devoid of contamination from the surrounding injured hepatocytes and other cell types in the liver. The affinity-purified mRNA is of high quality and allows downstream PCR- or high-throughput sequencing-based analysis of gene expression.","PeriodicalId":92955,"journal":{"name":"Seminars in virology","volume":"8 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2019-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7507956/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72755825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chicken Anemia Virus: Induction of Apoptosis by a Single Protein of a Single-Stranded DNA Virus 鸡贫血病毒:单链DNA病毒的单个蛋白诱导细胞凋亡

Seminars in virology Pub Date : 1998-08-01 DOI: 10.1006/smvy.1998.0154

Mathieu H.M. Noteborn, Astrid A.A.M. Danen-van Oorschot, Alex J. van der Eb

引用次数: 30

Adenovirus E3 Proteins: 14.7K, RID, and gp19K Inhibit Immune-Induced Cell Death; Adenovirus Death Protein Promotes Cell Death 腺病毒E3蛋白:14.7K、RID和gp19K抑制免疫诱导的细胞死亡腺病毒死亡蛋白促进细胞死亡

Seminars in virology Pub Date : 1998-08-01 DOI: 10.1006/smvy.1998.0156

William S.M. Wold , Ann E. Tollefson

引用次数: 23

INTRODUCTION: Apoptosis in Virus Infection 前言:病毒感染中的细胞凋亡

Seminars in virology Pub Date : 1998-08-01 DOI: 10.1006/smvy.1998.0148

Lois K. Miller, Eileen White

引用次数: 8

Modulation of Apoptosis by Herpesviruses 疱疹病毒对细胞凋亡的调控

Seminars in virology Pub Date : 1998-08-01 DOI: 10.1006/smvy.1998.0151

Elliott Kieff , Thomas Shenk

引用次数: 23

Regulation of Apoptosis by Adenovirus E1A and E1B Oncogenes 腺病毒E1A和E1B癌基因对细胞凋亡的调控

Seminars in virology Pub Date : 1998-08-01 DOI: 10.1006/smvy.1998.0155

Eileen White

{"title":"Regulation of Apoptosis by Adenovirus E1A and E1B Oncogenes","authors":"Eileen White","doi":"10.1006/smvy.1998.0155","DOIUrl":"10.1006/smvy.1998.0155","url":null,"abstract":"<div>Adenovirus E1A promotes apoptosis by interacting with and inhibiting negative regulators of cell cycle control. Binding of E1A to, and inhibition of, the transcriptional coadaptor p300 promotes accumulation of the p53 tumor suppressor protein which induces apoptosis. By inhibiting p300, E1A prevents the transcriptional activation ofmdm-2,the product of which interacts with and promotes the degradation of p53. Thus the E1A–p300 interaction disables the negative feedback loop to control p53 levels, which left unrestrained, cause apoptosis rather than growth arrest. The E1B 19K protein functions analogously to Bcl-2 to inhibit apoptosis by E1A, p53, and multiple other stimuli. The E1B 19K protein functions by at least two independent mechanisms to inhibit apoptosis. First, the E1B 19K protein binds to the pro-apoptotic Bax protein to prevent loss of mitochondrial membrane potential, caspase activation, and apoptosis. Second, the E1B 19K protein inhibits caspase interaction by interfering with the function of adaptor molecules such as FADD and Ced-4 that interact with and activate caspases. By inhibiting FADD-dependent activation of the caspase FLICE, the E1B 19K protein can disable both the TNF-α- and the Fas-mediated death signaling pathways which play an important role in immune surveillance against virus infection and cancer. The E1B 19K protein binds to Ced-4, and presumably mammalian Ced-4 homologues, and thereby prevents caspase activation. Thus, the study of the mechanism of regulation of apoptosis by the adenovirus transforming proteins has revealed important regulatory steps in death signaling pathways.</div>","PeriodicalId":92955,"journal":{"name":"Seminars in virology","volume":"8 6","pages":"Pages 505-513"},"PeriodicalIF":0.0,"publicationDate":"1998-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1006/smvy.1998.0155","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"51142463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 76

Baculovirus Regulation of Apoptosis 杆状病毒调控细胞凋亡

Seminars in virology Pub Date : 1998-08-01 DOI: 10.1006/smvy.1998.0149

Lois K. Miller, William J. Kaiser, Somasekar Seshagiri

引用次数: 30

Author Index for Volume 8 第8卷作者索引

Seminars in virology Pub Date : 1998-08-01 DOI: 10.1006/smvy.1998.0157

引用次数: 0

Induction of Apoptosis by Influenza Virus 流感病毒诱导细胞凋亡

Seminars in virology Pub Date : 1998-08-01 DOI: 10.1006/smvy.1998.0153

Stacey Schultz-Cherry , Robert M. Krug , Virginia S. Hinshaw

引用次数: 45