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Journal of pancreatology最新文献

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Recent advances in diagnosis, treatment, and prognosis of IgG4-related autoimmune pancreatitis: a narrative review igg4相关自身免疫性胰腺炎的诊断、治疗和预后研究进展
Journal of pancreatology Pub Date : 2022-11-24 DOI: 10.1097/JP9.0000000000000112
Xin-Tian He, B. Sun, Y. Nie, Wen Zhang
{"title":"Recent advances in diagnosis, treatment, and prognosis of IgG4-related autoimmune pancreatitis: a narrative review","authors":"Xin-Tian He, B. Sun, Y. Nie, Wen Zhang","doi":"10.1097/JP9.0000000000000112","DOIUrl":"https://doi.org/10.1097/JP9.0000000000000112","url":null,"abstract":"Immunoglobulin G4 (IgG4)-related autoimmune pancreatitis (AIP), also known as “type 1 AIP,” is a rare, chronic, and fibroinflammatory disease manifested as obstructive jaundice and enlargement of the pancreas, usually accompanied by extra-pancreatic organ involvement. The understanding of IgG4-related AIP is gradually deepening. In this review, we summarized the basic concepts, common clinical manifestations, and new progress of the disease including diagnostic, therapeutic strategies, and prognosis mainly based on published case reports, cohort studies, meta-analyses, and guidelines in the past 5 years. Issues such as diagnostic markers, risk factors for relapse, and more effective treatment still need to be further studied.","PeriodicalId":92925,"journal":{"name":"Journal of pancreatology","volume":"5 1","pages":"202 - 209"},"PeriodicalIF":0.0,"publicationDate":"2022-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42966468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pancreatic ductal adenocarcinoma holds unique features to form an immunosuppressive microenvironment: a narrative review 胰腺导管腺癌具有形成免疫抑制微环境的独特特征:叙述回顾
Journal of pancreatology Pub Date : 2022-11-24 DOI: 10.1097/JP9.0000000000000109
Qiang Zhou, Dan Chen, Junfeng Zhang, Jifeng Xiang, Tao Zhang, Huaizhi Wang, Yanyan Zhang
{"title":"Pancreatic ductal adenocarcinoma holds unique features to form an immunosuppressive microenvironment: a narrative review","authors":"Qiang Zhou, Dan Chen, Junfeng Zhang, Jifeng Xiang, Tao Zhang, Huaizhi Wang, Yanyan Zhang","doi":"10.1097/JP9.0000000000000109","DOIUrl":"https://doi.org/10.1097/JP9.0000000000000109","url":null,"abstract":"Pancreatic ductal adenocarcinoma (PDAC) is the most common type and composes about 90% of pancreatic cancer featured with high intra-tumoral heterogeneity and poor prognosis, which has been considered the least immunogenic cancer for decades. However, this characterization might be over-simplistic, and more sophisticated approaches are needed to develop effective treatment strategies. In this review, we aim to summarize studies involving PDAC immunity in different aspects to provide a multidimensional recognition and comprehensively understanding of the mechanisms underlying the tumor microenvironment (TME) of PDAC. A database search of peer-reviewed articles published in English between 2003 and 2022 in PubMed and the Web of Science was performed. Original articles and review articles relevant to the topic were selected. We emphasized the importance of investigating tumor-infiltrating lymphocytes (TILs) in pancreatic cancer, especially focusing on CD8+ T cells, along with indicating potential therapeutic strategies to turn the immune-cold PDACs into the immune-hot ones.","PeriodicalId":92925,"journal":{"name":"Journal of pancreatology","volume":"5 1","pages":"174 - 185"},"PeriodicalIF":0.0,"publicationDate":"2022-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43632606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Learning robotic distal pancreatectomy – The force awakens 学习机器人远端胰腺切除术-力量觉醒
Journal of pancreatology Pub Date : 2022-10-11 DOI: 10.1097/jp9.0000000000000099
P. Müller, B. Müller-Stich, T. Hackert, F. Nickel
