International journal of anesthesiology & pain medicine最新文献_第5页

Strategic and operational considerations in designing and executing multicenter pain trials 设计和执行多中心疼痛试验的战略和操作考虑

International journal of anesthesiology & pain medicine Pub Date : 2019-01-01 DOI: 10.21767/2471-982x-c1-005

L. Ecochard

引用次数: 0

Factors that influence the appearance of dural post-puncture headache in patients undergoing elective cesarean section. 影响择期剖宫产患者穿刺后硬脑膜头痛出现的因素。

International journal of anesthesiology & pain medicine Pub Date : 2019-01-01 DOI: 10.36648/2471-982X.5.1.25

Graciela María Frías Carrazana, Y. Bazán, Y. O. Sánchez, Secundino González Pardo, Bernardo Blanco-Zamora, R. Martínez

{"title":"Factors that influence the appearance of dural post-puncture headache in patients undergoing elective cesarean section.","authors":"Graciela María Frías Carrazana, Y. Bazán, Y. O. Sánchez, Secundino González Pardo, Bernardo Blanco-Zamora, R. Martínez","doi":"10.36648/2471-982X.5.1.25","DOIUrl":"https://doi.org/10.36648/2471-982X.5.1.25","url":null,"abstract":"An epidemiological, observational, analytical and retrospective study of cases and controls was conducted with women undergoing elective cesarean section under spinal anesthesia at the Carlos Manuel de Cespedes Hospital in Bayamo, Granma province, from February 2013 to December 2015; with the objective of identifying the risk factors hypothetically related to the appearance of postpuncture dural headache in obstetric patients undergoing elective cesarean section. All the patients who gave their consent to participate, their data collection form was prepared for the study that collected the variables of the study. In addition, with each hypothetically influencing factor, the estimate of the benefit frame (OR) and its 95% confidence intervals (95% CI) and the hypothesis test of Chi to Square were performed. The age less than 25 years, the history of previous headache, the diameter of the needle of 20 and 22G, the greater number of puncture attempts and the position of the seated patient are the risk factors related to the appearance of post-puncture headache dural, but not the body mass index higher than 30 in obstetric patients undergoing elective cesarean section.","PeriodicalId":92652,"journal":{"name":"International journal of anesthesiology & pain medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.36648/2471-982X.5.1.25","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69705374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

A rare case of Intramedullary spinal ependymoma presenting as isolated neck pain 一例罕见的髓内脊髓室管膜瘤，表现为孤立的颈部疼痛

International journal of anesthesiology & pain medicine Pub Date : 2019-01-01 DOI: 10.21767/2471-982x-c1-006

K. Jhaveri

引用次数: 1

Control Release Anesthetics to Enable an Integrated Anesthetic-mesenchymal Stromal Cell Therapeutic. 控制释放麻醉剂以实现综合麻醉剂间充质基质细胞治疗。

International journal of anesthesiology & pain medicine Pub Date : 2016-01-01 Epub Date: 2016-08-02 DOI: 10.21767/2471-982X.100012

T Maguire, M Davis, I Marrero-Berrios, C Zhu, C Gaughan, J Weinberg, D Manchikalapati, J SchianodiCola, H Kamath, R Schloss, J Yarmush

{"title":"Control Release Anesthetics to Enable an Integrated Anesthetic-mesenchymal Stromal Cell Therapeutic.","authors":"T Maguire, M Davis, I Marrero-Berrios, C Zhu, C Gaughan, J Weinberg, D Manchikalapati, J SchianodiCola, H Kamath, R Schloss, J Yarmush","doi":"10.21767/2471-982X.100012","DOIUrl":"10.21767/2471-982X.100012","url":null,"abstract":"<p><p>While general anesthetics control pain via consciousness regulation, local anesthetics (LAs) act by decreasing sensation in the localized area of administration by blocking nerve transmission to pain centers. Perioperative intra-articular administration of LAs is a commonly employed practice in orthopedic procedures to minimize patient surgical and post-surgical pain and discomfort. LAs are also co-administered with cellular mesenchymal stromal cell (MSC) therapies for a variety of tissue regenerative and inflammatory applications including osteoarthritis (OA) treatment; however, LAs can affect MSC viability and function. Therefore, finding an improved method to co-administer LAs with cells has become critically important. We have developed a sustained release LA delivery model that could enable the co-administration of LAs and MSCs. Encapsulation of liposomes within an alginate matrix leads to sustained release of bupivacaine as compared to bupivacaine-containing liposomes alone. Furthermore, drug release is maintained for a minimum of 4 days and the alginate-liposome capsules mitigated the adverse effects of bupivacaine on MSC viability.</p>","PeriodicalId":92652,"journal":{"name":"International journal of anesthesiology & pain medicine","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21767/2471-982X.100012","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36992213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Tannin Inhibits Histamine and SLIGRL-NH2-Induced Itch viaTRPV1 and TRPA1 Signaling Pathway 单宁通过atrpv1和TRPA1信号通路抑制组胺和sligrl - nh2诱导的瘙痒

International journal of anesthesiology & pain medicine Pub Date : 2001-12-07 DOI: 10.56718/ijp.20-002

