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International journal of blood research and disorders最新文献

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Impact of the Oscillating Bead Size and Shape on Induced Mechanical Stress on Red Blood Cells and Associated Hemolysis in Bead Milling 振荡珠的大小和形状对磨珠过程中红细胞机械应力和溶血的影响
International journal of blood research and disorders Pub Date : 2019-06-27 DOI: 10.23937/2469-5696/1410041
M. Tarasev, M. Muchnik, S. Chakraborty
{"title":"Impact of the Oscillating Bead Size and Shape on Induced Mechanical Stress on Red Blood Cells and Associated Hemolysis in Bead Milling","authors":"M. Tarasev, M. Muchnik, S. Chakraborty","doi":"10.23937/2469-5696/1410041","DOIUrl":"https://doi.org/10.23937/2469-5696/1410041","url":null,"abstract":"Citation: Tarasev M, Muchnik M, Chakraborty S (2019) Impact of the Oscillating Bead Size and Shape on Induced Mechanical Stress on Red Blood Cells and Associated Hemolysis in Bead Milling. Int J Blood Res Disord 6:041. doi.org/10.23937/2469-5696/1410041 Accepted: June 25, 2019: Published: June 27, 2019 Copyright: © 2019 Tarasev M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.","PeriodicalId":92793,"journal":{"name":"International journal of blood research and disorders","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44662908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Fatal Systemic Mucormycosis after Rabbit Anti-Thymocyte Globulin Therapy in a Severe Aplastic Anemia Patient 兔抗胸腺细胞球蛋白治疗严重再生障碍性贫血致死性全身毛霉病
International journal of blood research and disorders Pub Date : 2019-05-16 DOI: 10.23937/2469-5696/1410039
Tashiro Haruko, Oshima Yasutoshi, Sumiyoshi Ritsu, Matsuo Takuji, Y. Tadashi, M. Kensuke, Ooi Jun, Matsunaga Naohisa, Kikuchi Yoshinao, Shirafuji Naoki
{"title":"Fatal Systemic Mucormycosis after Rabbit Anti-Thymocyte Globulin Therapy in a Severe Aplastic Anemia Patient","authors":"Tashiro Haruko, Oshima Yasutoshi, Sumiyoshi Ritsu, Matsuo Takuji, Y. Tadashi, M. Kensuke, Ooi Jun, Matsunaga Naohisa, Kikuchi Yoshinao, Shirafuji Naoki","doi":"10.23937/2469-5696/1410039","DOIUrl":"https://doi.org/10.23937/2469-5696/1410039","url":null,"abstract":"Citation: Tashiro H, Oshima Y, Sumiyoshi R, Matsuo T, Yamamoto T, et al. (2019) Fatal Systemic Mucormycosis after Rabbit Anti-Thymocyte Globulin Therapy in a Severe Aplastic Anemia Patient. Int J Blood Res Disord 6:039. doi.org/10.23937/2469-5696/1410039 Accepted: May 14, 2019: Published: May 16, 2019 Copyright: © 2019 Tashiro H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.","PeriodicalId":92793,"journal":{"name":"International journal of blood research and disorders","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42749006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
MEK1/2 as a Therapeutic Target in Sickle Cell Disease MEK1/2作为镰状细胞病的治疗靶点
International journal of blood research and disorders Pub Date : 2019-04-04 DOI: 10.23937/2469-5696/1410038
R. Zennadi
{"title":"MEK1/2 as a Therapeutic Target in Sickle Cell Disease","authors":"R. Zennadi","doi":"10.23937/2469-5696/1410038","DOIUrl":"https://doi.org/10.23937/2469-5696/1410038","url":null,"abstract":"Identification of novel therapeutic targets has improved diagnostics and treatment of many diseases. Many innovative treatment strategies have been developed based on the newly identified biomarkers and key molecules. Most of the research focused on ways to manipulate signaling pathways by activating or suppressing them, validate new therapeutic targets for treatment, and epigenetic treatment of diseases. With the identification of aberrations in multiple growth pathways, the focus then shifted to the small molecules involved in these pathways for targeted therapy. In this communication/short review, we highlight the importance of identification of abnormal activation of the mitogen-activated protein kinase (MAPK), ERK1/2, and its upstream mediator MEK1/2, in erythrocytes in patients with sickle cell disease (SCD) critical for the adhesive interactions of these cells with the endothelium, and leukocytes promoting circulatory obstruction leading to tissue ischemia and infraction. We also discuss how targeting this signaling cascade with MEK1/2 inhibitors can reverse acute vasoocclusive crises in SCD.","PeriodicalId":92793,"journal":{"name":"International journal of blood research and disorders","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47111697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Lenalidomide Plus Dexamethasone is an Active Rescue Treatment for Myeloma with Severe Renal Impairment Failing to Bortezomib-Based Induction Therapy 来那度胺加地塞米松是一种积极的挽救治疗骨髓瘤严重肾功能损害失败硼替佐米为基础的诱导治疗
International journal of blood research and disorders Pub Date : 2018-12-31 DOI: 10.23937/2469-5696/1410031
M. Giuseppe, P. Domenico