{"title":"Learning robotic distal pancreatectomy – The force awakens","authors":"P. Müller, B. Müller-Stich, T. Hackert, F. Nickel","doi":"10.1097/jp9.0000000000000099","DOIUrl":"https://doi.org/10.1097/jp9.0000000000000099","url":null,"abstract":"","PeriodicalId":92925,"journal":{"name":"Journal of pancreatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45249645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
GSDME with a moonlighting function in pancreatic ductal adenocarcinoma: a narrative review GSDME在胰腺导管腺癌中具有兼职功能:一篇叙述性综述
Journal of pancreatology Pub Date : 2022-10-11 DOI: 10.1097/JP9.0000000000000104
Bo-Nian Huang
{"title":"GSDME with a moonlighting function in pancreatic ductal adenocarcinoma: a narrative review","authors":"Bo-Nian Huang","doi":"10.1097/JP9.0000000000000104","DOIUrl":"https://doi.org/10.1097/JP9.0000000000000104","url":null,"abstract":"Pancreatic ductal adenocarcinoma (PDAC) originates in the exocrine pancreas and accounts for 95% of pancreatic cancers, with 5-year survival rates of approximately 10%. Multiple factors are involved in PDAC pathogenesis, including internal genetic alterations and external inflammation-related stimuli. Overflow of exocrine pancreatic enzymes caused by PDAC obstruction inevitably results in autolysis of surrounding normal cells and extracellular matrix, generating tissue damage-related inflammation; however, this process does not cause autolysis of PDAC cells. How tumor cells acquire resistance to pancreatic enzymatic digestion has been ignored for a long time. In this review, we discuss how PDAC cells mobilize gasdermin E, a pore-forming protein, to achieve resistance to autolysis by pancreatic digestive enzymes.","PeriodicalId":92925,"journal":{"name":"Journal of pancreatology","volume":"5 1","pages":"198 - 201"},"PeriodicalIF":0.0,"publicationDate":"2022-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45443853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Artery encasement on preoperative CT scan does not preclude radical surgery: a case report utilizing sub-adventitial divestment for artery-involving pancreatic cancer. 术前CT扫描显示的动脉包膜不排除根治性手术:一例使用亚外动脉剥离治疗动脉累及胰腺癌的病例报告。
Journal of pancreatology Pub Date : 2022-10-11 DOI: 10.1097/jp9.0000000000000100
B. Cai, Zipeng Lu, Y. Miao
{"title":"Artery encasement on preoperative CT scan does not preclude radical surgery: a case report utilizing sub-adventitial divestment for artery-involving pancreatic cancer.","authors":"B. Cai, Zipeng Lu, Y. Miao","doi":"10.1097/jp9.0000000000000100","DOIUrl":"https://doi.org/10.1097/jp9.0000000000000100","url":null,"abstract":"","PeriodicalId":92925,"journal":{"name":"Journal of pancreatology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44353140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Timing, approach, and treatment strategies for infected pancreatic necrosis: a narrative review 感染性胰腺坏死的时机、方法和治疗策略：叙述性综述
Journal of pancreatology Pub Date : 2022-10-11 DOI: 10.1097/JP9.0000000000000105
F. Cao, W. Mei, Fei Li
{"title":"Timing, approach, and treatment strategies for infected pancreatic necrosis: a narrative review","authors":"F. Cao, W. Mei, Fei Li","doi":"10.1097/JP9.0000000000000105","DOIUrl":"https://doi.org/10.1097/JP9.0000000000000105","url":null,"abstract":"ancreatic necrosis occurs in approximately 15% to 20% of patients with acute pancreatitis (AP); 1/3 of patients are diagnosed with infected pancreatic necrosis (IPN), which has a mortality rate of 30%. It is the chief reason for the second “death peak” of AP patients in the later stage of the disease. [1] As one of the most vital treatment methods for IPN, pancreatic necrosectomy has developed rapidly in the past 30 years, including improvements and breakthroughs in surgical timing, approach, and strategies, and a significant reduction in postoperative mortality from the initial 30% to 40%. In particular, with the innovation of laparoscopic and endoscopic tech- niques, pancreatic surgeons have more choices in the face of IPN. Currently, how to optimize treatment and maximize the benefits for IPN patients has become a topic of great concern and controversy in the treatment of IPN.","PeriodicalId":92925,"journal":{"name":"Journal of pancreatology","volume":"5 1","pages":"159 - 163"},"PeriodicalIF":0.0,"publicationDate":"2022-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44677971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exosome-mediated cell–cell communication within pancreatic cancer tumor microenvironment: a narrative review 胰腺癌症肿瘤微环境中外源介导的细胞-细胞通讯：叙述性综述