H. Jwa, Seunghoon Kim, Hawon Jeon, Gi Yeon Park, Jung Ju Choi, Chul-Kyu Park

{"title":"Tannin Inhibits Histamine and SLIGRL-NH2-Induced Itch via\u0000\u0000TRPV1 and TRPA1 Signaling Pathway","authors":"H. Jwa, Seunghoon Kim, Hawon Jeon, Gi Yeon Park, Jung Ju Choi, Chul-Kyu Park","doi":"10.56718/ijp.20-002","DOIUrl":"https://doi.org/10.56718/ijp.20-002","url":null,"abstract":"Background: Tannin is a naturally occurring plant polyphenol. Its main characteristic is that it displays anti-oxidant, anti-inflammatory, anti-viral, and anti-proliferative biological activities. However, the mechanism by which tannin impacts itch remains unknown. In the present study, through behavioral analysis and calcium imaging, we examined the mechanism by which tannin reduces histaminergic itch and non-histaminergic itch. Methods: First, we confirmed that tannin inhibited itch in the scratching test with histamine, compound 48/80, and SLIGRL-NH2 treatment. Second, we confirmed that tannin inhibited capsaicin- and AITC-induced calcium responses in primary-cultured DRG neurons. Third, tannin blocked the capsaicin- and AITC-induced calcium responses in TRPV1- and TRPA1-expressing HEK293 cells, respectively. Results: These results reveal that tannin reduced histamine-dependent or independent itching by activating inhibitory signals of TRPV1 and TRPA1. Conclusions: Thus, our findings suggest that tannin may be a promising drug for the treatment of histamine or non-histamine-dependent itch. fetal bovine serum (FBS; Gibco-BRL, USA) and 1% penicillin – streptomycin (Sigma, USA). Transfection was performed with Lipofectamine 2000 (Invitrogen) at 70-80% confluency, and transfected cells were cultured in the culture medium for 48 hours before calcium imaging analysis. TRPV1 plasmid vector or TRPA1 transfected HEK293 cells were provided by Seok bae Oh from Seoul University. variety of blockers and transgenic mice. Our results demonstrated that tannin alleviates histaminergic itch and non-histaminergic itch via inhibitory signaling of TRPV1 and TRPA1.","PeriodicalId":92652,"journal":{"name":"International journal of anesthesiology & pain medicine","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2001-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84731986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum: Amputation for the Treatment of Complex Regional Pain Syndrome 更正:截肢治疗复杂局部疼痛综合征

International journal of anesthesiology & pain medicine Pub Date : 2001-12-07 DOI: 10.56718/ijp.11-1_c

Kun Kim, Y. Lee, Kyu Hyun Park, Jihoon Hwang, Si Gweon Nam, Sungchul Park, Young Uk Park, Jae Woo Lee, Noah Kim, J. Choi

引用次数: 0

Acute Aggravation of Post Procedural Spondylodiscitis and Paraspinal Abscess without Epidural Space Involvement after Lumbar Percutaneous Epidural Neuroplasty (PEN) 腰椎经皮硬膜外神经成形术后未累及硬膜外间隙的腰椎椎间盘炎和棘旁脓肿急性加重

International journal of anesthesiology & pain medicine Pub Date : 2001-12-07 DOI: 10.56718/ijp.19-005

J. Won, S. Yoon, Junhyug Jeong, Bousung Lee, Kwang-Nam Lee, Dong-Sung Kim, Jaedo Lee, Rakmin Choi, Jaeyoung Yang

{"title":"Acute Aggravation of Post Procedural Spondylodiscitis and Paraspinal Abscess without Epidural Space Involvement after Lumbar Percutaneous Epidural Neuroplasty (PEN)","authors":"J. Won, S. Yoon, Junhyug Jeong, Bousung Lee, Kwang-Nam Lee, Dong-Sung Kim, Jaedo Lee, Rakmin Choi, Jaeyoung Yang","doi":"10.56718/ijp.19-005","DOIUrl":"https://doi.org/10.56718/ijp.19-005","url":null,"abstract":"Various complications after Percutaneous epidural neuroplasty (PEN), such as mechanical catheter failure, bleeding, infection, and neurological damage, were reported. A 79 years-old male suffered from spondylodiscitis and paraspinal muscle infection without epidural space involvement after lumbar PEN. The postprocedural infection was difficult to diagnose, because the patient didn’t have common signs and symptoms of infections such as fever, malaise, redness or swelling and hot sense around wound. After 7 weeks of antibiotics treatment, the hospital discharge decision was made, because his lab values and vital sign were almost normal. Most of all, he was symptom free. Early detection of post procedural infection followed by the early administration of antibiotics should be the most important therapeutic strategy for better prognosis. pain unresponsive to other conservative treatments and elevated inflammatory markers . Obtaining bacterial blood cultures and baseline ESR and CRP are required in all patients with suspected spondylodiscitis. Plain radiographs of the spine are not recommended method for the early diagnosis of spondylodiscitis. Erosion of the base and upper plates or increasingly destructive kyphosis can manifest after days or weeks [7]. MRI remains the gold standard for the radiological diagnosis with 92% sensitivity and 96% specificity. MRI findings include decreased signal intensity from disc and adjacent vertebral bodies on T1-weighted images, increased signal intensity on T2-weighted images and loss of endplate definition on T1 weighting. MRI is also useful to measure the spatial extent of the infection or abscess formation. MRI findings of abscess include the presence of a region of high T2 signal, with low T1 signal and without enhancement (usually surrounded by a rim of enhancement)","PeriodicalId":92652,"journal":{"name":"International journal of anesthesiology & pain medicine","volume":"70 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2001-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77002886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0