{"title":"Lenalidomide Plus Dexamethasone is an Active Rescue Treatment for Myeloma with Severe Renal Impairment Failing to Bortezomib-Based Induction Therapy","authors":"M. Giuseppe, P. Domenico","doi":"10.23937/2469-5696/1410031","DOIUrl":"https://doi.org/10.23937/2469-5696/1410031","url":null,"abstract":"","PeriodicalId":92793,"journal":{"name":"International journal of blood research and disorders","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46303809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Results of the Single Center Pilot Randomized Russian Clinical Trial of Mesenchymal Stromal Cells in Severe Neutropenic Patients with Septic Shock (RUMCESS) 俄罗斯间充质基质细胞在严重中性粒细胞性败血症休克（RUMCESS）患者中的单中心试点随机临床试验结果
International journal of blood research and disorders Pub Date : 2018-12-31 DOI: 10.23937/2469-5696/1410033
Galstyan Gennadiy, M. Polina, Parovichnikova Elena, Kuzmina Larisa, T. Vera, Gemdzhian Eduard, S. Valeriy
{"title":"The Results of the Single Center Pilot Randomized Russian Clinical Trial of Mesenchymal Stromal Cells in Severe Neutropenic Patients with Septic Shock (RUMCESS)","authors":"Galstyan Gennadiy, M. Polina, Parovichnikova Elena, Kuzmina Larisa, T. Vera, Gemdzhian Eduard, S. Valeriy","doi":"10.23937/2469-5696/1410033","DOIUrl":"https://doi.org/10.23937/2469-5696/1410033","url":null,"abstract":"Citation: Galstyan G, Makarova P, Parovichnikova E, Kuzmina L, Troitskaya V, et al. (2018) The Results of the Single Center Pilot Randomized Russian Clinical Trial of Mesenchymal Stromal Cells in Severe Neutropenic Patients with Septic Shock (RUMCESS). Int J Blood Res Disord 5:033. doi. org/10.23937/2469-5696/1410033 Accepted: October 10, 2018: Published: October 12, 2018 Copyright: © 2018 Galstyan G, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.","PeriodicalId":92793,"journal":{"name":"International journal of blood research and disorders","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42638171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 14
Bioinformatics Analysis of Altered lncRNAs in Peripheral Blood Molecular Cells from Major Depressive Disorder (MDD) Patients 抑郁症患者外周血分子细胞lncRNA改变的生物信息学分析
International journal of blood research and disorders Pub Date : 2018-12-31 DOI: 10.23937/2469-5696/1410034
He Mingjun, Zhu Xiaoli, Niu Wei, K. Ling-ming, Yao Gaofeng, Zhang Li-yi
{"title":"Bioinformatics Analysis of Altered lncRNAs in Peripheral Blood Molecular Cells from Major Depressive Disorder (MDD) Patients","authors":"He Mingjun, Zhu Xiaoli, Niu Wei, K. Ling-ming, Yao Gaofeng, Zhang Li-yi","doi":"10.23937/2469-5696/1410034","DOIUrl":"https://doi.org/10.23937/2469-5696/1410034","url":null,"abstract":"Citation: He M, Zhu X, Niu W, Kong L, Yao G, et al. (2018) Bioinformatics Analysis of Altered lncRNAs in Peripheral Blood Molecular Cells from Major Depressive Disorder (MDD) Patients. Int J Blood Res Disord 5:034. doi.org/10.23937/2469-5696/1410034 Accepted: December 10, 2018: Published: December 12, 2018 Copyright: © 2018 He M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.","PeriodicalId":92793,"journal":{"name":"International journal of blood research and disorders","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43417577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Multiple Myeloma Associated with Dermatomyositis: A Short Report and Mini-Review 多发性骨髓瘤与皮肌炎:一个简短的报告和小型回顾
International journal of blood research and disorders Pub Date : 2018-12-31 DOI: 10.23937/2469-5696/1410029
I. M. Serajul, K. Pavel
{"title":"Multiple Myeloma Associated with Dermatomyositis: A Short Report and Mini-Review","authors":"I. M. Serajul, K. Pavel","doi":"10.23937/2469-5696/1410029","DOIUrl":"https://doi.org/10.23937/2469-5696/1410029","url":null,"abstract":"Citation: Islam MS, Kotoucek P (2018) Multiple Myeloma Associated with Dermatomyositis: A Short Report and Mini-Review. Int J Blood Res Disord 5:029. doi.org/10.23937/2469-5696/1410029 Accepted: June 18, 2018: Published: June 20, 2018 Copyright: © 2018 Islam MS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.","PeriodicalId":92793,"journal":{"name":"International journal of blood research and disorders","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43587775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Benign Lymphadenopathy Presented in a Malignant Pathway - A Rare Case of Proteinaceous Lymphadenopathy 以恶性途径表现的良性淋巴结病——一例罕见的蛋白缺乏性淋巴结病
International journal of blood research and disorders Pub Date : 2018-12-31 DOI: 10.23937/2469-5696/1410030
I. M. Serajul, K. Pavel
{"title":"Benign Lymphadenopathy Presented in a Malignant Pathway - A Rare Case of Proteinaceous Lymphadenopathy","authors":"I. M. Serajul, K. Pavel","doi":"10.23937/2469-5696/1410030","DOIUrl":"https://doi.org/10.23937/2469-5696/1410030","url":null,"abstract":"Citation: Islam MS, Kotoucek P (2018) Benign Lymphadenopathy Presented in a Malignant Pathway A Rare Case of Proteinaceous Lymphadenopathy. Int J Blood Res Disord 5:030. doi.org/10.23937/24695696/1410030 Accepted: June 28, 2018: Published: June 30, 2018 Copyright: © 2018 Islam MS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.","PeriodicalId":92793,"journal":{"name":"International journal of blood research and disorders","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43926806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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