Journal of pancreatology Pub Date : 2022-10-11 DOI: 10.1097/JP9.0000000000000108
Cheng Qin, Bangbo Zhao, Yuanyang Wang, Tianhao Li, Zeru Li, Tianyu Li, Yutong Zhao, Weibin Wang
{"title":"Exosome-mediated cell–cell communication within pancreatic cancer tumor microenvironment: a narrative review","authors":"Cheng Qin, Bangbo Zhao, Yuanyang Wang, Tianhao Li, Zeru Li, Tianyu Li, Yutong Zhao, Weibin Wang","doi":"10.1097/JP9.0000000000000108","DOIUrl":"https://doi.org/10.1097/JP9.0000000000000108","url":null,"abstract":"The significance of exosomes has emerged in a variety of physiological processes and diseases. Pancreatic cancer remains one of the most lethal diseases at present. Recently, increasing evidence has suggested that exosomes are vital for mediating the elaborate interaction of highly heterogeneous cell clusters within the pancreatic tumor microenvironment, contributing to activating pancreatic stellate cells and cancer-associated fibroblasts, compromising immune cells, and enhancing angiogenesis. Besides their natural and intrinsic roles, exosomes may provide a novel potential way for pancreatic cancer management and therapy as well. Thus, exosomes not only mediate cellular communication during pancreatic cancer progression but also serve as a promising player in precise pancreatic cancer management and treatment. To comprehensively summarize the role of exosomes in pancreatic cancer, we searched the PubMed database and reviewed all relevant original studies.","PeriodicalId":92925,"journal":{"name":"Journal of pancreatology","volume":"6 1","pages":"1 - 7"},"PeriodicalIF":0.0,"publicationDate":"2022-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45022710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical application of 3D reconstruction in pancreatic surgery: a narrative review 三维重建在胰腺外科的临床应用综述
Journal of pancreatology Pub Date : 2022-10-11 DOI: 10.1097/JP9.0000000000000107
Yiming Zhang, Yuanyuan Yang, Shu-jie Chen, Jianbing Ji, Huiting Ge, Heguang Huang
{"title":"Clinical application of 3D reconstruction in pancreatic surgery: a narrative review","authors":"Yiming Zhang, Yuanyuan Yang, Shu-jie Chen, Jianbing Ji, Huiting Ge, Heguang Huang","doi":"10.1097/JP9.0000000000000107","DOIUrl":"https://doi.org/10.1097/JP9.0000000000000107","url":null,"abstract":"Progress in medicine requires not only innovation and development in the medical field but also the integration of the technology of other fields into the medical field. As an important technological advancement, three-dimensional (3D) reconstruction transforms traditional two-dimensional images into 3D images that are more consistent with the physiological habits of human eyes. It has been applied to the bones, heart, liver, and maxillofacial area, promoting the progress of medical technology and surgeons. This article introduces the progress of 3D reconstruction technology in the clinical application of pancreatic surgery, from the preoperative, intraoperative, and postoperative perspectives, as well as the education of young surgeons. It also puts forward new ideas for the further development of pancreatic surgery.","PeriodicalId":92925,"journal":{"name":"Journal of pancreatology","volume":"6 1","pages":"18 - 22"},"PeriodicalIF":0.0,"publicationDate":"2022-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48590164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of antagonist peptides and chelators on the diagnostic performance of PET/CT using gallium-68–labeled somatostatin receptor antagonists 拮抗肽和螯合剂对使用镓-68标记生长抑素受体拮抗剂的PET/CT诊断性能的影响
Journal of pancreatology Pub Date : 2022-10-11 DOI: 10.1097/JP9.0000000000000101
Haiqun Xing, Wenjia Zhu, Yue-juan Cheng, Qiao Yang, R. Jia, Hongguang Zhao, C. Bai, Li Huo, Wenming Wu
{"title":"Impact of antagonist peptides and chelators on the diagnostic performance of PET/CT using gallium-68–labeled somatostatin receptor antagonists","authors":"Haiqun Xing, Wenjia Zhu, Yue-juan Cheng, Qiao Yang, R. Jia, Hongguang Zhao, C. Bai, Li Huo, Wenming Wu","doi":"10.1097/JP9.0000000000000101","DOIUrl":"https://doi.org/10.1097/JP9.0000000000000101","url":null,"abstract":"Objective: Different SSTR2 antagonists have been developed. This study aims to evaluate the impact of different peptides and chelators on the diagnostic performance of SSTR2 antagonists in well-differentiated NETs. Methods: In this prospective study, participants were equally randomized into 2 arms: arm A, participants would undergo a whole-body 68Ga-NODAGA-LM3 PET/CT scan on the first day and 68Ga-DOTA-LM3 PET/CT scan on the second day; arm B, participants would undergo a whole-body 68Ga-NODAGA-LM3 PET/CT scan on the first day and 68Ga-NODAGA-JR11 PET/CT scan on the second day. Biodistribution in normal organs, lesion detection ability, and tumor uptakes were compared within each arm. Results: A total of 40 participants (age, 49.5 ± 13.4, 21 men), 20 in each arm, were recruited in the study. In arm A, 68Ga-DOTA-LM3 showed lower background. However, the lesion detection ability (overall lesion detected, 445 vs 548; P = .005) and the lesion uptake (overall lesions SUVmax, 19.8 ± 17.2 vs 35.3 ± 28.8; P < .001) was significantly lower than those of 68Ga-NODAGA-LM3. In arm B, both 68Ga-NODAGA-LM3 and 68Ga-NODAGA-JR11 showed similar biodistribution and lesion uptake (SUVmax, 28.5 ± 23.8 vs 25.0 ± 20.0; P < .001) despite minor differences. The lesion detection ability was the same between these 2 tracers (overall lesion detected, 503 vs 503). Conclusions: The diagnostic performance of SSTR2 antagonists was sensitive to chelators. Both 68Ga-NODAGA-LM3 and 68Ga-NODAGA-JR11 outperformed 68Ga-DOTA-LM3 with higher lesion uptake and detection ability, of which 68Ga-NODAGA-LM3 had marginally but significantly higher lesion uptake.","PeriodicalId":92925,"journal":{"name":"Journal of pancreatology","volume":"6 1","pages":"28 - 33"},"PeriodicalIF":0.0,"publicationDate":"2022-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45634219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acute necrotizing pancreatitis: challenges and interventions—a narrative review 急性坏死性胰腺炎：挑战与干预——叙述性综述
Journal of pancreatology Pub Date : 2022-10-11 DOI: 10.1097/JP9.0000000000000103
Yongde Luo, Le Li, R. Kong, Y. Sui, Bei Sun
{"title":"Acute necrotizing pancreatitis: challenges and interventions—a narrative review","authors":"Yongde Luo, Le Li, R. Kong, Y. Sui, Bei Sun","doi":"10.1097/JP9.0000000000000103","DOIUrl":"https://doi.org/10.1097/JP9.0000000000000103","url":null,"abstract":"Acute pancreatitis (AP) is a complicated disease with rising incidence over the years. Twenty percent of AP will develop into acute necrotizing pancreatitis (ANP). Interventions for ANP have evolved from traditional open surgery to minimally invasive step-up approaches. Infected pancreatic necrosis (IPN) is the most serious event of ANP and associated with extremely poor prognosis. The contrast-enhanced computed tomography(CECT)-based classification of IPN describes various types of IPN and will help to carry out surgical interventions for each subtype. Nevertheless, many challenges are still remaining during the treatment of ANP. Including the balance between endoscopic and surgical approaches, and the selection of optimal timing of surgical intervention for infected necrosis. In nowadays treatment scenario of ANP, the necessity for open surgery remains to be debated. Despite of the development of advanced interventional techniques, postoperative residual infection (PRI) remains thorny, and effective prevention and treatment of PRI is of significance.","PeriodicalId":92925,"journal":{"name":"Journal of pancreatology","volume":"5 1","pages":"164 - 173"},"PeriodicalIF":0.0,"publicationDate":"2022-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42794694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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